List of works - Alastair Kerr

A multistage sequencing strategy pinpoints novel candidate alleles for Emery-Dreifuss muscular dystrophy and supports gene misregulation as its pathomechanism

scientific article published on 17 December 2019

A novel CpG island set identifies tissue-specific methylation at developmental gene loci

scientific article

A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes

scientific article

A rapid computational approach identifies SPICE1 as an Aurora kinase substrate

scientific article published on 28 November 2018

Analysis of RNA-Seq datasets reveals enrichment of tissue-specific splice variants for nuclear envelope proteins

scientific article published on 01 January 2018

Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data. 2nd Edn. Ed. M. R. Barnes. Wiley. 2007. 528 pages. ISBN 978-0-470-02620-5. Price £45. (paperback)

Cell type-specific DNA methylation at intragenic CpG islands in the immune system.

scientific article

Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells

scientific article

Co-transcriptional degradation of aberrant pre-mRNA by Xrn2.

scientific article

Comparative proteomic analyses of the nuclear envelope and pore complex suggests a wide range of heretofore unexpected functions

scientific article published on 27 September 2008

Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments

scientific article

Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments

article

Convergent genes shape budding yeast pericentromeres

article

Convergent genes shape budding yeast pericentromeres

scientific article published on 29 April 2020

CpG islands influence chromatin structure via the CpG-binding protein Cfp1.

scientific article published on April 2010

CpG methylation is targeted to transcription units in an invertebrate genome

scientific article

Evolution by leaps: gene duplication in bacteria

scientific article

Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria

scientific article

H3 k36 methylation helps determine the timing of cdc45 association with replication origins

scientific article

Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast

scientific article

Identical sets of methylated and nonmethylated genes in Ciona intestinalis sperm and muscle cells.

scientific article

In vitro BioID: mapping the CENP-A microenvironment with high temporal and spatial resolution

scientific article published on 20 March 2019

Inter-individual variability contrasts with regional homogeneity in the human brain DNA methylome

scientific article

Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively

scientific article

Lipids contribute to epigenetic control via chromatin structure and functions

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

scientific article

Many mechanisms, one entrance: membrane protein translocation into the nucleus

scientific article published on 12 February 2012

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα

scientific article published on 19 November 2012

Molecular and genetic analysis of condensin function in vertebrate cells

scientific article published on 14 May 2008

Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.

scientific article

Orphan CpG islands identify numerous conserved promoters in the mammalian genome

scientific article (publication date: 23 September 2010)

PuLSE: Quality control and quantification of peptide sequences explored by phage display libraries

scientific article published on 23 February 2018

Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations

scientific article

Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere

scientific article published on 4 February 2014

Structural evidence for Scc4-dependent localization of cohesin loading

scientific article published on 3 June 2015

Systematic base composition variation around the genome of Mycoplasma genitalium , but not Mycoplasma pneumoniae

article

TD-60 links RalA GTPase function to the CPC in mitosis.

scientific article published on 9 July 2015

Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson‐Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform

scientific article published on 07 January 2019

The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells

scientific article

The kinetochore prevents centromere-proximal crossover recombination during meiosis

scientific article

The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture ⬇️

scientific article

The molecular basis of variable phenotypic severity among common missense mutations causing Rett syndrome

scientific article published on 8 December 2015

The nuclear envelope proteome differs notably between tissues

scientific article

Tissue specificity in the nuclear envelope supports its functional complexity.

scientific article

Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis.

scientific article published on 31 May 2016

Tissue-specific NETs alter genome organization and regulation even in a heterologous system

scientific article published on 3 January 2017

Toxicity of overexpressed MeCP2 is independent of HDAC3 activity

article

List of works by Alastair Kerr

A multistage sequencing strategy pinpoints novel candidate alleles for Emery-Dreifuss muscular dystrophy and supports gene misregulation as its pathomechanism

A novel CpG island set identifies tissue-specific methylation at developmental gene loci

A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes

A rapid computational approach identifies SPICE1 as an Aurora kinase substrate

Analysis of RNA-Seq datasets reveals enrichment of tissue-specific splice variants for nuclear envelope proteins

Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data. 2nd Edn. Ed. M. R. Barnes. Wiley. 2007. 528 pages. ISBN 978-0-470-02620-5. Price £45. (paperback)

Cell type-specific DNA methylation at intragenic CpG islands in the immune system.

Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells

Co-transcriptional degradation of aberrant pre-mRNA by Xrn2.

Comparative proteomic analyses of the nuclear envelope and pore complex suggests a wide range of heretofore unexpected functions

Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments

Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments

Convergent genes shape budding yeast pericentromeres

Convergent genes shape budding yeast pericentromeres

CpG islands influence chromatin structure via the CpG-binding protein Cfp1.

CpG methylation is targeted to transcription units in an invertebrate genome

Evolution by leaps: gene duplication in bacteria

Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria

H3 k36 methylation helps determine the timing of cdc45 association with replication origins

Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast

Identical sets of methylated and nonmethylated genes in Ciona intestinalis sperm and muscle cells.

In vitro BioID: mapping the CENP-A microenvironment with high temporal and spatial resolution

Inter-individual variability contrasts with regional homogeneity in the human brain DNA methylome

Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively

Lipids contribute to epigenetic control via chromatin structure and functions

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

Many mechanisms, one entrance: membrane protein translocation into the nucleus

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα

Molecular and genetic analysis of condensin function in vertebrate cells

Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.

Orphan CpG islands identify numerous conserved promoters in the mammalian genome

PuLSE: Quality control and quantification of peptide sequences explored by phage display libraries

Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations

Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere

Structural evidence for Scc4-dependent localization of cohesin loading

Systematic base composition variation around the genome of Mycoplasma genitalium , but not Mycoplasma pneumoniae

TD-60 links RalA GTPase function to the CPC in mitosis.

Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson‐Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform

The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells

The kinetochore prevents centromere-proximal crossover recombination during meiosis

The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture ⬇️

The molecular basis of variable phenotypic severity among common missense mutations causing Rett syndrome

The nuclear envelope proteome differs notably between tissues

Tissue specificity in the nuclear envelope supports its functional complexity.

Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis.

Tissue-specific NETs alter genome organization and regulation even in a heterologous system

Toxicity of overexpressed MeCP2 is independent of HDAC3 activity