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List of works by Paul R. Langford

"Pathotyping" Multiplex PCR Assay for Haemophilus parasuis: a Tool for Prediction of Virulence

scientific article published on 14 June 2017

A BOX-SCAR fragment for the identification of Actinobacillus pleuropneumoniae

scientific article

A Neisseria meningitidis NMB1966 mutant is impaired for invasion of respiratory epithelial cells, survival in human blood and for virulence in vivo

scientific article published on 3 December 2008

A Unique Capsule Locus in the Newly Designated Actinobacillus pleuropneumoniae Serovar 16 and Development of a Diagnostic PCR Assay

scientific article published on 4 January 2017

A novel CRP-dependent regulon controls expression of competence genes in Haemophilus influenzae.

scientific article

A novel heme protein, the Cu,Zn-superoxide dismutase from Haemophilus ducreyi.

scientific article published on 21 May 2001

A novel neisserial shuttle plasmid: a useful new tool for meningococcal research

scientific article published on October 2005

A promoter probe plasmid based on green fluorescent protein : a strategy for studying meningococcal gene expression

scientific article

Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma

scientific article published on 25 August 2005

Actinobacillus pleuropneumoniae serotype 1 carrying the defined aroA mutation is fully avirulent in the pig.

scientific article published in April 2002

Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection

scientific article

Active copper- and zinc-containing superoxide dismutase in the cryptic genospecies of Haemophilus causing urogenital and neonatal infections discriminates them from Haemophilus influenzae sensu stricto

scientific article

Analysis of an Actinobacillus pleuropneumoniae multi-resistance plasmid, pHB0503.

scientific article published on 18 December 2008

Analysis of differential protein expression in Actinobacillus pleuropneumoniae by Surface Enhanced Laser Desorption Ionisation--ProteinChip (SELDI) technology

scientific article published in April 2004

Analysis of the Actinobacillus pleuropneumoniae ArcA regulon identifies fumarate reductase as a determinant of virulence

scientific article published on 31 March 2008

Analysis of the Actinobacillus pleuropneumoniae HlyX (FNR) regulon and identification of iron-regulated protein B as an essential virulence factor.

scientific article

Anti-mycobacterial activities of synthetic cationic α-helical peptides and their synergism with rifampicin.

scientific article published on 4 December 2013

Apa is a trimeric autotransporter adhesin of Actinobacillus pleuropneumoniae responsible for autoagglutination and host cell adherence.

scientific article

Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophages

scientific article published on March 2003

Bacterial [Cu,Zn]-superoxide dismutase: phylogenetically distinct from the eukaryotic enzyme, and not so rare after all!

scientific article

Bacterial copper- and zinc-cofactored superoxide dismutase contributes to the pathogenesis of systemic salmonellosis

scientific article published in August 1997

Bacterial superoxide dismutase and virulence

scientific article published in January 2002

Basal-Level Effects of (p)ppGpp in the Absence of Branched-Chain Amino Acids in Actinobacillus pleuropneumoniae

scientific article published on 26 March 2020

Biomarker discovery in infectious diseases using SELDI.

scientific article

Characterisation and genetic organisation of a 24-MDa plasmid from the Brazilian Purpuric Fever clone of Haemophilus influenzae biogroup aegyptius.

scientific article published on July 2002

Characterisation of a mobilisable plasmid conferring florfenicol and chloramphenicol resistance in Actinobacillus pleuropneumoniae

scientific article

Cloning and molecular characterization of Cu,Zn superoxide dismutase from Actinobacillus pleuropneumoniae.

scientific article

Copper-zinc superoxide dismutase in Haemophilus species

scientific article published on 01 March 1992

Correction: Impairment of IFN-Gamma Response to Synthetic Peptides of Mycobacterium tuberculosis in a 7-Day Whole Blood Assay

scientific article published on 4 October 2013

Correction: Transcriptional Profiling of Serogroup B Neisseria meningitidis Growing in Human Blood: An Approach to Vaccine Antigen Discovery

scientific article published on 28 September 2012

Deletion of the ferric uptake regulator Fur impairs the in vitro growth and virulence of Actinobacillus pleuropneumoniae

scientific article published on June 2005

Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study

scientific article (publication date: October 2013)

Development of a Haemophilus two-dimensional protein database

scientific article published on 01 August 1997

Development of a self-replicating plasmid system for Mycoplasma hyopneumoniae

scientific article published on 29 July 2013

Diagnosis of childhood tuberculosis and host RNA expression in Africa

scientific article published in May 2014

Differential contribution of sodC1 and sodC2 to intracellular survival and pathogenicity of Salmonella enterica serovar Choleraesuis

scientific article

Differential gene expression profiling of Actinobacillus pleuropneumoniae during induction of primary alveolar macrophage apoptosis in piglets.

scientific article published on 28 November 2014

Distribution, cloning, characterisation and mutagenesis of sodC, the gene encoding copper/zinc superoxide dismutase, a potential determinant of virulence, in Haemophilus ducreyi

scientific article published in April 1997

Draft Genome Sequences of the Type Strains of Actinobacillus indolicus (46K2C) and Actinobacillus porcinus (NM319), Two NAD-Dependent Bacterial Species Found in the Respiratory Tract of Pigs

scientific article published on 02 January 2020

Dysbiosis anticipating necrotizing enterocolitis in very premature infants

scientific article published on 23 October 2014

Erratum: Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis

scientific article published on 12 May 2015

Evidence for in vivo expression of transferrin-binding proteins in Haemophilus influenzae type b ⬇️

scientific article published on July 1, 1992

Expression of heterologous antigens in commensal Neisseria spp.: preservation of conformational epitopes with vaccine potential.

scientific article

Factor H, a regulator of complement activity, is a major determinant of meningococcal disease susceptibility in UK Caucasian patients

scientific article published in January 2006

Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis

scientific article

Functional diversity of three different DsbA proteins from Neisseria meningitidis

scientific article published in September 2004

Galleria mellonella - a novel infection model for the Mycobacterium tuberculosis complex

scientific article published on 01 January 2018

Galleria mellonella is an effective model to study Actinobacillus pleuropneumoniae infection

scientific article published on 20 November 2014

Gene content and diversity of the loci encoding biosynthesis of capsular polysaccharides of the 15 serovar reference strains of Haemophilus parasuis

scientific article published on 19 July 2013

Generation and evaluation of a Glaesserella (Haemophilus) parasuis capsular mutant

scientific article published on 24 February 2020

Generation of a Tn5 transposon library in Haemophilus parasuis and analysis by transposon-directed insertion-site sequencing (TraDIS) ⬇️

scientific article published on July 20, 2013

Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica

scientific article

Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis

scientific article

Growth of Haemophilus influenzae type b in continuous culture: effect of dilution rate on outer-membrane protein and lipopolysaccharide expression

scientific article published on 01 May 1992

Growth of Haemophilus influenzae type b in the presence of bovine aortal endothelial cells

scientific article published on 01 July 1991

Haemophilus influenzae microarrays: virulence and vaccines

scientific article

Haemophilus parasuis induces activation of NF-κB and MAP kinase signaling pathways mediated by toll-like receptors

scientific article

Harnessing natural transformation in Actinobacillus pleuropneumoniae: a simple method for allelic replacements

scientific article published in April 2004

High-throughput identification of conditionally essential genes in bacteria: from STM to TSM.

scientific article published in September 2006

ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76

scientific article published on 04 November 2007

Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae

scientific article

Identification of Actinobacillus pleuropneumoniae genes important for survival during infection in its natural host

scientific article

Identification of dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae

scientific article

Identification of genes transcribed by Haemophilus parasuis in necrotic porcine lung through the selective capture of transcribed sequences (SCOTS)

scientific article published on 16 September 2008

Identification of proteins of Propionibacterium acnes for use as vaccine candidates to prevent infection by the pig pathogen Actinobacillus pleuropneumoniae

scientific article

Identification of sodC encoding periplasmic [Cu,Zn]-superoxide dismutase in Salmonella

scientific article published in February 1996

Immunogenic outer-membrane proteins of Haemophilus influenzae type b in infection

scientific article published on 01 January 1992

Impairment of IFN-gamma response to synthetic peptides of Mycobacterium tuberculosis in a 7-day whole blood assay

scientific article

In vitro cytotoxicity of Haemophilus influenzae lipopolysaccharides for bovine aortal endothelial cells

scientific article published on 01 June 1991

Inactivation of NMB0419, Encoding a Sel1-Like Repeat (SLR) Protein, in Neisseria meningitidis Is Associated with Differential Expression of Genes Belonging to the Fur Regulon and Reduced Intraepithelial Replication

scientific article published on 6 March 2017

Late-Onset Bloodstream Infection and Perturbed Maturation of the Gastrointestinal Microbiota in Premature Infants

scientific article published on 13 July 2015

Lineage-specific virulence determinants of Haemophilus influenzae biogroup aegyptius

scientific article published in March 2012

Meningitis: latest developments

scientific article published in July 2011

Meningococcal biofilm growth on an abiotic surface - a model for epithelial colonization?

scientific article published on 21 April 2009

Molecular and genetic characterization of superoxide dismutase in Haemophilus influenzae type b.

scientific article

Multiplex PCR assay for unequivocal differentiation of Actinobacillus pleuropneumoniae serovars 1 to 3, 5 to 8, 10, and 12.

scientific article

Multiplex PCR that can distinguish between immunologically cross- reactive serovar 3, 6, and 8 Actinobacillus pleuropneumoniae strains

scientific article

Natural competence in strains of Actinobacillus pleuropneumoniae

scientific article

Natural genetic exchange between Haemophilus and Neisseria: intergeneric transfer of chromosomal genes between major human pathogens

scientific article published on October 1998

Necrosis from needlestick injury with live Actinobacillus pleuropneumoniae porcine vaccine

scientific article published on 04 October 2011

New plasmid tools for genetic analysis of Actinobacillus pleuropneumoniae and other pasteurellaceae

scientific article published on 7 August 2009

Occurrence of [copper, zinc]-cofactored superoxide dismutase in Pasteurella haemolytica and its serotype distribution

scientific article published in August 1996

Outer membrane proteins of gentamicin induced small colony variants of Pseudomonas aeruginosa

scientific article published in October 1989

PCR specific for Actinobacillus pleuropneumoniae serotype 3.

scientific article published in May 2008

PHiD-CV induces anti-Protein D antibodies but does not augment pulmonary clearance of nontypeable Haemophilus influenzae in mice.

scientific article

Palindromic Haemophilus DNA uptake sequences in presumed transcriptional terminators from H. influenzae and H. parainfluenzae

scientific article

Pasteurellaceae ComE1 proteins combine the properties of fibronectin adhesins and DNA binding competence proteins

scientific article

Periplasmic superoxide dismutase in meningococcal pathogenicity.

scientific article published on January 1998

Population-based analysis of Actinobacillus pleuropneumoniae ApxIVA for use as a DIVA antigen

scientific article published on 16 May 2010

Presence of copper- and zinc-containing superoxide dismutase in commensal Haemophilus haemolyticus isolates can be used as a marker to discriminate them from nontypeable H. influenzae isolates

scientific article

Prevalence of Actinobacillus pleuropneumoniae serovars in England and Wales.

scientific article published on October 2010

Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis

scientific article

Reduced DNA binding and uptake in the absence of DsbA1 and DsbA2 of Neisseria meningitidis due to inefficient folding of the outer-membrane secretin PilQ

scientific article published on 01 January 2008

Regulation of pga operon expression and biofilm formation in Actinobacillus pleuropneumoniae by sigmaE and H-NS

scientific article

Role of bacterial Mn-cofactored superoxide dismutase in oxidative stress responses, nasopharyngeal colonization, and sustained bacteremia caused by Haemophilus influenzae type b.

scientific article

Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus

scientific article

Superoxide dismutases of pathogenic and non-pathogenic Streptococcus suis type 2 isolates

scientific article published on 01 January 1991

The Adh adhesin domain is required for trimeric autotransporter Apa1-mediated Actinobacillus pleuropneumoniae adhesion, autoaggregation, biofilm formation and pathogenicity.

scientific article published on 2 March 2015

The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b).

scientific article

The generation of successive unmarked mutations and chromosomal insertion of heterologous genes in Actinobacillus pleuropneumoniae using natural transformation

scientific article

The role of the Shigella flexneri yihE gene in LPS synthesis and virulence

scientific article published in April 2004

The role of two periplasmic copper- and zinc-cofactored superoxide dismutases in the virulence of Salmonella choleraesuis

scientific article published in March 2002

The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis

scientific article published on 24 December 2014

Transcriptional Profiling of Serogroup B Neisseria meningitidis Growing in Human Blood: An Approach to Vaccine Antigen Discovery ⬇️

scientific article published on June 22, 2012

Transcriptional profiling of Neisseria meningitidis interacting with human epithelial cells in a long-term in vitro colonization model

scientific article published on 26 August 2013

Transposon mutagenesis in Mycoplasma hyopneumoniae using a novel mariner-based system for generating random mutations

scientific article

Two TonB systems in Actinobacillus pleuropneumoniae: their roles in iron acquisition and virulence.

scientific article

Use of proteins identified through a functional genomic screen to develop a protein subunit vaccine that provides significant protection against virulent Streptococcus suis in pigs

scientific article published on 4 December 2017

[Cu,Zn]-Superoxide dismutase mutants of the swine pathogen Actinobacillus pleuropneumoniae are unattenuated in infections of the natural host.

scientific article published on August 2000

recF in Actinobacillus pleuropneumoniae ⬇️

scientific article published on February 11, 1992

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