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List of works by Penelope J. Hallett

A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).

scientific article

ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress

scientific article

Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease

scientific article

Biochemical Fractionation of Brain Tissue for Studies of Receptor Distribution and Trafficking

scientific article published on 01 January 2008

Development of Histocompatible Primate‐Induced Pluripotent Stem Cells for Neural Transplantation ⬇️

scientific article published on July 1, 2011

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

scientific article

Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking

scientific journal article

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

scientific article published on 31 December 2013

Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.

scientific article published on 23 September 2015

Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression

scientific article

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons

scientific journal article

Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain.

scientific article published on 29 March 2018

Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.

scientific article

Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients.

scientific article

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

scientific article published in Scientific Reports

Long-term health of dopaminergic neuron transplants in Parkinson's disease patients.

scientific article

Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts

scientific article published on 01 October 2019

Neurite Collapse and Altered ER Ca Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

scientific article published on 27 December 2018

No evidence for disease-like processes in fetal transplants

scientific article published on 2 September 2009

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease

scientific article published on 12 April 2014

Progressive decline of glucocerebrosidase in aging and Parkinson's disease.

scientific article

Rationale for and use of NMDA receptor antagonists in Parkinson's disease.

scientific article published on May 2004

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease

scientific article published on 08 November 2019

Seq-ing Markers of Midbrain Dopamine Neurons.

scientific article published in January 2017

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

scientific article published on 27 June 2020

Striatal delta opioid receptor binding in experimental models of Parkinson's disease and dyskinesia

scientific article published in January 2007

Striatal histone modifications in models of levodopa-induced dyskinesia

scientific article

Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease

scientific article published on 26 February 2015

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

scientific article

Synaptic recruitment of AMPA glutamate receptor subunits in levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate.

scientific article published in February 2010

The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.

scientific article

The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress

scientific article published on 24 August 2018

Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity

scientific article published on 06 August 2020

Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection.

scientific article published on 29 May 2014

α-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

scientific article

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