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List of works by Amin Rostami-Hodjegan

A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations

scientific article published on 22 May 2020

A PBPK Model to Predict Disposition of CYP3A‐Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction

scientific article published on September 26, 2012

A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women

scientific article published on January 25, 2013

A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease–Drug Interactions: Suppression of CYP3A by IL-6

scientific article published on April 10, 2013

A new rapidly absorbed paracetamol tablet containing sodium bicarbonate. I. A four-way crossover study to compare the concentration-time profile of paracetamol from the new paracetamol/sodium bicarbonate tablet and a conventional paracetamol tablet

A pregnancy physiologically based pharmacokinetic (p‐PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4

scientific article published on November 1, 2012

A re-evaluation and validation of ontogeny functions for cytochrome P450 1A2 and 3A4 based on in vivo data

scientific article

Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro–in vivo extrapolation of oral drug absorption

scientific article published on 08 October 2012

Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions

scientific article published on May 30, 2013

Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?

scientific article published on 10 August 2016

Altered Bioavailability and Pharmacokinetics in Crohn’s Disease: Capturing Systems Parameters for PBPK to Assist with Predicting the Fate of Orally Administered Drugs

scientific article published in 2022

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz.

scientific article published on 27 March 2018

Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6.

scientific article published on 10 July 2016

Application of in vitro-in vivo extrapolation (IVIVE) and physiologically based pharmacokinetic (PBPK) modelling to investigate the impact of the CYP2C8 polymorphism on rosiglitazone exposure

scientific article published on January 11, 2013

Application of permeability-limited physiologically-based pharmacokinetic models: Part I–digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux

scientific article published on May 22, 2013

Application of permeability‐limited physiologically-based pharmacokinetic models: Part II-prediction of p‐glycoprotein mediated drug–drug interactions with digoxin

scientific article published on May 19, 2013

Application of the MechPeff model to predict passive effective intestinal permeability in the different regions of the rodent small intestine and colon

scientific article

Application of the Nested Enzyme-Within-Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

scientific article published on 28 September 2020

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability

scientific article

Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter‐system extrapolation factors

scientific article published on July 4, 2011

Assessment of inter-individual variability in predicted phenytoin clearance

scientific article published in December 2009

Choice of LC-MS methods for the absolute quantification of drug-metabolizing enzymes and transporters in human tissue: a comparative cost analysis

scientific article published on 6 February 2015

Comparison of the rates of disintegration, gastric emptying, and drug absorption following administration of a new and a conventional paracetamol formulation, using gamma scintigraphy

scientific article published on October 1, 2003

Data Generated by Quantitative Liquid Chromatography-Mass Spectrometry Proteomics Are Only the Start and Not the Endpoint: Optimization of Quantitative Concatemer-Based Measurement of Hepatic Uridine-5'-Diphosphate-Glucuronosyltransferase Enzymes wi

scientific article published on 26 March 2018

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

scientific article published on 14 December 2015

Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations

scientific article published on November 1, 2010

Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

scientific article

Do Children Have the Same Vulnerability to Metabolic Drug–Drug Interactions as Adults? A Critical Analysis of the Literature

scientific article published on May 1, 2013

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments

scientific article published on 5 February 2018

Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19

scientific article published on March 1, 2014

Expression of hepatic drug-metabolizing cytochrome p450 enzymes and their intercorrelations: a meta-analysis

scientific article published on 30 May 2014

Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

scientific article

Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination

scientific article published on 10 March 2016

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

scientific article published on 28 September 2016

IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

scientific article published on 23 September 2016

Identification of the effect of multiple polymorphisms on the pharmacokinetics of simvastatin and simvastatin acid using a population-modeling approach

scientific article published on 5 March 2014

Implications of inter-correlation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: a case study with repaglinide

scientific article

In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition

scientific article published on 3 February 2016

Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information

scientific article

In‐depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: Part I – Applications and rationale behind the use of open source‐code software

scientific article published in 2023

In‐depth analysis of patterns in selection of different physiologically‐based pharmacokinetic modeling tools: Part II — Assessment of model reusability and comparison between open and non‐open source‐code software

scientific article published in 2023

Is Cmax/AUC Useful for Bioequivalence Testing?

scientific article published on 01 December 1997

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation

scientific article

Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine-Drug Interactions

scientific article published on 14 May 2020

Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson??s disease

scientific article published on June 1, 1998

Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans

scientific article

Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors.

scientific article

PBPK models for the prediction of in vivo performance of oral dosage forms

scientific article published in European Journal of Pharmaceutical Sciences in June 2014

Physiological-based pharmacokinetic modeling trends in pharmaceutical drug development over the last 20-years; In-depth analysis of applications, organizations, and platforms

scientific article published on 15 December 2020

Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

scientific article published on May 30, 2012

Physiologically based pharmacokinetic modelling to guide drug delivery in older people

scientific article published on 04 September 2018

Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics during Pregnancy: Achievements and Shortcomings

scientific article published on July 1, 2012

Population-based mechanistic prediction of oral drug absorption

scientific article published on 21 April 2009

Predicting drug–drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach

scientific article published on March 1, 2013

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

scientific article published on 29 March 2016

Prediction of concentration-time profile and its inter-individual variability following the dermal drug absorption

scientific article published on 19 April 2012

Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation

scientific article published on 30 November 2017

Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

scientific article published on January 2014

Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver

scientific article published on 30 April 2020

Quantifying gut wall metabolism: methodology matters

scientific article published on 30 December 2016

Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase (UGT) Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

scientific article

Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine

scientific article published on 20 January 2020

Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: a case study using the BCS/BDDCS Class II drug nifedipine

scientific article

Response to “The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models”

scientific article published on 05 November 2012

Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence

scientific article published on 12 October 2017

Systematic and quantitative assessment of the effect of chronic kidney disease on CYP2D6 and CYP3A4/5.

scientific article

The Proton Pump Inhibitor, Omeprazole, but Not Lansoprazole or Pantoprazole, Is a Metabolism-Dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel

scientific article published on July 27, 2011

The absorption kinetics of ketoconazole plays a major role in explaining the reported variability in the level of interaction with midazolam: Interplay between formulation and inhibition of gut wall and liver metabolism

scientific article published on 21 December 2016

The modulating effects of endogenous substances on drug metabolising enzymes and implications for inter-individual variability and quantitative prediction

scientific article published on January 2014

Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance

scientific article published on 09 November 2018

Utility of Model-Based Approaches for Informing Dosing Recommendations in Specific Populations: Report From the Public AAPS Workshop

scientific article published on July 2016