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List of works by Nicholas J. Mantis

A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking

scientific article

A Collection of Single-Domain Antibodies that Crowd Ricin Toxin's Active Site

scientific article published on 17 December 2018

A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication

scientific article published on 29 March 2020

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

scientific article published on 02 September 2016

A Supercluster of Neutralizing Epitopes at the Interface of Ricin's Enzymatic (RTA) and Binding (RTB) Subunits.

scientific article published on 23 November 2017

A monoclonal antibody that targets the conserved core/lipid A region of lipopolysaccharide affects motility and reduces intestinal colonization of both classical and El Tor Vibrio cholerae biotypes.

scientific article

A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin

scientific article

A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles.

scientific article

A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin

scientific article

Alpha-galactosylceramide (αGalCer) Enhances Vaccine-induced Protection in a Model of Ricin Intoxication

scientific article published on 4 April 2018

An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation

scientific article published on 29 October 2019

Analysis of adhesion molecules involved in leukocyte homing into the basolateral pockets of mouse Peyer's patch M cells

scientific article published in February 2004

Applications in Stimulated Emission Depletion Microscopy: Localization of a Protein Toxin in the Endoplasmic Reticulum Following Retrograde Transport

scientific article

Association of a protective monoclonal IgA with the O antigen of Salmonella enterica serovar Typhimurium impacts type 3 secretion and outer membrane integrity.

scientific article

Biomedical Applications of Lumazine Synthase

scientific article published on 12 May 2018

Biophysical characterization and immunization studies of dominant negative inhibitor (DNI), a candidate anthrax toxin subunit vaccine.

scientific article

Characterization of a novel high-affinity monoclonal immunoglobulin G antibody against the ricin B subunit

scientific article

Chimeric plantibody passively protects mice against aerosolized ricin challenge

scientific article

Collaboration of epithelial cells with organized mucosal lymphoid tissues.

scientific article

Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice

scientific article

Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens.

scientific article

Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity

scientific article published on 01 July 2018

Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies

scientific article

Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB).

scientific article

Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen

scientific article published on April 2013

Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils.

scientific article published on 8 April 2016

Evaluation of lumazine synthase from Bacillus anthracis as a presentation platform for polyvalent antigen display.

scientific article published on 24 July 2017

Evidence for widespread epithelial damage and coincident production of monocyte chemotactic protein 1 in a murine model of intestinal ricin intoxication

scientific article published on 5 February 2007

FRUIT, a scar-free system for targeted chromosomal mutagenesis, epitope tagging, and promoter replacement in Escherichia coli and Salmonella enterica.

scientific article

Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies

scientific article published on 01 September 2018

Folding domains within the ricin toxin A subunit as targets of protective antibodies

scientific article

Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants

scientific article

High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine

scientific article published on 18 October 2017

High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin

scientific article published on 11 October 2017

High-throughput, cell-based screens to identify small-molecule inhibitors of ricin toxin and related category b ribosome inactivating proteins (RIPs).

scientific article

Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge.

scientific article published on 27 July 2016

Identification of new classes of ricin toxin inhibitors by virtual screening

scientific article

Identification of small molecules that suppress ricin-induced stress-activated signaling pathways

scientific article

Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen

scientific article

Immunity to Ricin: Fundamental Insights into Toxin–Antibody Interactions ⬇️

scientific article published on January 1, 2012

Immunization of mice with peptomers covalently coupled to aluminum oxide nanoparticles

scientific article published on 01 August 1999

Immunization of mice with recombinant gp41 in a systemic prime/mucosal boost protocol induces HIV-1-specific serum IgG and secretory IgA antibodies

scientific article

Immunoglobulin A antibodies against ricin A and B subunits protect epithelial cells from ricin intoxication

scientific article

Inhibition of Salmonella enterica serovar typhimurium motility and entry into epithelial cells by a protective antilipopolysaccharide monoclonal immunoglobulin A antibody.

scientific article

Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies

scientific article published on 23 March 2020

Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site

scientific article published on 10 January 2020

LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity

scientific article published on 02 August 2013

Localization of non-linear neutralizing B cell epitopes on ricin toxin's enzymatic subunit (RTA)

scientific article

Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies

scientific article

Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits

scientific article published on 20 April 2021

Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage.

scientific article

Mucosal vaccines for biodefense.

scientific article published on January 2012

Neutralizing activity and protective immunity to ricin toxin conferred by B subunit (RTB)-specific Fab fragments

scientific article published on 17 April 2013

Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro

scientific article published on 15 June 2013

Neutralizing monoclonal antibodies directed against defined linear epitopes on domain 4 of anthrax protective antigen

scientific article published on 24 August 2009

Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice.

scientific article

Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells

scientific article

Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin

scientific article published on 13 February 2020

Phenotypic Analysis of a Population of IgA+ Cells in the Follicle-Associated Epithelium of Mouse Peyer's Patches

scientific article published on 20 April 2015

Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit.

scientific article published on 22 December 2011

Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide.

scientific article published on 9 April 2015

Progress and challenges associated with the development of ricin toxin subunit vaccines

scientific article published on 21 March 2016

Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB).

scientific article

Rapid effects of a protective O-polysaccharide-specific monoclonal IgA on Vibrio cholerae agglutination, motility, and surface morphology

scientific article

Recent advances in the development of vaccines against ricin

scientific article published on 25 January 2016

Rediscovering IgA

scientific article published on 01 November 2011

Rescue of rhesus macaques from the lethality of aerosolized ricin toxin

scientific article published on 10 January 2019

Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant α-helix in ricin toxin's enzymatic subunit ⬇️

scientific article published on June 29, 2012

Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway.

scientific article published on 24 January 2006

Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance

scientific article published on 10 December 2015

Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin ⬇️

scientific article published on September 9, 2011

Sampling of Candida albicans and Candida tropicalis by Langerin-positive dendritic cells in mouse Peyer's patches.

scientific article published on 16 September 2015

Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut

scientific article

Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin-Ab complexes

scientific article published on 16 July 2019

Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins

scientific article published on 17 February 2022

Sites of vulnerability on ricin B chain revealed through epitope mapping of toxin-neutralizing monoclonal antibodies

scientific article published on 09 November 2020

Small-molecule inhibitors of ricin and Shiga toxins.

scientific article

Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin's binding subunit

scientific article

Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization.

scientific article published on 10 April 2013

Stepwise engineering of heterodimeric single domain camelid VHH antibodies that passively protect mice from ricin toxin.

scientific article

Structural Analysis of Single Domain Antibodies Bound to a Second Neutralizing Hot Spot on Ricin Toxin's Enzymatic Subunit

scientific article

Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.

scientific article published on 9 May 2016

Sub-domains of ricin's B subunit as targets of toxin neutralizing and non-neutralizing monoclonal antibodies

scientific article

TNF Family Cytokines Induce Distinct Cell Death Modalities in the A549 Human Lung Epithelial Cell Line when Administered in Combination with Ricin Toxin

scientific article published on 01 August 2019

TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death

scientific article published on 26 September 2018

The Factor H-binding site of CspZ as a protective target against multi-strain, tick-transmitted Lyme disease

scientific article published on 02 March 2020

The nadB gene of Salmonella typhimurium complements the nicotinic acid auxotrophy of Shigella flexneri

scientific article published in October 1996

Thermal stability and epitope integrity of a lyophilized ricin toxin subunit vaccine

scientific article published on 29 August 2018

Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection

scientific article

Three-dimensional reconstruction of murine Peyer's patches from immunostained cryosections

scientific article published on 4 November 2013

Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids

scientific article published in 2022

Transient suppression of Shigella flexneri type 3 secretion by a protective O-antigen-specific monoclonal IgA ⬇️

scientific article

Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies

scientific article published on 18 July 2017

Vaccines against the category B toxins: Staphylococcal enterotoxin B, epsilon toxin and ricin.

scientific article

Vibrio cholerae O1 secretes an extracellular matrix in response to antibody-mediated agglutination

scientific article published on 2 January 2018

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