List of works - Keith Jones

A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation

scientific article published on 01 March 2007

A model β-sheet interaction and thermodynamic analysis of β-strand mimetics

scientific article published on 01 July 2015

An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56

scientific article published on 22 February 2017

Cancer Drug Discovery 2010: from molecules to medicine.

scientific article

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).

scientific article

Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit.

scientific article published on 10 February 2010

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.

scientific article

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

scientific article published on 22 December 2016

Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger

scientific article published on 15 May 2015

Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2

scientific article

HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target.

scientific article

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

scientific article

Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition

scientific article

Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72

scientific article published on 06 December 2019

Lysine-Targeting Covalent Inhibitors.

scientific article published on 29 August 2017

N-N bond-forming cyclization for the one-pot synthesis of N-aryl[3,4-d]pyrazolopyrimidines.

scientific article published on 26 June 2012

Privileged Structures and Polypharmacology within and between Protein Families.

scientific article

Recent advances in cancer therapeutics.

scientific article

Small-Molecule Inhibitors of the Protein Methyltransferase SET7/9 Identified in a High-Throughput Screen ⬇️

scientific article published on July 5, 2012

Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes.

scientific article published in November 2005

Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. ⬇️

scientific article

Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine

scientific article published on 6 September 2017

Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?

scientific article

Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex

scientific article published on 25 April 2017

Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.

scientific article

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design

scientific article

The synthesis and structure revision of NSC-134754

scientific article published on 01 February 2014

List of works by Keith Jones

A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation

A model β-sheet interaction and thermodynamic analysis of β-strand mimetics

An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56

Cancer Drug Discovery 2010: from molecules to medicine.

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).

Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit.

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger

Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2

HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target.

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition

Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72

Lysine-Targeting Covalent Inhibitors.

N-N bond-forming cyclization for the one-pot synthesis of N-aryl[3,4-d]pyrazolopyrimidines.

Privileged Structures and Polypharmacology within and between Protein Families.

Recent advances in cancer therapeutics.

Small-Molecule Inhibitors of the Protein Methyltransferase SET7/9 Identified in a High-Throughput Screen ⬇️

Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes.

Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. ⬇️

Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine

Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?

Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex

Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design

The synthesis and structure revision of NSC-134754