List of works - Yury Polikanov

A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes

scientific article published on 11 May 2020

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome

scientific article

A synthetic antibiotic class overcoming bacterial multidrug resistance

scientific article published on 27 October 2021

An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance

scientific article published on 15 February 2024

Analysis of distant communication on defined chromatin templates in vitro.

scientific article published on January 2009

Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome

scientific article published in February 2018

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

scientific article

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

scientific article published on 28 May 2015

Elements of ribosomal drug resistance and specificity.

scientific article published on 13 September 2012

Erratum for Khabibullina et al., "Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides"

scientific article published on 27 January 2020

High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition

scientific article published on 07 February 2019

Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome

scientific article published on 13 April 2016

Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome

scientific article published on 06 March 2020

Internucleosomal Interactions Mediated by Histone Tails Allow Distant Communication in Chromatin ⬇️

scientific article published on April 19, 2012

Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel. ⬇️

scientific article published on 28 August 2017

Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.

scientific article

Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site

scientific article published on 01 February 2019

Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA

scientific article

Nucleosome-free DNA regions differentially affect distant communication in chromatin

scientific article published on 9 December 2016

Nucleosomes can form a polar barrier to transcript elongation by RNA polymerase II

scientific article published on 01 November 2006

Probability of the site juxtaposition determines the rate of protein-mediated DNA looping

scientific article

Pseudouridinylation of mRNA coding sequences alters translation

scientific article published on 31 October 2019

Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome

scientific article published on 12 August 2020

Structural and evolutionary insights into ribosomal RNA methylation.

scientific article published in February 2018

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

scientific article

Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides

scientific article published on 24 May 2019

Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition

scientific article published on 08 October 2019

Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel

scientific article published on 29 June 2020

The Odilorhabdin Antibiotic Biosynthetic Cluster and Acetyltransferase Self-Resistance Locus Are Niche and Species Specific

scientific article published on 11 January 2022

The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation

scientific article

List of works by Yury Polikanov

A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome

A synthetic antibiotic class overcoming bacterial multidrug resistance

An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance

Analysis of distant communication on defined chromatin templates in vitro.

Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

Elements of ribosomal drug resistance and specificity.

Erratum for Khabibullina et al., "Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides"

High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition

Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome

Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome

Internucleosomal Interactions Mediated by Histone Tails Allow Distant Communication in Chromatin ⬇️

Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel. ⬇️

Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.

Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site

Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA

Nucleosome-free DNA regions differentially affect distant communication in chromatin

Nucleosomes can form a polar barrier to transcript elongation by RNA polymerase II

Probability of the site juxtaposition determines the rate of protein-mediated DNA looping

Pseudouridinylation of mRNA coding sequences alters translation

Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome

Structural and evolutionary insights into ribosomal RNA methylation.

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides

Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition

Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel

The Odilorhabdin Antibiotic Biosynthetic Cluster and Acetyltransferase Self-Resistance Locus Are Niche and Species Specific

The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation