Search filters

List of works by Robert Lambkin-Williams

A COVID-19 human viral challenge model. Learning from experience

scientific article published on 12 August 2020

A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.

scientific article published on 19 January 2016

A Synthetic Influenza Virus Vaccine Induces a Cellular Immune Response That Correlates with Reduction in Symptomatology and Virus Shedding in a Randomized Phase Ib Live-Virus Challenge in Humans.

scientific article published on 20 May 2015

A Tool for Investigating Asthma and COPD Exacerbations: A Newly Manufactured and Well Characterised GMP Wild-Type Human Rhinovirus for Use in the Human Viral Challenge Model

scientific article

A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.

scientific article

A hypothesis: the conjunction of soldiers, gas, pigs, ducks, geese and horses in northern France during the Great War provided the conditions for the emergence of the "Spanish" influenza pandemic of 1918-1919.

scientific article

A new intranasal influenza vaccine based on a novel polycationic lipid-ceramide carbamoyl-spermine (CCS). II. Studies in mice and ferrets and mechanism of adjuvanticity

scientific article published on 18 January 2011

A plant-produced influenza subunit vaccine protects ferrets against virus challenge

scientific article

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

scientific article

Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model

scientific article published on 13 January 2016

Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study

scientific article (publication date: 19 November 2015)

An Intranasal Proteosome-Adjuvanted Trivalent Influenza Vaccine Is Safe, Immunogenic & Efficacious in the Human Viral Influenza Challenge Model. Serum IgG & Mucosal IgA Are Important Correlates of Protection against Illness Associated with Infection

scientific article

Animal models in influenza vaccine testing.

scientific article

Associations between Human Leukocyte Antigens and Nonresponsiveness to Influenza Vaccine

scientific article published on December 14, 2001

Comparing influenza and RSV viral and disease dynamics in experimentally infected adults predicts clinical effectiveness of RSV antivirals

scientific article published on 28 May 2013

Correction: Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model

scientific article published on 9 June 2016

Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination

scientific article

DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial

scientific article

Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification

scientific article published on 05 October 2016

Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge.

scientific article published on 28 October 2015

Flu: Effect of Vaccine in Elderly Care Home Residents: A Randomized Trial

scientific article published on 01 December 2007

Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans

scientific article

Immunogenicity, protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine

scientific article published on 21 April 2010

In vivo prophylactic activity of QR-435 against H3N2 influenza virus infection.

scientific article

Influenza A (H3) illness and viral aerosol shedding from symptomatic naturally infected and experimentally infected cases

scientific article published on 23 July 2020

Influenza virus carrying neuraminidase with reduced sensitivity to oseltamivir carboxylate has altered properties in vitro and is compromised for infectivity and replicative ability in vivo

scientific article

Inhibition of viral and bacterial trigger-stimulated prostaglandin E2 by a throat lozenge containing flurbiprofen: An in vitro study using a human respiratory epithelial cell line

scientific article published on 24 September 2020

Interfering vaccine (defective interfering influenza A virus) protects ferrets from influenza, and allows them to develop solid immunity to reinfection.

scientific article

Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge

scientific article (publication date: 2014)

Lack of evidence for complete resistance of peripheral blood mononuclear cells to HIV-1 and HIV-2 infection

scientific article published in March 2008

Longitudinal analysis of leukocyte differentials in peripheral blood of patients with acute respiratory viral infections

scientific article published on 28 September 2013

Longitudinal study of an epitope-biased serum haemagglutination-inhibition antibody response in rabbits immunized with type A influenza virions

scientific article published in February 1996

Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection.

scientific article

Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment

scientific article published on 13 July 2020

Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection

scientific article

Non-responders to egg grown influenza vaccine seroconvert after booster immunization with MDCK cell grown vaccine.

scientific article published on June 2003

Oral GS-5806 activity in a respiratory syncytial virus challenge study.

scientific article

Phase 2 Randomized Trial of the Safety and Efficacy of MHAA4549A, a Broadly Neutralizing Monoclonal Antibody, in a Human Influenza A Virus Challenge Model

scientific article published on 14 August 2017

Preclinical in vitro activity of QR-435 against influenza A virus as a virucide and in paper masks for prevention of viral transmission

scientific article published in September 2007

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

scientific article

Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans

scientific article

Reply to Hunsberger and Memoli, "Efficacy Analysis in Healthy-Volunteer Influenza Challenge Trials: Intention To Treat".

scientific article

Strong local and systemic protective immunity induced in the ferret model by an intranasal virosome-formulated influenza subunit vaccine

scientific article published in October 2004

The Effect of Influenza Virus on the Human Oropharyngeal Microbiome

scientific article published on 01 May 2019

The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo.

scientific article published on August 2002

The effective rate of influenza reassortment is limited during human infection

scientific article

The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics.

scientific article

The manufacturing of human viral challenge agents for use in clinical studies to accelerate the drug development process

article published in 2018

The threat of avian influenza H5N1: 'do we have the tools for the job'?

scientific article

Treatment of epidemic and pandemic influenza with neuraminidase and M2 proton channel inhibitors

scientific article published on January 1, 2003

Use of a human influenza challenge model to assess person-to-person transmission: proof-of-concept study.

scientific article published on 30 November 2011

Use of qualitative integrative cycler PCR (qicPCR) to identify optimal therapeutic dosing time-points in a Respiratory Syncytial Virus Human Viral Challenge Model (hVCM).

scientific article published on 31 August 2015

Viral load drives disease in humans experimentally infected with respiratory syncytial virus

scientific article

Virus-specific antibody secreting cell, memory B-cell, and sero-antibody responses in the human influenza challenge model.

scientific article published on 10 January 2014