List of works - Keng-Chang Tsai

3D-QSAR studies on PU3 analogues by comparative molecular field analysis

scientific article published on 01 February 2004

A Practical Synthesis of Zanamivir Phosphonate Congeners with Potent Anti-influenza Activity ⬇️

scientific article published on October 14, 2011

A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies

A ligand-based molecular modeling study on some matrix metalloproteinase-1 inhibitors using several 3D QSAR techniques

scientific article published on 01 September 2004

A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors.

scientific article

Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses

scholarly article by Peng-Hao Hsu et al published June 2018 in European Journal of Medicinal Chemistry

Astragalus membranaceus-Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors

scientific article published on 03 March 2020

Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq.

scientific article

Characterization of binding site of closed-state KCNQ1 potassium channel by homology modeling, molecular docking, and pharmacophore identification

scientific article published on 01 July 2005

Characterizing the structure-function relationship reveals the mode of action of a novel antimicrobial peptide, P1, from jumper ant Myrmecia pilosula

scientific article published on 4 May 2017

Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors

scientific article published on 12 December 2015

Construction of a 3D model of nattokinase, a novel fibrinolytic enzyme from Bacillus natto. A novel nucleophilic catalytic mechanism for nattokinase.

scientific article published in January 2005

Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites.

scientific article published on 28 August 2015

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation.

scientific article

Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies

scientific article published on 01 June 2006

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

scientific article published on 6 June 2016

Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics.

scientific article published on 14 December 2015

Engineering a nanopore with co-chaperonin function

scientific article published on 11 December 2015

Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model

scientific article

Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling.

scientific article published on 22 February 2008

GSK-3 inhibition through GLP-1R allosteric activation mediates the neurogenesis promoting effect of P7C3 after cerebral ischemic/reperfusional injury in mice

scientific article published on 04 September 2018

How to generate reliable and predictive CoMFA models

scientific article published on January 2011

Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO.

scientific article published on 18 February 2016

Implementing the Fisher's discriminant ratio in a k-means clustering algorithm for feature selection and data set trimming.

scientific article

Isolation, characterization, and molecular modeling of a rheumatoid factor from a Hepatitis C virus infected patient with Sjögren's syndrome

scientific article published on 30 December 2013

Modeling ligand-receptor interaction for some MHC class II HLA-DR4 peptide mimetic inhibitors using several molecular docking and 3D QSAR techniques

scientific article published on 01 September 2005

Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors

scientific article published on December 2014

Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors

scientific article published on 11 May 2016

Peramivir analogues bearing hydrophilic side chains exhibit higher activities against H275Y mutant than wild-type influenza virus.

scientific article published on 21 November 2017

Peramivir conjugates as orally available agents against influenza H275Y mutant

scientific article published on 24 December 2017

Phage display-mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom.

scientific article

Pharmacophore Mapping for Kv1.5 Potassium Channel Blockers

Pharmacophore identification of alpha(1A)-adrenoceptor antagonists

scientific article published in February 2005

Predicting Ligand Binding Sites on Protein Surfaces by 3-Dimensional Probability Density Distributions of Interacting Atoms

scientific article

Prediction of Carbohydrate Binding Sites on Protein Surfaces with 3-Dimensional Probability Density Distributions of Interacting Atoms ⬇️

scientific article published on July 25, 2012

Protein-Protein Interaction Site Predictions with Three-Dimensional Probability Distributions of Interacting Atoms on Protein Surfaces ⬇️

scientific article published on June 6, 2012

Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface

scientific article

Sarkosyl-Induced Helical Structure of an Antimicrobial Peptide GW-Q6 Plays an Essential Role in the Binding of Surface Receptor OprI in Pseudomonas aeruginosa

scientific article

Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors

scientific article published on 30 October 2014

Single chain antibody fragment with serine protease inhibitory property capable of neutralizing toxicity of Trimeresurus mucrosquamatus venom

article

Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors

scientific article published on 01 September 2007

Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease

scientific article published in August 2006

Supervised feature ranking using a genetic algorithm optimized artificial neural network

scientific article published in July 2006

Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity.

scientific article published on 12 September 2007

Tamiphosphor monoesters as effective anti-influenza agents

scientific article published on 2 May 2014

The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition.

scientific article

The effect of different electrostatic potentials on docking accuracy: A case study using DOCK5.4

scientific article published in 2008

The first pharmacophore model for potent NF-kappaB inhibitors

scientific article published on 8 August 2009

The pharmacophore hypotheses of IKr potassium channel blockers: novel class III antiarrhythmic agents

scientific article published on 01 September 2004

List of works by Keng-Chang Tsai

3D-QSAR studies on PU3 analogues by comparative molecular field analysis

A Practical Synthesis of Zanamivir Phosphonate Congeners with Potent Anti-influenza Activity ⬇️

A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies

A ligand-based molecular modeling study on some matrix metalloproteinase-1 inhibitors using several 3D QSAR techniques

A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors.

Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses

Astragalus membranaceus-Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors

Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq.

Characterization of binding site of closed-state KCNQ1 potassium channel by homology modeling, molecular docking, and pharmacophore identification

Characterizing the structure-function relationship reveals the mode of action of a novel antimicrobial peptide, P1, from jumper ant Myrmecia pilosula

Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors

Construction of a 3D model of nattokinase, a novel fibrinolytic enzyme from Bacillus natto. A novel nucleophilic catalytic mechanism for nattokinase.

Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites.

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation.

Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics.

Engineering a nanopore with co-chaperonin function

Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model

Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling.

GSK-3 inhibition through GLP-1R allosteric activation mediates the neurogenesis promoting effect of P7C3 after cerebral ischemic/reperfusional injury in mice

How to generate reliable and predictive CoMFA models

Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO.

Implementing the Fisher's discriminant ratio in a k-means clustering algorithm for feature selection and data set trimming.

Isolation, characterization, and molecular modeling of a rheumatoid factor from a Hepatitis C virus infected patient with Sjögren's syndrome

Modeling ligand-receptor interaction for some MHC class II HLA-DR4 peptide mimetic inhibitors using several molecular docking and 3D QSAR techniques

Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors

Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors

Peramivir analogues bearing hydrophilic side chains exhibit higher activities against H275Y mutant than wild-type influenza virus.

Peramivir conjugates as orally available agents against influenza H275Y mutant

Phage display-mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom.

Pharmacophore Mapping for Kv1.5 Potassium Channel Blockers

Pharmacophore identification of alpha(1A)-adrenoceptor antagonists

Predicting Ligand Binding Sites on Protein Surfaces by 3-Dimensional Probability Density Distributions of Interacting Atoms

Prediction of Carbohydrate Binding Sites on Protein Surfaces with 3-Dimensional Probability Density Distributions of Interacting Atoms ⬇️

Protein-Protein Interaction Site Predictions with Three-Dimensional Probability Distributions of Interacting Atoms on Protein Surfaces ⬇️

Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface

Sarkosyl-Induced Helical Structure of an Antimicrobial Peptide GW-Q6 Plays an Essential Role in the Binding of Surface Receptor OprI in Pseudomonas aeruginosa

Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors

Single chain antibody fragment with serine protease inhibitory property capable of neutralizing toxicity of Trimeresurus mucrosquamatus venom

Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors

Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease

Supervised feature ranking using a genetic algorithm optimized artificial neural network

Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity.

Tamiphosphor monoesters as effective anti-influenza agents

The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition.

The effect of different electrostatic potentials on docking accuracy: A case study using DOCK5.4

The first pharmacophore model for potent NF-kappaB inhibitors

The pharmacophore hypotheses of IKr potassium channel blockers: novel class III antiarrhythmic agents