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List of works by Ignacio Varela

A Truncated Variant of ASCC1, a Novel Inhibitor of NF-κB, Is Associated with Disease Severity in Patients with Rheumatoid Arthritis

scientific article published on 26 October 2015

A comprehensive catalogue of somatic mutations from a human cancer genome

scientific article

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer

scientific article published on 8 December 2014

A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis.

scientific article published on 04 October 2016

A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

scientific article

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

scientific article

A novel mutation in ADAMTS13 of a child with Upshaw-Schulman Syndrome

scientific article published on 24 July 2014

A small-cell lung cancer genome with complex signatures of tobacco exposure

scientific article

ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer

scientific article published in 2021

Abstract 983: Intratumor heterogeneity in non-small cell lung cancer inferred by multi-region exome sequencing

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

scientific article

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

scientific article published on 26 April 2011

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

scientific article

Analysis of the mutational landscape of classic Hodgkin lymphoma identifies disease heterogeneity and potential therapeutic targets

scientific article

Analysis pipelines for cancer genome sequencing in mice

scientific article published on 06 January 2020

AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes.

scientific article published on 19 August 2003

CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity

article

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice

scientific article

Characterization of gene mutations and copy number changes in acute myeloid leukemia using a rapid target enrichment protocol

scientific article published on 7 November 2014

Clonal haematopoiesis is not prevalent in survivors of childhood cancer.

scientific article published on 3 April 2017

Colorectal adenomas contain multiple somatic mutations that do not coincide with synchronous adenocarcinoma specimens

scientific article

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

scientific article

Complex landscapes of somatic rearrangement in human breast cancer genomes

scientific article

Correction: Colorectal adenomas contain multiple somatic mutations that do not coincide with synchronous adenocarcinoma specimens.

scientific article published on 10 April 2015

Corrigendum: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

scientific article published in Nature

Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture

scientific article published on 18 April 2013

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.

scientific article published on 20 September 2016

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies

scientific article published on 27 April 2016

Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution

scientific article

Evaluation of Toll-like-receptor gene family variants as prognostic biomarkers in rheumatoid arthritis

scientific article published on 7 May 2017

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

scientific article published on 24 January 2018

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

scientific article

From immature lamin to premature aging: molecular pathways and therapeutic opportunities.

scientific article published on 23 December 2005

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

scientific article

HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia

scientific article published on 01 December 2020

Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions

scientific article

Identification of a germline F692L drug resistance variant in cis with Flt3-internal tandem duplication in knock-in mice

scientific article published on 12 May 2016

Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.

scientific article published on March 2003

Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures

scientific article published on 25 July 2015

Inflammatory and immune response genes have significantly altered expression in schizophrenia.

scientific article

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

scientific article (publication date: 8 March 2012)

Intratumoral heterogeneity and clonal evolution in blood malignancies and solid tumors

scientific article published on 16 August 2017

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

scientific article

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

scientific article

Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice.

scientific article published on November 2008

Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia

scientific article published on 23 August 2017

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice

scientific article

Mutational processes molding the genomes of 21 breast cancers

scientific article

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

scientific article published on 31 March 2008

PLCG1 mutations in cutaneous T-cell lymphomas

scientific article published on 4 February 2014

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

scientific article published on 28 April 2008

Rapid parallel acquisition of somatic mutations afterNPM1in acute myeloid leukaemia evolution

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

scientific article

Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas.

scientific article

Sin3b interacts with Myc and decreases Myc levels

scientific article

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

article published in 2018

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

scientific article

Somatic structural rearrangements in genetically engineered mouse mammary tumors

scientific article

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

scientific article

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

article

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

scientific article

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane

scientific article published on 8 September 2015

The Life History of 21 Breast Cancers

The landscape of cancer genes and mutational processes in breast cancer

scientific article (publication date: 16 May 2012)

The life history of 21 breast cancers

scientific article (publication date: 25 May 2012)

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

scientific article (publication date: 28 October 2010)

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

scientific article published on 07 May 2018

V617F hematopoietic clones are present several years prior to MPN diagnosis and follow different expansion kinetics

scientific article published on 12 June 2017

Whole exome sequencing of adenoid cystic carcinoma

scientific article published on 17 June 2013

Whole-exome sequencing in splenic marginal zone lymphoma reveals mutations in genes involved in marginal zone differentiation.

scientific article

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