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List of works by Johan M. Thevelein

A Split-Ubiquitin Two-Hybrid Screen for Proteins Physically Interacting with the Yeast Amino Acid Transceptor Gap1 and Ammonium Transceptor Mep2 ⬇️

scientific article published on September 2, 2011

A bifunctional TPS-TPP enzyme from yeast confers tolerance to multiple and extreme abiotic-stress conditions in transgenic Arabidopsis.

scientific article

A central integrator of transcription networks in plant stress and energy signalling

scientific article published in August 2007

A mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1K1876M, specifically affects glucose- and acidification-induced cAMP signalling and not the basal cAMP level.

scientific article published on July 1999

A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2.

scientific article

A short regulatory domain restricts glycerol transport through yeast Fps1p.

scientific article

A sustainable wood biorefinery for low-carbon footprint chemicals production

scientific article published on 13 February 2020

ABI4 mediates the effects of exogenous trehalose on Arabidopsis growth and starch breakdown

scientific article published on 23 September 2006

Aberrant Intracellular pH Regulation Limiting Glyceraldehyde-3-Phosphate Dehydrogenase Activity in the Glucose-Sensitive Yeast tps1Δ Mutant

scientific article published on 27 October 2020

Absence of glucose-induced cAMP signaling in the Saccharomyces cerevisiae mutants cat1 and cat3 which are deficient in derepression of glucose-repressible proteins

scientific article published on 01 January 1990

Activation of trehalase during growth induction by nitrogen sources in the yeast Saccharomyces cerevisiae depends on the free catalytic subunits of cAMP-dependent protein kinase, but not on functional Ras proteins

scientific article published on 01 August 1994

Activation state of protein kinase A as measured in permeabilised Saccharomyces cerevisiae cells correlates with PKA-controlled phenotypes in vivo

scientific article published in March 2003

Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae.

scientific article

Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast.

scientific article published in March 2006

An integrated framework for discovery and genotyping of genomic variants from high-throughput sequencing experiments

scientific article published on 11 January 2014

An unexpected plethora of trehalose biosynthesis genes in Arabidopsis thaliana

scientific article published in November 2001

Aquaporin expression and freeze tolerance in Candida albicans

scientific article published on October 2005

Aquaporin expression correlates with freeze tolerance in baker's yeast, and overexpression improves freeze tolerance in industrial strains

scientific article

Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro

scientific article published on 14 May 2013

Characterization of the Pho89 phosphate transporter by functional hyperexpression in Saccharomyces cerevisiae

scientific article published on 8 July 2008

Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum

scientific article

Combined inactivation of the Candida albicans GPR1 and TPS2 genes results in avirulence in a mouse model for systemic infection

scientific article published on 11 February 2008

Comparative polygenic analysis of maximal ethanol accumulation capacity and tolerance to high ethanol levels of cell proliferation in yeast

scientific article

Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex.

scientific article

Control of glucose influx into glycolysis and pleiotropic effects studied in different isogenic sets of Saccharomyces cerevisiae mutants in trehalose biosynthesis

scientific article published on 01 January 1995

Correction: Agp2, a Member of the Yeast Amino Acid Permease Family, Positively Regulates Polyamine Transport at the Transcriptional Level.

scientific article published in July 2013

Correlation between glucose/fructose discrepancy and hexokinase kinetic properties in different Saccharomyces cerevisiae wine yeast strains

scientific article published on 23 October 2007

Deletion of SFI1, a novel suppressor of partial Ras-cAMP pathway deficiency in the yeast Saccharomyces cerevisiae, causes G(2) arrest.

scientific article

Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering.

scientific article published on 21 June 2013

Differential requirement of the yeast sugar kinases for sugar sensing in establishing the catabolite-repressed state.

scientific article

Directly from Galpha to protein kinase A: the kelch repeat protein bypass of adenylate cyclase.

scientific article published on 5 November 2007

Discrepancy in glucose and fructose utilisation during fermentation by Saccharomyces cerevisiae wine yeast strains

scientific article published in May 2004

Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy

scientific article

Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation

scientific article

Disruption of the Kluyveromyces lactis GGS1 gene causes inability to grow on glucose and fructose and is suppressed by mutations that reduce sugar uptake

scientific article

During the initiation of fermentation overexpression of hexokinase PII in yeast transiently causes a similar deregulation of glycolysis as deletion of Tps1

scientific article published on 01 February 1998

Engineering tolerance to industrially relevant stress factors in yeast cell factories.

scientific article published on 06 June 2017

Evidence for inositol triphosphate as a second messenger for glucose-induced calcium signalling in budding yeast

scientific article published on 15 November 2003

Evidence for involvement of Saccharomyces cerevisiae protein kinase C in glucose induction of HXT genes and derepression of SUC2.

scientific article published in May 2002

Evidence for rapid uptake of D-galacturonic acid in the yeast Saccharomyces cerevisiae by a channel-type transport system

scientific article published on 19 June 2012

Expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters.

scientific article

Expression of escherichia coli otsA in a Saccharomyces cerevisiae tps1 mutant restores trehalose 6-phosphate levels and partly restores growth and fermentation with glucose and control of glucose influx into glycolysis.

scientific article published on August 2000

Extensive expression regulation and lack of heterologous enzymatic activity of the Class II trehalose metabolism proteins from Arabidopsis thaliana.

scientific article

Feedback inhibition on cell wall integrity signaling by Zds1 involves Gsk3 phosphorylation of a cAMP-dependent protein kinase regulatory subunit

scientific article published on 18 April 2003

Flavor-Active Esters: Adding Fruitiness to Beer

scientific article published on 01 January 2003

Flavour formation in fungi: characterisation of KlAtf, the Kluyveromyces lactis orthologue of the Saccharomyces cerevisiae alcohol acetyltransferases Atf1 and Atf2

scientific article published on 29 February 2008

Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation

scientific article published on 01 February 1999

Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras.

scientific article published on 13 October 2017

Functioning and evolutionary significance of nutrient transceptors.

scientific article published on 03 August 2009

G-protein-coupled receptor Gpr1 and G-protein Gpa2 of cAMP-dependent signaling pathway are involved in glucose-induced pexophagy in the yeast Saccharomyces cerevisiae

scientific article

Genetic mapping of quantitative phenotypic traits in Saccharomyces cerevisiae ⬇️

scientific article published on January 24, 2012

Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae.

scientific article

Glucose exerts opposite effects on mRNA versus protein and activity levels of Pde1, the low-affinity cAMP phosphodiesterase from budding yeast, Saccharomyces cerevisiae

scientific article published on 01 December 1997

Glucose-induced activation of plasma membrane H(+)-ATPase in mutants of the yeast Saccharomyces cerevisiae affected in cAMP metabolism, cAMP-dependent protein phosphorylation and the initiation of glycolysis

scientific article published on July 1992

Glucose-induced cAMP signalling in yeast requires both a G-protein coupled receptor system for extracellular glucose detection and a separable hexose kinase-dependent sensing process

scientific article published on 01 October 2000

Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast

scientific article published on 31 January 2012

Glucose-sensing and -signalling mechanisms in yeast.

scientific article

Glucose-sensing mechanisms in eukaryotic cells.

scientific article

Heterologous aquaporin (AQY2-1) expression strongly enhances freeze tolerance of Schizosaccharomyces pombe

scientific article published in January 2005

Identification of genes responsible for improved cryoresistance in fermenting yeast cells

scientific article published on 01 April 2000

Identification of genes with nutrient-controlled expression by PCR-mapping in the yeast Saccharomyces cerevisiae

scientific article published on 01 August 1997

Identification of multiple interacting alleles conferring low glycerol and high ethanol yield in Saccharomyces cerevisiae ethanolic fermentation

scientific article

Identification of novel causative genes determining the complex trait of high ethanol tolerance in yeast using pooled-segregant whole-genome sequence analysis.

scientific article published on 7 March 2012

Impact of pitching rate on yeast fermentation performance and beer flavour

scientific article published on 19 November 2008

Improved linkage analysis of Quantitative Trait Loci using bulk segregants unveils a novel determinant of high ethanol tolerance in yeast

scientific article

In vivo phosphorylation of Ser21 and Ser83 during nutrient-induced activation of the yeast protein kinase A (PKA) target trehalase

scientific article published on 15 November 2012

Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae.

scientific article

Isolation and characterization of brewer's yeast variants with improved fermentation performance under high-gravity conditions.

scientific article published on 8 December 2006

Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco

scientific article

Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast.

scientific article

Major sulfonate transporter Soa1 in Saccharomyces cerevisiae and considerable substrate diversity in its fungal family.

scientific article published on 6 February 2017

Molecular and physiological characterization of the NAD-dependent glycerol 3-phosphate dehydrogenase in the filamentous fungus Aspergillus nidulans.

scientific article published in January 2001

Molecular cloning of the neutral trehalase gene from Kluyveromyces lactis and the distinction between neutral and acid trehalases.

scientific article published in April 1997

Molecular mechanisms controlling phosphate-induced downregulation of the yeast Pho84 phosphate transporter

scientific article published in June 2009

Molecular mechanisms controlling the localisation of protein kinase A.

scientific article

Molecular mechanisms of feedback inhibition of protein kinase A on intracellular cAMP accumulation.

scientific article published on 13 April 2012

Monitoring the influence of high-gravity brewing and fermentation temperature on flavour formation by analysis of gene expression levels in brewing yeast

scientific article published on 27 August 2008

Multi-level response of the yeast genome to glucose ⬇️

scientific article published on October 15, 2003

Multiple effects of protein phosphatase 2A on nutrient-induced signalling in the yeast Saccharomyces cerevisiae

scientific article

Mutational analysis of putative phosphate- and proton-binding sites in the Saccharomyces cerevisiae Pho84 phosphate:H(+) transceptor and its effect on signalling to the PKA and PHO pathways

scientific article published in August 2012

Novel mechanisms in nutrient activation of the yeast protein kinase A pathway.

scientific article published on June 2008

Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae

scientific article

Nutrient sensing systems for rapid activation of the protein kinase A pathway in yeast

scientific article published in February 2005

Nutrient-induced signal transduction through the protein kinase A pathway and its role in the control of metabolism, stress resistance, and growth in yeast.

scientific article

PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability.

scientific article

Parameters affecting ethyl ester production by Saccharomyces cerevisiae during fermentation.

scientific article published on 9 November 2007

Peptides induce persistent signaling from endosomes by a nutrient transceptor

scientific article published on 04 March 2012

Phosphoinositides in yeast: genetically tractable signalling.

scientific article

Physiological and molecular analysis of the stress response of Saccharomyces cerevisiae imposed by strong inorganic acid with implication to industrial fermentations

scientific article published on 23 November 2009

Pkh1 interacts with and phosphorylates components of the yeast Gcn2/eIF2α system.

scientific article published on 3 February 2012

Polygenic Analysis in Absence of Major Effector Unveils Novel Components in Yeast Flavor Ester Biosynthesis

scientific article published on 28 August 2018

Polygenic analysis of very high acetic acid tolerance in the yeast Saccharomyces cerevisiae reveals a complex genetic background and several new causative alleles

scientific article published on 16 July 2020

Possible involvement of a phosphatidylinositol-type signaling pathway in glucose-induced activation of plasma membrane H(+)-ATPase and cellular proton extrusion in the yeast Saccharomyces cerevisiae

scientific article published on 01 August 1994

Production and biological function of volatile esters in Saccharomyces cerevisiae ⬇️

scientific article published on 06 April 2009

QTL analysis of high thermotolerance with superior and downgraded parental yeast strains reveals new minor QTLs and converges on novel causative alleles involved in RNA processing.

scientific article

Quantitative trait analysis of yeast biodiversity yields novel gene tools for metabolic engineering.

scientific article

Reconstitution of ethanolic fermentation in permeabilized spheroplasts of wild-type and trehalose-6-phosphate synthase mutants of the yeast Saccharomyces cerevisiae

scientific article published on 01 July 2000

Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae: novel variations of STRE-mediated transcription control?

scientific article published on 01 September 1996

Regulation of maltose utilization in Saccharomyces cerevisiae by genes of the RAS/protein kinase A pathway

scientific article published on 01 February 1997

Sex and sugar in yeast: two distinct GPCR systems.

scientific article

Signal transduction in yeast.

scientific article published on December 1994

Stimulation of the yeast high osmolarity glycerol (HOG) pathway: evidence for a signal generated by a change in turgor rather than by water stress

scientific article published on 01 April 2000

Stress tolerance of the Saccharomyces cerevisiae adenylate cyclase fil1 (CYR1) mutant depends on Hsp26.

scientific article published on 6 October 2010

The Arabidopsis trehalose-6-P synthase AtTPS1 gene is a regulator of glucose, abscisic acid, and stress signaling. ⬇️

scientific article published on 29 October 2004

The G protein-coupled receptor Gpr1 and the Galpha protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans.

scientific article

The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae

scientific article published in November 2003

The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity.

scientific article

The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage

scientific article

The Saccharomyces cerevisiae alcohol acetyl transferase gene ATF1 is a target of the cAMP/PKA and FGM nutrient-signalling pathways

scientific article

The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle

scientific article published in September 2000

The Saccharomyces cerevisiae type 2A protein phosphatase Pph22p is biochemically different from mammalian PP2A.

scientific article

The XXth International Conference on Yeast Genetics and Molecular Biology, Prague.

scientific article published in January 2002

The activation loop of PKA catalytic isoforms is differentially phosphorylated by Pkh protein kinases in Saccharomyces cerevisiae.

scientific article

The cell division cycle gene CDC60 encodes cytosolic leucyl-tRNA synthetase in Saccharomyces cerevisiae

scientific article published on October 12, 1992

The eukaryotic plasma membrane as a nutrient-sensing device.

scientific article published in October 2004

The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae.

scientific article

The high general stress resistance of the Saccharomyces cerevisiae fil1 adenylate cyclase mutant (Cyr1Lys1682) is only partially dependent on trehalose, Hsp104 and overexpression of Msn2/4-regulated genes

scientific article published on January 2004

The molecular biology of fruity and floral aromas in beer and other alcoholic beverages.

scientific article

The protein quality control system manages plant defence compound synthesis

scientific article published on 10 November 2013

The role of hexose transport and phosphorylation in cAMP signalling in the yeast Saccharomyces cerevisiae.

scientific article published in April 2001

The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes.

scientific article

The trehalose pathway regulates mitochondrial respiratory chain content through hexokinase 2 and cAMP in Saccharomyces cerevisiae

scientific article

Towards valorization of pectin-rich agro-industrial residues: Engineering of Saccharomyces cerevisiae for co-fermentation of d-galacturonic acid and glycerol

scientific article published in 2022

Transcript analysis of 1003 novel yeast genes using high-throughput northern hybridizations.

scientific article published in June 2001

Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor

scientific article

Trehalase activity in extracts of Phycomyces blakesleeanus spores following the induction of germination by heat activation

scientific article published on 01 December 1981

Trehalases and trehalose hydrolysis in fungi ⬇️

scientific article published on September 15, 1997

Trehalose accumulation in mutants of Saccharomyces cerevisiae deleted in the UDPG-dependent trehalose synthase-phosphatase complex

scientific article published on 01 April 1997

Trehalose metabolism and glucose sensing in plants

scientific article published in February 2005

Trehalose-6-phosphate synthase as an intrinsic selection marker for plant transformation

scientific article published on 4 November 2005

Truncation of Arabidopsis thaliana and Selaginella lepidophylla trehalose-6-phosphate synthase unlocks high catalytic activity and supports high trehalose levels on expression in yeast.

scientific article published on August 2002

Uncoupling of the glucose growth defect and the deregulation of glycolysis in Saccharomyces cerevisiae Tps1 mutants expressing trehalose-6-phosphate-insensitive hexokinase from Schizosaccharomyces pombe

scientific article published in September 2003

Unique genetic basis of the distinct antibiotic potency of high acetic acid production in the probiotic yeast Saccharomyces cerevisiae var. boulardii

scientific article published on 01 September 2019

Why do microorganisms have aquaporins?

scientific article published on 10 January 2006

Yeast 3-phosphoinositide-dependent protein kinase-1 (PDK1) orthologs Pkh1-3 differentially regulate phosphorylation of protein kinase A (PKA) and the protein kinase B (PKB)/S6K ortholog Sch9.

scientific article published on 29 April 2011

Yeast nutrient transceptors provide novel insight in the functionality of membrane transporters

scientific article published on 11 October 2013

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