Search filters

List of works by Timothy P. Hickling

A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

scientific article published on 08 October 2019

A mathematical model of the effect of immunogenicity on therapeutic protein pharmacokinetics.

scientific article published on 30 August 2013

A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins: part 1-theoretical model.

scientific article

A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins: part 2-model applications

scientific article

A recombinant trimeric surfactant protein D carbohydrate recognition domain inhibits respiratory syncytial virus infection in vitro and in vivo

scientific article published in November 1999

A review of quantitative modeling of B cell responses to antigenic challenge.

scientific article published on 19 October 2014

Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets

scientific article published on September 2005

Association of antibodies to hepatitis C virus glycoproteins 1 and 2 (anti-E1E2) with HCV disease.

scientific article published on 22 January 2008

Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies

scientific article published on 30 November 2015

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.

scientific article

Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33.

scientific article published in March 2006

Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33.

scientific article

Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding

scientific article

Induction of TNF-alpha release from human buffy coat cells by Pseudomonas aeruginosa is reduced by lung surfactant protein A

scientific article published on 01 October 1998

Mannan binding lectin and viral hepatitis

scientific article published on 20 November 2006

Preclinical studies of PF-04849285, an interferon-α8 fusion protein for the treatment of HCV.

scientific article

Recombinant human L-ficolin directly neutralizes hepatitis C virus entry.

scientific article published on 15 May 2014

Severe fibrosis in hepatitis C virus-infected patients is associated with increased activity of the mannan-binding lectin (MBL)/MBL-associated serine protease 1 (MASP-1) complex

scientific article

Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry.

scientific article published on 29 July 2010

The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models.

scientific article

Therapeutic outcomes, assessments, risk factors and mitigation efforts of immunogenicity of therapeutic protein products.

scientific article published on 14 March 2015

Paulina is supported by:

About Paulina

Help