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List of works by Robert S. Phillips

19F-NMR reveals metal and operator-induced allostery in MerR.

scientific article published on 10 May 2007

6-Nitro-L-tryptophan: a novel spectroscopic probe of trp aporepressor and human serum albumin

scientific article published in April 1988

A Mannose Family Phosphotransferase System Permease and Associated Enzymes Are Required for Utilization of Fructoselysine and Glucoselysine in Salmonella enterica Serovar Typhimurium.

scientific article published on 22 June 2015

A Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase mutant derivative highly active and stereoselective on phenylacetone and benzylacetone.

scientific article published on 5 February 2007

A matrix-assisted laser desorption/ionization compatible reagent for tagging tryptophan residues

scientific article

A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population

scientific article published on 19 October 2011

A redox-active FKBP-type immunophilin functions in accumulation of the photosystem II supercomplex in Arabidopsis thaliana.

scholarly article

A resonance Raman study of substrate and inhibitor binding to protocatechuate-3,4-dioxygenase

scientific article published in November 1978

A straightforward kinetic evidence for coexistence of "induced fit" and "selected fit" in the reaction mechanism of a mutant tryptophan indole lyase Y72F from Proteus vulgaris

scientific article published on 30 July 2014

Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media

scientific article

Aminoacrylate intermediates in the reaction of Citrobacter freundii tyrosine phenol-lyase

scientific article published on 01 August 2006

Aspartic acid 214 in Citrobacter freundii tyrosine phenol-lyase ensures sufficient C--H-acidity of the external aldimine intermediate and proper orientation of the cofactor at the active site

scientific article published on 16 May 2006

Asymmetric kinetics of protein structural changes.

scientific article

Asymmetric reduction and oxidation of aromatic ketones and alcohols using W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus

scientific article published on 01 January 2007

Benzimidazole analogs of (L)-tryptophan are substrates and inhibitors of tryptophan indole lyase from Escherichia coli

scientific article published on 18 March 2013

Benzoate decreases the binding of cis,cis-muconate to the BenM regulator despite the synergistic effect of both compounds on transcriptional activation.

scientific article

Binding of phenol and analogues to alanine complexes of tyrosine phenol-lyase from Citrobacter freundii: implications for the mechanisms of alpha,beta-elimination and alanine racemization

scientific article published on 01 November 1993

Bioactivation of Catha edulis alkaloids: enzymatic ketonization of norpseudoephedrine

scientific article published on 01 January 1982

Cellobiose oxidase from Phanerochaete chrysosporium. Stopped-flow spectrophotometric analysis of pH-dependent reduction

scientific article published on 01 July 1992

Chemistry and diversity of pyridoxal-5'-phosphate dependent enzymes.

scientific article

Cold inactivation and dissociation into dimers of Escherichia coli tryptophanase and its W330F mutant form

scientific article published in May 1998

Cold-induced enzyme inactivation: how does cooling lead to pyridoxal phosphate-aldimine bond cleavage in tryptophanase?

scientific article published in February 2002

Conformational changes and loose packing promote E. coli Tryptophanase cold lability

scientific article

Crystal Structure of d-Ornithine/d-Lysine Decarboxylase, a Stereoinverting Decarboxylase: Implications for Substrate Specificity and Stereospecificity of Fold III Decarboxylases

scientific article published on 01 February 2019

Crystal Structures of Wild-Type and F448A Mutant Citrobacter freundii Tyrosine Phenol-Lyase Complexed with a Substrate and Inhibitors: Implications for the Reaction Mechanism

scientific article published on 12 October 2018

Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity

scientific article

Crystallographic Snapshots of Tyrosine Phenol-lyase Show That Substrate Strain Plays a Role in C–C Bond Cleavage

scientific article

Crystals of tryptophan indole-lyase and tyrosine phenol-lyase form stable quinonoid complexes

scientific article

Detection of open and closed conformations of tryptophan synthase by 15N-heteronuclear single-quantum coherence nuclear magnetic resonance of bound 1-15N-L-tryptophan

scientific article published on 25 August 2003

Differential effects of bromination on substrates and inhibitors of kynureninase from Pseudomonas fluorescens

scientific article published in January 2003

Differential effects of temperature and hydrostatic pressure on the formation of quinonoid intermediates from L-Trp and L-Met by H463F mutant Escherichia coli tryptophan indole-lyase

scientific article published in November 2005

Dopamine-B-hydroxylase: suicide inhibition by the novel olefinic substrate, 1-phenyl-1-aminomethylethene

scientific article published on January 1983

Effects of alpha-deuteration and of aza and thia analogs of L-tryptophan on formation of intermediates in the reaction of Escherichia coli tryptophan indole-lyase.

scientific article

Effects of hydrostatic pressure on the conformational equilibrium of tryptophan synthase from Salmonella typhimurium.

scientific article

Effects of pressure and osmolytes on the allosteric equilibria of Salmonella typhimurium tryptophan synthase

scientific article published on 12 November 2012

Enzymatic syntheses of 6-(4H-selenolo[3,2-b]pyrrolyl)-L-alanine, 4-(6H-selenolo[2,3-b]pyrrolyl)-L-alanine, and 6-(4H-furo[3,2-b]pyrrolyl-L-alanine

scientific article published in March 1999

Enzymatic synthesis of aza-l-tyrosines

scientific article published in August 2001

Evidence of preorganization in quinonoid intermediate formation from L-Trp in H463F mutant Escherichia coli tryptophan indole-lyase from effects of pressure and pH.

scientific article published on 10 August 2012

Excited state tautomerization of azaindole

scientific article

Formation in vitro of hybrid dimers of H463F and Y74F mutant Escherichia coli tryptophan indole-lyase rescues activity with L-tryptophan

scientific article published in March 2002

High-efficiency incorporation in vivo of tyrosine analogues with altered hydroxyl acidity in place of the catalytic tyrosine-14 of Delta 5-3-ketosteroid isomerase of Comamonas (Pseudomonas) testosteroni: effects of the modifications on isomerase kin

scientific article

Histidine ligand protonation and redox potential in the rieske dioxygenases: role of a conserved aspartate in anthranilate 1,2-dioxygenase

scientific article published in November 2003

Hydrostatic pressure affects the conformational equilibrium of Salmonella typhimurium tryptophan synthase

scientific article published on May 2005

Hysteresis and negative cooperativity in human UDP-glucose dehydrogenase.

scientific article

I86A/C295A mutant secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus has broadened substrate specificity for aryl ketones

scientific article published on 2 August 2016

Indole can act as an extracellular signal to regulate biofilm formation of Escherichia coli and other indole-producing bacteria

scientific article published in July 2003

Indole protects tryptophan indole-lyase, but not tryptophan synthase, from inactivation by trifluoroalanine

scientific article published in August 1992

Influence of steric bulk and electrostatics on the hydroxylation regiospecificity of tryptophan hydroxylase: characterization of methyltryptophans and azatryptophans as substrates

scientific article published on 01 December 1999

Inhibition of Escherichia coli tryptophan indole-lyase by tryptophan homologues

scientific article published in August 2014

Inhibition of tyrosine phenol-lyase by tyrosine homologues.

scientific article

Inhibition of tyrosine phenol-lyase from Citrobacter freundii by 2-azatyrosine and 3-azatyrosine

scientific article published in December 2001

Insights into the mechanism of Pseudomonas dacunhae aspartate beta-decarboxylase from rapid-scanning stopped-flow kinetics

scientific article published in June 2010

Interactions of Escherichia coli tryptophanase with quasisubstrates and monovalent cations studied by the circular dichroism and fluorescence methods.

scientific article

Investigation of the role of 3-hydroxyanthranilic acid in the degradation of lignin by white-rot fungus Pycnoporus cinnabarinus

scientific article published on 01 March 2001

Ionization state of pyridoxal 5'-phosphate in D-serine dehydratase, dialkylglycine decarboxylase and tyrosine phenol-lyase and the influence of monovalent cations as inferred by 31P NMR spectroscopy

scientific article

Kinetics and mechanism of superoxide reduction by two-iron superoxide reductase from Desulfovibrio vulgaris

scientific article published in April 2002

Kinetics of the superoxide reductase catalytic cycle

scientific article published on 4 August 2003

Ligand effects on the limited proteolysis of phenylalanine hydroxylase: evidence for multiple conformational states

scientific article published on 01 February 1983

Mass defect labeling of cysteine for improving peptide assignment in shotgun proteomic analyses

scientific article

Methionine gamma-lyase: mechanistic deductions from the kinetic pH-effects. The role of the ionic state of a substrate in the enzymatic activity.

scientific article

Mutation of Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase at Trp-110 affects stereoselectivity of aromatic ketone reduction.

scientific article

Oxygenation of fluorinated tyrosines by mushroom tyrosinase releases fluoride ion

scientific article published on 01 January 1990

Preparation and photophysical properties of a caged kynurenine

scientific article published on 06 March 2012

Preparation of 3-bromo-L-tyrosine and 3,5-dibromo-L-tyrosine

scientific article

Pressure and temperature jump relaxation kinetics of the conformational change in Salmonella typhimurium tryptophan synthase L-serine complex: large activation compressibility and heat capacity changes demonstrate the contribution of solvation

scientific article published on 17 September 2008

Properties of tryptophan indole-lyase from a piezophilic bacterium, Photobacterium profundum SS9

scientific article published on 21 November 2010

Protein expression in Escherichia coli S17-1 biofilms: impact of indole.

scientific article

Quantitative effects of allosteric ligands and mutations on conformational equilibria in Salmonella typhimurium tryptophan synthase

scientific article published on 17 November 2007

Racemization of enantiopure secondary alcohols by Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase.

scientific article published on 22 March 2013

Reaction of Pseudomonas fluorescens kynureninase with beta-benzoyl-L-alanine: detection of a new reaction intermediate and a change in rate-determining step

scientific article published in March 2004

Reactions of O-acyl-L-serines with tryptophanase, tyrosine phenol-lyase, and tryptophan synthase

scientific article

Regioselective nitration of N(alpha),N(1)-bis(trifluoroacetyl)-L-tryptophan methyl ester: efficient synthesis of 2-nitro and 6-nitro-N-trifluoroacetyl-L-tryptophan methyl ester

scientific article

Role of aspartate-133 and histidine-458 in the mechanism of tryptophan indole-lyase from Proteus vulgaris

scientific article published in September 2003

Role of lysine-256 in Citrobacter freundii tyrosine phenol-lyase in monovalent cation activation

scientific article published in November 2004

Salmonella utilizes D-glucosaminate via a mannose family phosphotransferase system permease and associated enzymes.

scientific article published on 08 July 2013

Site-directed mutagenesis of tyrosine-71 to phenylalanine in Citrobacter freundii tyrosine phenol-lyase: evidence for dual roles of tyrosine-71 as a general acid catalyst in the reaction mechanism and in cofactor binding

scientific article published on 01 September 1995

Stereospecificity of Pseudomonas fluorescens kynureninase for diastereomers of beta-methylkynurenine

scientific article published on 01 August 1999

Stopped-flow studies of the reaction of D-tartronate semialdehyde-2-phosphate with human neuronal enolase and yeast enolase 1.

scientific article published on 26 January 2010

Structure and Mechanism of d-Glucosaminate-6-phosphate Ammonia-lyase: A Novel Octameric Assembly for a Pyridoxal 5'-Phosphate-Dependent Enzyme, and Unprecedented Stereochemical Inversion in the Elimination Reaction of a d-Amino Acid

scientific article published on 05 May 2021

Structure and mechanism of kynureninase.

scientific article

Substituent effects on the reaction of beta-benzoylalanines with Pseudomonas fluorescens kynureninase

scientific article published on September 2010

Substituents effects on activity of kynureninase from Homo sapiens and Pseudomonas fluorescens

scientific article published on 01 June 2013

Substrate and inhibitor specificity of kynurenine monooxygenase from Cytophaga hutchinsonii

scientific article published on 04 March 2017

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.

scientific article

The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway Is Related to the Heme-Dependent Dioxygenase Superfamily †

scientific article

The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway Is Related to the Heme-Dependent Dioxygenase Superfamily,

article published in 2007

The catalytic mechanism of kynureninase from Pseudomonas fluorescens: evidence for transient quinonoid and ketimine intermediates from rapid-scanning stopped-flow spectrophotometry

scientific article published in June 1998

The catalytic mechanism of kynureninase from Pseudomonas fluorescens: insights from the effects of pH and isotopic substitution on steady-state and pre-steady-state kinetics

scientific article published in February 1998

The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site-directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity

scientific article

The crystal structure of the Pseudomonas dacunhae aspartate-beta-decarboxylase dodecamer reveals an unknown oligomeric assembly for a pyridoxal-5'-phosphate-dependent enzyme

scientific article

The design and synthesis of a selective inhibitor of fucosyltransferase VI.

scientific article published in April 2004

The environments of Trp-248 and Trp-330 in tryptophan indole-lyase from Escherichia coli

scientific article published on 01 July 1990

The mechanism of Escherichia coli tryptophan indole-lyase: substituent effects on steady-state and pre-steady-state kinetic parameters for aryl-substituted tryptophan derivatives.

scientific article

The mechanism of alpha-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase. What is the role of quinonoid intermediates?

scientific article published in November 2004

The phosphate of pyridoxal-5'-phosphate is an acid/base catalyst in the mechanism of Pseudomonas fluorescens kynureninase.

scientific article published on 9 January 2014

The reaction of indole with the aminoacrylate intermediate of Salmonella typhimurium tryptophan synthase: observation of a primary kinetic isotope effect with 3-[(2)H]indole

scientific article published in December 2004

The role of acidic dissociation of substrate's phenol group in the mechanism of tyrosine phenol-lyase

scientific article published in April 2003

The role of glutamic acid-69 in the activation of Citrobacter freundii tyrosine phenol-lyase by monovalent cations.

scientific article published on July 2000

The role of substrate strain in the mechanism of the carbon-carbon lyases

scientific article published on 28 June 2014

The role of the catalytic base in the protein tyrosine kinase Csk

scientific article published on 01 September 1995

The stereospecificity of secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus is partially determined by active site water.

scientific article published in January 2001

Three-dimensional structure of kynureninase from Pseudomonas fluorescens

scientific article

Threonine-124 and phenylalanine-448 in Citrobacter freundii tyrosine phenol-lyase are necessary for activity with L-tyrosine

scientific article published in May 2002

Tryptophanase from Proteus vulgaris: the conformational rearrangement in the active site, induced by the mutation of Tyrosine 72 to phenylalanine, and its mechanistic consequences.

scientific article published on 3 January 2006

Tyrosine phenol-lyase and tryptophan indole-lyase encapsulated in wet nanoporous silica gels: Selective stabilization of tertiary conformations

scientific article published on April 2004

Xerogel-encapsulated W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus performs asymmetric reduction of hydrophobic ketones in organic solvents

scientific article published on 01 January 2007

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