List of works - Matthew D Cheeseman

A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.

scientific article

A novel strategy for the asymmetric synthesis of chiral cyclopropane carboxaldehydes

scientific article published on 17 March 2005

A temporary stereocentre approach for the asymmetric synthesis of chiral cyclopropane-carboxaldehydes

scientific article published on 8 July 2009

An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56

scientific article published on 22 February 2017

Asymmetric synthesis of chiral δ-lactones containing multiple contiguous stereocenters

scientific article published on 14 June 2011

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).

scientific article

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.

scientific article

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

scientific article published on 22 December 2016

Efficient asymmetric synthesis of chiral hydroxy-gamma-butyrolactones

scientific article

Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.

scientific article

Flexible strategy for the synthesis of pyrrolizidine alkaloids

scientific article published on 18 July 2008

Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition

scientific article

Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72

scientific article published on 06 December 2019

Lysine-Targeting Covalent Inhibitors.

scientific article published on 29 August 2017

N-N bond-forming cyclization for the one-pot synthesis of N-aryl[3,4-d]pyrazolopyrimidines.

scientific article published on 26 June 2012

Privileged Structures and Polypharmacology within and between Protein Families.

scientific article

Stereoselective synthesis of (E)-trisubstituted alpha,beta-unsaturated amides and acids

scientific article published on 30 June 2005

Synthesis of (+)-DGDP and (-)-7-epialexine

scientific article

Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex

scientific article published on 25 April 2017

Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.

scientific article

List of works by Matthew D Cheeseman

A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.

A novel strategy for the asymmetric synthesis of chiral cyclopropane carboxaldehydes

A temporary stereocentre approach for the asymmetric synthesis of chiral cyclopropane-carboxaldehydes

An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56

Asymmetric synthesis of chiral δ-lactones containing multiple contiguous stereocenters

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Efficient asymmetric synthesis of chiral hydroxy-gamma-butyrolactones

Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.

Flexible strategy for the synthesis of pyrrolizidine alkaloids

Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition

Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72

Lysine-Targeting Covalent Inhibitors.

N-N bond-forming cyclization for the one-pot synthesis of N-aryl[3,4-d]pyrazolopyrimidines.

Privileged Structures and Polypharmacology within and between Protein Families.

Stereoselective synthesis of (E)-trisubstituted alpha,beta-unsaturated amides and acids

Synthesis of (+)-DGDP and (-)-7-epialexine

Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex

Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.