List of works - Anders Bach

A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity

scientific article published on 27 August 2019

A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

scientific article published on 17 November 2009

A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain.

scientific article published in August 2011

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

scientific article

A sequential binding mechanism in a PDZ domain.

scientific article

Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION

scientific article published on 9 November 2015

Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies.

scientific article published on 11 November 2015

Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase.

scientific article published on 13 November 2014

Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions

scientific article

Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97.

scientific article published on 27 November 2010

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

scientific article

Common structural basis for constitutive activity of the ghrelin receptor family

scientific article

Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example.

scientific article

Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction

scientific article published in January 2009

Design, synthesis, and characterization of fatty acid derivatives of a dimeric peptide-based postsynaptic density-95 (PSD-95) inhibitor

scientific article published on 30 January 2015

Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction

scientific article published on 4 June 2009

Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery

scientific article published on 23 January 2020

Effects of Dimeric PSD-95 Inhibition on Excitotoxic Cell Death and Outcome After Controlled Cortical Impact in Rats.

scientific article published on 21 August 2017

Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function

scientific article published on 28 March 2016

Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats

scientific article

Energetic pathway sampling in a protein interaction domain.

scientific article

Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor

scientific article published on 23 June 2006

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

scientific article

In vitro and in vivo effects of a novel dimeric inhibitor of PSD-95 on excitotoxicity and functional recovery after experimental traumatic brain injury

scientific article published on 17 November 2016

Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

scientific article

Ligand binding by PDZ domains.

scientific article published on 07 June 2012

Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

scientific article published on 24 September 2008

Molecular architecture of the Jumonji C family histone demethylase KDM5B

scientific article published on 11 March 2019

Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases

scientific article published on 29 May 2018

Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

scientific article published on 19 May 2005

PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions

scientific article

PSD-95 uncoupling from NMDA receptors by Tat- N-dimer ameliorates neuronal depolarization in cortical spreading depression

scientific article published on 22 April 2016

Rigidified clicked dimeric ligands for studying the dynamics of the PDZ1-2 supramodule of PSD-95.

scientific article

Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

scientific article published on 02 March 2019

Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains.

scientific article

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

scientific article

Targeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein family

scientific article

The dynamics of linear polyubiquitin

scientific article published on 14 October 2020

UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: comparison with the NMDA receptor antagonist MK-801.

scientific article

Unique interaction pattern for a functionally biased ghrelin receptor agonist

scientific article published on 14 March 2011

List of works by Anders Bach

A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity

A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain.

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

A sequential binding mechanism in a PDZ domain.

Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION

Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies.

Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase.

Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions

Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97.

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

Common structural basis for constitutive activity of the ghrelin receptor family

Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example.

Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction

Design, synthesis, and characterization of fatty acid derivatives of a dimeric peptide-based postsynaptic density-95 (PSD-95) inhibitor

Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction

Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery

Effects of Dimeric PSD-95 Inhibition on Excitotoxic Cell Death and Outcome After Controlled Cortical Impact in Rats.

Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function

Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats

Energetic pathway sampling in a protein interaction domain.

Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

In vitro and in vivo effects of a novel dimeric inhibitor of PSD-95 on excitotoxicity and functional recovery after experimental traumatic brain injury

Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

Ligand binding by PDZ domains.

Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

Molecular architecture of the Jumonji C family histone demethylase KDM5B

Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases

Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions

PSD-95 uncoupling from NMDA receptors by Tat- N-dimer ameliorates neuronal depolarization in cortical spreading depression

Rigidified clicked dimeric ligands for studying the dynamics of the PDZ1-2 supramodule of PSD-95.

Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains.

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

Targeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein family

The dynamics of linear polyubiquitin

UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: comparison with the NMDA receptor antagonist MK-801.

Unique interaction pattern for a functionally biased ghrelin receptor agonist