List of works - Alessandro Contini

1H-Azepine-2-oxo-5-amino-5-carboxylic Acid: A 310 Helix Inducer and an Effective Tool for Functionalized Gold Nanoparticles

scientific article published on 14 May 2015

1H-Azepine-4-amino-4-carboxylic acid: a new α,α-disubstituted ornithine analogue capable of inducing helix conformations in short Ala-Aib pentapeptides

scientific article published on 11 June 2012

2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: an appealing scaffold for the design of Rac1-Tiam1 protein-protein interaction inhibitors

scientific article published on 21 February 2014

A highly diastereoselective synthesis of α-hydroxy-β-amino acid derivatives via a Lewis acid catalyzed three-component condensation reaction.

scientific article published on November 2010

A tendril perversion in a helical oligomer: trapping and characterizing a mobile screw-sense reversal

scientific article published on 25 January 2017

An Updated Test of AMBER Force Fields and Implicit Solvent Models in Predicting the Secondary Structure of Helical, β-Hairpin, and Intrinsically Disordered Peptides

scientific article published on 19 January 2016

Asymmetric Modular Synthesis of a Semirigid Dipeptide Mimetic by Cascade Cycloaddition/Ring Rearrangement and Borohydride Reduction

scientific article published on 25 March 2014

Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models

scientific article published on 19 July 2013

Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts.

scientific article published on 9 August 2016

Computational investigation of the nucleophilic reaction between methylthiolate and 4-bromo-3-methylamino-isothiazole 1,1-dioxide

Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity.

scientific article

Expedient chemical synthesis of 75mer DNA binding domain of MafA: an insight on its binding to insulin enhancer

scientific article published on 04 April 2012

Explicit Ligand Hydration Shells Improve the Correlation between MM-PB/GBSA Binding Energies and Experimental Activities.

scientific article published on 16 May 2013

Identification of the first enantiopure Rac1-Tiam1 protein-protein interaction inhibitor and its optimized synthesis via phosphine free remote group directed hydroarylation

scientific article published on 26 December 2018

Isothiazoles. Part XV. A mild and efficient synthesis of new antiproliferative 5-sulfanylsubstituted 3-alkylaminoisothiazole 1,1-dioxides

scientific article published on 15 March 2006

Mechanism of Stabilization of Helix Secondary Structure by Constrained Cα-Tetrasubstituted α-Amino Acids

scientific article published on 12 January 2015

Model peptides containing the 3-sulfanyl-norbornene amino acid, a conformationally constrained cysteine analogue effective inducer of 310-helix secondary structures

article

Molecular dynamic simulation of mGluR5 amino terminal domain: essential dynamics analysis captures the agonist or antagonist behaviour of ligands

scientific article published on 14 February 2013

Molecular dynamics and tubulin polymerization kinetics study on 1,14-heterofused taxanes: evidence of stabilization of the tubulin head-to-tail dimer-dimer interaction.

scientific article

Molecular insights into dimerization inhibition of c-Maf transcription factor

scholarly article by Sara Pellegrino published in December 2014

Non-natural 3-Arylmorpholino-β-amino Acid as a PPII Helix Inducer

scientific article published on 30 July 2020

Origin of Helical Screw Sense Selectivity Induced by Chiral Constrained Cα-Tetrasubstituted α-Amino Acids in Aib-based Peptides

scientific article published on 22 October 2015

Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases.

scientific article published on 27 November 2017

Rescoring Virtual Screening Results with the MM-PBSA Methods: Beware of Internal Dielectric Constants

scientific article published on 15 May 2019

Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.

scientific article

SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease

scientific article

Stereodivergent synthesis of 5-aminopipecolic acids and application in the preparation of a cyclic RGD peptidomimetic as a nanomolar αVβ3 integrin ligand

scientific article published on 01 May 2018

Synthesis and "double-faced" antioxidant activity of polyhydroxylated 4-thiaflavans

scientific article published on 13 July 2005

Synthesis and conformational analysis of peptides embodying 2,3-methanopipecolic acids.

scientific article published on 7 August 2017

Synthesis, structural, and biological evaluation of bis-heteroarylmaleimides and bis-heterofused imides

scientific article published on 16 August 2011

Tandem Tetrahydroisoquinoline-4-carboxylic Acid/β-Alanine as a New Construct Able To Induce a Flexible Turn

scientific article

Tautomeric equilibria of [1]benzopyrano[3,4-d]imidazol-4(3H)-ones, a theoretical and NMR study

scientific article published on 01 January 2006

Tetrahydro-4 H-(pyrrolo[3,4- d]isoxazol-3-yl)methanamine: A Bicyclic Diamino Scaffold Stabilizing Parallel Turn Conformations

scientific article published on 18 September 2018

Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target

scientific article published on January 2009

VCD spectroscopy as an excellent probe of chiral metal complexes containing a carbon monoxide vibrational chromophore

scientific article published on 01 June 2015

Virtual screening approach for the identification of new Rac1 inhibitors

scientific article published on July 2009

[2 + 4] and [4 + 2] cycloadditions of o-thioquinones with 1,3-dienes: a computational study

scientific article published on 01 July 2006

β-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species.

scientific article published on 7 October 2016

List of works by Alessandro Contini

1H-Azepine-2-oxo-5-amino-5-carboxylic Acid: A 310 Helix Inducer and an Effective Tool for Functionalized Gold Nanoparticles

1H-Azepine-4-amino-4-carboxylic acid: a new α,α-disubstituted ornithine analogue capable of inducing helix conformations in short Ala-Aib pentapeptides

2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: an appealing scaffold for the design of Rac1-Tiam1 protein-protein interaction inhibitors

A highly diastereoselective synthesis of α-hydroxy-β-amino acid derivatives via a Lewis acid catalyzed three-component condensation reaction.

A tendril perversion in a helical oligomer: trapping and characterizing a mobile screw-sense reversal

An Updated Test of AMBER Force Fields and Implicit Solvent Models in Predicting the Secondary Structure of Helical, β-Hairpin, and Intrinsically Disordered Peptides

Asymmetric Modular Synthesis of a Semirigid Dipeptide Mimetic by Cascade Cycloaddition/Ring Rearrangement and Borohydride Reduction

Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models

Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts.

Computational investigation of the nucleophilic reaction between methylthiolate and 4-bromo-3-methylamino-isothiazole 1,1-dioxide

Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity.

Expedient chemical synthesis of 75mer DNA binding domain of MafA: an insight on its binding to insulin enhancer

Explicit Ligand Hydration Shells Improve the Correlation between MM-PB/GBSA Binding Energies and Experimental Activities.

Identification of the first enantiopure Rac1-Tiam1 protein-protein interaction inhibitor and its optimized synthesis via phosphine free remote group directed hydroarylation

Isothiazoles. Part XV. A mild and efficient synthesis of new antiproliferative 5-sulfanylsubstituted 3-alkylaminoisothiazole 1,1-dioxides

Mechanism of Stabilization of Helix Secondary Structure by Constrained Cα-Tetrasubstituted α-Amino Acids

Model peptides containing the 3-sulfanyl-norbornene amino acid, a conformationally constrained cysteine analogue effective inducer of 310-helix secondary structures

Molecular dynamic simulation of mGluR5 amino terminal domain: essential dynamics analysis captures the agonist or antagonist behaviour of ligands

Molecular dynamics and tubulin polymerization kinetics study on 1,14-heterofused taxanes: evidence of stabilization of the tubulin head-to-tail dimer-dimer interaction.

Molecular insights into dimerization inhibition of c-Maf transcription factor

Non-natural 3-Arylmorpholino-β-amino Acid as a PPII Helix Inducer

Origin of Helical Screw Sense Selectivity Induced by Chiral Constrained Cα-Tetrasubstituted α-Amino Acids in Aib-based Peptides

Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases.

Rescoring Virtual Screening Results with the MM-PBSA Methods: Beware of Internal Dielectric Constants

Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.

SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease

Stereodivergent synthesis of 5-aminopipecolic acids and application in the preparation of a cyclic RGD peptidomimetic as a nanomolar αVβ3 integrin ligand

Synthesis and "double-faced" antioxidant activity of polyhydroxylated 4-thiaflavans

Synthesis and conformational analysis of peptides embodying 2,3-methanopipecolic acids.

Synthesis, structural, and biological evaluation of bis-heteroarylmaleimides and bis-heterofused imides

Tandem Tetrahydroisoquinoline-4-carboxylic Acid/β-Alanine as a New Construct Able To Induce a Flexible Turn

Tautomeric equilibria of [1]benzopyrano[3,4-d]imidazol-4(3H)-ones, a theoretical and NMR study

Tetrahydro-4 H-(pyrrolo[3,4- d]isoxazol-3-yl)methanamine: A Bicyclic Diamino Scaffold Stabilizing Parallel Turn Conformations

Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target

VCD spectroscopy as an excellent probe of chiral metal complexes containing a carbon monoxide vibrational chromophore

Virtual screening approach for the identification of new Rac1 inhibitors

[2 + 4] and [4 + 2] cycloadditions of o-thioquinones with 1,3-dienes: a computational study

β-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species.