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List of works by Filip Cuyckens

A comparison between HPLC-dynamic reaction cell-ICP-MS and HPLC-sector field-ICP-MS for the detection of glutathione-trapped reactive drug metabolites using clozapine as a model compound

article

A pilot study on the use of laser ablation-ICP-mass spectrometry for assessing/mapping the distribution of a drug and its metabolites across the body compartments of rats

A pre-column derivatization method allowing quantitative metabolite profiling of carboxyl and phenolic hydroxyl group containing pharmaceuticals in human plasma via liquid chromatography-inductively coupled plasma-tandem mass spectrometry (LC-ICP-MS/

A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation

scientific article

Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects

scientific article published on 8 January 2009

Absorption, metabolism, and excretion of oral ¹⁴C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men.

scientific article published on 8 December 2014

Adduct ion formation as a tool for the molecular structure assessment of ten isomers in traveling wave and trapped ion mobility spectrometry

scientific article published on 13 June 2019

An atmospheric pressure ionization source using a high voltage target compared to electrospray ionization for the LC/MS analysis of pharmaceutical compounds.

scientific article published on 4 May 2017

Antiprotozoal and antiangiogenic saponins from Apodytes dimidiata

scientific article published on 23 May 2011

Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes

scientific article published on 20 February 2019

Atmospheric Pressure Ionization Using a High Voltage Target Compared to Electrospray Ionization.

scientific article published on 28 November 2016

Characterization of organosulfates from the photooxidation of isoprene and unsaturated fatty acids in ambient aerosol using liquid chromatography/(-) electrospray ionization mass spectrometry

scientific article published in March 2008

Characterization of polar organosulfates in secondary organic aerosol from the green leaf volatile 3-Z-hexenal

scientific article published on 17 October 2014

Combined Liquid Chromatography-Infrared Ion Spectroscopy for Identification of Regioisomeric Drug Metabolites

scientific article published on 3 April 2017

Comparison of triple quadrupole and high-resolution TOF-MS for quantification of peptides

scientific article published in March 2012

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

article

Determination of the glycosylation site in flavonoid mono-O-glycosides by collision-induced dissociation of electrospray-generated deprotonated and sodiated molecules

scientific article

Determination of the total drug-related chlorine and bromine contents in human blood plasma using high performance liquid chromatography-tandem ICP-mass spectrometry (HPLC-ICP-MS/MS).

scientific article

Development and validation of a novel quantification approach for gradient elution reversed phase high-performance liquid chromatography coupled to tandem ICP-mass spectrometry (RP-HPLC-ICP-MS/MS) and its application to diclofenac and its related co

scientific article published on 26 April 2017

Direct stereochemical assignment of hexose and pentose residues in flavonoid O-glycosides by fast atom bombardment and electrospray ionization mass spectrometry

scientific article

Disposition, metabolism, and excretion of [14C]doripenem after a single 500-milligram intravenous infusion in healthy men.

scientific article published on 21 July 2008

Enhanced performance for the analysis of prostaglandins and thromboxanes by liquid chromatography-tandem mass spectrometry using a new atmospheric pressure ionization source.

scientific article

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration

scientific article published in January 2009

Fast high-performance liquid chromatography method for quality control of soy extracts

scientific article published on 01 June 2004

Flexible nano- and microliter injections on a single liquid chromatography-mass spectrometry system: Minimizing sample preparation and maximizing linear dynamic range

scientific article published on 27 September 2017

HPLC/ICP-MS in combination with "reverse" online isotope dilution in drug metabolism studies

scientific article published on 22 February 2012

Herbal remedy-associated acute renal failure secondary to Cape aloes

scientific article published in March 2002

High sensitivity and selectivity in quantitative analysis of drugs in biological samples using 4-column multidimensional micro-UHPLC-MS enabling enhanced sample loading capacity

scientific article

High volume injections of biological samples for sensitive metabolite profiling and quantitation

scientific article published in December 2014

High-Resolution Mass Spectrometry Quantification: Impact of Differences in Data Processing of Centroid and Continuum Data

scientific article published on 17 December 2018

High-resolution MS: first choice for peptide quantification?

scientific article published in May 2013

High-resolution laser ablation-inductively coupled plasma-mass spectrometry imaging of cisplatin-induced nephrotoxic side effects

scientific article

Hyphenation of reverse-phase HPLC and ICP-MS for metabolite profiling--application to a novel antituberculosis compound as a case study

scientific article published on 4 May 2007

Identifying metabolite ions of peptide drugs in the presence of an in vivo matrix background

scientific article published in March 2012

Improved liquid chromatography—Online radioactivity detection for metabolite profiling

scientific article published in October 2008

In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin

scientific article published on 11 November 2016

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

scientific article published on 10 March 2009

Infrared ion spectroscopy: New opportunities for small-molecule identification in mass spectrometry - A tutorial perspective

scientific article published on 24 October 2019

Ion mobility mass spectrometry: Small molecule applications

scientific article published on 04 June 2019

Ionisation efficiencies can be predicted in complicated biological matrices: A proof of concept

scientific article published on 31 May 2018

IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers

scientific article

Mass Spectrometry Imaging of Drug Related Crystal-Like Structures in Formalin-Fixed Frozen and Paraffin-Embedded Rabbit Kidney Tissue Sections

scientific article published on 18 September 2015

Mass spectrometric methods for the characterisation and differentiation of isomeric O-diglycosyl flavonoids

scientific article published in May 2001

Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry

scientific article published on 03 March 2018

Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.

scientific article

Montmorillonite and Laponite Clay Materials for the Solidification of Lipid-Based Formulations for the Basic Drug Blonanserin: In Vitro and in Vivo Investigations

scientific article published in August 2018

Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

scientific article

One drop chemical derivatization--DESI-MS analysis for metabolite structure identification

scientific article published on July 2015

Optimization of a liquid chromatography method based on simultaneous electrospray ionization mass spectrometric and ultraviolet photodiode array detection for analysis of flavonoid glycosides

scientific article published in January 2002

Optimization of flow splitting and make-up flow conditions in liquid chromatography/electrospray ionization mass spectrometry

scientific article published on 01 February 2019

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

scientific article

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

scientific article

Product ion mobility as a promising tool for assignment of positional isomers of drug metabolites

scientific article published on 4 November 2011

Quantitative Metabolite Profiling of an Amino Group Containing Pharmaceutical in Human Plasma via Precolumn Derivatization and High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry

scientific article

Rapid quantification of 14 saponins of Maesa lanceolata by UPLC-MS/MS.

scientific article published on 13 February 2010

Selective drug metabolite trace analysis by very high-volume injections and heartcut two-dimensional (2D)-ultrahigh performance liquid chromatography (UHPLC)

scientific article published on 24 April 2019

Speciation analysis of bromine-containing drug metabolites in feces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution

scientific article published on 30 August 2011

Strategies and analytical workflows to extend the dynamic range in quantitative LC-MS/MS analysis

scientific article published on 17 June 2019

Structural characterization of chromone C-glucosides in a toxic herbal remedy

scientific article published in January 2003

Structural characterization of flavonol di-O-glycosides from Farsetia aegyptia by electrospray ionization and collision-induced dissociation mass spectrometry

scientific article published in January 2005

Structure characterization of flavonoid O-diglycosides by positive and negative nano-electrospray ionization ion trap mass spectrometry

scientific article published in November 2001

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity

scientific article published on 20 November 2014

The application of liquid chromatography-electrospray ionization mass spectrometry and collision-induced dissociation in the structural characterization of acylated flavonol O-glycosides from the seeds of Carrichtera annua.

scientific article published in January 2003

Translational safety biomarkers of colonic barrier integrity in the rat

scientific article published on 20 May 2018

Use of relative 12C/14C isotope ratios to estimate metabolite concentrations in the absence of authentic standards

scientific article published in January 2012

Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development.

scientific article

Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

scientific article published on February 2009

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