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List of works by Judy Hirst

A Self-Assembled Respiratory Chain that Catalyzes NADH Oxidation by Ubiquinone-10 Cycling between Complex I and the Alternative Oxidase

scientific article published on 23 November 2015

A scalable, GFP-based pipeline for membrane protein overexpression screening and purification

scientific article published on 29 June 2005

A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase

scientific article published on 22 July 2013

A ternary mechanism for NADH oxidation by positively charged electron acceptors, catalyzed at the flavin site in respiratory complex I

scientific article published on 12 June 2011

ATR-FTIR Redox Difference Spectroscopy ofYarrowia lipolyticaand Bovine Complex I†

scientific article published on 01 May 2006

An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis

scientific article published on 19 August 2007

Analysis of the subunit composition of complex I from bovine heart mitochondria

scientific article published on 22 February 2003

Antisymmetric exchange in [2Fe-2S]1+ clusters: EPR of the Rieske protein from Thermus thermophilus at pH 14.

scientific article published in May 2004

Architecture of mammalian respiratory complex I.

scientific article published on 7 September 2014

Atomically defined mechanism for proton transfer to a buried redox centre in a protein

scientific article

Bovine complex I is a complex of 45 different subunits.

scientific article

Breaking and re-forming the disulfide bond at the high-potential, respiratory-type Rieske [2Fe-2S] center of thermus thermophilus: characterization of the sulfhydryl state by protein-film voltammetry

scientific article published in November 2002

Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system

scientific article published on 7 September 2015

Comment on "Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry"

scientific article published on 07 November 2019

Complete Thermodynamic Characterization of Reduction and Protonation of thebc1-type Rieske [2Fe-2S] Center ofThermus thermophilus

scientific article published on 01 October 2001

Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex.

scientific article published in March 2021

Correction to “Reversible Interconversion of CO2 and Formate by a Molybdenum-Containing Formate Dehydrogenase”

scientific article published on 24 March 2015

Correlating kinetic and structural data on ubiquinone binding and reduction by respiratory complex I.

scientific article

Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy

scientific article published on 19 May 2022

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states ⬇️

scientific article published on 18 June 2018

Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I

scientific article published on 19 January 2022

Definition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identification of two new subunits.

scientific article

Deleting the IF1-like ζ subunit from Paracoccus denitrificans ATP synthase is not sufficient to activate ATP hydrolysis

scientific article published in January 2018

Detection and interpretation of redox potential optima in the catalytic activity of enzymes

scientific article

Direct assignment of EPR spectra to structurally defined iron-sulfur clusters in complex I by double electron-electron resonance

scientific article

Direct observation of redox-linked histidine protonation changes in the iron-sulfur protein of the cytochrome bc1 complex by ATR-FTIR spectroscopy

scientific article

Effects of biguanides on oxidative phosphorylation

article published in 2014

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

scientific article published on September 2014

Electrocatalytic Voltammetry of Succinate Dehydrogenase: Direct Quantification of the Catalytic Properties of a Complex Electron-Transport Enzyme

scientific article published in 1996

Elucidating the mechanisms of coupled electron transfer and catalytic reactions by protein film voltammetry

scientific article

Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I

scientific article

Erratum: Atomically defined mechanism for proton transfer to a buried redox centre in a protein

scientific article published in Nature

Exploring interactions between the 49 kDa and ND1 subunits in mitochondrial NADH-ubiquinone oxidoreductase (complex I) by photoaffinity labeling

scientific article

Fast voltammetric studies of the kinetics and energetics of coupled electron-transfer reactions in proteins.

scientific article published in January 2000

Fast-scan cyclic voltammetry of protein films on pyrolytic graphite edge electrodes: characteristics of electron exchange

scientific article published in December 1998

Formation and characterization of an all-ferrous Rieske cluster and stabilization of the [2Fe-2S]0 core by protonation

scholarly article

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects

scientific article published in October 2017

GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:ubiquinone oxidoreductase (complex I)

scientific article (publication date: 19 October 2001)

Global Observation of Hydrogen/Deuterium Isotope Effects on Bidirectional Catalytic Electron Transport in an Enzyme: Direct Measurement by Protein-Film Voltammetry

scientific article published in 1997

High-resolution structure of the soluble, respiratory-type Rieske protein from Thermus thermophilus: analysis and comparison

scientific article

Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells

scientific article published on 27 May 2020

Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases

scientific article

Interactions between phospholipids and NADH:ubiquinone oxidoreductase (complex I) from bovine mitochondria

scientific article published in January 2006

Interpreting the Catalytic Voltammetry of Electroactive Enzymes Adsorbed on Electrodes

Interpreting the catalytic voltammetry of an adsorbed enzyme by considering substrate mass transfer, enzyme turnover, and interfacial electron transport

scientific article published in January 2006

Investigating the function of [2Fe-2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

scientific article

Investigation of NADH binding, hydride transfer, and NAD(+) dissociation during NADH oxidation by mitochondrial complex I using modified nicotinamide nucleotides

scientific article

Investigation of the mechanism of proton translocation by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria: does the enzyme operate by a Q-cycle mechanism?

scientific article published on December 2006

Kinetic evidence against partitioning of the ubiquinone pool and the catalytic relevance of respiratory-chain supercomplexes.

scientific article

Kinetics and Mechanism of Redox-Coupled, Long-Range Proton Transfer in an Iron−Sulfur Protein. Investigation by Fast-Scan Protein-Film Voltammetry

scientific article published in 1998

Mechanisms of redox-coupled proton transfer in proteins: role of the proximal proline in reactions of the [3Fe-4S] cluster in Azotobacter vinelandii ferredoxin I

scientific article

Mechanistic Study of Photoelectrochemical Reactions: Phototransient Experiments

article

Mitochondrial Supercomplexes Do Not Enhance Catalysis by Quinone Channeling

scholarly article by Justin G Fedor published in September 2018

Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation

scientific article published on 03 August 2020

Mitochondrial complex I.

scientific article published on 18 March 2013

Modelling electrode reactions using the strongly implicit procedure

Modulation of heme redox potential in the cytochrome c6 family

scientific article

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase

scientific article

Mössbauer spectroscopy on respiratory complex I: the iron-sulfur cluster ensemble in the NADH-reduced enzyme is partially oxidized

scientific article published on 9 December 2011

Off-pathway, oxygen-dependent thiamine radical in the Krebs cycle.

scientific article

Open questions: respiratory chain supercomplexes-why are they there and what do they do?

scientific article

Oxidation-State-Dependent Binding Properties of the Active Site in a Mo-Containing Formate Dehydrogenase.

scientific article published on 21 June 2017

Photoelectrochemical reduction of meta-halonitrobenzenes and related species

Production of reactive oxygen species by complex I (NADH:ubiquinone oxidoreductase) from Escherichia coli and comparison to the enzyme from mitochondria

scientific article

Reaction of complex metalloproteins studied by protein-film voltammetry

Reactions of the flavin mononucleotide in complex I: a combined mechanism describes NADH oxidation coupled to the reduction of APAD+, ferricyanide, or molecular oxygen

scientific article published in December 2009

Redox properties of the [2Fe-2S] center in the 24 kDa (NQO2) subunit of NADH:ubiquinone oxidoreductase (complex I).

scientific article published in August 2002

Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species

scientific article published on March 2009

Reduction of the iron-sulfur clusters in mitochondrial NADH:ubiquinone oxidoreductase (complex I) by EuII-DTPA, a very low potential reductant

scientific article published on 24 July 2008

Reduction potentials of Rieske clusters: importance of the coupling between oxidation state and histidine protonation state

scientific article published in October 2003

Reevaluating the relationship between EPR spectra and enzyme structure for the iron sulfur clusters in NADH:quinone oxidoreductase

scholarly article

Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure

scientific article

Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 2. Effects on heme coordination and function

scientific article

Respiratory Complex I in Bos taurus and Paracoccus denitrificans Pumps Four Protons across the Membrane for Every NADH Oxidized.

scientific article published on 7 February 2017

Reversibility and efficiency in electrocatalytic energy conversion and lessons from enzymes

scientific article

Reversible and Selective Interconversion of Hydrogen and Carbon Dioxide into Formate by a Semiartificial Formate Hydrogenlyase Mimic

scientific article published on 28 October 2019

Reversible glutathionylation of complex I increases mitochondrial superoxide formation

scientific article published on 20 March 2003

Reversible interconversion of CO2 and formate by a molybdenum-containing formate dehydrogenase

scientific article published on 23 October 2014

Reversible interconversion of carbon dioxide and formate by an electroactive enzyme

scientific article

Reversible, electrochemical interconversion of NADH and NAD+ by the catalytic (Ilambda) subcomplex of mitochondrial NADH:ubiquinone oxidoreductase (complex I).

scientific article

Roles of the disulfide bond and adjacent residues in determining the reduction potentials and stabilities of respiratory-type Rieske clusters

scientific article published in May 2005

Small-volume potentiometric titrations: EPR investigations of Fe-S cluster N2 in mitochondrial complex I.

scientific article published on 20 April 2016

Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides

scientific article published on 26 January 2023

Structure of inhibitor-bound mammalian complex I

scientific article published on 16 October 2020

Structure of mammalian respiratory complex I

scientific article published on 10 August 2016

Structure of subcomplex Iβ of mammalian respiratory complex I leads to new supernumerary subunit assignments

scientific article

Structure of the Deactive State of Mammalian Respiratory Complex I.

scientific article published on 21 January 2018

Structure of the deactive state of mammalian respiratory complex I

Subunit NDUFV3 is present in two distinct isoforms in mammalian complex I.

scientific article published on 08 December 2016

Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer

scientific article published on 10 March 2011

The Enigma of the Respiratory Chain Supercomplex

scientific article published on April 2017

The Inhibition of Mitochondrial Complex I (NADH:Ubiquinone Oxidoreductase) by Zn2+

scientific article published in Journal of Biological Chemistry

The deactive form of respiratory complex I from mammalian mitochondria is a Na+/H+ antiporter

scientific article published on August 2012

The dichotomy of complex I: a sodium ion pump or a proton pump

scientific article

The flavoprotein subcomplex of complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria: insights into the mechanisms of NADH oxidation and NAD+ reduction from protein film voltammetry

scientific article published on 27 February 2007

The mechanism of catalysis by type-II NADH:quinone oxidoreductases.

scientific article published on 9 January 2017

The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

scientific article

The mitochondrial-encoded subunits of respiratory complex I (NADH:ubiquinone oxidoreductase): identifying residues important in mechanism and disease

scientific article published on 01 June 2011

The nuclear encoded subunits of complex I from bovine heart mitochondria

scientific article (publication date: 10 July 2003)

The post-translational modifications of the nuclear encoded subunits of complex I from bovine heart mitochondria.

scientific article published on 22 February 2005

The production of reactive oxygen species by complex I.

scientific article

The respiratory complexes I from the mitochondria of two Pichia species

scientific article

The subunit composition of mitochondrial NADH:ubiquinone oxidoreductase (complex I) from Pichia pastoris

scientific article

Towards the molecular mechanism of respiratory complex I.

scientific article

Transhydrogenation reactions catalyzed by mitochondrial NADH-ubiquinone oxidoreductase (Complex I).

scientific article published on 15 November 2007

Truncation of subunit ND2 disrupts the threefold symmetry of the antiporter-like subunits in complex I from higher metazoans

scientific article

Unusual oxidative chemistry of N(omega)-hydroxyarginine and N-hydroxyguanidine catalyzed at an engineered cavity in a heme peroxidase

scientific article

Using Hyperfine Electron Paramagnetic Resonance Spectroscopy to Define the Proton-Coupled Electron Transfer Reaction at Fe-S Cluster N2 in Respiratory Complex I.

scientific article published on 17 October 2017

Very Rapid, Cooperative Two-Electron/Two-Proton Redox Reactions of [3Fe−4S] Clusters: Detection and Analysis by Protein-Film Voltammetry

scientific article published in 1998

Voltammetric studies of bidirectional catalytic electron transport in Escherichia coli succinate dehydrogenase: comparison with the enzyme from beef heart mitochondria

scientific article published in August 1999

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