Search filters

List of works by Peter Gmeiner

(18)F- and (68)Ga-Labeled Neurotensin Peptides for PET Imaging of Neurotensin Receptor 1.

scientific article published on 23 June 2016

1,1'-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands

scientific article published in November 2009

1,4-Disubstituted aromatic piperazines with high 5-HT2A/D2 selectivity: Quantitative structure-selectivity investigations, docking, synthesis and biological evaluation

scientific article published on 6 August 2015

18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor.

scientific article

2,2-dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands

scientific article published on 01 July 1999

2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.

scientific article

2-Dibenzylaminobutane-1,4-diol: A versatile intermediate for a chirospecific β-amino acid synthesis

2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist

scientific article

3,4,6-Tri-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranosyl Phenylthiosulfonate: A Thiol-Reactive Agent for the Chemoselective18F-Glycosylation of Peptides

scientific article published on 01 January 2007

A General Approach to Dehydro-Freidinger Lactams: Ex-Chiral Pool Synthesis and Spectroscopic Evaluation as Potential Reverse Turn Inducers†

scientific article published on 01 January 2003

A Highly Efficient Type I β-Turn Mimetic Simulating an Asx-Pro-Turn-Like Structure

scientific article published on 09 June 2011

A Highly Practical RCM Approach towards a Molecular Building Kit of Spirocyclic Reverse Turn Mimics

scientific article published on 01 August 2006

A chimeric ligand approach leading to potent antiprion active acridine derivatives: design, synthesis, and biological investigations

scientific article

A consecutive Diels–Alder approach toward a Tet repressor directed combinatorial library

A gene regulation system with four distinct expression levels

scientific article published on August 2006

A new D₂ dopamine receptor agonist allosterically modulates A(2A) adenosine receptor signalling by interacting with the A(2A)/D₂ receptor heteromer

scientific article published on 30 December 2011

A series of 18F-labelled pyridinylphenyl amides as subtype-selective radioligands for the dopamine D3 receptor

scientific article

A simple chemical method for synthesizing malonyl hemiesters of 21-hydroxypregnanes, potential intermediates in cardenolide biosynthesis

scientific article

Activation and allosteric modulation of a muscarinic acetylcholine receptor

scientific article

Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine

scientific article published on 09 March 2020

Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists

scientific article

Active-state models of ternary GPCR complexes: determinants of selective receptor-G-protein coupling

scientific article

An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor

scientific article published on 01 June 2020

An efficient and practical EPC synthesis of β-amino acids from L-asparagine

scholarly article by Peter Gmeiner published 25 August 2010 in Archiv der Pharmazie - Chemistry in Life Sciences

An efficient and practical total synthesis of (+)-vincamine from L-aspartic acid

article by Peter Gmeiner et al published May 1990 in Journal of Organic Chemistry

Analogs of the dopamine D4 receptor ligand FAUC 113 with planar- and central-chirality

article published in 2002

Analogues of FAUC 73 revealing new insights into the structural requirements of nonaromatic dopamine D3 receptor agonists

scientific article published in January 2004

Anhydrotetracycline-peptide conjugates as representatives for ligand-based transactivating systems

scientific article published on 22 June 2010

Argyreia nervosa (Burm. f.): receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches

scientific article

Aromatic ring functionalization of benzolactam derivatives: New potent dopamine D3 receptor ligands

scientific article published on 22 December 2010

Arrestin-Bound Rhodopsin: A Molecular Structure and its Impact on the Development of Biased GPCR Ligands.

scientific article

Asymmetric synthesis of β-aminotetralins by electrophilic amination

article published in 1994

Attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity by the novel selective dopamine D3-receptor partial agonist FAUC 329 predominantly in the nucleus accumbens of mice

scientific article published in September 2003

Azaindol derivatives I: Asymmetric synthesis of new alpha-amino acids

scientific article

Azaindol-Derivate II: Synthese und analgetische Wirkung von Pyrazolo[1,5-a]pyridinen

scientific article published on 01 September 1988

Azaindole derivatives with high affinity for the dopamine D4 receptor: Synthesis, ligand binding studies and comparison of molecular electrostatic potential maps

scientific article published on 01 January 1999

Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179).

scientific article

Benzyl Phenylsemicarbazides: A Chemistry-Driven Approach Leading to G Protein-Biased Dopamine D4 Receptor Agonists with High Subtype Selectivity

scientific article published on 30 October 2019

Beta-analogs of PLG (L-prolyl-L-leucyl-glycinamide): ex-chiral pool syntheses and dopamine D2 receptor modulating effects

scientific article

Bi- und tricyclische Ergolinanaloge mit dopaminergen Eigenschaften

scientific article published on 01 June 1994

Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modeling of the putative bioactive conformation

scientific article published on 15 November 2005

Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

scientific article published on 22 October 2020

Biodistribution studies of two 18F-labeled pyridinylphenyl amides as subtype selective radioligands for the dopamine D3 receptor

scientific article published on 26 December 2013

Bioisosteric replacement leading to biologically active [2.2]paracyclophanes with altered binding profiles for aminergic G-protein-coupled receptors

scientific article published on October 2010

Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W.1.4)

article

Bivalent dopamine D2 receptor ligands: synthesis and binding properties

scientific article published on 3 June 2011

Bivalent molecular probes for dopamine D2-like receptors

scientific article published on 25 October 2011

Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain

scientific journal article

Characterization of the molecular fragment that is responsible for agonism of pergolide at serotonin 5-Hydroxytryptamine2B and 5-Hydroxytryptamine2A receptors

scientific article

Chirospecific and subtype selective dopamine receptor binding of heterocyclic methoxynaphthamide analogs

scientific article published in June 2005

Chirospecific synthesis of spirocyclic beta-lactams and their characterization as potent type II beta-turn inducing peptide mimetics

scientific article published in January 2006

Class A G-protein-coupled receptor (GPCR) dimers and bivalent ligands

scientific article published on 04 June 2013

Click chemistry based solid phase supported synthesis of dopaminergic phenylacetylenes

scientific article

Click chemistry based synthesis of dopamine D4 selective receptor ligands for the selection of potential PET tracers

scientific article

Click chemistry on solid phase: parallel synthesis of N-benzyltriazole carboxamides as super-potent G-protein coupled receptor ligands

scientific article

Click chemistry on solid support: synthesis of a new REM resin and application for the preparation of tertiary amines

Click linker: efficient and high-yielding synthesis of a new family of SPOS resins by 1,3-dipolar cycloaddition

scientific article

Click-chemistry-derived tetracycline-amino acid conjugates exhibiting exceptional potency and exclusive recognition of the reverse tet repressor

scientific article

Clozapine derived 2,3-dihydro-1H-1,4- and 1,5-benzodiazepines with D4 receptor selectivity: synthesis and biological testing

scientific article published in May 2004

CoMFA and CoMSIA investigations of dopamine D3 receptor ligands leading to the prediction, synthesis, and evaluation of rigidized FAUC 365 analogues

scholarly article by Ismail Salama et al published September 2006 in Bioorganic & Medicinal Chemistry

CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists

scientific article published in April 2005

Comparative MD Simulations Indicate a Dual Role for Arg1323.50 in Dopamine-Dependent D2R Activation

scientific article published on 7 January 2016

Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), [...]

scientific article

Conformationally Restricted Peptide Mimetics by Ring-Closing Olefin Metathesis

Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype

scientific article

Conjugation of Short Peptides to Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Determines M2R Selectivity

scientific article published on 22 May 2019

Covalent agonists for studying G protein-coupled receptor activation

scientific article

Covalent molecular probes for class A G protein-coupled receptors: advances and applications

scientific article published on 22 April 2015

Cross-receptor interactions between dopamine D2L and neurotensin NTS1 receptors modulate binding affinities of dopaminergics

scientific article published on 11 April 2011

Cyclic amidines as benzamide bioisosteres: EPC synthesis and SAR studies leading to the selective dopamine D4 receptor agonist FAUC 312.

scientific article

Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.

scientific article published on 12 May 2009

Development of Covalent Ligand–Receptor Pairs to Study the Binding Properties of Nonpeptidic Neurotensin Receptor 1 Antagonists

scientific article published on 27 January 2016

Development of a bivalent dopamine D₂ receptor agonist

scientific article published on 31 October 2011

Development of a metabolically stable neurotensin receptor 2 (NTS2) ligand

scientific article

Development of molecular tools based on the dopamine D3 receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior

scientific article published on 29 April 2017

Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy

scientific article published in February 2002

Diarylpropane-1,3-dione derivatives as TetR-inducing tetracycline mimetics: Synthesis and biological investigations

scientific article published in December 2009

Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs

scientific article published on 30 September 2016

Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling

scientific article published on 08 November 2019

Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure

scientific article

Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker

scientific article

Discovery of dopamine D₄ receptor antagonists with planar chirality

scientific article published on 5 February 2013

Discovery of highly potent and neurotensin receptor 2 selective neurotensin mimetics

scientific article published on 29 March 2011

Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus

scientific article

Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

scientific article published in August 2009

Dopamine D2-like receptor agonists induce penile erection in male rats: differential role of D2, D3 and D4 receptors in the paraventricular nucleus of the hypothalamus

scientific article published on 20 July 2011

Dopamine D3 receptor ligands: recent advances in the control of subtype selectivity and intrinsic activity

scientific article published on 15 December 2006

Dopamine agonist-induced penile erection and yawning: a comparative study in outbred Roman high- and low-avoidance rats

scientific article published on 8 May 2013

Dopamine autoreceptor agonists: computational studies, synthesis and biological investigations

scholarly article by Peter Gmeiner et al published August 1993 in Bioorganic & Medicinal Chemistry Letters

Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo

scientific article published on 14 October 2019

Efficient EPC synthesis of β-aminobutanoic acid

Efficient Synthesis of Heterocyclic Neurotensin Receptor Ligands by Microwave-Assisted Aminocarbonylation

Efficient methodology for the preparation of β-aminotetralin derivatives via electrophilic amination

Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid

scientific article published on 01 March 1999

Enantiomerically Pure Amino Alcohols and Diamino Alcohols from L-Aspartic Acid. Application to the Synthesis of Epi- and Diepislaframine

Enantiopure 4- and 5-Aminopiperidin-2-ones: Regiocontrolled Synthesis and Conformational Characterization as Bioactive β-Turn Mimetics

scientific article published on 01 November 2000

Enantiospecific synthesis and receptor binding of novel dopamine receptor ligands employing natural 4-hydroxyproline as a practical and flexible building block

Engineering a GPCR-ligand pair that simulates the activation of D(2L) by Dopamine

scientific article published on 24 September 2009

Evaluation of lactam-bridged neurotensin analogues adjusting psi(Pro10) close to the experimentally derived bioactive conformation of NT(8-13).

scientific article published in October 2004

Evaluation of18F-Labeled Benzodioxine Piperazine-Based Dopamine D4Receptor Ligands: Lipophilicity as a Determinate of Nonspecific Binding

scientific article published on 23 November 2011

Ex-chiral pool synthesis and receptor binding studies of 4-substituted prolinol derivatives

FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia

scientific article published on 6 March 2004

Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles

scientific article published in June 2005

Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists

scientific article published in June 2006

Fancy bioisosteres: synthesis and dopaminergic properties of the endiyne FAUC 88 as a novel non-aromatic D3 agonist

scientific article published in January 2005

Fancy bioisosteres: synthesis, SAR, and pharmacological investigations of novel nonaromatic dopamine D3 receptor ligands

scientific article published in July 2005

Fast and efficient (18) F-labeling by [(18) f]fluorophenylazocarboxylic esters

scientific article published on 11 December 2013

Fluorescence Labeling of Neurotensin(8-13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity

scientific article published on 19 November 2019

Fluoro-substituted phenylazocarboxamides: Dopaminergic behavior and N-arylating properties for irreversible binding

scientific article published on 17 December 2014

Functional characterization of a partial loss-of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis

scientific article published on 22 December 2009

Functionally selective dopamine D2/D3 receptor agonists comprising an enyne moiety

scientific article

Functionally selective dopamine D₂, D₃ receptor partial agonists

scientific article (publication date: 12 June 2014)

Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725.

scientific article published in September 2002

GPCR crystal structures: Medicinal chemistry in the pocket

scientific article

GPCRs als hochrelevante Targets für die Wirkstoffentwicklung

General synthesis of enantiomerically pure β-amino acids

H-CRRETAWAC-OH, a lead structure for the development of radiotracer targeting integrin α5β1?

scientific article

Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M2R Affinity and Selectivity.

scientific article published on 16 October 2017

Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions

scientific article published on 9 March 2011

Histidine 6.55 is a major determinant of ligand-biased signaling in dopamine D2L receptor

scientific article published on 16 December 2010

Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias

article

Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for β-Arrestin-Biased D2R Agonists

scientific article

Identification of the Beer Component Hordenine as Food-Derived Dopamine D2 Receptor Agonist by Virtual Screening a 3D Compound Database

scientific article published on 10 March 2017

Impact of the proline residue on ligand binding of neurotensin receptor 2 (NTS2)-selective peptide-peptoid hybrids

scientific article

Improved radiosynthesis and preliminary in vivo evaluation of a (18)F-labeled glycopeptide-peptoid hybrid for PET imaging of neurotensin receptor 2.

scientific article published on 7 February 2015

In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors

scientific article published on 19 August 2007

In vivo monitoring of the antiangiogenic effect of neurotensin receptor-mediated radiotherapy by small-animal positron emission tomography: a pilot study

scientific article

Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists

scientific article (publication date: 10 October 2002)

Investigation of Inactive-State κ Opioid Receptor Homodimerization via Single-Molecule Microscopy Using New Antagonistic Fluorescent Probes

scientific article published on 25 March 2020

Labeling and glycosylation of peptides using click chemistry: a general approach to (18)F-glycopeptides as effective imaging probes for positron emission tomography

scientific article

Mimicking of Arginine by Functionalized Nω-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples

scientific article published on 11 February 2016

Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes

scientific article published in February 2005

Molecular Determinants of Biased Agonism at the Dopamine D2 Receptor

article

Molecular Dynamics Simulations of the Effect of the G-Protein and Diffusible Ligands on the β2-Adrenergic Receptor

article

Molecular building kit of fused-proline-derived peptide mimetics allowing specific adjustment of the dihedral Psi angle

scientific article published on 24 October 2007

Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library

scientific article published on 23 June 2015

Muscarinic receptors as model targets and antitargets for structure-based ligand discovery

scientific article published on 25 July 2013

NTS2-selective neurotensin mimetics with tetrahydrofuran amino acids

scientific article

Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies

scientific article

Novel HO-DPAT (hydroxy-2-dipropylaminotetralin) isomers: Stereoselective synthesis and receptor binding studies

scholarly article by Peter Gmeiner et al published November 1994 in Bioorganic & Medicinal Chemistry Letters

Novel azulene derivatives for the treatment of erectile dysfunction

scientific article published on 06 October 2012

Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensin receptor 1.

scientific article published on 27 August 2008

Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists

scientific article

Novel triazolopeptides: chirospecific synthesis and conformational studies of proline derived analogs

On the terminal homologation of physiologically active peptides as a means of increasing stability in human serum--neurotensin, opiorphin, B27-KK10 epitope, NPY.

scientific article published on May 2011

Optimization and synthesis of an18F-labeled dopamine D3receptor ligand using [18F]fluorophenylazocarboxylictert-butylester

scientific article published on 28 December 2015

Optimization of Click Chemistry Using Azide and Alkyne Scavenger Resins

Optimizing the Expression of Human Dopamine Receptors in Escherichia coli

scientific article published in 2021

Oxabenzomorphane: Synthese ZNS-wirksamer Hexahydro-2,7-methano-1,5-benzoxazonine

Oxabenzomorphane: Synthese, Reaktionen und ZNS-Wirkung von 2,6-Methano-1-benzoxocinen

scientific article published on 01 March 1987

Oxabenzomorphane: Über ZNS-Wirkungen von Hexahydro-2,7-methano-1,5-benzoxazoninen

scientific article published on 01 June 1988

PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain

scientific article

Parallel synthesis and biological screening of dopamine receptor ligands taking advantage of a click chemistry based BAL linker

scientific article

Parallel synthesis of potent dopaminergic N-phenyltriazole carboxamides applying a novel click chemistry based phenol linker

scientific article published on 25 June 2009

Peptide backbone modifications on the C-terminal hexapeptide of neurotensin

scientific article

Pharmacological profile of 2-bromoterguride at human dopamine D2, porcine serotonin 5-hydroxytryptamine 2A, and α2C-adrenergic receptors, and its antipsychotic-like effects in rats

scientific article published on 17 July 2013

Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists

scientific article published in September 2005

Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles

scientific article published on 01 September 2000

Phenylpiperazinylmethylindolecarboxylates and derivatives as selective D(4)-ligands

scientific article

Photochromic Dopamine Receptor Ligands Based on Dithienylethenes and Fulgides

scientific article published on 26 June 2017

Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands

scientific article published on 01 November 1999

Planar chiral indoles: synthesis and biological effects of the enantiomers

Potent haloperidol derivatives covalently binding to the dopamine D2 receptor

scientific article published on 20 June 2017

Practical EPC synthesis of 1,2- and 1,3-amino alcohols

Practical ex-chiral-pool methodology for the synthesis of dopaminergic tetrahydroindoles

scholarly article by Markus Bergauer et al published January 2004 in Tetrahedron

Proline derived spirobarbiturates as highly effective beta-turn mimetics incorporating polar and functionalizable constraint elements

scientific article

Pyrane, CXXIII. Regio- und diastereoselektive Synthesen von Hexahydro-4a,9-propanoxanthenonen

Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules

scientific article

Quinpramine is a novel compound effective in ameliorating brain autoimmune disease

scientific article

Radical arylation of tyrosine and its application in the synthesis of a highly selective neurotensin receptor 2 ligand

scientific article

Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor.

scientific article

Rational design of agonists for bitter taste receptor TAS2R14: from modeling to bench and back

scientific article published on 24 June 2019

Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).

scientific article published in August 2001

Recent advances in the search for D3- and D4-selective drugs: probes, models and candidates

scientific article published on 12 January 2011

Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M2 Receptor

scientific article published on 01 April 2020

Regioselective Transformation of Malic Acid: A Practical Method for the Construction of Enantiomerically Pure Indolizidines

Regiospecific Introduction of Halogens on the 2-Aminobiphenyl Subunit Leading to Highly Potent and Selective M3 Muscarinic Acetylcholine Receptor Antagonists and Weak Inverse Agonists

scientific article published on 09 April 2020

SCRF-DFT and NMR comparison of tetracycline and 5a,6-anhydrotetracycline in solution

scientific article

Selective GPCR ligands

scientific article published on 14 March 2015

Selective agonists for dopamine/neurotensin receptor heterodimers

scientific article

Selektive Dopamin D-2 Autorezeptor Agonisten mit 8-Azaindol Substruktur: Synthese und theoretische Untersuchungen

scientific article published on 01 July 1994

Spontaneous butenolide ring formation of pregnane-21-O-malonyl hemiesters under mild reaction conditions is facilitated by the 14β-hydroxy group present in all natural cardenolides

Stereocontrolled dopamine receptor binding and subtype selectivity of clebopride analogues synthesized from aspartic acid

scientific article published in October 2003

Stereoelectronically controlled cyclization reactions on the way toperi-fused tetrahydropyrazolo[1,5-a]pyridines as aza analogs of ergoline partial structures

Structural insights into µ-opioid receptor activation

scientific article

Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair

scientific article

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

scientific article

Structure-Based Design and Discovery of New M2 Receptor Agonists

scientific article published on 2 November 2017

Structure-Guided Screening for Functionally Selective D2 Dopamine Receptor Ligands from a Virtual Chemical Library

scientific article published on 28 August 2017

Structure-based design of Tet repressor to optimize a new inducer specificity

scientific article

Structure-based development of a subtype-selective orexin 1 receptor antagonist

scientific article published on 15 July 2020

Structure-based development of caged dopamine D2/D3 receptor antagonists

scientific article published on 21 January 2020

Structure-based discovery of opioid analgesics with reduced side effects

scientific article

Structure-based evolution of subtype-selective neurotensin receptor ligands

scientific article published on 23 September 2014

Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists

scientific article published on 19 April 2016

Structure-guided development of heterodimer-selective GPCR ligands

scientific article

Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands

scientific article

Subtype Selective Tetracycline Agonists and their Application for a Two-Stage Regulatory System

scientific article published on 01 September 2006

Synthese anellierter Oxabenzomorphane

Synthese von ZNS-Wirkstoffen: Pyran-, thiopyran- und piperidinanellierte Oxa-carbabenzomorphane

Syntheses and radiofluorination of two derivatives of 5-cyano-indole as selective ligands for the dopamine subtype-4 receptor

Syntheses, receptor bindings, in vitro and in vivo stabilities and biodistributions of DOTA-neurotensin(8-13) derivatives containing β-amino acid residues - a lesson about the importance of animal experiments

scientific article published in December 2013

Synthesis and Dopamine Receptor Binding Studies of Homochiral 8-Aminopyrido[1,2-a]indoles

scientific article published on 01 July 1995

Synthesis and Dopamine Receptor Binding of 3-Phenylazepino[5,4,3-c,d]indole Derivatives

scientific article published on 01 April 1995

Synthesis and binding profile of haloperidol-based bivalent ligands targeting dopamine D(2)-like receptors

scientific article published on 3 July 2014

Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype

scientific article published on 24 March 2006

Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents

scientific article

Synthesis and evaluation of a (18)F-labeled diarylpyrazole glycoconjugate for the imaging of NTS1-positive tumors

scientific article published on 6 November 2013

Synthesis and evaluation of fluoro substituted pyridinylcarboxamides and their phenylazo analogues for potential dopamine D3 receptor PET imaging

scientific article published in December 2014

Synthesis and in vitro evaluation of iodine labelled pyrazolo[1,5-a]pyridines as highly selective dopamine D4 receptor ligands

Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype

scientific article

Synthesis of (S)-3,4-Diaminobutanenitriles as Precursors for 3-Amino-GABA Derivatives

scientific article published on 01 March 1995

Synthesis of Amines and Amino Alcohols by Electrophilic Amination and Highly Stereoselective Reduction

Synthesis of Tricyclic Azaergoline Analogues Synthese tricyclischer Azaergolin-Analoga

article published in 1990

Synthesis of a (68)ga-labeled peptoid-Peptide hybrid for imaging of neurotensin receptor expression in vivo

scientific article published on 21 May 2010

Synthesis of dihydrooxazole analogues derived from linezolid

Synthesis of optically active α,β-disubstituted β-amino nitriles and β-amino acids starting from asparagine

Synthesis of pyrazolylvinyl ketones from furan derivatives

scientific article published on 01 May 2019

Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET.

scientific article published on 26 October 2010

Synthesis, pharmacological investigation and computational studies on a tricyclic ergoline analog with selective dopamine autoreceptor activity

scientific article published on July 1995

Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.

scientific article

Tetracycline sensing using novel doxycycline derivatives immobilized on different surface plasmon resonance biosensor surfaces

scientific article published on February 2010

The azulene framework as a novel arene bioisostere: design of potent dopamine D4 receptor ligands inducing penile erection

scientific article published in March 2009

The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65.

scientific article

The bulky N6 substituent of cabergoline is responsible for agonism of this drug at 5-hydroxytryptamine 5-HT2A and 5-HT2B receptors and thus is a determinant of valvular heart disease

scientific article published on 25 April 2011

The pH probe CypHer™5E is effectively quenched by FM dyes

scientific article published on 10 February 2013

The structural evolution of dopamine D3 receptor ligands: structure-activity relationships and selected neuropharmacological aspects

scientific article published on 14 August 2006

The therapeutically anti-prion active antibody-fragment scFv-W226: paramagnetic relaxation-enhanced NMR spectroscopy aided structure elucidation of the paratope-epitope interface

scientific article published in August 2010

Theranostic Value of Multimers: Lessons Learned from Trimerization of Neurotensin Receptor Ligands and Other Targeting Vectors

scientific article published on 10 March 2017

Triazolopeptides: chirospecific synthesis and cis/trans prolyl ratios of structural isomers

Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments

scientific article published on 2 June 2006

Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments

scientific article

Tricyclic azaergoline analogues: synthesis, structural modifications, and pharmacological studies

scientific article published in October 1992

Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level

scientific article

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes

scientific article published in 2021

[18F]Fluorophenylazocarboxylates: Design and Synthesis of Potential Radioligands for Dopamine D3 and μ-Opioid Receptor

scientific article published on 6 December 2017

Paulina is supported by:

About Paulina

Help