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List of works by María-José Camarasa

"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains.

scientific article published in April 2001

(F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase

scientific article published on 26 June 2019

1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activity

scientific article published on November 1994

3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2', 5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-xylo- and -ribofuranose]-3'-spiro-5''-[4''-amino-1'', 2''-oxathiole 2''

3′--Cyano-3′-deoxythymidine

4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action

scientific article

4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family.

scientific article published in April 2001

4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus

scientific article

4-Benzyloxy-γ-Sultone Derivatives: Discovery of a Novel Family of Non-Nucleoside Inhibitors of Human Cytomegalovirus and Varicella Zoster Virus

5'-O-Tritylated Nucleoside Derivatives: Inhibition of Thymidine Phosphorylase and Angiogenesis

scientific article published on 04 May 2006

5‘-O-Tritylinosine and Analogues as Allosteric Inhibitors of Human Thymidine Phosphorylase

scientific article published on 01 September 2006

5′-Trityl-Substituted Thymidine Derivatives as a Novel Class of Antileishmanial Agents:Leishmania infantumEndoG as a Potential Target

article

7,5'-O-dibenzylinosines: synthesis and studies on their conformational properties

scientific article published in January 2007

7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase

scientific article published on 01 October 1998

9-Arylpurines as a novel class of enterovirus inhibitors.

scientific article

A Cyclic Enamine Derived from 1,2-O-Isopropylidene-α-d-xylofuranose As a Novel Carbohydrate Intermediate To Achieve Skeletal Diversity

scientific article published on 01 September 2006

A Novel Class of Cationic and Non-Peptidic Small Molecules as Hits for the Development of Antimicrobial Agents

article

Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.

scientific article published on November 1998

Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.

scientific article

Aldol Reaction of Nucleoside 5′-Carboxaldehydes with Acetone. Synthesis of 5′-C-Chain Extended Thymidine Derivatives

Aldol reaction of reducing sugars. Convenient stereoselective synthesis of ribofuranosylacetone and chiral dienones

Alkylidene carbenes as intermediates in the synthesis of highly functionalized branched-chain sugars and nucleosides

Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers.

scientific article published on 21 October 2015

Anti-angiogenic activity of a novel multi-substrate analogue inhibitor of thymidine phosphorylase

scientific article published in January 2002

Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

scientific article published on 12 June 2017

Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine-containing drugs

scientific article published in January 2010

Comparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase

scholarly article in RSC Advances, vol. 5 no. 69, 2015

Conformational Studies of 3′-Spironucleosides (TSAO-T and Analogues) by NMR Spectroscopy

Conservation of antiviral activity and improved selectivity in PMEO-DAPym upon pyrimidine to triazine scaffold hopping

scientific article published on 11 August 2015

Crystal Structure of tert -Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket

scientific article

Design and Discovery of a Novel Dipeptidyl-peptidase IV (CD26)-Based Prodrug Approach

article by Carlos García-Aparicio et al published August 2006 in Journal of Medicinal Chemistry

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone

scientific article published on 15 October 2010

Design, synthesis, and biological evaluation of unconventional aminopyrimidine, aminopurine, and amino-1,3,5-triazine methyloxynucleosides

scientific article

Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes?

scientific article published on 28 June 2006

Dipeptidyl Peptidase IV (DPPIV/CD26)-Based Prodrugs of Hydroxy-Containing Drugs

scientific article published on 03 February 2012

Dipeptidyl peptidase IV dependent water-soluble prodrugs of highly lipophilic bicyclic nucleoside analogues

scientific article published on 18 February 2011

Dipeptidyl peptidase IV-activated prodrugs of anti-varicella zoster virus bicyclic nucleoside analogues containing different self-cleavage spacer systems

scientific article published on 6 August 2012

Discovery and SAR studies of a novel class of cytotoxic 1,4-disubstituted piperidines via Ugi reaction

scientific article

Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile

scientific article published on 29 March 2006

Efficient conversion of tetrapeptide-based TSAO prodrugs to the parent drug by dipeptidyl-peptidase IV (DPPIV/CD26).

scientific article published on August 2007

Efficient synthesis and anti-enteroviral activity of 9-arylpurines

scientific article published on 17 January 2012

Evidence for the Involvement of the Small Subunit of HIV-1 Reverse Transcriptase (RT) in the TSAO-Resistance

article

Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

scientific article

From β-Amino-γ-sultone to Unusual Bicyclic Pyridine and Pyrazine Heterocyclic Systems: Synthesis and Cytostatic and Antiviral Activities

article

Functional characterization of chimeric reverse transcriptases with polypeptide subunits of highly divergent HIV-1 group M and O strains.

scientific article published on 15 May 2001

Glycosyl-oxycarbonylaminosulfonyl-2',3'-dideoxynucleoside derivatives as lipophilic nucleotide mimics. Synthesis and anti-HIV activity.

scientific article published on October 1993

HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase

scientific article published on January 1993

Hybrids of [TSAO-T]-[foscarnet]: The first conjugate of foscarnet with a non-nucleoside reverse transcriptase inhibitor through a labile covalent ester bond

scientific article published on June 2004

Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replication

scientific article

Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase

scientific article published in December 2001

Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.

scientific article published in June 2001

Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59).

scientific article published on 21 April 2009

Improving the antiviral efficacy and selectivity of HIV-1 reverse transcriptase inhibitor TSAO-T by the introduction of functional groups at the N-3 position

scientific article published on October 2005

Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: replacement of a triphenylmethoxy moiety with substituted amines and carboxamides

scientific article published in September 2003

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones.

scientific article

Intramolecular cation-pi interactions as the driving force to restrict the conformation of certain nucleosides

scientific article published in March 2010

Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase.

scientific article

Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus.

scientific article published on October 1993

Leishmania infantum EndoG is an endo/exo-nuclease essential for parasite survival

scientific article

Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.

scientific article published on 17 January 2015

Microwave-Assisted Synthesis of 9-Arylpurines

scientific article published on 01 March 2009

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.

scientific article

Mitochondrial thymidine kinase inhibitors

scientific article

Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1.

scientific article

N-(glucopyranosid-3-yl)--alanyl--alanyl--isoglutamine and related tripeptide analogues of muramyl dipeptide

N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase

scientific article published in May 2003

N1-Substituted Thymine Derivatives as Mitochondrial Thymidine Kinase (TK-2) Inhibitors

scientific article published on 01 December 2006

Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase

scientific article published in February 2003

Novel 9-Arylpurines, as Selective Inhibitors of In Vitro Enterovirus Replication

scientific article published in 2009

Novel Analogues of the Anti-HIV-1 Agent TSAO-T Modified at the 3′-Spiro Moiety

article

Novel L-lyxo and 5'-deoxy-5'-modified TSAO-T analogs: synthesis and anti-HIV-1 activity.

scientific article published on November 1996

Novel N-3 substituted TSAO-T derivatives: synthesis and anti-HIV-evaluation.

scientific article

Novel TSAO Derivatives Modified at Positions 3′ and 4′ Of the Spiro Moiety

scientific article published on 01 April 1999

Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.

scientific article published on February 2005

Novel aldol-type cyclocondensation of O-mesyl (methylsulphonyl) cyanohydrins. Application to the stereospecific synthesis of branched-chain sugars

Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach

scientific article published on 9 May 2014

Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships

scientific article published in January 2007

Novel series of TSAO-T derivatives. Synthesis and anti-HIV-1 activity of 4-, 5-, and 6-substituted pyrimidine analogues.

scientific article published on February 1994

Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme

scientific article published on 9 October 2013

One-pot synthesis of polycyclic nucleosides with unusual molecular skeletons.

scientific article published in December 2009

Optimization of a Class of Tryptophan Dendrimers That Inhibit HIV Replication Leads to a Selective, Specific, and Low-Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71.

scientific article published on 31 May 2016

Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?

scientific article

Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients

scientific article published in June 2000

Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides

scientific article published on 6 June 2013

Prodrugs of Antiviral Nucleosides Cleavable by Dipeptidyl-Peptidase-IV (CD26)

scientific article published in 2008

Prodrugs of Nucleoside Triphosphates as a Sound and Challenging Approach: A Pioneering Work That Opens a New Era in the Direct Intracellular Delivery of Nucleoside Triphosphates

scientific article published on 27 August 2018

Pyrido[2,1-f]purine-2,4-dione derivatives as a novel class of highly potent human A(3) adenosine receptor antagonists.

scientific article

Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase

scientific article published on 23 April 2019

Radical cyclizations on sugar templates: Stereoselective synthesis of fused γ-butyrolactones of carbohydrates

article by Sonsoles Velázquez & María-José Camarasa published November 1994 in Tetrahedron: Asymmetry

Reactivity of the 4-amino-5H-1,2-oxathiole-2,2-dioxide heterocyclic system: a combined experimental and theoretical study

scientific article

Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications

scientific article published on January 2012

Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.

scientific article published on January 2004

Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors

scientific article published on 20 December 2019

Selective human adenosine A3 antagonists based on pyrido[2,1-f]purine-2,4-diones: novel features of hA3 antagonist binding.

scientific article

Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides

scientific article published on 12 May 2011

Sensitivity of (138 Glu-->Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors

scientific article

Sensitivity/resistance profile of a simian immunodeficiency virus containing the reverse transcriptase gene of human immunodeficiency virus type 1 (HIV-1) toward the HIV-1-specific non-nucleoside reverse transcriptase inhibitors

scientific article

Stereoselective Synthesis of 3-C-Branched-Chain Sugars by Aldol Reaction of Furanos-3-Uloses with Acetone

Stereoselective synthesis of [3.3.0] fused lactones (γ-butyrolactones) of sugars and nucleosides by free radical intramolecular cyclization

Stereospecific synthesis of branched-chain sugars by a novel aldol-type cyclocondensation

Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future.

scientific article published on September 2008

Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid.

scientific article published on 22 December 2016

Structure-activity relationship studies on a novel family of specific HIV-1 reverse transcriptase inhibitors.

scientific article published on September 2003

Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.

scientific article

Synthesis and Anti-HIV-1 Activity of 4- and 5-Substituted 1,2,3-Triazole-TSAO Derivatives

article

Synthesis and Biological Studies of Mutagenic Ribonucleoside Analogues as Potential Inducers of Error Catastrophe of Riboviruses

scientific article published in 2009

Synthesis and Evaluation of Antiviral Activity of 3'-C-Cyano-3'-Deoxynucleosides

Synthesis and NMR conformational studies of stable analogues of 2-deoxy-α-D-ribose-1-phosphate

Synthesis and SAR of 9-Arylpurines as Novel Inhibitors of Enterovirus Replication

scientific article published in 2009

Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.

scientific article published on May 1995

Synthesis and anti-HIV-1 activity of novel TSAO-T derivatives modified at the 2'- and 5'-positions of the sugar moiety.

scientific article published on June 1995

Synthesis and antiproliferative activity of 6-phenylaminopurines.

scientific article published on 30 September 2014

Synthesis and evaluation of thymine-derived carboxamides against mitochondrial thymidine kinase (TK-2) and related enzymes

scientific article published in October 2004

Synthesis and structural characterization of pyrimidine bi- and tricyclic nucleosides with sugar puckers conformationally locked into the eastern region of the pseudorotational cycle.

scientific article published in August 2003

Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach

scientific article published on August 2002

Synthesis of 3′-Spiro-Substituted Nucleosides: Chemistry of TSAO Nucleoside Derivatives

Synthesis of [1-[3′,5′-Bis-O-(tert-butyldimethylsilyl)-β-d-arabino- and β-d-ribofuranosyl]cytosine]-2′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide). Analogues of the highly specific anti-HIV-1 agent TSAO-T

article

Synthesis of highly condensed polycyclic carbohydrates by reaction of a spirocyclic enamino sulfonate derived from d-xylofuranose with bifunctional reagents.

scientific article published on 14 November 2007

Synthesis of novel Bi-, Tri-, and tetracyclic nucleosides by reaction of a common cyclic enamine derived from TSAO-T with nucleophiles

scientific article published in December 2004

Synthesis, NMR studies and theoretical calculations of novel 3-spiro-branched ribofuranoses

TSAO analogues. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl 3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) purine and purine-modified nucleosides.

scientific article published on October 1993

TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase

scientific article published on January 2004

TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: recent progress.

scientific article

Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids

scientific article published on 13 July 2011

The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs

scientific article

The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors

scientific article published on 15 April 2005

The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action

scientific article

The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A.

scientific article

Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications

scientific article

Thymidine phosphorylase is noncompetitively inhibited by 5'-O-trityl-inosine (KIN59) and related compounds.

scientific article

Towards new thymidine phosphorylase/PD-ECGF inhibitors based on the transition state of the enzyme reaction

scientific article published in May 2003

Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41.

scientific article published on 21 October 2015

Unprecedented lability of the 5'-O-tert-butyldimethylsilyl group from 3'-spiro-5''-(4''-acylamino-1'',2''-oxathiole-2'',2''-dioxide) nucleoside derivatives via neighboring group participation of the 4''-acylamino residue.

scientific article published in February 2006

Unusual lability of 5'-O-tert-butyldimethylsilyl group on 4''-acyl TSAO derivatives

scientific article published in May 2003

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