List of works - Pitter F Huesgen

A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment

scientific article published on 15 April 2021

A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif

article

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.

scientific article published on 22 February 2016

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

scientific article published on 22 September 2015

An advanced method for the release, enrichment and purification of high-quality Arabidopsis thaliana rosette leaf trichomes enables profound insights into the trichome proteome

scientific article published on 28 January 2022

An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana

scientific article published on 01 April 2019

Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome

scientific article

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry.

scientific article

DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis

scientific article published on 01 October 2019

Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Subst

scientific article published on 08 August 2019

Deg/HtrA proteases as components of a network for photosystem II quality control in chloroplasts and cyanobacteria

scientific article published on 02 September 2009

Dual function of a secreted fungalysin metalloprotease in Ustilago maydis

scientific article published on 19 June 2018

Dual specificities of the glyoxysomal/peroxisomal processing protease Deg15 in higher plants.

scholarly article

Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease.

scientific article

Enzymatic properties, evidence for in vivo expression, and intracellular localization of shewasin D, the pepsin homolog from Shewanella denitrificans

scientific article

Eukaryotic GCP1 is a conserved mitochondrial protein required for progression of embryo development beyond the globular stage in Arabidopsis thaliana

scientific article published on 12 October 2009

ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease

scientific article published on 31 January 2020

Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity

scientific article

Heterologous expression and characterization of a novel serine protease from Daphnia magna: A possible role in susceptibility to toxic cyanobacteria

article

Host apoplastic cysteine protease activity is suppressed during the mutualistic association of Lolium perenne and Epichloë festucae

scientific article published on 19 February 2021

Identification and relative quantification of native and proteolytically generated protein C-termini from complex proteomes: C-terminome analysis

scientific article

Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics

scientific article

LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification

scientific article published on 24 November 2014

MANTI: Automated Annotation of Protein N-Termini for Rapid Interpretation of N-Terminome Data Sets

scientific article published on 17 March 2021

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers

scientific article published on 05 April 2019

Molecular composition of the human primary visual cortex profiled by multimodal mass spectrometry imaging

scientific article published on 10 April 2018

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

scientific article published on 19 July 2017

New beginnings and new ends - Methods for large-scale characterization of protein termini and their use in plant biology

article

Overexpression of human BAG3<sup>P209L</sup> in mice causes restrictive cardiomyopathy ⬇️

scientific article published on 11 June 2021

Photodamaged D1 protein is degraded in Arabidopsis mutants lacking the Deg2 protease

scientific article published on 4 December 2006

Photoprotective Acclimation of the Arabidopsis thaliana Leaf Proteome to Fluctuating Light

scientific article published on 05 March 2020

Positional proteomics for identification of secreted proteoforms released by site-specific processing of membrane proteins

scientific article published on 20 September 2018

Profiling of Protein N-Termini and Their Modifications in Complex Samples.

scientific article

Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.

scientific article

Proteome-wide analysis of protein carboxy termini: C terminomics

scientific article published on 6 June 2010

Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids

scientific article published on 16 September 2013

Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen

scientific article

Quantitative proteomics in plant protease substrate identification.

scientific article published on 11 May 2017

RC1339/APRc from Rickettsia conorii is a novel aspartic protease with properties of retropepsin-like enzymes

scientific article

Recombinant Deg/HtrA proteases from Synechocystis sp. PCC 6803 differ in substrate specificity, biochemical characteristics and mechanism.

scientific article published on May 2011

Sensitive Determination of Proteolytic Proteoforms in Limited Microscale Proteome Samples

scientific article published on 30 August 2019

Sirtilins - the new old members of the vitamin K-dependent coagulation factor family

scientific article published on 13 February 2019

Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites.

scientific article

Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site

scientific article published on 02 October 2019

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition

scientific article published on 21 July 2020

Structure of the Mycosin-1 Protease from the Mycobacterial ESX-1 Protein Type VII Secretion System

scientific article

The DEG15 serine protease cleaves peroxisomal targeting signal 2-containing proteins in Arabidopsis

scientific article published on 24 October 2008

The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH)

scientific article published on 25 June 2019

The Podocyte Protease Web: Uncovering the Gatekeepers of Glomerular Disease

scientific article published on 19 September 2018

The family of Deg/HtrA proteases in plants

scientific article

The mouse heart mitochondria N terminome provides insights into ClpXP-mediated proteolysis

scientific article published on 28 May 2020

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury

scientific article published on 03 December 2018

The serine protease HhoA from Synechocystis sp. strain PCC 6803: substrate specificity and formation of a hexameric complex are regulated by the PDZ domain

scientific article

TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function ⬇️

scientific article published on November 18, 2011

List of works by Pitter F Huesgen

A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment

A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

An advanced method for the release, enrichment and purification of high-quality Arabidopsis thaliana rosette leaf trichomes enables profound insights into the trichome proteome

An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana

Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry.

DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis

Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Subst

Deg/HtrA proteases as components of a network for photosystem II quality control in chloroplasts and cyanobacteria

Dual function of a secreted fungalysin metalloprotease in Ustilago maydis

Dual specificities of the glyoxysomal/peroxisomal processing protease Deg15 in higher plants.

Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease.

Enzymatic properties, evidence for in vivo expression, and intracellular localization of shewasin D, the pepsin homolog from Shewanella denitrificans

Eukaryotic GCP1 is a conserved mitochondrial protein required for progression of embryo development beyond the globular stage in Arabidopsis thaliana

ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease

Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity

Heterologous expression and characterization of a novel serine protease from Daphnia magna: A possible role in susceptibility to toxic cyanobacteria

Host apoplastic cysteine protease activity is suppressed during the mutualistic association of Lolium perenne and Epichloë festucae

Identification and relative quantification of native and proteolytically generated protein C-termini from complex proteomes: C-terminome analysis

Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics

LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification

MANTI: Automated Annotation of Protein N-Termini for Rapid Interpretation of N-Terminome Data Sets

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers

Molecular composition of the human primary visual cortex profiled by multimodal mass spectrometry imaging

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

New beginnings and new ends - Methods for large-scale characterization of protein termini and their use in plant biology

Overexpression of human BAG3<sup>P209L</sup> in mice causes restrictive cardiomyopathy ⬇️

Photodamaged D1 protein is degraded in Arabidopsis mutants lacking the Deg2 protease

Photoprotective Acclimation of the Arabidopsis thaliana Leaf Proteome to Fluctuating Light

Positional proteomics for identification of secreted proteoforms released by site-specific processing of membrane proteins

Profiling of Protein N-Termini and Their Modifications in Complex Samples.

Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.

Proteome-wide analysis of protein carboxy termini: C terminomics

Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids

Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen

Quantitative proteomics in plant protease substrate identification.

RC1339/APRc from Rickettsia conorii is a novel aspartic protease with properties of retropepsin-like enzymes

Recombinant Deg/HtrA proteases from Synechocystis sp. PCC 6803 differ in substrate specificity, biochemical characteristics and mechanism.

Sensitive Determination of Proteolytic Proteoforms in Limited Microscale Proteome Samples

Sirtilins - the new old members of the vitamin K-dependent coagulation factor family

Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites.

Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition

Structure of the Mycosin-1 Protease from the Mycobacterial ESX-1 Protein Type VII Secretion System

The DEG15 serine protease cleaves peroxisomal targeting signal 2-containing proteins in Arabidopsis

The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH)

The Podocyte Protease Web: Uncovering the Gatekeepers of Glomerular Disease

The family of Deg/HtrA proteases in plants

The mouse heart mitochondria N terminome provides insights into ClpXP-mediated proteolysis

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury

The serine protease HhoA from Synechocystis sp. strain PCC 6803: substrate specificity and formation of a hexameric complex are regulated by the PDZ domain

TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function ⬇️