List of works - Sonsoles Velázquez

"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains.

scientific article published in April 2001

4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action

scientific article

4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family.

scientific article published in April 2001

4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus

scientific article

4-Benzyloxy-γ-Sultone Derivatives: Discovery of a Novel Family of Non-Nucleoside Inhibitors of Human Cytomegalovirus and Varicella Zoster Virus

A Cyclic Enamine Derived from 1,2-O-Isopropylidene-α-d-xylofuranose As a Novel Carbohydrate Intermediate To Achieve Skeletal Diversity

scientific article published on 01 September 2006

Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.

scientific article published on November 1998

Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine-containing drugs

scientific article published in January 2010

Comparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase

scholarly article in RSC Advances, vol. 5 no. 69, 2015

Design and Discovery of a Novel Dipeptidyl-peptidase IV (CD26)-Based Prodrug Approach

article by Carlos García-Aparicio et al published August 2006 in Journal of Medicinal Chemistry

Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes?

scientific article published on 28 June 2006

Dipeptidyl Peptidase IV (DPPIV/CD26)-Based Prodrugs of Hydroxy-Containing Drugs

scientific article published on 03 February 2012

Dipeptidyl peptidase IV dependent water-soluble prodrugs of highly lipophilic bicyclic nucleoside analogues

scientific article published on 18 February 2011

Dipeptidyl peptidase IV-activated prodrugs of anti-varicella zoster virus bicyclic nucleoside analogues containing different self-cleavage spacer systems

scientific article published on 6 August 2012

Dipeptidyl-peptidase IV (DPP IV/CD26)-activated prodrugs: a successful strategy for improving water solubility and oral bioavailability

scientific article

Discovery and SAR studies of a novel class of cytotoxic 1,4-disubstituted piperidines via Ugi reaction

scientific article

Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile

scientific article published on 29 March 2006

Efficient conversion of tetrapeptide-based TSAO prodrugs to the parent drug by dipeptidyl-peptidase IV (DPPIV/CD26).

scientific article published on August 2007

Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV.

scientific article published on July 2001

From β-Amino-γ-sultone to Unusual Bicyclic Pyridine and Pyrazine Heterocyclic Systems: Synthesis and Cytostatic and Antiviral Activities

article

Hybrids of [TSAO-T]-[foscarnet]: The first conjugate of foscarnet with a non-nucleoside reverse transcriptase inhibitor through a labile covalent ester bond

scientific article published on June 2004

Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase

scientific article published in December 2001

Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.

scientific article published in June 2001

Improving the antiviral efficacy and selectivity of HIV-1 reverse transcriptase inhibitor TSAO-T by the introduction of functional groups at the N-3 position

scientific article published on October 2005

N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase

scientific article published in May 2003

Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.

scientific article published on February 2005

Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships

scientific article published in January 2007

Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme

scientific article published on 9 October 2013

Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

scientific article published on August 1997

Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base

scientific article

Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region

scientific article

Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus

scientific article published on 22 October 2007

Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides

scientific article published on 6 June 2013

Prodrugs of Antiviral Nucleosides Cleavable by Dipeptidyl-Peptidase-IV (CD26)

scientific article published in 2008

Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase

scientific article published on 23 April 2019

Radical cyclizations on sugar templates: Stereoselective synthesis of fused γ-butyrolactones of carbohydrates

article by Sonsoles Velázquez & María-José Camarasa published November 1994 in Tetrahedron: Asymmetry

Reactivity of the 4-amino-5H-1,2-oxathiole-2,2-dioxide heterocyclic system: a combined experimental and theoretical study

scientific article

Stereoselective synthesis of [3.3.0] fused lactones (γ-butyrolactones) of sugars and nucleosides by free radical intramolecular cyclization

Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.

scientific article

Synthesis and structural characterization of pyrimidine bi- and tricyclic nucleosides with sugar puckers conformationally locked into the eastern region of the pseudorotational cycle.

scientific article published in August 2003

Synthesis of 2′-C-cyano-2′-deoxy- and 2′-C-cyano-2′,3′-dideoxy-β-d-arabinofuranosyl nucleosides

article published in 1992

Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach

scientific article published on August 2002

Synthesis of 3′-Spiro-Substituted Nucleosides: Chemistry of TSAO Nucleoside Derivatives

Synthesis of [1-[3′,5′-Bis-O-(tert-butyldimethylsilyl)-β-d-arabino- and β-d-ribofuranosyl]cytosine]-2′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide). Analogues of the highly specific anti-HIV-1 agent TSAO-T

article

Synthesis, NMR studies and theoretical calculations of novel 3-spiro-branched ribofuranoses

TSAO Derivatives: Highly Specific Inhibitors of Human Immunodeficiency Virus Type-1 (HIV-1) Replication

article

TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase

scientific article published on January 2004

TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: recent progress.

scientific article

The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs

scientific article

The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors

scientific article published on 15 April 2005

The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A.

scientific article

Unexpected Results in the Reaction of 5′-Tosyl TSAO-m3T With Amines

Unprecedented lability of the 5'-O-tert-butyldimethylsilyl group from 3'-spiro-5''-(4''-acylamino-1'',2''-oxathiole-2'',2''-dioxide) nucleoside derivatives via neighboring group participation of the 4''-acylamino residue.

scientific article published in February 2006

Unusual lability of 5'-O-tert-butyldimethylsilyl group on 4''-acyl TSAO derivatives

scientific article published in May 2003

List of works by Sonsoles Velázquez

"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains.

4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action

4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family.

4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus

4-Benzyloxy-γ-Sultone Derivatives: Discovery of a Novel Family of Non-Nucleoside Inhibitors of Human Cytomegalovirus and Varicella Zoster Virus

A Cyclic Enamine Derived from 1,2-O-Isopropylidene-α-d-xylofuranose As a Novel Carbohydrate Intermediate To Achieve Skeletal Diversity

Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.

Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine-containing drugs

Comparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase

Design and Discovery of a Novel Dipeptidyl-peptidase IV (CD26)-Based Prodrug Approach

Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes?

Dipeptidyl Peptidase IV (DPPIV/CD26)-Based Prodrugs of Hydroxy-Containing Drugs

Dipeptidyl peptidase IV dependent water-soluble prodrugs of highly lipophilic bicyclic nucleoside analogues

Dipeptidyl peptidase IV-activated prodrugs of anti-varicella zoster virus bicyclic nucleoside analogues containing different self-cleavage spacer systems

Dipeptidyl-peptidase IV (DPP IV/CD26)-activated prodrugs: a successful strategy for improving water solubility and oral bioavailability

Discovery and SAR studies of a novel class of cytotoxic 1,4-disubstituted piperidines via Ugi reaction

Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile

Efficient conversion of tetrapeptide-based TSAO prodrugs to the parent drug by dipeptidyl-peptidase IV (DPPIV/CD26).

Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV.

From β-Amino-γ-sultone to Unusual Bicyclic Pyridine and Pyrazine Heterocyclic Systems: Synthesis and Cytostatic and Antiviral Activities

Hybrids of [TSAO-T]-[foscarnet]: The first conjugate of foscarnet with a non-nucleoside reverse transcriptase inhibitor through a labile covalent ester bond

Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase

Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.

Improving the antiviral efficacy and selectivity of HIV-1 reverse transcriptase inhibitor TSAO-T by the introduction of functional groups at the N-3 position

N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase

Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.

Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships

Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme

Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base

Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region

Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus

Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides

Prodrugs of Antiviral Nucleosides Cleavable by Dipeptidyl-Peptidase-IV (CD26)

Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase

Radical cyclizations on sugar templates: Stereoselective synthesis of fused γ-butyrolactones of carbohydrates

Reactivity of the 4-amino-5H-1,2-oxathiole-2,2-dioxide heterocyclic system: a combined experimental and theoretical study

Stereoselective synthesis of [3.3.0] fused lactones (γ-butyrolactones) of sugars and nucleosides by free radical intramolecular cyclization

Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.

Synthesis and structural characterization of pyrimidine bi- and tricyclic nucleosides with sugar puckers conformationally locked into the eastern region of the pseudorotational cycle.

Synthesis of 2′-C-cyano-2′-deoxy- and 2′-C-cyano-2′,3′-dideoxy-β-d-arabinofuranosyl nucleosides

Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach

Synthesis of 3′-Spiro-Substituted Nucleosides: Chemistry of TSAO Nucleoside Derivatives

Synthesis of [1-[3′,5′-Bis-O-(tert-butyldimethylsilyl)-β-d-arabino- and β-d-ribofuranosyl]cytosine]-2′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide). Analogues of the highly specific anti-HIV-1 agent TSAO-T

Synthesis, NMR studies and theoretical calculations of novel 3-spiro-branched ribofuranoses

TSAO Derivatives: Highly Specific Inhibitors of Human Immunodeficiency Virus Type-1 (HIV-1) Replication

TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase

TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: recent progress.

The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs

The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors

The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A.

Unexpected Results in the Reaction of 5′-Tosyl TSAO-m3T With Amines

Unprecedented lability of the 5'-O-tert-butyldimethylsilyl group from 3'-spiro-5''-(4''-acylamino-1'',2''-oxathiole-2'',2''-dioxide) nucleoside derivatives via neighboring group participation of the 4''-acylamino residue.

Unusual lability of 5'-O-tert-butyldimethylsilyl group on 4''-acyl TSAO derivatives