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List of works by Matthew D Cheeseman

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Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).

scientific article
Lysine-Targeting Covalent Inhibitors.

scientific article published on 29 August 2017
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

scientific article published on 22 December 2016
Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.

scientific article
Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition

scientific article
An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56

scientific article published on 22 February 2017
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.

scientific article
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms

scientific article
N-N bond-forming cyclization for the one-pot synthesis of N-aryl[3,4-d]pyrazolopyrimidines.

scientific article published on 26 June 2012
A temporary stereocentre approach for the asymmetric synthesis of chiral cyclopropane-carboxaldehydes

scientific article published on 8 July 2009
Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex

scientific article published on 25 April 2017
Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.

scientific article
Synthesis of (+)-DGDP and (-)-7-epialexine

scientific article
Flexible strategy for the synthesis of pyrrolizidine alkaloids

scientific article published on 18 July 2008
Efficient asymmetric synthesis of chiral hydroxy-gamma-butyrolactones

scientific article
A novel strategy for the asymmetric synthesis of chiral cyclopropane carboxaldehydes

scientific article published on 17 March 2005
Asymmetric synthesis of chiral δ-lactones containing multiple contiguous stereocenters

scientific article published on 14 June 2011
Privileged Structures and Polypharmacology within and between Protein Families.

scientific article
Supplementary Figure S8 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Figure 4 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Supplementary Figure S1 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Supplementary Figure S2 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Figure 6 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Data from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Figure 5 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Figure 1 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Supplementary Figure S9 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Supplementary Figure S4 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Stereoselective synthesis of (E)-trisubstituted alpha,beta-unsaturated amides and acids

scientific article published on 30 June 2005
Supplementary Figure S5 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Figure 2 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Supplementary Tables S1-S13 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72

scientific article published on 06 December 2019
Figure 3 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Supplementary Figure S3 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Supplementary Figure S7 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Supplementary Figure S10 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Supplementary Figure S6 from NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

scientific article published on 9 January 2025

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