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List of works by Thomas Thum

A novel multi-parametric analysis of non-invasive methods to assess animal distress during chronic pancreatitis

scientific article published on 01 October 2019

A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes

scientific article

A practical guide for investigating cardiac physiology using living myocardial slices

scientific article published on 10 September 2020

A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol

scientific article (publication date: November 2003)

A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction

scientific article published on 17 September 2013

ADMA, endothelial progenitor cells, and cardiovascular risk.

scientific article

Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and d

scientific article published on 29 September 2006

Activation of the miR-17 family and miR-21 during murine kidney ischemia-reperfusion injury.

scientific article published on October 2013

Acute coronary syndromes and acute heart failure: a diagnostic dilemma and high-risk combination. A statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology

scientific article published on 29 April 2020

Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.

scientific article published on 18 January 2007

Aldosterone mediated dysfunction of human endothelial progenitor cells - Mechanisms and therapeutic opportunities

Analytical approaches in microRNA therapeutics.

scientific article

Androgen metabolism in thymus of fetal and adult rats

scientific article

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

scientific article published in 2022

Annual meeting of the American Heart Association. Dallas, Texas, USA, 13-16 November 2005.

scientific article published in May 2006

Aroclor 1254 modulates gene expression of nuclear transcription factors: implications for albumin gene transcription and protein synthesis in rat hepatocyte cultures

scientific journal article

Aromatase inhibition attenuates desflurane-induced preconditioning against acute myocardial infarction in male mouse heart in vivo

scientific article

Association between Circular RNA CDR1as and Post-Infarction Cardiac Function in Pig Ischemic Heart Failure: Influence of the Anti-Fibrotic Natural Compounds Bufalin and Lycorine

scientific article published on 14 August 2020

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors

scientific article published on 02 September 2019

Biogenesis and regulation of cardiovascular microRNAs.

scientific article published on July 2011

Blood-based microRNA profiling in patients with cardiac amyloidosis

scientific article published in PLoS ONE

Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells

scientific article published on 09 February 2006

Breakthrough in cachexia treatment through a novel selective androgen receptor modulator?!

scientific article

Butanedione monoxime increases the viability and yield of adult cardiomyocytes in primary cultures

scientific article

CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure

scientific article published on 22 October 2020

Cardiac dissonance without conductors: how dicer depletion provokes chaos in the heart.

scientific article

Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

scientific article

Cardiac fibroblasts on the fast track--scleraxis: from Achilles' heel to anti-fibrotic therapy

scientific article published on 20 May 2009

Cardiac fibrosis revisited by microRNA therapeutics

scientific article published on 18 July 2012

Cardiac regeneration by progenitor cells--bedside before bench?

scientific article

Cardiovascular importance of the microRNA-23/27/24 family

scientific article

Cellular dedifferentiation of endothelium is linked to activation and silencing of certain nuclear transcription factors: implications for endothelial dysfunction and vascular biology.

scientific article published on April 2000

Circulating and urinary microRNAs in kidney disease.

scientific article published on 10 May 2012

Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension.

scientific article published on 2 June 2008

Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure

scientific article published on 24 March 2014

Circulating miR-133a and miR-423-5p fail as biomarkers for left ventricular remodeling after myocardial infarction

scientific article published on 22 January 2013

Circulating miR-210 predicts survival in critically ill patients with acute kidney injury

scientific article

Circulating miR-423_5p fails as a biomarker for systemic ventricular function in adults after atrial repair for transposition of the great arteries.

scientific article

Circulating microRNAs are not eliminated by hemodialysis

scientific article (publication date: 2012)

Circulating microRNAs as biomarkers and potential paracrine mediators of cardiovascular disease

scientific article published on 01 October 2010

Circulating microRNAs as potential biomarkers of aerobic exercise capacity

scientific article published on 20 December 2013

Circulating microRNAs in Fabry Disease

scientific article published on 24 October 2019

Circulating microRNAs in patients with Shiga-Toxin-producing E. coli O104:H4 induced hemolytic uremic syndrome

scientific article

Common Mechanistic Pathways in Cancer and Heart Failure

scientific article published on 22 October 2020

Comparison of different miR-21 inhibitor chemistries in a cardiac disease model

scientific article published on February 2011

Conversion from conventional in-centre thrice-weekly haemodialysis to short daily home haemodialysis ameliorates uremia-associated clinical parameters

scientific article published on 27 February 2011

Cytochrome P450 mono-oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat.

scientific article published in August 2000

Detection and transport mechanisms of circulating microRNAs in neurological, cardiac and kidney diseases.

scientific article published on January 2013

Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes

scientific article published on 13 September 2007

Development and characterization of anti-fibrotic natural compound similars with improved effectivity

scientific article published on 02 March 2022

Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome

scientific article

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models

scientific article published on 23 February 2014

Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial

scientific article

Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis

scientific article

Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence

scientific article

Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes

scientific article published on 01 March 2007

Endothelial progenitor cell dysfunction: mechanisms and therapeutic approaches

scientific article published on 01 August 2007

Endothelial progenitor cells in pulmonary arterial hypertension.

scientific article published on January 2010

Epigenetic modifications in cardiovascular disease.

scientific article published on 11 January 2012

Erythropoietin in Kidney Disease and Type 2 Diabetes ⬇️

scientific article published on January 27, 2011

European Society of Cardiology/Heart Failure Association position paper on the role and safety of new glucose-lowering drugs in patients with heart failure

scientific article published on 09 December 2019

Exosomes: new players in cell-cell communication.

scientific article published on 10 August 2012

Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers

scientific article

Functional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularization

scientific article

GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in v

scientific article published on 07 August 2007

Gene expression in distinct regions of the heart

scientific article (publication date: 18 March 2000)

Glucocorticoid insensitivity at the hypoxic blood-brain barrier can be reversed by inhibition of the proteasome.

scientific article published on 17 February 2011

Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line.

scientific article published on December 2003

Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I

scientific article published on 28 August 2007

Growth hormone treatment improves markers of systemic nitric oxide bioavailability via the insulin-like growth factor-1 Importance for endothelial progenitor cells

Hallmarks of ion channel gene expression in end-stage heart failure

scientific article

Heart Failure Association of the European Society of Cardiology Update on Sodium Glucose Co-transporter-2 Inhibitors in Heart Failure (an update on the Sodium-glucose co-transporter 2 inhibitors in heart failure: beyond glycaemic control. The positi

scientific article published on 17 October 2020

Heterocellular signalling and crosstalk in the heart in ischaemia and heart failure

scientific article published on 08 April 2014

Identification of cardiovascular microRNA targetomes.

scientific article published on 24 August 2011

Identification of major CYP2C9 and CYP2C19 polymorphisms by fluorescence resonance energy transfer analysis

scientific article published on 01 September 2002

Impact of a Met(11)Thr single nucleotide polymorphism of surfactant protein D on allergic airway inflammation in a murine asthma model

scientific article published on 01 April 2014

Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans

scientific article

Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction

scientific article

Increase of pro-inflammatory cytokine expression in non-demyelinating early cerebral lesions in nervous canine distemper

scientific article

Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures.

scientific article

Inhibition of proteasome-mediated glucocorticoid receptor degradation restores nitric oxide bioavailability in myocardial endothelial cells in vitro.

scientific article published on 23 May 2014

Integrative Bioinformatic Analyses of Global Transcriptome Data Decipher Novel Molecular Insights into Cardiac Anti-Fibrotic Therapies ⬇️

scientific article published on 02 July 2020

Isolation and cultivation of Ca2+ tolerant cardiomyocytes from the adult rat: improvements and applications

scientific article

LC-MS/MS and GC-MS/MS measurement of plasma and urine di-paracetamol and 3-nitro-paracetamol: proof-of-concept studies on a novel human model of oxidative stress based on oral paracetamol administration

scientific article published on 2 April 2014

LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases

scientific article (publication date: 21 July 2000)

LINCing MALAT1 and angiogenesis

scientific article published on 01 April 2014

LOX-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor Oct-1 in human coronary arterial endothelium

scientific article

Letter by Thum et al regarding article, "Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma ag

scientific article published in March 2008

Limitations of gait speed as an independent predictor of mortality and morbidity in cardiac patients

scientific article published on 01 August 2011

Liraglutide for weight loss in obese people

scientific article published in February 2010

Macrophage microRNA-155 promotes cardiac hypertrophy and failure.

scientific article published on 16 August 2013

Malfunction of endothelial progenitor cells and endothelial function in patients with Fabry disease

Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease

scientific article published on 8 July 2010

Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.

scientific article

Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism?

scientific article

Metabolism of verapamil: 24 new phase I and phase II metabolites identified in cell cultures of rat hepatocytes by liquid chromatography-tandem mass spectrometry

scientific article

MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors

scientific article

MicroRNA target sites as genetic tools to enhance promoter-reporter specificity for the purification of pancreatic progenitor cells from differentiated embryonic stem cells.

scientific article

MicroRNA therapeutics in cardiovascular medicine ⬇️

scientific article published on December 13, 2011

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

scientific journal article

MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart ⬇️

scientific article published on April 27, 2012

MicroRNA-223 made its way into vascular research

scientific article published in December 2013

MicroRNA-24 antagonism prevents renal ischemia reperfusion injury

scientific article

MicroRNA-24 regulates vascularity after myocardial infarction

scientific article published on 25 July 2011

MicroRNA-based therapy in cardiology

scientific article published on March 2014

MicroRNAs and vascular (dys)function.

scientific article published on 23 July 2011

MicroRNAs as circulating biomarkers for heart failure: questions about MiR-423-5p

scientific article published on 01 May 2010

MicroRNAs as mediators and therapeutic targets in chronic kidney disease ⬇️

scientific article published on March 22, 2011

MicroRNAs associated with ischemia-reperfusion injury and cardioprotection by ischemic pre- and postconditioning: protectomiRs

scientific article published on 23 May 2014

MicroRNAs deciding cardiac stem cell fate

scientific article published on 18 October 2012

MicroRNAs in diabetes and diabetes-associated complications ⬇️

scientific article published on June 1, 2012

MicroRNAs in hypertension: mechanisms and therapeutic targets.

scientific article published on February 2012

MicroRNAs in idiopathic childhood nephrotic syndrome

scientific article published on 11 February 2013

MicroRNAs in myocardial infarction.

scientific article published on February 2013

MicroRNAs in platelet biogenesis and function

scientific article published on 10 July 2012

MicroRNAs in platelet physiology and pathology.

scientific article published on January 2013

MicroRNAs in the bile of patients with biliary strictures after liver transplantation

scientific article published on June 2014

MicroRNAs in the broken heart.

scientific article published on November 2007

MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure

scientific article (publication date: 17 July 2007)

MicroRNAs in vascular biology – metabolism and atherosclerosis

scientific article published on 08 March 2012

MicroRNAs looping around angiogenesis

scientific article published on 01 November 2011

MicroRNAs play a role in spontaneous recovery from acute liver failure

scientific article

MicroRNAs: from basic regulation towards therapeutic approaches--passion, caution and patience required

scientific article published on 01 August 2010

MicroRNA‐Based Therapeutic Approaches in the Cardiovascular System ⬇️

scientific article published on October 14, 2010

Microparticles and microRNAs of endothelial progenitor cells ameliorate acute kidney injury ⬇️

scientific article published on August 1, 2012

Microvesicles as novel biomarkers and therapeutic targets in transplantation medicine.

scientific article

Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function: simply effects of optimized drug treatment?

scientific article published on 15 June 2005

Molecular diagnosis of a familial nonhemolytic hyperbilirubinemia (Gilbert's syndrome) in healthy subjects

scientific article published on 01 October 2000

New insight into healing mechanisms of the infarcted heart

scientific article published on 01 January 2010

Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure

scientific journal article

No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure

scientific article published on 23 August 2008

Non-coding RNAs in cardiac remodeling and heart failure.

scientific article published on August 2013

Non-coding RNAs in cardiovascular ageing

scientific article published on February 2014

Non-coding RNAs: key players in cardiac disease

scientific article published on 10 July 2019

Novel biomarkers for acute myocardial infarction: is microRNA the new kid on the block?

scientific article published on 8 November 2013

Novel non‐coding RNA‐based therapeutic approaches to prevent statin‐induced liver damage ⬇️

scientific article published on August 20, 2012

Novel techniques and targets in cardiovascular microRNA research

scientific article

Nutritional iron deficiency in patients with chronic illnesses

scientific article published on 01 December 2007

Obesity and risk of myocardial infarction: the INTERHEART study

scientific article published on 01 April 2006

Organic nitrates differentially modulate circulating endothelial progenitor cells and endothelial function in patients with symptomatic coronary artery disease

scientific article published on 31 January 2011

PCBs alter gene expression of nuclear transcription factors and other heart-specific genes in cultures of primary cardiomyocytes: possible implications for cardiotoxicity

scientific article published in December 2002

Pathologic endothelial response and impaired function of circulating angiogenic cells in patients with Fabry disease

scientific article published on 20 November 2012

Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension.

scientific article published on 6 October 2017

Preclinical development of a miR-132 inhibitor for heart failure treatment

scientific article published on 31 January 2020

Prevention of liver cancer cachexia-induced cardiac wasting and heart failure

scientific article published on 29 August 2013

RNA-based diagnostic and therapeutic strategies for cardiovascular disease

scientific article published on 11 June 2019

Recent patents on cardiovascular stem cells

scientific article published on 01 January 2008

Recent patents on stem cell transplantation in cardiovascular medicine

Regulated microRNAs in the CSF of patients with multiple sclerosis: a case-control study

scientific article published on 17 October 2012

Regulation and function of miRNA-21 in health and disease.

scientific article published on 07 July 2011

Regulation of cardiac and renal ischemia–reperfusion injury by microRNAs ⬇️

scientific article published on 08 July 2013

Regulatory RNAs and paracrine networks in the heart.

scientific article published on 21 February 2014

Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro

scientific article published on 01 February 2022

Reprogramming of gene expression in cultured cardiomyocytes and in explanted hearts by the myosin ATPase inhibitor butanedione monoxime

scientific article published in February 2001

Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice.

scientific article published on 7 July 2010

Review focus on the role of microRNA in cardiovascular biology and disease ⬇️

scientific article published on 07 February 2012

Role of miR-21 in the pathogenesis of atrial fibrosis

scientific article

Role of microRNAs in immunity and organ transplantation.

scientific article published on 08 December 2011

SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway

scientific journal article

SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation ⬇️

scientific article published on September 4, 2012

Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism

scientific journal article

Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes

scientific article published on 21 October 2010

Sodium glucose co-transporter-2 inhibitors in heart failure: beyond glycaemic control. The Position Paper of the Heart Failure Association of the European Society of Cardiology

scientific article published on 02 July 2020

Sports or statins for atheroprotection? New insight from Kruppel-like factor 2

scientific article published on 30 August 2006

Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine

scientific article published on 10 October 2005

TLR-4+ peripheral blood monocytes and cardiovascular events in patients with chronic kidney disease--a prospective follow-up study

scientific article published on 14 January 2011

TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

scientific article published on 27 January 2013

Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

scientific article

Testosterone, cytochrome P450, and cardiac hypertrophy

scientific article published in October 2002

The BALANCE study too early to speculate on mortality effects

scientific article published on 01 January 2010

The IGF-1 receptor as a therapeutic target to improve endothelial progenitor cell function

scientific article published in May 2008

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy.

scientific article published on January 2012

The smooth long noncoding RNA SENCR

scientific article published on 01 June 2014

Tilarginine in patients with acute myocardial infarction and cardiogenic shock

scientific article published in September 2007

Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury.

scientific article published on 7 June 2007

Transforming growth factor-β-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21.

scientific article published on 17 November 2011

Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease ⬇️

scientific article published on December 14, 2010

Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipients

scientific article published on 3 August 2011

Verapamil metabolism in distinct regions of the heart and in cultures of cardiomyocytes of adult rats.

scientific article published in May 2001

Verapamil: identification of novel metabolites in cultures of primary human hepatocytes and human urine by LC-MS(n) and LC-NMR.

scientific article

Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells

scientific article

Verapamil: new insight into the molecular mechanism of drug oxidation in the human heart

scientific article published in September 2002

miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development.

scientific article published on 7 November 2010

miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.

scientific article

miRNAGE-34 induces cardiac damAGE.

scientific article published on 23 April 2013

miRNAs involved in the generation, maintenance, and differentiation of pluripotent cells ⬇️

scientific article published on 09 June 2012

microRNA therapeutics in cardiovascular disease models.

scientific article published on 02 October 2013

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