Search filters

List of works by Hiroto Hatakeyama

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

scientific article

A DNA microarray-based analysis of the host response to a nonviral gene carrier: a strategy for improving the immune response.

scientific article

A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells.

scientific article published on 25 January 2016

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.

scientific article published on 4 April 2016

A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma.

scientific article published on 15 September 2010

A neutral envelope-type nanoparticle containing pH-responsive and SS-cleavable lipid-like material as a carrier for plasmid DNA.

scientific article published on 6 February 2013

A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma.

scientific article

A new peptide motif present in the protective antigen of anthrax toxin exerts its efficiency on the cellular uptake of liposomes and applications for a dual-ligand system.

scientific article published on 15 March 2011

A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.

scientific article published on 21 June 2009

Advances in an active and passive targeting to tumor and adipose tissues.

scientific article

An apolipoprotein E modified liposomal nanoparticle: ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells

scientific article published on 12 February 2014

An aptamer ligand based liposomal nanocarrier system that targets tumor endothelial cells

scientific article

Anti-tumor effect via passive anti-angiogenesis of PEGylated liposomes encapsulating doxorubicin in drug resistant tumors.

scientific article published on 24 May 2016

Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer

scientific article published on 16 September 2016

Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain. ⬇️

scientific article published on 8 September 2014

Assessment of In Vivo siRNA Delivery in Cancer Mouse Models

scientific article published on January 2016

Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system.

scientific article

Comparative study of the sensitivities of cancer cells to doxorubicin, and relationships between the effect of the drug-efflux pump P-gp.

scientific article published in January 2014

Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake

scientific article published on 8 May 2010

Determinants of Intestinal Availability for P-glycoprotein Substrate Drugs Estimated by Extensive Simulation With Mathematical Absorption Models.

scientific article published on 4 May 2017

Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid

scientific article

Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery ⬇️

scientific article published on April 5, 2011

Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system

scientific article published in May 2009

Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA.

scientific article published on 24 May 2011

Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo

scientific article

Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system.

scientific article published on 9 April 2013

Global Comparison of Changes in the Number of Test-Positive Cases and Deaths by Coronavirus Infection (COVID-19) in the World

scientific article published on 18 June 2020

HSP70 Inhibition Synergistically Enhances the Effects of Magnetic Fluid Hyperthermia in Ovarian Cancer

scientific article published on 21 February 2017

Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes.

scientific article

Improvement of doxorubicin efficacy using liposomal anti-polo-like kinase 1 siRNA in human renal cell carcinomas

scientific article published on 12 May 2014

In vitro optimization of 2'-OMe-4'-thioribonucleoside-modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle

scientific article published on 11 September 2013

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.

scientific article published on 23 April 2014

Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP).

scientific article published on 23 October 2017

Intracellular stability of 2'-OMe-4'-thioribonucleoside modified siRNA leads to long-term RNAi effect

scientific article published on 12 March 2012

Lipid Envelope-Type Nanoparticle Incorporating a Multifunctional Peptide for Systemic siRNA Delivery to the Pulmonary Endothelium ⬇️

scientific article published on August 21, 2013

Multifunctional Envelope-Type Nano Device: Evolution from Nonselective to Active Targeting System.

scientific article published on 05 June 2015

Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

scientific article published on 23 October 2015

Ornithine and tryptophan analogs as efficient polycations for short interference RNA delivery to tumor cells

scientific article published on January 2010

Poor outcome with anti-programmed death-ligand 1 (PD-L1) antibody due to poor pharmacokinetic properties in PD-1/PD-L1 blockade-sensitive mouse models

scientific article published on 01 February 2020

RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system

scientific article published on 11 October 2013

Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells

scientific article published on 18 December 2015

Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers.

scientific article

Silencing of VEGFR2 by RGD-Modified Lipid Nanoparticles Enhanced the Efficacy of Anti-PD-1 Antibody by Accelerating Vascular Normalization and Infiltration of T Cells in Tumors

scientific article published on 04 December 2020

Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy ⬇️

scientific article published on June 20, 2012

Size-dependent specific targeting and efficient gene silencing in peritoneal macrophages using a pH-sensitive cationic liposomal siRNA carrier

scientific article published on 6 September 2015

Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference

scientific article published on September 23, 2011

Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid.

scientific article published on 22 March 2011

The effect of liposomal size on the targeted delivery of doxorubicin to Integrin αvβ3-expressing tumor endothelial cells ⬇️

scientific article published on April 24, 2013

The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors.

scientific article published on January 2013

The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice

scientific article published on January 2014

Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes

scientific article published on 10 May 2007

[Development of an efficient short interference RNA (siRNA) delivery system with a new pH-sensitive cationic lipid]

scientific article published on 01 January 2012

[Novel material and strategy for gene delivery]

scientific article published on 01 October 2007

Paulina is supported by:

About Paulina

Help