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List of works by Massimo Locati

2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.

scientific article published on June 2005

A membrane-proximal basic domain and cysteine cluster in the C-terminal tail of CCR5 constitute a bipartite motif critical for cell surface expression

scientific article published on 20 August 2001

ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity

scientific article published on 14 February 2018

Aberrant CXCR4 Signaling at Crossroad of WHIM Syndrome and Waldenstrom's Macroglobulinemia

scientific article published on 08 August 2020

Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14.

scientific article

Adenosine A2a receptor-mediated, normoxic induction of HIF-1 through PKC and PI-3K-dependent pathways in macrophages.

scientific article published on 15 May 2007

Allosteric inhibitors of chemoattractant receptors: opportunities and pitfalls

scientific article published on 20 April 2008

An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15.

scientific article

Anti-phospholipid antibody mediated fetal loss: still an open question from a pathogenic point of view

scientific article published on 01 April 2010

Anti-phospholipid induced murine fetal loss: novel protective effect of a peptide targeting the β2 glycoprotein I phospholipid-binding site. Implications for human fetal loss.

scientific article published on 22 December 2011

Atypical chemokine receptors: from silence to sound.

scientific article published on February 2013

Chemoattractant receptors and leukocyte recruitment: more than cell migration.

scientific article published on 24 February 2009

Chemokine decoy receptors: new players in reproductive immunology

scientific article published on January 2008

Chemokine receptors intracellular trafficking.

scientific article published on 06 May 2010

Chemokines and Cancer: A Fatal Attraction ⬇️

scientific article published on April 12, 2011

Chemokines and chemokine receptors: an overview.

scientific article published on January 2009

Chemokines as pharmacological targets

scientific article published on June 2008

Chemokines in immunopathology: From dark sides to clinical translation

Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

scientific article published in June 2004

Chemokines: a superfamily of chemotactic cytokines.

scientific article published on January 1996

Control of murine Ly6Chigh monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6

scientific article published on 13 April 2012

Convergent pathways of macrophage polarization: The role of B cells

scientific article published on 01 August 2010

Correction: Convergent pathways of macrophage polarization: The role of B cells

D6 as a Decoy and Scavenger Receptor for Inflammatory CC Chemokines in the Skin

Design of Noncompetitive Interleukin-8 Inhibitors Acting on CXCR1 and CXCR2

scientific article published on 01 August 2007

Differential regulation of chemokine production by Fcgamma receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2).

scientific article published on 30 May 2006

Differential regulation of iron homeostasis during human macrophage polarized activation

scientific article

Dissecting trafficking and signaling of atypical chemokine receptors.

scientific article

ERK-Dependent Downregulation of the Atypical Chemokine Receptor D6 Drives Tumor Aggressiveness in Kaposi Sarcoma

scientific article published on 02 April 2014

Effect of donepezil on the expression and responsiveness to LPS of CHRNA7 and CHRFAM7A in macrophages: A possible link to the cholinergic anti-inflammatory pathway

scientific article published on 24 April 2019

Encapsulated mesenchymal stem cells for in vivo immunomodulation

scientific article published on 18 July 2012

Epicardial fat thickness: relationship with plasma visfatin and plasminogen activator inhibitor-1 levels in visceral obesity.

scientific article published on 20 February 2008

Expression of chemokines and chemokine receptors in human colon cancer

scientific article

Expression of the atypical chemokine receptor D6 in human alveolar macrophages in COPD.

scientific article published in January 2013

Expression of the α7 nAChR subunit duplicate form (CHRFAM7A) is down-regulated in the monocytic cell line THP-1 on treatment with LPS.

scientific article published on January 2011

Extracellular and intracellular decoys in the tuning of inflammatory cytokines and Toll-like receptors: the new entry TIR8/SIGIRR.

scientific article published on 12 December 2003

Flow cytometry applications for the analysis of chemokine receptor expression and function

scientific article published on 24 January 2014

Gene expression profile activated by the chemokine CCL5/RANTES in human neuronal cells

scientific article

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

scientific article published on 4 January 2013

HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation.

scientific article published on August 1997

Hepatocyte growth factor enhances CXCR4 expression favoring breast cancer cell invasiveness.

scientific article published on October 2005

Housekeeping by chemokine scavenging

IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes

scientific article

IL-8 induces a specific transcriptional profile in human neutrophils: synergism with LPS for IL-1 production

article

Identification of serum and tissue micro-RNA expression profiles in different stages of inflammatory bowel disease

scientific article

Impact of the anti-inflammatory agent bindarit on the chemokinome: selective inhibition of the monocyte chemotactic proteins

scientific article

Increased inflammation in mice deficient for the chemokine decoy receptor D6.

scientific article

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals

scientific article

Inhibition of Monocyte Chemotaxis to C-C Chemokines by Antisense Oligonucleotide for Cytosolic Phospholipase A

scientific article published in Journal of Biological Chemistry

Interleukin 10 increases CCR5 expression and HIV infection in human monocytes

scientific article published on February 1998

International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors

scientific article

Interplay of inflammation, immunity, and organ-specific adiposity with cardiovascular risk.

scientific article published on 14 September 2014

Iron levels in polarized macrophages: regulation of immunity and autoimmunity.

scientific article published on 16 March 2012

Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype ⬇️

scientific article published on April 21, 2011

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

scholarly article by Peter J. Murray et al published August 2014 in Immunity

Macrophage activation and polarization

scientific article (publication date: 2008)

Macrophage activation and polarization as an adaptive component of innate immunity

scientific article published on January 2013

Macrophage activation and polarization: nomenclature and experimental guidelines

scientific article (publication date: 17 July 2014)

Macrophage diversity and polarization in atherosclerosis: a question of balance

scientific article published on 20 August 2009

Macrophage plasticity and polarization in tissue repair and remodelling

scientific article

Macrophage polarization comes of age.

scientific article

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

scientific article (publication date: November 2002)

Macrophages have a grip on the gut

scientific article published on 01 July 2014

MiR-146b Mediates Endotoxin Tolerance in Human Phagocytes

scientific article published on 14 September 2015

Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b

scientific article published on 24 June 2013

Never Underestimate the Power of a Neutrophil

New Insights on the Emerging Genomic Landscape of CXCR4 in Cancer: A Lesson from WHIM

scientific article published on 03 April 2020

New nomenclature for atypical chemokine receptors

scientific article published in March 2014

New vistas on macrophage differentiation and activation

scientific article published on January 2007

Non-signaling chemokine receptors: mechanism of action and role in vivo.

scientific article published on 02 June 2008

Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.

scholarly article

Notch1 regulates chemotaxis and proliferation by controlling the CC-chemokine receptors 5 and 9 in T cell acute lymphoblastic leukaemia

scientific article published on 09 December 2011

Orchestration of macrophage polarization

Phenotypic activation and pharmacological outcomes of spontaneously differentiated human monocyte-derived macrophages

scientific article published on 23 December 2014

Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice.

scientific article

Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways.

scientific article published on 14 August 2015

Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6.

scholarly article

Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor.

scientific article

Recognition versus adaptive up-regulation and degradation of CC chemokines by the chemokine decoy receptor D6 are determined by their N-terminal sequence

scientific article published on 24 July 2009

Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation

scientific article published on 14 May 2008

Regulatory pathways in inflammation

scientific article published on 26 March 2007

Review: Structure-function and biological properties of the atypical chemokine receptor D6.

scientific article published on 29 August 2012

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology

scientific article published on 8 November 2011

Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection

scientific article published on 11 August 2008

Role of the chemokine scavenger receptor D6 in balancing inflammation and immune activation

scientific article published in January 2009

Selective induction of phospholipase D1 in pathogen-activated human monocytes

scientific article

Selective modulation of protein kinase A I and II reveals distinct roles in thyroid cell gene expression and growth.

scientific article published on 3 August 2006

Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.

scientific article

Shaping and tuning of the chemokine system by regulation of receptor expression and signaling: dendritic cells as a paradigm.

scientific article

Silent chemoattractant receptors: D6 as a decoy and scavenger receptor for inflammatory CC chemokines

scientific article

Synergism Between Platelet Activating Factor and C-C Chemokines for Arachidonate Release in Human Monocytes

scientific article published on 01 March 1994

Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects

scientific article (publication date: March 2009)

Synergy-inducing chemokines enhance CCR2 ligand activities on monocytes

scientific article published in April 2009

Systemic and cellular consequences of macrophage control of iron metabolism ⬇️

scientific article published on January 30, 2013

Targeting Chemokines in Cancer

Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief

scientific article

Targeting tumour-associated macrophages

scientific article published on September 2007

The Atypical Chemokine Receptor 2 Limits Progressive Fibrosis after Acute Ischemic Kidney Injury

scientific article published on 16 November 2018

The Chemokine Decoy Receptor D6 Prevents Excessive Inflammation and Adverse Ventricular Remodeling After Myocardial Infarction

scientific article published on 12 July 2012

The Italian Society of Immunology: past, present and future.

scientific article

The Yin Yang of Cancer Related Inflammation

article

The biochemistry and biology of the atypical chemokine receptors.

scientific article published on July 2012

The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses

article

The chemokine system in cancer biology and therapy

scientific article published on 08 December 2009

The chemokine system: tuning and shaping by regulation of receptor expression and coupling in polarized responses.

scientific article

The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6

scientific article published on 20 October 2009

The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis

scientific article published on 01 July 2019

The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury

scientific article published on 27 November 2017

Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation

scientific article published on 21 February 2009

Tumor-associated macrophages as a paradigm of macrophage plasticity, diversity, and polarization: lessons and open questions

scientific article published on July 2013

Tuning inflammation and immunity by chemokine sequestration: decoys and more

scientific article published on December 2006

Tuning of innate immunity and polarized responses by decoy receptors

scientific article published on October 2003

Understanding fibrosis pathogenesis via modeling macrophage-fibroblast interplay in immune-metabolic context

scientific article published in 2022

beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.

scientific article

β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6

scientific article

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