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List of works by Jan-Henning Klusmann

A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients.

scientific article

Analysis of GATA1 mutations in Down syndrome transient myeloproliferative disorder and myeloid leukemia

scientific article published on 29 June 2011

Biology-Driven Approaches to Prevent and Treat Relapse of Myeloid Neoplasia after Allogeneic Hematopoietic Stem Cell Transplantation

scientific article published on 15 January 2019

CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo

scientific article published on June 2017

Characterization of oncogenes on chromosome 21 identified by shRNA-based viability screening.

scientific article

Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood

scientific article published on 05 December 2018

Chromosome 21 gain is dispensable for transient myeloproliferative disorder driven by a novel GATA1 mutation

scientific article published on 24 February 2020

Classification of pediatric acute myeloid leukemia based on miRNA expression profiles

scientific article

Concomitant aberrant overexpression of RUNX1 and NCAM in regenerating bone marrow of myeloid leukemia of Down's syndrome

scientific article published on 17 October 2006

DNMT3A mutations are rare in childhood acute myeloid leukemia

scientific article published on 17 June 2011

Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1

scientific article published on 15 May 2005

Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis

scientific article

Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia

scientific article published on 12 February 2018

Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia

scientific article published on 03 May 2011

GATA1s exerts developmental stage-specific effects in human hematopoiesis

scientific article published on 22 March 2018

GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia

scientific article

Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells

scientific article published on 02 June 2017

Granulocyte colony-stimulating factor (G-CSF) treatment of childhood acute myeloid leukemias that overexpress the differentiation-defective G-CSF receptor isoform IV is associated with a higher incidence of relapse

scientific article

Hematologic Response to Vorinostat Treatment in Relapsed Myeloid Leukemia of Down Syndrome

scientific article published on 18 May 2016

High frequency of copy number alterations in myeloid leukaemia of Down syndrome.

scientific article

Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy

scientific article published on 12 September 2013

Improved generation of patient-specific induced pluripotent stem cells using a chemically-defined and matrigel-based approach.

scientific article published in June 2013

Improved outcome of pediatric patients with acute megakaryoblastic leukemia in the AML-BFM 04 trial

scientific article published on 28 April 2015

Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells

scientific article

Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells

scientific article

Janus kinase mutations in the development of acute megakaryoblastic leukemia in children with and without Down's syndrome

scientific article published on 19 April 2007

LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia

scientific article

Long non-coding RNAs as central regulators of hematopoiesis and leukemogenesis

scientific article

Lost in translation: pluripotent stem cell-derived hematopoiesis

scientific article (publication date: November 2015)

Low frequency of type-I and type-II aberrations in myeloid leukemia of Down syndrome, underscoring the unique entity of this disease

scientific article published in April 2012

Low-dose cytarabine to prevent myeloid leukemia in children with Down syndrome: TMD Prevention 2007 study

scientific article published on 01 July 2018

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

scientific article published on 01 September 2019

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

scientific article published on 11 July 2019

MicroRNA-106b~25 cluster is upregulated in relapsed MLL-rearranged pediatric acute myeloid leukemia

scientific article published on 24 June 2016

MicroRNA-125b-5p mimic inhibits acute liver failure.

scientific article published on 23 June 2016

Molecular Approaches to Treating Pediatric Leukemias

scientific article published on 06 September 2019

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study

scientific article published on 28 July 2016

Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations

scientific article published on 27 March 2012

Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups

scientific article published on 07 June 2011

Prospects and challenges of reprogrammed cells in hematology and oncology.

scientific article published on 02 August 2012

Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells

scientific article published on 24 April 2017

Refined sgRNA efficacy prediction improves large- and small-scale CRISPR-Cas9 applications

scientific article

Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012.

scientific article published on 22 February 2018

The Regulatory Roles of Long Noncoding RNAs in Acute Myeloid Leukemia

scientific article published on 09 July 2019

The non-coding RNA landscape of human hematopoiesis and leukemia.

scientific article

The role of matched sibling donor allogeneic stem cell transplantation in pediatric high-risk acute myeloid leukemia: results from the AML-BFM 98 study

scientific article published on 20 September 2011

The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells ⬇️

scientific article published on December 29, 2011

The stem cell-specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia

scientific article published on 01 December 2019

Therapy reduction in patients with Down syndrome and myeloid leukemia: the international ML-DS 2006 trial

scientific article published on 11 April 2017

Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

scientific article

YBX1 Indirectly Targets Heterochromatin-Repressed Inflammatory Response-Related Apoptosis Genes through Regulating CBX5 mRNA

scientific article published on 23 June 2020

[GATA1-mutation associated leukemia in children with trisomy 21 mosaic]

scientific article published on 18 April 2012

lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling.

scientific article published on 16 October 2017

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia

scientific article

miR-139-5p controls translation in myeloid leukemia through EIF4G2.

scientific article published on 13 July 2015

miR-9 is a tumor suppressor in pediatric AML with t(8;21).

scientific article published on 25 November 2013

miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFβ and Wnt signaling

scientific article published on April 2014

miRNAs can increase the efficiency of ex vivo platelet generation

scientific article published on 5 July 2012

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