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List of works by James W. Bainbridge

A peptide encoded by exon 6 of VEGF (EG3306) inhibits VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivo.

scientific article published on March 2003

A pilot randomised controlled trial comparing the post-operative pain experience following vitrectomy with a 20-gauge system and the 25-gauge transconjunctival system

scientific article published on 26 August 2009

A prospective controlled study of a 10/0 absorbable polyglactin suture for corneal incision phacoemulsification

scientific article published on 01 January 1998

A prospective longitudinal study of retinal structure and function in achromatopsia.

scientific article

A randomized trial to assess functional and structural effects of ranibizumab versus laser in diabetic macular edema (the LUCIDATE study).

scientific article

A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye.

scientific article published on 20 August 2015

AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa

scientific article published in August 2003

AAV-mediated gene therapy for retinal disorders: from mouse to man.

scientific article published on 17 April 2008

AAV-mediated knockdown of peripherin-2 in vivo using miRNA-based hairpins

scientific article published on 10 December 2009

AIDS education in rural Uganda--a way forward.

scientific article

Absence of chx10 causes neural progenitors to persist in the adult retina

scientific journal article

Absence of ocular malignant transformation after sub-retinal delivery of rAAV2/2 or integrating lentiviral vectors in p53-deficient mice

scientific article published on 24 November 2011

Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization

scientific article published on 26 June 2017

Airbag injury and bilateral globe rupture

scientific article

An immune response after intraocular administration of an adenoviral vector containing a beta galactosidase reporter gene slows retinal degeneration in the rd mouse

scientific article

Apelin is required for non-neovascular remodeling in the retina.

scientific article

Assessing a novel depot delivery strategy for noninvasive administration of VEGF/PDGF RTK inhibitors for ocular neovascular disease.

scientific article

Assessment and in vivo scoring of murine experimental autoimmune uveoretinitis using optical coherence tomography

scientific article (publication date: 2013)

CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization

scientific article

Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration.

scientific article

Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age.

scientific article published on 9 June 2015

Clinical efficacy and mechanistic evaluation of aflibercept for proliferative diabetic retinopathy (acronym CLARITY): a multicentre phase IIb randomised active-controlled clinical trial.

scientific article published on 14 September 2015

Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase

scientific article

Complement factor h is critical in the maintenance of retinal perfusion

scientific article published on 18 June 2009

Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells.

scientific article

Dark-adaptation functions in molecularly confirmed achromatopsia and the implications for assessment in retinal therapy trials.

scientific article

Decreased visual acuity in patients with cytomegalovirus retinitis and AIDS.

scientific article published in February 2000

Delivery of anti-angiogenic molecular therapies for retinal disease.

scientific article published on 23 February 2010

Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65.

scientific article published on 22 September 2016

Diagnosis of Theodore's superior limbic keratoconjunctivitis

scientific article published on 01 January 1998

Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling

scientific article (publication date: 2012)

Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis

scientific article published on 12 May 2016

EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV.

scientific article published on 13 June 2006

Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs.

scientific article published in June 2017

Effect of gene therapy on visual function in Leber's congenital amaurosis

scientific article

Endogenous Erythropoietin Protects Neuroretinal Function in Ischemic Retinopathy ⬇️

scientific article published on February 17, 2012

Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging

scientific article published on 04 January 2016

Evaluation of telemedicine for slit lamp examination of the eye following cataract surgery.

scientific article published on April 2003

External ocular myiasis due to Oestrus ovis in a tourist returning from North Africa

scientific article published in January 1998

Face-down positioning or posturing after macular hole surgery

scientific article

Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models

scientific article published on 17 August 2016

Gene augmentation trials using the Rpe65-deficient dog: contributions towards development and refinement of human clinical trials.

scientific article published on January 2012

Gene replacement therapy in the retinal degeneration slow (rds) mouse: the effect on retinal degeneration following partial transduction of the retina

scientific article published in October 2001

Gene supplementation therapy for recessive forms of inherited retinal dystrophies.

scientific article published on 27 October 2011

Gene therapy for ocular angiogenesis.

scientific article

Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors

scientific article published on 19 March 2009

Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors

scientific article published in February 2010

Gene therapy in the second eye of RPE65-deficient dogs improves retinal function

scientific article published on 12 August 2010

Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179

scientific article

Gene transfer of an engineered zinc finger protein enhances the anti-angiogenic defense system

scientific article

HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia

scientific article published on 14 June 2010

Hsp90 inhibition protects against inherited retinal degeneration

scientific article published on 02 December 2013

Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye.

scientific article published on 23 January 2017

Hypoxia-regulated transgene expression in experimental retinal and choroidal neovascularization

scientific article

IL-4 regulates specific Arg-1(+) macrophage sFlt-1-mediated inhibition of angiogenesis.

scientific article published on 13 June 2015

Improvement of neuronal visual responses in the superior colliculus in Prph2(Rd2/Rd2) mice following gene therapy

scientific article published in January 2004

In vivo gene transfer to the mouse eye using an HIV-based lentiviral vector; efficient long-term transduction of corneal endothelium and retinal pigment epithelium

scientific article published in November 2001

Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1.

scientific article published in March 2002

Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration

scientific article published in March 2003

Intraocular lens implants and risk of endophthalmitis.

scientific article

Intraocular oxygen distribution in advanced proliferative diabetic retinopathy

scientific article published on 02 July 2011

Investigation of Aberrant Splicing Induced by AIPL1 Variations as a Cause of Leber Congenital Amaurosis.

scientific article published on December 2015

Is eye padding routinely necessary after uncomplicated phacoemulsification?

scientific article published in January 1998

Keeping an eye on clinical trials in 2008.

scientific article published on 13 March 2008

Kinetics of transgene expression in mouse retina following sub-retinal injection of recombinant adeno-associated virus

scientific article published in February 2002

LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.

scientific article

Late neuroprogenitors contribute to normal retinal vascular development in a Hif2a-dependent manner.

scientific article published on 3 April 2018

Lentiviral-vector-mediated expression of murine IL-1 receptor antagonist or IL-10 reduces the severity of endotoxin-induced uveitis

scientific article

Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy

scientific article

Long-term effect of gene therapy on Leber's congenital amaurosis

scientific article published on 4 May 2015

Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy

scientific article published in September 2003

Long-term preservation of cones and improvement in visual function following gene therapy in a mouse model of leber congenital amaurosis caused by guanylate cyclase-1 deficiency.

scientific article

Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy

scientific article published in April 2005

Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization--Brief Report.

scientific article

Nature of subretinal fluid in patients undergoing vitrectomy for macular hole: a cytopathological and optical coherence tomography study

scientific article published in December 2008

Nature of the visual loss in observers with Leber's congenital amaurosis caused by specific mutations in RPE65.

scientific article published on 25 September 2014

Novel CCR3 Antagonists Are Effective Mono- and Combination Inhibitors of Choroidal Neovascular Growth and Vascular Permeability

scientific article published on 15 July 2015

Ocular complications of intravenous cidofovir for cytomegalovirus retinitis in patients with AIDS.

scientific article

Oxygen sensing in retinal health and disease

scientific article

PIMS (Positioning In Macular hole Surgery) trial - a multicentre interventional comparative randomised controlled clinical trial comparing face-down positioning, with an inactive face-forward position on the outcome of surgery for large macular hole

scientific article

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina.

scientific article published on 21 July 2013

Pilot randomised controlled trial of face-down positioning following macular hole surgery

scientific article published on 23 September 2011

Pilot randomised controlled trial of face-down posturing following phacovitrectomy for macular hole

scientific article published on 23 September 2011

Pilot randomised controlled trial of face-down posturing following phacovitrectomy for macular hole.

scientific article

Positioning In Macular hole Surgery (PIMS): statistical analysis plan for a randomised controlled trial

scientific article

Postoperative evaluation of patients following ophthalmic surgery

scientific article

Predicting visual outcome following retinectomy for retinal detachment

scientific article

Preserved outer retina in AIPL1 Leber's congenital amaurosis: implications for gene therapy

scientific article published on 14 January 2015

Prospects for gene therapy of inherited retinal disease

scientific article

Prospects for retinal gene replacement therapy.

scientific article published on 18 March 2009

RPE65 gene therapy slows cone loss in Rpe65-deficient dogs

scientific article

Ranibizumab pretreatment in diabetic vitrectomy: a pilot randomised controlled trial (the RaDiVit study).

scientific article published on 12 May 2017

Refractory diabetic macular edema ⬇️

scientific article published on July 1, 2010

Repair of the degenerate retina by photoreceptor transplantation.

scientific article published on 17 December 2012

Repeatability of Spectralis OCT measurements of macular thickness and volume in diabetic macular edema

scientific article published on 21 November 2012

Reply to comment on “Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration” by Luhmann et al. (Exp. Eye Res. 107, February 2013, 80–87)

scientific article published in June 2013

Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy.

scientific article published on July 2000

Restoration of vision after transplantation of photoreceptors

scientific article published on May 2012

Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors

scientific article published on 21 April 2021

Retinal dystrophies and gene therapy.

scientific article

Retinal gene therapy

scientific article published on 01 June 2018

Retinal structure and function in achromatopsia: implications for gene therapy.

scientific article published on 20 October 2013

Spectral sensitivity measurements reveal partial success in restoring missing rod function with gene therapy

scientific article published on November 2015

Stabilization of myeloid-derived HIFs promotes vascular regeneration in retinal ischemia

scientific article published on 03 October 2019

Stable and efficient intraocular gene transfer using pseudotyped EIAV lentiviral vectors

scientific article published in March 2006

Stable rAAV-mediated transduction of rod and cone photoreceptors in the canine retina

scientific article published in August 2003

Stickler syndrome

scientific article published on 01 September 2008

Subretinal abscess after scleral buckling surgery: a rare risk of retinal surgery

scientific article published on 01 February 2007

Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice.

scientific article

Success in sight: The eyes have it! Ocular gene therapy trials for LCA look promising

scientific article

Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina.

scientific article

The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.

scientific article published on 2 July 2009

The relevance of chemokine signalling in modulating inherited and age-related retinal degenerations

scientific article published on January 2014

The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors.

scientific article published on 21 August 2014

The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice

scientific article

Transcriptional Profiling Uncovers Human Hyalocytes as a Unique Innate Immune Cell Population

scientific article published on 11 September 2020

Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel From Embryonic Stem Cell-Derived Self-Forming Retina.

scientific article published on 27 May 2015

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation.

scientific article published on 13 March 2017

Vascular endothelial growth factor-A165b ameliorates outer-retinal barrier and vascular dysfunction in the diabetic retina

scientific article

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

scientific journal article

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