List of works - Jouni Jokela

4-Methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides.

scientific article

A Novel Cyanobacterial Nostocyclopeptide is a Potent Antitoxin against Microcystins

scientific article published on 23 June 2010

A Report on Finding a New Peptide Aldehyde from Cyanobacterium Nostoc sp. Bahar M by LC-MS and Marfey's Analysis

scientific article published on 20 April 2019

A combined impedance and AlphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium

scientific article published on 30 August 2012

A liquid chromatography–mass spectrometric method for the detection of cyclic β-amino fatty acid lipopeptides

scientific article published on 15 February 2016

Allelopathy of Baltic Sea cyanobacteria: no evidence for the role of nodularin

article

Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides

scientific article published on 06 February 2019

Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria ⬇️

scientific article

Analysis of an inactive cyanobactin biosynthetic gene cluster leads to discovery of new natural products from strains of the genus Microcystis ⬇️

scientific article

Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria ⬇️

scientific article

Antifungal compounds from cyanobacteria. ⬇️

scientific article

Biochemical characterization of a cyanobactin arginine--prenylase from the autumnalamide biosynthetic pathway

Biodegradation of two tetrameric lignin model compounds by a mixed bacterial culture

scientific article published in November 1985

Biosynthesis of microcystin hepatotoxins in the cyanobacterial genus Fischerella. ⬇️

scientific article

Biosynthesis of the Bis-Prenylated Alkaloids Muscoride A and B

scientific article published on 19 November 2019

Carotenoid Biosynthesis in Calothrix sp. 336/3: Composition of Carotenoids on Full Medium, During Diazotrophic Growth and After Long-Term H2 Photoproduction.

scientific article published on 12 August 2016

Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes

scientific article published on 19 June 2019

Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria

Convergent evolution of [D-Leucine(1)] microcystin-LR in taxonomically disparate cyanobacteria ⬇️

scientific article

Culture-independent evidence for the persistent presence and genetic diversity of microcystin-producing Anabaena (Cyanobacteria) in the Gulf of Finland

scientific article

CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria

scientific article

Cyanobacteria as a Source for Novel Anti-Leukemic Compounds

scientific article published on 26 August 2015

Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells.

scientific article published on 3 April 2014

Cyanobacteria produce a high variety of hepatotoxic peptides in lichen symbiosis

scientific article published on 26 March 2012

Cyanobactins-ribosomal cyclic peptides produced by cyanobacteria

scientific article published on 27 February 2010

Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants. ⬇️

scientific article published on 14 September 2017

Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

scientific article published on 24 December 2019

Description of Aliinostoc alkaliphilum sp. nov. (Nostocales, Cyanobacteria), a New Bioactive Metabolite-Producing Strain from Salina Verde (Pantanal, Brazil) and Taxonomic Distribution of Bioactive Metabolites in Nostoc and Nostoc-like Genera

scientific article published in 2022

Development of a chip assay and quantitative PCR for detecting microcystin synthetase E gene expression

scientific article published on 16 April 2010

Direct evidence for production of microcystins by Anabaena strains from the Baltic Sea

scientific article

Direct pathway cloning and expression of the radiosumin biosynthetic gene cluster

scientific article published in 2023

Discovering protein kinase C active plants growing in Finland utilizing automated bioassay combined to LC/MS.

scientific article

Discovery of a pederin family compound in a non-symbiotic bloom-forming cyanobacterium. ⬇️

scientific article published on 23 March 2018

Discovery of rare and highly toxic microcystins from lichen-associated cyanobacterium Nostoc sp. strain IO-102-I ⬇️

scientific article published on October 2004

Distinct roles of carbohydrate esterase family CE16 acetyl esterases and polymer-acting acetyl xylan esterases in xylan deacetylation.

scientific article

Evidence for positive selection acting on microcystin synthetase adenylation domains in three cyanobacterial genera

scientific article

Genetic Organization of Anabaenopeptin and Spumigin Biosynthetic Gene Clusters in the Cyanobacterium Sphaerospermopsis torques-reginae ITEP-024.

scientific article published on 13 January 2017

Genome mining expands the chemical diversity of the cyanobactin family to include highly modified linear peptides

scientific article published in August 2013

Genome-derived insights into the biology of the hepatotoxic bloom-forming cyanobacterium Anabaena sp. strain 90

scientific article

Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway ⬇️

scientific article

Highly diverse cyanobactins in strains of the genus Anabaena. ⬇️

scientific article published on 11 December 2009

Identification and structural analysis of cereal arabinoxylan-derived oligosaccharides by negative ionization HILIC-MS/MS

scientific article published on 12 September 2018

Identification of geosmin and 2-methylisoborneol in cyanobacteria and molecular detection methods for the producers of these compounds.

scientific article published on January 2015

Isolation and identification of cyclic lipopeptides from Paenibacillus ehimensis, strain IB-X-b

scientific article published on 8 October 2014

Lichen species identity and diversity of cyanobacterial toxins in symbiosis.

scientific article published on 6 March 2013

Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis.

scientific article

Microcystin Production in the Tripartite Cyanolichen Peltigera leucophlebia

article

N-Prenylation of Tryptophan by an Aromatic Prenyltransferase from the Cyanobactin Biosynthetic Pathway ⬇️

scientific article published on 03 December 2018

Natural occurrence of microcystin synthetase deletion mutants capable of producing microcystins in strains of the genus Anabaena (Cyanobacteria).

scientific article published in April 2008

New structural variants of aeruginosin produced by the toxic bloom forming cyanobacterium Nodularia spumigena ⬇️

scientific article (publication date: 2013)

Nodularin uptake and induction of oxidative stress in spinach (Spinachia oleracea)

article by Nina Lehtimäki et al published April 2011 in The Journal of Plant Physiology

Nostocyclopeptide-M1: a potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and OATP1B1.

scientific article published on 24 January 2011

Nostophycin biosynthesis is directed by a hybrid polyketide synthase-nonribosomal peptide synthetase in the toxic cyanobacterium Nostoc sp. strain 152. ⬇️

scientific article published on 23 September 2011

Nostosins, Trypsin Inhibitors Isolated from the Terrestrial Cyanobacterium Nostoc sp. Strain FSN

scientific article published on 01 August 2014

Novel Aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent

scientific article

Pathologic findings and toxin identification in cyanobacterial (Nodularia spumigena) intoxication in a dog.

scientific article published on 8 August 2011

Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria.

scientific article

Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis. ⬇️

scientific article published on 27 April 2018

Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products

scientific article

Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543. ⬇️

scientific article published on 9 October 2017

Pseudoaeruginosins, nonribosomal peptides in Nodularia spumigena

scientific article

Quantitative real-time PCR detection of toxic Nodularia cyanobacteria in the Baltic Sea

scientific article published on 2 February 2007

Rearranged Biosynthetic Gene Cluster and Synthesis of Hassallidin E in Planktothrix serta PCC 8927.

scientific article

Recurrent adenylation domain replacement in the microcystin synthetase gene cluster. ⬇️

scientific article

Secondary metabolite from Nostoc XPORK14A inhibits photosynthesis and growth of Synechocystis PCC 6803.

scientific article published in June 2014

Shared PKS Module in Biosynthesis of Synergistic Laxaphycins ⬇️

scientific article published on 16 September 2020

Shared PKS modules in biosynthesis of synergistic laxaphycins ⬇️

Simultaneous Production of Anabaenopeptins and Namalides by the Cyanobacterium Nostoc sp. CENA543.

scientific article published on 21 September 2017

Sphaerocyclamide, a prenylated cyanobactin from the cyanobacterium Sphaerospermopsis sp. LEGE 00249 ⬇️

scientific article published in Scientific Reports

Structural analysis of linear mixed-linkage glucooligosaccharides by tandem mass spectrometry

scientific article

The Biosynthesis of Rare Homo-Amino Acid Containing Variants of Microcystin by a Benthic Cyanobacterium. ⬇️

scientific article published on 7 May 2019

The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus ('Penicillium islandicum'). ⬇️

scientific article

The genetic basis for O-acetylation of the microcystin toxin in cyanobacteria.

scientific article published in July 2013

The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol-dependent manner.

scientific article

The non-ribosomal assembly and frequent occurrence of the protease inhibitors spumigins in the bloom-forming cyanobacterium Nodularia spumigena ⬇️

scientific article published on 19 August 2009

The structure and biosynthesis of heinamides A1–A3 and B1–B5, antifungal members of the laxaphycin lipopeptide family ⬇️

scientific article

The swinholide biosynthetic gene cluster from a terrestrial cyanobacterium Nostoc sp. UHCC 0450. ⬇️

scientific article published on 17 November 2017

Two alternative starter modules for the non-ribosomal biosynthesis of specific anabaenopeptin variants in Anabaena (Cyanobacteria).

scientific article

List of works by Jouni Jokela

4-Methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides.

A Novel Cyanobacterial Nostocyclopeptide is a Potent Antitoxin against Microcystins

A Report on Finding a New Peptide Aldehyde from Cyanobacterium Nostoc sp. Bahar M by LC-MS and Marfey's Analysis

A combined impedance and AlphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium

A liquid chromatography–mass spectrometric method for the detection of cyclic β-amino fatty acid lipopeptides

Allelopathy of Baltic Sea cyanobacteria: no evidence for the role of nodularin

Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides

Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria ⬇️

Analysis of an inactive cyanobactin biosynthetic gene cluster leads to discovery of new natural products from strains of the genus Microcystis ⬇️

Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria ⬇️

Antifungal compounds from cyanobacteria. ⬇️

Biochemical characterization of a cyanobactin arginine--prenylase from the autumnalamide biosynthetic pathway

Biochemical characterization of a cyanobactin arginine--prenylase from the autumnalamide biosynthetic pathway

Biodegradation of two tetrameric lignin model compounds by a mixed bacterial culture

Biosynthesis of microcystin hepatotoxins in the cyanobacterial genus Fischerella. ⬇️

Biosynthesis of the Bis-Prenylated Alkaloids Muscoride A and B

Carotenoid Biosynthesis in Calothrix sp. 336/3: Composition of Carotenoids on Full Medium, During Diazotrophic Growth and After Long-Term H2 Photoproduction.

Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes

Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria

Convergent evolution of [D-Leucine(1)] microcystin-LR in taxonomically disparate cyanobacteria ⬇️

Culture-independent evidence for the persistent presence and genetic diversity of microcystin-producing Anabaena (Cyanobacteria) in the Gulf of Finland

CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria

Cyanobacteria as a Source for Novel Anti-Leukemic Compounds

Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells.

Cyanobacteria produce a high variety of hepatotoxic peptides in lichen symbiosis

Cyanobactins-ribosomal cyclic peptides produced by cyanobacteria

Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants. ⬇️

Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

Description of Aliinostoc alkaliphilum sp. nov. (Nostocales, Cyanobacteria), a New Bioactive Metabolite-Producing Strain from Salina Verde (Pantanal, Brazil) and Taxonomic Distribution of Bioactive Metabolites in Nostoc and Nostoc-like Genera

Development of a chip assay and quantitative PCR for detecting microcystin synthetase E gene expression

Direct evidence for production of microcystins by Anabaena strains from the Baltic Sea

Direct pathway cloning and expression of the radiosumin biosynthetic gene cluster

Discovering protein kinase C active plants growing in Finland utilizing automated bioassay combined to LC/MS.

Discovery of a pederin family compound in a non-symbiotic bloom-forming cyanobacterium. ⬇️

Discovery of rare and highly toxic microcystins from lichen-associated cyanobacterium Nostoc sp. strain IO-102-I ⬇️

Distinct roles of carbohydrate esterase family CE16 acetyl esterases and polymer-acting acetyl xylan esterases in xylan deacetylation.

Evidence for positive selection acting on microcystin synthetase adenylation domains in three cyanobacterial genera

Genetic Organization of Anabaenopeptin and Spumigin Biosynthetic Gene Clusters in the Cyanobacterium Sphaerospermopsis torques-reginae ITEP-024.

Genome mining expands the chemical diversity of the cyanobactin family to include highly modified linear peptides

Genome-derived insights into the biology of the hepatotoxic bloom-forming cyanobacterium Anabaena sp. strain 90

Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway ⬇️

Highly diverse cyanobactins in strains of the genus Anabaena. ⬇️

Identification and structural analysis of cereal arabinoxylan-derived oligosaccharides by negative ionization HILIC-MS/MS

Identification of geosmin and 2-methylisoborneol in cyanobacteria and molecular detection methods for the producers of these compounds.

Isolation and identification of cyclic lipopeptides from Paenibacillus ehimensis, strain IB-X-b

Lichen species identity and diversity of cyanobacterial toxins in symbiosis.

Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis.

Microcystin Production in the Tripartite Cyanolichen Peltigera leucophlebia

N-Prenylation of Tryptophan by an Aromatic Prenyltransferase from the Cyanobactin Biosynthetic Pathway ⬇️

Natural occurrence of microcystin synthetase deletion mutants capable of producing microcystins in strains of the genus Anabaena (Cyanobacteria).

New structural variants of aeruginosin produced by the toxic bloom forming cyanobacterium Nodularia spumigena ⬇️

Nodularin uptake and induction of oxidative stress in spinach (Spinachia oleracea)

Nostocyclopeptide-M1: a potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and OATP1B1.

Nostophycin biosynthesis is directed by a hybrid polyketide synthase-nonribosomal peptide synthetase in the toxic cyanobacterium Nostoc sp. strain 152. ⬇️

Nostosins, Trypsin Inhibitors Isolated from the Terrestrial Cyanobacterium Nostoc sp. Strain FSN

Novel Aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent

Pathologic findings and toxin identification in cyanobacterial (Nodularia spumigena) intoxication in a dog.

Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria.

Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis. ⬇️

Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products

Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543. ⬇️

Pseudoaeruginosins, nonribosomal peptides in Nodularia spumigena

Quantitative real-time PCR detection of toxic Nodularia cyanobacteria in the Baltic Sea

Rearranged Biosynthetic Gene Cluster and Synthesis of Hassallidin E in Planktothrix serta PCC 8927.

Recurrent adenylation domain replacement in the microcystin synthetase gene cluster. ⬇️

Secondary metabolite from Nostoc XPORK14A inhibits photosynthesis and growth of Synechocystis PCC 6803.

Shared PKS Module in Biosynthesis of Synergistic Laxaphycins ⬇️

Shared PKS modules in biosynthesis of synergistic laxaphycins ⬇️

Simultaneous Production of Anabaenopeptins and Namalides by the Cyanobacterium Nostoc sp. CENA543.

Sphaerocyclamide, a prenylated cyanobactin from the cyanobacterium Sphaerospermopsis sp. LEGE 00249 ⬇️

Structural analysis of linear mixed-linkage glucooligosaccharides by tandem mass spectrometry

The Biosynthesis of Rare Homo-Amino Acid Containing Variants of Microcystin by a Benthic Cyanobacterium. ⬇️

The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus ('Penicillium islandicum'). ⬇️

The genetic basis for O-acetylation of the microcystin toxin in cyanobacteria.

The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol-dependent manner.

The non-ribosomal assembly and frequent occurrence of the protease inhibitors spumigins in the bloom-forming cyanobacterium Nodularia spumigena ⬇️

The structure and biosynthesis of heinamides A1–A3 and B1–B5, antifungal members of the laxaphycin lipopeptide family ⬇️

The swinholide biosynthetic gene cluster from a terrestrial cyanobacterium Nostoc sp. UHCC 0450. ⬇️

Two alternative starter modules for the non-ribosomal biosynthesis of specific anabaenopeptin variants in Anabaena (Cyanobacteria).