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List of works by Jeffrey W. Tyner

"Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease

scientific article

A case study of personalized therapy for osteosarcoma.

scientific article published on 22 March 2013

A molecular case report: functional assay of tyrosine kinase inhibitors in cells from a patient's primary renal cell carcinoma.

scientific article published on 28 November 2012

A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia

scientific article

AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance

scientific article

AZD4320, a dual inhibitor of Bcl-2 and Bcl-xL, induces tumor regression in hematological cancer models without dose-limiting thrombocytopenia

scientific article published on 28 September 2020

Activating alleles of JAK3 in acute megakaryoblastic leukemia

scientific article published on July 2006

Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease

scientific article

An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma

scientific article published on 30 August 2012

Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia

scientific article published on 16 January 2014

Apoptosis in the airways: another balancing act in the epithelial program.

scientific article

Belinostat and panobinostat (HDACI): in vitro and in vivo studies in thyroid cancer

scientific article published on 04 July 2013

Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.

scientific article

CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

scientific article published on 19 October 2010

CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection

scientific journal article

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

scientific article published on 13 November 2018

CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia.

scientific article

CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathwa

scientific article published on 31 July 2013

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

scientific article

Causal role for JAK2 V617F in thrombosis.

scientific article published on November 2013

Comparison of methods to identify aberrant expression patterns in individual patients: augmenting our toolkit for precision medicine

scientific article

Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia

scientific article

Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2 ⬇️

scientific article published on August 20, 2012

Dynamic and nuclear expression of PDGFRα and IGF-1R in alveolar Rhabdomyosarcoma

scientific article published on 08 August 2013

Effect of dasatinib against thyroid cancer cell lines in vitro and a xenograft model in vivo ⬇️

scientific article published on January 20, 2012

FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248).

scientific article published on 14 September 2006

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins.

scientific article

Functional characterization of an activating TEK mutation in acute myeloid leukemia: a cellular context-dependent activating mutation

scientific article published on 2 April 2009

Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma

scientific article published on 25 August 2020

Functional integration of acute myeloid leukemia into the vascular niche.

scientific article

Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib

scientific article published on 01 December 2022

Genomic landscape of neutrophilic leukemias of ambiguous diagnosis

scientific article published on 31 July 2019

Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate

scientific article

High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia

scientific article published on 10 July 2008

High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

scientific article published on 5 February 2008

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

scientific article published on 15 December 2008

HitWalker: variant prioritization for personalized functional cancer genomics

scientific article

Imatinib and Dasatinib Inhibit Hemangiosarcoma and Implicate PDGFR-β and Src in Tumor Growth

scientific article

In vitro sensitivity to dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre-B acute lymphoblastic leukemia

scientific article published on 28 October 2011

JAK2 V617F down-modulates MPL.

scientific article published in May 2012

Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening

scientific article

Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization

scientific article published on 08 January 2014

MET receptor sequence variants R970C and T992I lack transforming capacity

scientific article

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia.

scientific article

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML

scientific article

PDGFRβ reverses EphB4 signaling in alveolar rhabdomyosarcoma

scientific article

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

scientific article published on 18 May 2008

Phosphoproteomics microarray screen reveals novel interaction between MPL and Tensin2: implications for biology, disease and therapeutics

scientific article published on 15 August 2011

Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations

scientific article published on 09 January 2014

Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies

scientific article published on 11 April 2011

RNAi screen for rapid therapeutic target identification in leukemia patients

scholarly article

RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia

scientific article

Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia

scientific article published on 08 June 2020

SGX393 inhibits the CML mutant Bcr-AblT315I and preempts in vitro resistance when combined with nilotinib or dasatinib.

scholarly article

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

scientific article published on 17 July 2018

TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

scientific article published on 09 September 2021

TSLP Signaling Network Revealed by SILAC-Based Phosphoproteomics ⬇️

scientific article published on February 16, 2012

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia

scientific article published on 7 March 2013

Targeting survivin and p53 in pediatric acute lymphoblastic leukemia.

scientific article

The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile

scientific article published on 19 April 2011

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition

scientific article published on 30 September 2013

The PI3K/Akt1 pathway enhances steady-state levels of FANCL.

scientific article published on 19 June 2013

The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells

scientific article published on 02 May 2019

The function of the pleckstrin homology domain in BCR-ABL-mediated leukemogenesis.

scientific article

The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment

scientific article published on 29 July 2013

The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia

scientific article published on 7 December 2012

Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells determine their commitment to apoptosis

scientific article published on 10 April 2013

p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes

scientific article

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