Search filters

List of works by Nick E. Le Brun

A Diatom Ferritin Optimized for Iron Oxidation but Not Iron Storage.

scientific article

A new role for heme, facilitating release of iron from the bacterioferritin iron biomineral

scientific article published on 23 November 2010

A tetranuclear Cu(I) cluster in the metallochaperone protein CopZ

scientific article

An EPR investigation of non-haem iron sites in Escherichia coli bacterioferritin and their interaction with phosphate. A study using nitric oxide as a spin probe.

scientific article

Atx1-like chaperones and their cognate P-type ATPases: copper-binding and transfer.

scientific article published on 16 January 2007

Bacillus subtilis ResA is a thiol-disulfide oxidoreductase involved in cytochrome c synthesis.

scientific article published on 7 March 2003

Bacterial iron detoxification at the molecular level

scientific article published on 12 October 2020

Bacterial iron-sulfur regulatory proteins as biological sensor-switches

scientific article published on 06 March 2012

Biochemical properties of Paracoccus denitrificans FnrP: reactions with molecular oxygen and nitric oxide

scientific article published on 20 January 2016

Bioinorganic chemistry

scientific article published on 18 January 2013

Characterization of [4Fe-4S]-containing and cluster-free forms of Streptomyces WhiD.

scientific article

Characterization of a putative NsrR homologue in Streptomyces venezuelae reveals a new member of the Rrf2 superfamily

scientific article published on 8 September 2016

Charge compensated binding of divalent metals to bacterioferritin: H+ release associated with cobalt(II) and zinc(II) binding at dinuclear metal sites

scientific article published on 01 November 1996

Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence

scientific article

CopAb, the second N-terminal soluble domain of Bacillus subtilis CopA, dominates the Cu(I)-binding properties of CopAab

scientific article published on 01 May 2012

CopZ fromBacillus subtilisinteracts in vivo with a copper exporting CPx-type ATPase CopA

scientific article published on 01 March 2003

Copper-mediated dimerization of CopZ, a predicted copper chaperone from Bacillus subtilis

scientific article published in December 2002

Core formation in Escherichia coli bacterioferritin requires a functional ferroxidase center

scientific article published in December 2003

Crystal Structure and Biophysical Properties of Bacillus subtilis BdbD: AN OXIDIZING THIOL:DISULFIDE OXIDOREDUCTASE CONTAINING A NOVEL METAL SITE

scientific article

Crystal Structure of the Transcription Regulator RsrR Reveals a [2Fe-2S] Cluster Coordinated by Cys, Glu, and His Residues

scientific article published on 01 February 2019

Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding

scientific article published on 20 April 2017

Cu(I)- and proton-binding properties of the first N-terminal soluble domain of Bacillus subtilis CopA

scientific journal article

Detection of sulfide release from the oxygen-sensing [4Fe-4S] cluster of FNR.

scientific article published on 22 May 2006

Differentiated, Promoter-specific Response of [4Fe-4S] NsrR DNA Binding to Reaction with Nitric Oxide.

scientific article

Distinct characteristics of Ag+ and Cd2+ binding to CopZ from Bacillus subtilis

scientific article published on 22 May 2008

Diversity of Fe2+ entry and oxidation in ferritins.

scientific article published on 14 March 2017

Effect of phosphate on bacterioferritin-catalysed iron(II) oxidation.

scientific article

Effects of substitutions in the CXXC active-site motif of the extracytoplasmic thioredoxin ResA

scientific article

Electron and Proton Transfers Modulate DNA Binding by the Transcription Regulator RsrR

scientific article published on 03 March 2020

Electron transfer ferredoxins with unusual cluster binding motifs support secondary metabolism in many bacteria

scientific article published on 23 August 2018

Fe-haem bound to Escherichia coli bacterioferritin accelerates iron core formation by an electron transfer mechanism.

scientific article

Ferritins: furnishing proteins with iron

scientific article

Formation of protein-coated iron minerals

scientific article

Generation of 34S-substituted protein-bound [4Fe-4S] clusters using 34S-L-cysteine

scientific article published on 22 January 2019

Heme binding to the second, lower-affinity site of the global iron regulator Irr from Rhizobium leguminosarum promotes oligomerization.

scientific article

Heme-responsive DNA binding by the global iron regulator Irr from Rhizobium leguminosarum.

scientific article published on 16 March 2010

High Cu(I) and low proton affinities of the CXXC motif of Bacillus subtilis CopZ.

scientific article published in August 2008

Identification of the ferroxidase centre of Escherichia coli bacterioferritin

scientific article

Influence of association state and DNA binding on the O₂-reactivity of [4Fe-4S] fumarate and nitrate reduction (FNR) regulator

scientific article published on October 2014

Influence of the environment on the [4Fe-4S]2+ to [2Fe-2S]2+ cluster switch in the transcriptional regulator FNR.

scientific article

Insights into methionine S-methylation in diverse organisms

scientific article published on 26 May 2022

Interaction of nitric oxide with non-haem iron sites of Escherichia coli bacterioferritin: reduction of nitric oxide to nitrous oxide and oxidation of iron(II) to iron(III).

scientific article published on August 1997

Interaction of the Streptomyces Wbl protein WhiD with the principal sigma factor σHrdB depends on the WhiD [4Fe-4S] cluster

scientific article published on 16 April 2020

Iron Oxidation in<i>Escherichia coli</i>Bacterioferritin Ferroxidase Centre, a Site Designed to React Rapidly with H<sub>2</sub>O<sub>2</sub>but Slowly with O<sub>2</sub>

scientific article published in 2021

Iron core mineralisation in prokaryotic ferritins.

scientific article published on 11 April 2010

Iron detoxification properties of Escherichia coli bacterioferritin. Attenuation of oxyradical chemistry.

scientific article

Iron-sulfur cluster sensor-regulators

scientific article published on 02 March 2012

Iron-sulfur clusters as biological sensors: the chemistry of reactions with molecular oxygen and nitric oxide

scientific article published on 29 September 2014

Kinetic analysis of copper transfer from a chaperone to its target protein mediated by complex formation.

scientific article published on 12 January 2017

Kinetic and structural characterization of an intermediate in the biomineralization of bacterioferritin

scientific article

MCD, EPR and NMR spectroscopic studies of rabbit hemopexin and its heme binding domain

scientific article published on 01 December 1995

Mass Spectrometric Identification of [4Fe-4S](NO)x Intermediates of Nitric Oxide Sensing by Regulatory Iron-Sulfur Cluster Proteins

scientific article published on 07 February 2019

Mass spectrometric detection of iron nitrosyls, sulfide oxidation and mycothiolation during nitrosylation of the NO sensor [4Fe-4S] NsrR.

scientific article published in June 2018

Mass spectrometric identification of intermediates in the O2-driven [4Fe-4S] to [2Fe-2S] cluster conversion in FNR.

scientific article

Mass spectrometric studies of Cu(I)-binding to the N-terminal domains of B. subtilis CopA and influence of bacillithiol

scientific article published on 13 October 2018

Mass spectrometry of B. subtilis CopZ: Cu(i)-binding and interactions with bacillithiol.

scientific article

Mechanism of Ferrous Iron Binding and Oxidation by Ferritin from a Pennate Diatom

scientific article

Mechanism of [4Fe-4S](Cys)4 cluster nitrosylation is conserved among NO-responsive regulators.

scientific article

Mechanisms of iron mineralization in ferritins: one size does not fit all.

scientific article published on 19 April 2014

Mechanisms of iron- and O-sensing by the [4Fe-4S] cluster of the global iron regulator RirA

scientific article published on 17 September 2019

Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins

scientific article

Mechanistic insights into Cu(I) cluster transfer between the chaperone CopZ and its cognate Cu(I)-transporting P-type ATPase, CopA

scientific article

Molecular Basis for Specificity of the Extracytoplasmic Thioredoxin ResA

scientific article published in Journal of Biological Chemistry

Monitoring the iron status of the ferroxidase center of Escherichia coli bacterioferritin using fluorescence spectroscopy

scientific article

Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster

scientific journal article

NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulphur proteins in Arabidopsis thaliana.

scientific article

Nitrosylation of Nitric-Oxide-Sensing Regulatory Proteins Containing [4Fe-4S] Clusters Gives Rise to Multiple Iron-Nitrosyl Complexes.

scientific article

NosL is a dedicated copper chaperone for assembly of the CuZ center of nitrous oxide reductase

scientific article published on 18 April 2019

NsrR from Streptomyces coelicolor is a nitric oxide-sensing [4Fe-4S] cluster protein with a specialized regulatory function.

scientific article published on 14 March 2015

PerR controls oxidative stress defence and aerotolerance but not motility-associated phenotypes of Campylobacter jejuni.

scientific article published on 12 May 2015

Protein-template-driven formation of polynuclear iron species

scientific article published in January 2004

Pumping iron: does bacterioferritin contain a redox-driven iron pump?

scientific article published on February 1997

Reaction of O2 with a diiron protein generates a mixed-valent Fe2+/Fe3+ center and peroxide

scientific article published on 18 January 2019

Reactions of nitric oxide and oxygen with the regulator of fumarate and nitrate reduction, a global transcriptional regulator, during anaerobic growth of Escherichia coli.

scientific article published on January 2008

Redox-Sensing Iron-Sulfur Cluster Regulators.

scientific article

Redox-sensing iron-sulfur cluster regulators

scientific article

Replacement of Methionine as the Axial Ligand of Achromobacter cycloclastes Cytochrome C554 at High pH Values Revealed by Absorption, EPR and MCD Spectroscopy

scientific article published on 01 October 1994

Reversible cycling between cysteine persulfide-ligated [2Fe-2S] and cysteine-ligated [4Fe-4S] clusters in the FNR regulatory protein.

scientific article

Routes of iron entry into, and exit from, the catalytic ferroxidase sites of the prokaryotic ferritin SynFtn

scientific article published on 01 February 2020

RsmA is an anti-sigma factor that modulates its activity through a [2Fe-2S] cluster cofactor.

scientific article published on 31 August 2007

Second Coordination Sphere Effects on the Mechanistic Pathways for Dioxygen Activation by a Ferritin: Involvement of a Tyr Radical and the Identification of a Cation Binding Site

scientific article published in 2022

Sensing iron availability via the fragile [4Fe-4S] cluster of the bacterial transcriptional repressor RirA.

scientific article published on 23 October 2017

Signal perception by FNR: the role of the iron-sulfur cluster

scientific article published in December 2008

Site-directed replacement of the coaxial heme ligands of bacterioferritin generates heme-free variants.

scientific article

Spectroscopic studies of cobalt(II) binding to Escherichia coli bacterioferritin.

scientific article

Structural and Mechanistic Studies of a Stabilized Subunit Dimer Variant of Escherichia coli Bacterioferritin Identify Residues Required for Core Formation

scientific article

Structural basis for iron mineralization by bacterioferritin

scientific article

Structural basis of Redox-coupled protein substrate selection by the cytochrome c biosynthesis protein ResA.

scientific article published on 26 March 2004

Structural heterogeneity of Pseudomonas aeruginosa bacterioferritin

scientific article published on December 1994

Structure and Cu(I)-binding properties of the N-terminal soluble domains of Bacillus subtilis CopA

scientific article

Structure and Functional Properties of Bacillus subtilis Endospore Biogenesis Factor StoA

scientific article

Structure of a Wbl protein and implications for NO sensing by M. tuberculosis.

scientific article published on 22 December 2017

Studies of the cytochrome subunits of menaquinone:cytochrome c reductase (bc complex) of Bacillus subtilis. Evidence for the covalent attachment of heme to the cytochrome b subunit

scientific article published on 01 April 1998

Superoxide-mediated amplification of the oxygen-induced switch from [4Fe-4S] to [2Fe-2S] clusters in the transcriptional regulator FNR.

scholarly article

Techniques for the production, isolation, and analysis of iron-sulfur proteins

scientific article published in January 2014

The B-type channel is a major route for iron entry into the ferroxidase center and central cavity of bacterioferritin.

scientific article

The Molecular Bases of the Dual Regulation of Bacterial Iron Sulfur Cluster Biogenesis by CyaY and IscX.

scientific article published in January 2017

The N-terminal domains of Bacillus subtilis CopA do not form a stable complex in the absence of their inter-domain linker

scientific article published on 13 November 2017

The N-terminal soluble domains of Bacillus subtilis CopA exhibit a high affinity and capacity for Cu(I) ions

scientific article published in January 2009

The O2 sensitivity of the transcription factor FNR is controlled by Ser24 modulating the kinetics of [4Fe-4S] to [2Fe-2S] conversion.

scholarly article

The active-site cysteinyls and hydrophobic cavity residues of ResA are important for cytochrome c maturation in Bacillus subtilis

scientific article

The dddP gene of Roseovarius nubinhibens encodes a novel lyase that cleaves dimethylsulfoniopropionate into acrylate plus dimethyl sulfide

scientific article published on 8 April 2010

The iron oxidation and hydrolysis chemistry of Escherichia coli bacterioferritin

scientific article published in April 2000

The role of ResA in type II cytochrome c maturation.

scientific article

The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster

scientific article

There's NO stopping NsrR, a global regulator of the bacterial NO stress response.

scientific article published on 16 February 2010

Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin.

scientific article published on 16 October 2015

Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin.

scientific article

Three Pseudomonas putida FNR Family Proteins with Different Sensitivities to O2.

scientific article published on 13 May 2015

Tyr25, Tyr58 and Trp133 of Escherichia coli bacterioferritin transfer electrons between iron in the central cavity and the ferroxidase centre

scientific article

nosX is essential for whole-cell N2O reduction in Paracoccus denitrificans but not for assembly of copper centres of nitrous oxide reductase

scientific article published on 04 September 2020

Paulina is supported by:

About Paulina

Help