List of works - María D. Díaz-de-Villegas

(alphaMe)Nva: stereoselective syntheses and preferred conformations of selected model peptides

article

1,3-Dipolar cycloaddition of diazomethane to chiral azlactones. Experimental and theoretical studies

article published in 1997

1,3-Dipolar cycloaddition of diazomethane with a chiral azlactone

A chiral hydrazone derived from d-glyceraldehyde: a convenient starting material for the stereoselective synthesis of α-hydrazino acids

A new approach to the stereoselective synthesis of conveniently protected α-allyl substituted amino acids; chiral key compounds in the synthesis of constrained peptide isostere constituents

article by Ramón Badorrey et al published January 1997 in Tetrahedron: Asymmetry

A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo

scientific article

A practical method for the absolute configuration assignment of α-amino acids using their Pd(dmba) amino acidato complexes

A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aβ, α-synuclein, and amylin amyloid fibrils as well as amyloid-containing Staphylococcus aureus biofilms

scientific article published on 09 November 2018

A simple synthesis of (−)-(1S,2R)-allocoronamic acid in its enantiomerically pure form

article by Carlos Cativiela et al published January 1995 in Tetrahedron: Asymmetry

A straightforward synthesis of (−)-(1S,2R)-Allonorcoronamic acid using D-mannitol as the chiral source

Action of diazomethane on (Z/E)-2-methyl(or phenyl)-4-benzylidene-5(4H)-oxazolones

Action of diazomethane on methyl (Z(or E))-2-(acylamino)cinnamates. A new route to methyl (Z)-2-(acylamino)-3-methylcinnamates

Allylation and propargylation of chiral cyanopropanoates: an efficient route to long chain alpha-substituted alpha-methyl alpha-amino acids

scientific article

An Expeditious Method for the First Asymmetric Synthesis of Dexoxadrol from the Chiral Pool

Asymmetric Diels-Alder reaction of a chiral azlactone

Asymmetric Hetero Diels-Alder Reaction of N-Benzylimines Derived from R-Glyceraldehyde: A New Approach to Homochiral Piperidine Building Blocks and its Application to the Synthesis of (2R)-4-Oxopipecolic Acid

article published in 1997

Asymmetric Synthesis of .beta.-Lactams. Highly Diastereoselective Alkylation of Chiral 2-Cyano Esters

Asymmetric Synthesis of ES-285, an Anticancer Agent Isolated from Marine Sources

Asymmetric Synthesis of a Novel Conformationally Constrained D-Lysine Analogue with a Piperidine Skeleton

article by Pablo Etayo et al published July 2008 in European Journal of Organic Chemistry

Asymmetric homologation of ketones. A new entry to orthogonally protected (2R,4R)-piperidine-2,4-dicarboxylic acid

scientific article published in October 2008

Asymmetric synthesis of 3,3-diphenyl-2-methylalanine, a new unusual α-amino acid for peptides of biological interest

Base-Controlled Diastereodivergent Synthesis of (R)- and (S)-2-Substituted-4-alkylidenepiperidines by the Wadsworth−Emmons Reaction

scientific article published on 01 February 2007

Chiral 2-Cyanocinnamates in Conjugate Addition Asymmetric Enolate Trapping Reactions

article

Chiral 2-acetamidoacrylates in conjugate addition – asymmetric enolate trapping reactions. Asymmetric synthesis of phenylalanine

article

Chiral 2-cyano esters as synthetic intermediates in the synthesis of R and S α-methylvaline

Chiral Amino Diol Derivatives as New Modular Organocatalysts for the Enantioselective α-Chlorination of Cyclic β-Keto Esters

article published in 2010

Chiral iminoesters derived from D-glyceraldehyde in [3 + 2] cycloaddition reactions. Asymmetric synthesis of a key intermediate in the synthesis of neuramidinase inhibitors

scientific article published on 5 November 2013

Debenzylative Cycloetherification as a Synthetic Tool in the Diastereoselective Synthesis of 3,6-Disubstituted Hexahydro-2H-furo[3,2-b]pyrroles, PDE1 Enzyme Inhibitors with an Antiproliferative Effect on Melanoma Cells

scientific article published on 06 April 2020

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice

scientific article published on 21 June 2019

Diastereoselective Construction of the 6-Oxa-2-azabicyclo[3.2.1]octane Scaffold from Chiral α-Hydroxyaldehyde Derivatives by the Aza-Prins Reaction

scientific article published on 17 July 2017

Diastereoselective Strecker reaction of imines derived from D-glyceraldehyde. A new route to β-hydroxy-α-amino acids

Diastereoselective reduction of ketimines derived from (R)-3,4-dihydroxybutan-2-one: an alternative route to key intermediates for the synthesis of anticancer agent ES-285

Diastereoselective synthesis of (1S,2S,3R,4R) and (1R,2S,3R,4S)-bicyclo[2.2.1]hept-2-amino-2,3-dicarboxylic acids: New conformationally-constrained (S)-aspartic acid analogues

article by Maria Elena Buñuel Magdalena et al published May 1996 in Tetrahedron: Asymmetry

Efficient Stereodivergent Synthesis of cis-(2R,4S)- and trans-(2R,4R)-4-Phosphonomethyl-2-piperidinecarboxylic Acids from the Same Chiral Imine Derived from (R)-Glyceraldehyde

Efficient access to all four stereoisomers of phenylalanine cyclopropane analogues by chiral HPLC

scientific article published on 01 January 1999

Efficient asymmetric synthesis of amino acids through hydrogenation of the didehydroamino acid residue in cyclic imino-ester derivatives

Efficient stereoselective synthesis of enantiopure cis- and trans-1,2,4-trisubstituted piperidines

Expedient asymmetric synthesis of (2S,3S)-Boc-phenylalanine epoxide, a key intermediate for the synthesis of biologically active compounds

First Stereoselective Synthesis of (1R,2R,4R)- and (1S,2R,4S)-2-Substituted-1-azabicyclo[2.2.1]heptanes

First asymmetric synthesis of an acyclic β,β-dialkylated-γ-aminobutyric acid

High-performance liquid chromatographic enantioseparation of unusual amino acid derivatives with axial chirality on polysaccharide-based chiral stationary phases

scientific article published on 24 February 2015

Highly Stereoselective Synthesis of Stereochemically Defined Polyhydroxylated Propargylamines by Alkynylation ofN-Benzylimines Derived from (R)-Glyceraldehyde

Highly diastereoselective cyanation of methyl ketimines obtained from (R)-glyceraldehyde.

scientific article

Homogeneous hydrogenation of tetrasubstituted alkene moieties in prochiral didehydro amino acid derivatives catalysed by iridium complexes

scholarly article by Javier A. Cabeza et al published 1988 in Journal of the Chemical Society. Perkin transactions 1

Iridium-catalysed homogeneous hydrogenation of prochiral enamides containing tetrasubstituted alkene moieties

scholarly article by Luis Oro et al published 1983 in Journal of the Chemical Society. Chemical communications

Lipopeptaibol Metabolites of Tolypocladium geodes: Total Synthesis, Preferred Conformation, and Membrane Activity

scientific article published on 01 August 2003

Michael addition of carbonyl compounds to nitroolefins under the catalysis of new pyrrolidine-based bifunctional organocatalysts

scientific article published on 16 January 2018

N-[Bis(methylthio)methylene]-didehydroalanine methyl ester a new and excellent dienophile for the synthesis of 2-aminonorbornene-2-carboxylic acid

article published in 1993

New Efficient Synthesis of 1-Aminocyclopropanecarboxylic Acid (ACC)

New approaches to the asymmetric synthesis of α-methylphenylalanine

New α,β-didehydroamino acid derivatives as precursors in the synthesis of 1-aminocyclopropanecarboxylic acids

On the synthesis of (S)-α-methylaspartic acid by diastereoselective alkylation of a chiral 2-cyanopropanoate

Organocatalysis in Enantioselective α-Functionalization of 2-Cyanoacetates

Organocatalyzed Enantioselective Desymmetrization of Diols in the Preparation of Chiral Building Blocks

scientific article published on 02 October 2012

Recent advances in enantioselective organocatalyzed anhydride desymmetrization and its application to the synthesis of valuable enantiopure compounds.

scientific article published on 06 July 2011

Recent progress on the stereoselective synthesis of acyclic quaternary α-amino acids

Reversal of the stereochemical course of the addition of phenylmagnesium bromide to N-benzylimines derived from R-glyceraldehyde depending on the O-protecting group and its application to the synthesis of both enantiomers of phenylglycine

article

Stereocontrolled synthesis of all four stereoisomers of fully protected 2-amino-3-hydroxypentanoic acid from imines derived from d-glyceraldehyde

Stereocontrolled synthesis of orthogonally protected 2-substituted 4-aminopiperidines.

scientific article published on 27 May 2009

Stereoselective Synthesis of Chiral 2,3-Disubstituted 2,3-Dihydro-4(1H)-pyridones

Stereoselective amination of chiral enolates: Synthesis of chiral key intermediates for β-lactam antibiotics

Stereoselective amination of chiral enolates: Synthesis of enantiomerically pure α,β-diamino acids, chiral key compounds in the synthesis of conformationally constrained peptido- and non-peptidomimetics

article by Ramón Badorrey et al published November 1995 in Tetrahedron: Asymmetry

Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position

scientific article published on 12 March 2019

Stereoselective synthesis and biological evaluation of d-fagomine, d-3-epi-fagomine and d-3,4-epi-fagomine analogs from d-glyceraldehyde acetonide as a common building block

scientific article published on 29 October 2012

Stereoselective synthesis of α-hydroxy-β-amino acids using D-glyceraldehyde as the homochiral source

article published in 1996

Stereospecific synthesis of N-[Bis(methylthio)methylene]-α,β- didehydroamino acid methyl esters, new synthons in the synthesis of α-amino acids

Study of the Reactions between Vinylmagnesium Bromide and Imines Derived from (R)-Glyceraldehyde − The Key Step in the Stereodivergent Synthesis of Conveniently Protected, Enantiopure syn- and anti-2-Amino-1,3,4-butanetriol Derivatives

Study of the asymmetric diels-alder reaction of a chiral azlactone

Study of the reaction of a chiral oxazolone with oxosulphonium methylides as cyclopropanating agents

Study of the reaction of imines derived from (R)-glyceraldehyde with Danishefsky's diene

Switch in regioselectivity of epoxide ring-opening by changing the organometallic reagent

scientific article published on 21 October 2011

Synthesis and chemical resolution of unique α,β-didehydroamino acids with a chiral axis

Synthesis and conformational properties of model dipeptides containing novel axially chiral α,β-didehydroamino acids at the (i+1) position of a β-turn conformation

Synthesis of (R)- 3-alkyl-3-benzyl-2-azetidinones in enantiomerically pure form

Synthesis of (R)- and (S)-2-amino-2-methylbutanoic acid (Iva) in enantiomerically pure form

Synthesis of (R)- and (S)-3-benzyl-3-methyl-2-azetidinone in enantiomerically pure form

Synthesis of (R)-quinuclidine-2-carboxylic acid in enantiomerically pure form

Synthesis of (S)-N-tert-butoxycarbonyl-N,O-isopropylidene-α-methylserinal: A potential building block for the asymmetric synthesis of non-natural amino acids

Synthesis of Cyanocinnamic Esters by the Knoevenagel Reaction

Synthesis of new conformationally rigid phenylalanine analogues

Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins

scientific article published on 27 March 2017

The First Asymmetric Synthesis of 1,4-Dideoxy-1,4-imino-d-talitol

The synthesis of enantiomerically pure (2R)-α-methylisoserine

Unexpected epimerization at C2in the Horner–Wadsworth–Emmons reaction of chiral 2-substituted-4-oxopiperidines

scientific article published on 19 July 2006

Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed.

scientific article published on 28 January 2016

Wittig olefination of methyl (1S, 2R)-1-benzamido-2-formylcyclopropanecarboxylate. A powerful tool for the synthesis of new conformationally constrained cyclopropyl amino acids

article by Carlos Cativiela et al published April 1996 in Tetrahedron

List of works by María D. Díaz-de-Villegas

(alphaMe)Nva: stereoselective syntheses and preferred conformations of selected model peptides

1,3-Dipolar cycloaddition of diazomethane to chiral azlactones. Experimental and theoretical studies

1,3-Dipolar cycloaddition of diazomethane with a chiral azlactone

A chiral hydrazone derived from d-glyceraldehyde: a convenient starting material for the stereoselective synthesis of α-hydrazino acids

A new approach to the stereoselective synthesis of conveniently protected α-allyl substituted amino acids; chiral key compounds in the synthesis of constrained peptide isostere constituents

A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo

A practical method for the absolute configuration assignment of α-amino acids using their Pd(dmba) amino acidato complexes

A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aβ, α-synuclein, and amylin amyloid fibrils as well as amyloid-containing Staphylococcus aureus biofilms

A simple synthesis of (−)-(1S,2R)-allocoronamic acid in its enantiomerically pure form

A straightforward synthesis of (−)-(1S,2R)-Allonorcoronamic acid using D-mannitol as the chiral source

Action of diazomethane on (Z/E)-2-methyl(or phenyl)-4-benzylidene-5(4H)-oxazolones

Action of diazomethane on methyl (Z(or E))-2-(acylamino)cinnamates. A new route to methyl (Z)-2-(acylamino)-3-methylcinnamates

Allylation and propargylation of chiral cyanopropanoates: an efficient route to long chain alpha-substituted alpha-methyl alpha-amino acids

An Expeditious Method for the First Asymmetric Synthesis of Dexoxadrol from the Chiral Pool

Asymmetric Diels-Alder reaction of a chiral azlactone

Asymmetric Hetero Diels-Alder Reaction of N-Benzylimines Derived from R-Glyceraldehyde: A New Approach to Homochiral Piperidine Building Blocks and its Application to the Synthesis of (2R)-4-Oxopipecolic Acid

Asymmetric Synthesis of .beta.-Lactams. Highly Diastereoselective Alkylation of Chiral 2-Cyano Esters

Asymmetric Synthesis of ES-285, an Anticancer Agent Isolated from Marine Sources

Asymmetric Synthesis of a Novel Conformationally Constrained D-Lysine Analogue with a Piperidine Skeleton

Asymmetric homologation of ketones. A new entry to orthogonally protected (2R,4R)-piperidine-2,4-dicarboxylic acid

Asymmetric synthesis of 3,3-diphenyl-2-methylalanine, a new unusual α-amino acid for peptides of biological interest

Base-Controlled Diastereodivergent Synthesis of (R)- and (S)-2-Substituted-4-alkylidenepiperidines by the Wadsworth−Emmons Reaction

Chiral 2-Cyanocinnamates in Conjugate Addition Asymmetric Enolate Trapping Reactions

Chiral 2-acetamidoacrylates in conjugate addition – asymmetric enolate trapping reactions. Asymmetric synthesis of phenylalanine

Chiral 2-cyano esters as synthetic intermediates in the synthesis of R and S α-methylvaline

Chiral Amino Diol Derivatives as New Modular Organocatalysts for the Enantioselective α-Chlorination of Cyclic β-Keto Esters

Chiral iminoesters derived from D-glyceraldehyde in [3 + 2] cycloaddition reactions. Asymmetric synthesis of a key intermediate in the synthesis of neuramidinase inhibitors

Debenzylative Cycloetherification as a Synthetic Tool in the Diastereoselective Synthesis of 3,6-Disubstituted Hexahydro-2H-furo[3,2-b]pyrroles, PDE1 Enzyme Inhibitors with an Antiproliferative Effect on Melanoma Cells

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice

Diastereoselective Construction of the 6-Oxa-2-azabicyclo[3.2.1]octane Scaffold from Chiral α-Hydroxyaldehyde Derivatives by the Aza-Prins Reaction

Diastereoselective Strecker reaction of imines derived from D-glyceraldehyde. A new route to β-hydroxy-α-amino acids

Diastereoselective reduction of ketimines derived from (R)-3,4-dihydroxybutan-2-one: an alternative route to key intermediates for the synthesis of anticancer agent ES-285

Diastereoselective synthesis of (1S,2S,3R,4R) and (1R,2S,3R,4S)-bicyclo[2.2.1]hept-2-amino-2,3-dicarboxylic acids: New conformationally-constrained (S)-aspartic acid analogues

Efficient Stereodivergent Synthesis of cis-(2R,4S)- and trans-(2R,4R)-4-Phosphonomethyl-2-piperidinecarboxylic Acids from the Same Chiral Imine Derived from (R)-Glyceraldehyde

Efficient access to all four stereoisomers of phenylalanine cyclopropane analogues by chiral HPLC

Efficient asymmetric synthesis of amino acids through hydrogenation of the didehydroamino acid residue in cyclic imino-ester derivatives

Efficient stereoselective synthesis of enantiopure cis- and trans-1,2,4-trisubstituted piperidines

Expedient asymmetric synthesis of (2S,3S)-Boc-phenylalanine epoxide, a key intermediate for the synthesis of biologically active compounds

First Stereoselective Synthesis of (1R,2R,4R)- and (1S,2R,4S)-2-Substituted-1-azabicyclo[2.2.1]heptanes

First asymmetric synthesis of an acyclic β,β-dialkylated-γ-aminobutyric acid

High-performance liquid chromatographic enantioseparation of unusual amino acid derivatives with axial chirality on polysaccharide-based chiral stationary phases

Highly Stereoselective Synthesis of Stereochemically Defined Polyhydroxylated Propargylamines by Alkynylation ofN-Benzylimines Derived from (R)-Glyceraldehyde

Highly diastereoselective cyanation of methyl ketimines obtained from (R)-glyceraldehyde.

Homogeneous hydrogenation of tetrasubstituted alkene moieties in prochiral didehydro amino acid derivatives catalysed by iridium complexes

Iridium-catalysed homogeneous hydrogenation of prochiral enamides containing tetrasubstituted alkene moieties

Lipopeptaibol Metabolites of Tolypocladium geodes: Total Synthesis, Preferred Conformation, and Membrane Activity

Michael addition of carbonyl compounds to nitroolefins under the catalysis of new pyrrolidine-based bifunctional organocatalysts

N-[Bis(methylthio)methylene]-didehydroalanine methyl ester a new and excellent dienophile for the synthesis of 2-aminonorbornene-2-carboxylic acid

New Efficient Synthesis of 1-Aminocyclopropanecarboxylic Acid (ACC)

New approaches to the asymmetric synthesis of α-methylphenylalanine

New α,β-didehydroamino acid derivatives as precursors in the synthesis of 1-aminocyclopropanecarboxylic acids

On the synthesis of (S)-α-methylaspartic acid by diastereoselective alkylation of a chiral 2-cyanopropanoate

Organocatalysis in Enantioselective α-Functionalization of 2-Cyanoacetates

Organocatalyzed Enantioselective Desymmetrization of Diols in the Preparation of Chiral Building Blocks

Recent advances in enantioselective organocatalyzed anhydride desymmetrization and its application to the synthesis of valuable enantiopure compounds.

Recent progress on the stereoselective synthesis of acyclic quaternary α-amino acids

Reversal of the stereochemical course of the addition of phenylmagnesium bromide to N-benzylimines derived from R-glyceraldehyde depending on the O-protecting group and its application to the synthesis of both enantiomers of phenylglycine

Stereocontrolled synthesis of all four stereoisomers of fully protected 2-amino-3-hydroxypentanoic acid from imines derived from d-glyceraldehyde

Stereocontrolled synthesis of orthogonally protected 2-substituted 4-aminopiperidines.

Stereoselective Synthesis of Chiral 2,3-Disubstituted 2,3-Dihydro-4(1H)-pyridones

Stereoselective amination of chiral enolates: Synthesis of chiral key intermediates for β-lactam antibiotics

Stereoselective amination of chiral enolates: Synthesis of enantiomerically pure α,β-diamino acids, chiral key compounds in the synthesis of conformationally constrained peptido- and non-peptidomimetics

Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position

Stereoselective synthesis and biological evaluation of d-fagomine, d-3-epi-fagomine and d-3,4-epi-fagomine analogs from d-glyceraldehyde acetonide as a common building block

Stereoselective synthesis of α-hydroxy-β-amino acids using D-glyceraldehyde as the homochiral source

Stereospecific synthesis of N-[Bis(methylthio)methylene]-α,β- didehydroamino acid methyl esters, new synthons in the synthesis of α-amino acids

Study of the Reactions between Vinylmagnesium Bromide and Imines Derived from (R)-Glyceraldehyde − The Key Step in the Stereodivergent Synthesis of Conveniently Protected, Enantiopure syn- and anti-2-Amino-1,3,4-butanetriol Derivatives

Study of the asymmetric diels-alder reaction of a chiral azlactone

Study of the reaction of a chiral oxazolone with oxosulphonium methylides as cyclopropanating agents

Study of the reaction of imines derived from (R)-glyceraldehyde with Danishefsky's diene

Switch in regioselectivity of epoxide ring-opening by changing the organometallic reagent

Synthesis and chemical resolution of unique α,β-didehydroamino acids with a chiral axis

Synthesis and conformational properties of model dipeptides containing novel axially chiral α,β-didehydroamino acids at the (i+1) position of a β-turn conformation

Synthesis of (R)- 3-alkyl-3-benzyl-2-azetidinones in enantiomerically pure form

Synthesis of (R)- and (S)-2-amino-2-methylbutanoic acid (Iva) in enantiomerically pure form

Synthesis of (R)- and (S)-3-benzyl-3-methyl-2-azetidinone in enantiomerically pure form

Synthesis of (R)-quinuclidine-2-carboxylic acid in enantiomerically pure form

Synthesis of (S)-N-tert-butoxycarbonyl-N,O-isopropylidene-α-methylserinal: A potential building block for the asymmetric synthesis of non-natural amino acids

Synthesis of Cyanocinnamic Esters by the Knoevenagel Reaction