List of works - Karl Swärd

A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle

scientific article published on 13 October 2015

ATP depletion and cell death in the neonatal lamb ductus arteriosus

scientific article

Ablation of SM22alpha decreases contractility and actin contents of mouse vascular smooth muscle

scientific article published in March 2004

An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFalpha up-regulates 5-HT(2A)-mediated contraction

scientific article published on December 2002

Antagonistic relationship between the unfolded protein response and myocardin-driven transcription in smooth muscle

scientific article published on 10 February 2020

ApoA-I Milano stimulates lipolysis in adipose cells independently of cAMP/PKA activation

scientific article published on 26 October 2015

Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice.

scientific article

Arterial remodeling and plasma volume expansion in caveolin-1-deficient mice

scientific article

Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction

scientific article published on September 2016

Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle.

scientific article

Biochemical and functional correlates of an increased membrane density of caveolae in hypertrophic rat urinary bladder

scientific article

Biomechanical properties and innervation of the female caveolin-1-deficient detrusor.

scientific article

Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle

scientific article published on 15 July 2014

CD14 Is a Co-Receptor for TLR4 in the S100A9-Induced Pro-Inflammatory Response in Monocytes

scientific article

Caveolae-associated signalling in smooth muscle.

scientific article published in May 2004

Cavin-3 (PRKCDBP) deficiency reduces the density of caveolae in smooth muscle

scientific article

Cholesterol dependence of vascular ERK1/2 activation and growth in response to stretch: role of endothelin-1

scientific journal article

Cholesterol depletion disrupts caveolae and differentially impairs agonist-induced arterial contraction

scientific article published in August 2002

Cholesterol depletion impairs vascular reactivity to endothelin-1 by reducing store-operated Ca2+ entry dependent on TRPC1.

scientific article published on 9 October 2003

Contractile effects of polycations in permeabilized smooth muscle

scientific article published in June 1998

Correction: The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells

scientific article published on 17 July 2015

Deletion of Dicer in smooth muscle affects voiding pattern and reduces detrusor contractility and neuroeffector transmission

scientific article

Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice

scientific article

Detrusor induction of miR-132/212 following bladder outlet obstruction: association with MeCP2 repression and cell viability

scientific article

Dietary rose hip exerts antiatherosclerotic effects and increases nitric oxide-mediated dilation in ApoE-null mice

scientific article

Differential dependence of stretch and shear stress signaling on caveolin-1 in the vascular wall

scientific article

Disproportionally low clearance of macromolecules from the plasma to the peritoneal cavity in a mouse model of peritoneal dialysis

scientific article published on 18 October 2006

Diverse effects of oats on cholesterol metabolism in C57BL/6 mice correlate with expression of hepatic bile acid-producing enzymes

scientific article

Effect of glibenclamide on membrane response to metabolic inhibition in smooth muscle of rat portal vein

scientific article

Effect of melatonin on age associated changes in Guinea pig bladder function

scientific article published in April 2007

Effects of metabolic inhibition on cytoplasmic calcium and contraction in smooth muscle of rat portal vein

scientific article

Effects of oats on plasma cholesterol and lipoproteins in C57BL/6 mice are substrain specific

scientific article

Effects of oxygen tension on energetics of cultured vascular smooth muscle

scientific article

Effects of polyamine synthesis inhibition on polyamines, growth and mechanical properties in hypertrophic rat urinary bladder

scientific article published in June 1998

Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization

scientific article published on 18 December 2015

Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.

scientific article

Emerging roles of the myocardin family of proteins in lipid and glucose metabolism

scientific article

Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.

scientific article

Female pig urethral tone is dependent on Rho guanosine triphosphatases and Rho-associated kinase

scientific article published in May 2004

Gene Expression and MicroRNA Expression Analysis in Small Arteries of Spontaneously Hypertensive Rats. Evidence for ER Stress

scientific article

HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition

scientific article

Human urinary bladder smooth muscle is dependent on membrane cholesterol for cholinergic activation

scientific article

Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway

scientific article

Identification of the intermediate filament protein synemin/SYNM as a target of myocardin family coactivators

scientific article published on 28 August 2019

Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice

scientific article

Impaired nerve-mediated relaxation of penile tissue from caveolin-1 deficient mice

scientific article

Increased Rho activation and PKC-mediated smooth muscle contractility in the absence of caveolin-1

scientific article published on 01 December 2006

Induction of angiotensin-converting enzyme after miR-143/145 deletion is critical for impaired smooth muscle contractility.

scientific article published on October 2014

Influence of mitochondrial inhibition on global and local [Ca(2+)](I) in rat tail artery

scientific article

Inhibition of Polyamine Formation Antagonizes Vascular Smooth Muscle Cell Proliferation and Preserves the Contractile Phenotype

scientific article published on 08 April 2014

Inhibition of Polyamine Uptake Potentiates the Anti-Proliferative Effect of Polyamine Synthesis Inhibition and Preserves the Contractile Phenotype of Vascular Smooth Muscle Cells

scientific article published on 20 November 2015

Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum

scientific article published in January 2000

Inhibition of polyamine synthesis influences contractility of intestinal smooth muscle in culture

scientific article published on 01 July 1997

Late onset vascular dysfunction in the R6/1 model of Huntington's disease.

scientific article

Long-term regulation of contractility and calcium current in smooth muscle

scientific article published in November 1997

Loss of Vascular Myogenic Tone in miR-143/145 Knockout Mice Is Associated With Hypertension-Induced Vascular Lesions in Small Mesenteric Arteries

scientific article published on 7 December 2017

Lovastatin induces relaxation and inhibits L-type Ca(2+) current in the rat basilar artery.

scientific article

Melatonin restores impaired contractility in aged guinea pig urinary bladder

scientific article

MicroRNA-Dependent Control of Serotonin-Induced Pulmonary Arterial Contraction

scientific article published on 11 August 2017

MicroRNAs are essential for stretch-induced vascular smooth muscle contractile differentiation via microRNA (miR)-145-dependent expression of L-type calcium channels

scientific article

MicroRNAs in Bladder Outlet Obstruction: Relationship to Growth and Matrix Remodelling

scientific article

Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness

scientific article

Myocardin Family Members Drive Formation of Caveolae

scientific article

Neurite outgrowth in cultured mouse pelvic ganglia - Effects of neurotrophins and bladder tissue

scientific article published on 18 March 2017

Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP

scientific article published in Scientific Reports

Non-uniform changes in membrane receptors in the rat urinary bladder following outlet obstruction

scientific article published on 21 May 2015

Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes

scientific article published on 28 February 2006

Polyamines increase Ca2+ sensitivity in permeabilized smooth muscle of guinea pig ileum

scientific article published in June 1994

Polyamines inhibit myosin phosphatase and increase LC20 phosphorylation and force in smooth muscle

scientific article published on 01 September 1995

Pressurized carbon dioxide as a potential tool for decellularization of pulmonary arteries for transplant purposes

scientific article published on 04 March 2020

Regulation of Ca2+ channel and phosphatase activities by polyamines in intestinal and vascular smooth muscle--implications for cellular growth and contractility

scientific article

Regulation of Smooth Muscle Dystrophin and Synaptopodin 2 Expression by Actin Polymerization and Vascular Injury

scientific article published in June 2015

Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization

scientific article published on 8 December 2016

Regulation of vascular smooth muscle mechanotransduction by microRNAs and L-type calcium channels

scientific article published on January 2013

Role of smooth muscle YAP and TAZ in protection against phenotypic modulation, inflammation, and aneurysm development

scientific article published in 2022

Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBPα-dependent manner

scientific article

Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle

scientific article

Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.

scientific article published on 6 June 2015

Stretch-induced contractile differentiation of vascular smooth muscle: sensitivity to actin polymerization inhibitors

scientific article published on 29 January 2003

Stretch-sensitive down-regulation of the miR-144/451 cluster in vascular smooth muscle and its role in AMP-activated protein kinase signaling

scientific article

Targeting smooth muscle microRNAs for therapeutic benefit in vascular disease ⬇️

scientific article published on April 21, 2013

The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells

scientific article published on 4 May 2015

The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction.

scientific article

Transvascular protein transport in mice lacking endothelial caveolae

scientific article published on 24 February 2006

Unaltered size selectivity of the glomerular filtration barrier in caveolin-1 knockout mice.

scientific article published on 27 May 2009

Vascular smooth muscle cell proliferation depends on caveolin-1-regulated polyamine uptake

scientific article published on 21 November 2014

Vasopressin-induced mouse urethral contraction is modulated by caveolin-1.

scientific article published on 28 January 2015

[Caveolae-invaginations in the cell membrane with complex function. Defects in caveolae gene connected to severe congenital diseases]

scientific article published on 01 June 2010

List of works by Karl Swärd

A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle

ATP depletion and cell death in the neonatal lamb ductus arteriosus

Ablation of SM22alpha decreases contractility and actin contents of mouse vascular smooth muscle

An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFalpha up-regulates 5-HT(2A)-mediated contraction

Antagonistic relationship between the unfolded protein response and myocardin-driven transcription in smooth muscle

ApoA-I Milano stimulates lipolysis in adipose cells independently of cAMP/PKA activation

Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice.

Arterial remodeling and plasma volume expansion in caveolin-1-deficient mice

Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction

Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle.

Biochemical and functional correlates of an increased membrane density of caveolae in hypertrophic rat urinary bladder

Biomechanical properties and innervation of the female caveolin-1-deficient detrusor.

Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle

CD14 Is a Co-Receptor for TLR4 in the S100A9-Induced Pro-Inflammatory Response in Monocytes

Caveolae-associated signalling in smooth muscle.

Cavin-3 (PRKCDBP) deficiency reduces the density of caveolae in smooth muscle

Cholesterol dependence of vascular ERK1/2 activation and growth in response to stretch: role of endothelin-1

Cholesterol depletion disrupts caveolae and differentially impairs agonist-induced arterial contraction

Cholesterol depletion impairs vascular reactivity to endothelin-1 by reducing store-operated Ca2+ entry dependent on TRPC1.

Contractile effects of polycations in permeabilized smooth muscle

Correction: The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells

Deletion of Dicer in smooth muscle affects voiding pattern and reduces detrusor contractility and neuroeffector transmission

Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice

Detrusor induction of miR-132/212 following bladder outlet obstruction: association with MeCP2 repression and cell viability

Dietary rose hip exerts antiatherosclerotic effects and increases nitric oxide-mediated dilation in ApoE-null mice

Differential dependence of stretch and shear stress signaling on caveolin-1 in the vascular wall

Disproportionally low clearance of macromolecules from the plasma to the peritoneal cavity in a mouse model of peritoneal dialysis

Diverse effects of oats on cholesterol metabolism in C57BL/6 mice correlate with expression of hepatic bile acid-producing enzymes

Effect of glibenclamide on membrane response to metabolic inhibition in smooth muscle of rat portal vein

Effect of melatonin on age associated changes in Guinea pig bladder function

Effects of metabolic inhibition on cytoplasmic calcium and contraction in smooth muscle of rat portal vein

Effects of oats on plasma cholesterol and lipoproteins in C57BL/6 mice are substrain specific

Effects of oxygen tension on energetics of cultured vascular smooth muscle

Effects of polyamine synthesis inhibition on polyamines, growth and mechanical properties in hypertrophic rat urinary bladder

Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization

Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.

Emerging roles of the myocardin family of proteins in lipid and glucose metabolism

Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.

Female pig urethral tone is dependent on Rho guanosine triphosphatases and Rho-associated kinase

Gene Expression and MicroRNA Expression Analysis in Small Arteries of Spontaneously Hypertensive Rats. Evidence for ER Stress

HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition

Human urinary bladder smooth muscle is dependent on membrane cholesterol for cholinergic activation

Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway

Identification of the intermediate filament protein synemin/SYNM as a target of myocardin family coactivators

Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice

Impaired nerve-mediated relaxation of penile tissue from caveolin-1 deficient mice

Increased Rho activation and PKC-mediated smooth muscle contractility in the absence of caveolin-1

Induction of angiotensin-converting enzyme after miR-143/145 deletion is critical for impaired smooth muscle contractility.

Influence of mitochondrial inhibition on global and local [Ca(2+)](I) in rat tail artery

Inhibition of Polyamine Formation Antagonizes Vascular Smooth Muscle Cell Proliferation and Preserves the Contractile Phenotype

Inhibition of Polyamine Uptake Potentiates the Anti-Proliferative Effect of Polyamine Synthesis Inhibition and Preserves the Contractile Phenotype of Vascular Smooth Muscle Cells

Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum

Inhibition of polyamine synthesis influences contractility of intestinal smooth muscle in culture

Late onset vascular dysfunction in the R6/1 model of Huntington's disease.

Long-term regulation of contractility and calcium current in smooth muscle

Loss of Vascular Myogenic Tone in miR-143/145 Knockout Mice Is Associated With Hypertension-Induced Vascular Lesions in Small Mesenteric Arteries

Lovastatin induces relaxation and inhibits L-type Ca(2+) current in the rat basilar artery.

Melatonin restores impaired contractility in aged guinea pig urinary bladder

MicroRNA-Dependent Control of Serotonin-Induced Pulmonary Arterial Contraction

MicroRNAs are essential for stretch-induced vascular smooth muscle contractile differentiation via microRNA (miR)-145-dependent expression of L-type calcium channels

MicroRNAs in Bladder Outlet Obstruction: Relationship to Growth and Matrix Remodelling

Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness

Myocardin Family Members Drive Formation of Caveolae

Neurite outgrowth in cultured mouse pelvic ganglia - Effects of neurotrophins and bladder tissue

Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP

Non-uniform changes in membrane receptors in the rat urinary bladder following outlet obstruction

Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes

Polyamines increase Ca2+ sensitivity in permeabilized smooth muscle of guinea pig ileum

Polyamines inhibit myosin phosphatase and increase LC20 phosphorylation and force in smooth muscle

Pressurized carbon dioxide as a potential tool for decellularization of pulmonary arteries for transplant purposes

Regulation of Ca2+ channel and phosphatase activities by polyamines in intestinal and vascular smooth muscle--implications for cellular growth and contractility

Regulation of Smooth Muscle Dystrophin and Synaptopodin 2 Expression by Actin Polymerization and Vascular Injury

Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization

Regulation of vascular smooth muscle mechanotransduction by microRNAs and L-type calcium channels

Role of smooth muscle YAP and TAZ in protection against phenotypic modulation, inflammation, and aneurysm development

Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBPα-dependent manner

Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle

Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.

Stretch-induced contractile differentiation of vascular smooth muscle: sensitivity to actin polymerization inhibitors