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List of works by Kevin Wickman

A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons

scientific article published on March 2016

Abnormal heart rate regulation in GIRK4 knockout mice.

scientific article published in January 1998

Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice.

scientific article published on April 2008

Acute cocaine exposure weakens GABA(B) receptor-dependent G-protein-gated inwardly rectifying K+ signaling in dopamine neurons of the ventral tegmental area.

scientific article

Altered neurotransmission in the mesolimbic reward system of Girk mice

scientific article published on 16 June 2010

Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons.

scientific article

Behavioral characterization of mice lacking GIRK/Kir3 channel subunits.

scientific article published on July 2008

Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation

scientific article

Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum

scientific article published on 6 December 2007

Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system.

scientific article published on January 2012

Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells.

scientific article

Contribution of the Kir3.1 subunit to the muscarinic-gated atrial potassium channel IKACh

scientific article published in Journal of Biological Chemistry

Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain

scientific article

Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons

scientific article published on May 2013

Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators

scientific article

Distinct populations of spinal cord lamina II interneurons expressing G-protein-gated potassium channels

scientific article published on 01 November 2006

Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model.

scientific article published in June 2001

Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases.

scientific article

G Protein-Gated K+ Channel Ablation in Forebrain Pyramidal Neurons Selectively Impairs Fear Learning.

scientific article

G beta gamma binds directly to the G protein-gated K+ channel, IKACh

scientific article published on 01 December 1995

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.

scientific article published in February 2016

G-protein regulation of ion channels.

scientific article

G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization

scientific article published on 22 October 2013

G-protein-gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids

scientific article published on 16 December 2015

GIRK Channel Activity in Dopamine Neurons of the Ventral Tegmental Area Bidirectionally Regulates Behavioral Sensitivity to Cocaine

scientific article published on 05 March 2019

GIRK Channel Plasticity and Implications for Drug Addiction.

scientific article

GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner

scientific article published on May 2015

GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior

scientific article

GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol.

scientific article published on 11 May 2015

GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells

scientific article published on 08 June 2020

Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling.

scientific article

HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways

scientific article published on 19 April 2014

Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice

scientific article

ICln is essential for cellular and early embryonic viability.

scientific article

Identification and characterization of alternative splice variants of the mouse Trek2/Kcnk10 gene.

scientific article published on 31 July 2011

Impact of acute and persistent excitation of prelimbic pyramidal neurons on motor activity and trace fear learning

scientific article published on 04 January 2021

Inhibition of Pyramidal Neurons in the Basal Amygdala Promotes Fear Learning

scientific article published on 01 September 2018

Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol.

scientific article

Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297.

scientific article

Molecular and cellular diversity of neuronal G-protein-gated potassium channels.

scientific article

New insights into the therapeutic potential of Girk channels.

scientific article

Partial structure, chromosome localization, and expression of the mouse Girk4 gene.

scientific article published in March 1997

Partial structure, chromosome localization, and expression of the mouse Icln gene

scientific article published in March 1997

Preface

Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes

scientific article

RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.

scientific article published on 28 October 2007

RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate

scientific article published on 06 December 2013

RGS6/Gβ5 Complex Accelerates I KACh Gating Kinetics in Atrial Myocytes and Modulates Parasympathetic Regulation of Heart Rate ⬇️

scientific article published on September 30, 2010

RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling.

scientific article published on 22 April 2014

Repeated cocaine weakens GABA(B)-Girk signaling in layer 5/6 pyramidal neurons in the prelimbic cortex.

scientific article published on 2 October 2013

Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice.

scientific article published on 29 July 2016

Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels

scientific journal article

Sex differences in GABA(B)R-GIRK signaling in layer 5/6 pyramidal neurons of the mouse prelimbic cortex

scientific article published on 2 April 2015

Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia.

scientific article published in March 2004

Spinal G-protein-gated potassium channels contribute in a dose-dependent manner to the analgesic effect of mu- and delta- but not kappa-opioids.

scientific article

Structural characterization of the mouse Girk genes.

scientific article published on February 2002

Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh

scientific article (publication date: 30 April 1999)

Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells.

scientific article published on 22 June 2009

Suppression of inhibitory G protein signaling in forebrain pyramidal neurons triggers plasticity of glutamatergic neurotransmission in the nucleus accumbens core.

scientific article published on 25 January 2017

Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice

scientific article published in 2021

Targeting inhibitory cerebellar circuitry to alleviate behavioral deficits in a mouse model for studying idiopathic autism

scientific article published on 16 March 2020

The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I.

scientific article published in March 2005

Tyrosine phosphorylation of K(ir)3.1 in spinal cord is induced by acute inflammation, chronic neuropathic pain, and behavioral stress.

scientific article published on 13 October 2005

VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir 3 channels and reduces stress-induced hyperthermia in mice

scientific article published on 30 May 2019

Vesicular dopamine release elicits an inhibitory postsynaptic current in midbrain dopamine neurons

scientific article

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