List of works - Christophe Romier

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.

scientific article published on 2 March 2018

ANP32E is a histone chaperone that removes H2A.Z from chromatin

scientific article

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines

scientific article

Assembly of protein complexes by coexpression in prokaryotic and eukaryotic hosts: an overview

scientific article published on January 2008

Automated unrestricted multigene recombineering for multiprotein complex production

scientific article published on 3 May 2009

Baculovirus VP1054 is an acquired cellular PURα, a nucleic acid-binding protein specific for GGN repeats.

scientific article published on 29 May 2013

Characterization and production of protein complexes by co-expression in Escherichia coli

scientific article published on January 2015

Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants

article

Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly

scientific article

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies

scientific article published on 19 September 2006

Combattre les maladies négligées en ciblant sélectivement leurs enzymes épigénétiques : le cas de la désacétylase 8 (HDAC8) de Schistosoma mansoni

scientific article

Complex Reconstitution and Characterization by Combining Co-expression Techniques in Escherichia coli with High-Throughput.

scientific article published on January 2016

Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20)

scientific article

Crystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly

scientific article

DNA binding by Sgf11 protein affects histone H2B deubiquitination by Spt-Ada-Gcn5-acetyltransferase (SAGA).

scientific article published on 07 February 2014

Deciphering correct strategies for multiprotein complex assembly by co-expression: application to complexes as large as the histone octamer

scientific article published on 12 February 2011

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups

scientific article

Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation

scientific article

Dissecting the interaction network of multiprotein complexes by pairwise coexpression of subunits in E. coli

scientific article published on 01 February 2001

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives

scientific article published on January 2015

Expression in Escherichia coli: becoming faster and more complex.

scientific article published on 17 February 2013

Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study

scientific article published on 5 March 2011

Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni.

scientific article published on 16 October 2014

Functional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domain

scientific article (publication date: 22 November 2002)

HDAC8: a multifaceted target for therapeutic interventions

scientific article published on 23 May 2015

Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni

scientific article

Histone folds mediate selective heterodimerization of yeast TAF(II)25 with TFIID components yTAF(II)47 and yTAF(II)65 and with SAGA component ySPT7.

scientific article published on March 2001

History of the Strasbourg Society of Biology

scientific article published on 6 July 2017

Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors

scientific article

Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family

scientific article

Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8.

scientific article published on 3 September 2014

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

scientific article published on 5 June 2018

Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.

scientific article published on 22 June 2017

Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni

scientific article published on January 2016

Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1

scientific article

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni

scientific article

Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate 102 as the active site nucleophile

scientific article

NF-Y Recruitment of TFIID, Multiple Interactions with Histone Fold TAFIIs

scientific article published in Journal of Biological Chemistry

Noncanonical Tandem SH2 Enables Interaction of Elongation Factor Spt6 with RNA Polymerase II

scientific article

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies

scientific article published on 31 July 2018

One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity

scientific article published on 14 November 2019

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.

scientific article published in June 2017

Purification, crystallization, and preliminary x-ray diffraction studies of tRNA-guanine transglycosylase from Zymomonas mobilis

scientific article published on 01 April 1996

Recognition of single-stranded DNA by nuclease P1: High resolution crystal structures of complexes with substrate analogs ⬇️

scientific article published on September 1, 1998

Robots, pipelines, polyproteins: enabling multiprotein expression in prokaryotic and eukaryotic cells

scientific article published on 17 March 2011

Schistosome sirtuins as drug targets

scientific article published on January 2015

Sequence and structure requirements for specific recognition of HIV-1 TAR and DIS RNA by the HIV-1 Vif protein

scientific article published in July 2012

Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination

scientific article

Slight sequence variations of a common fold explain the substrate specificities of tRNA-guanine transglycosylases from the three kingdoms

scientific article published on 01 October 1997

Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics.

scientific article

Strategies for bacterial expression of protein-peptide complexes: application to solubilization of papillomavirus E6

scientific article published on 14 July 2011

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni

scientific article

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

scientific article published on 30 November 2017

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

scientific article

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2)

scientific article published on 20 September 2019

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

scientific article

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

scientific article published on 01 February 2019

Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as Sm HDAC8 Inhibitors for the Treatment of Schistosomiasis

scientific article published on 4 July 2018

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

scientific article

TFIID TAF6-TAF9 Complex Formation Involves the HEAT Repeat-containing C-terminal Domain of TAF6 and Is Modulated by TAF5 Protein

scientific article

The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y

scientific article

The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger

scientific article

The histone fold is a key structural motif of transcription factor TFIID.

scientific article

The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.

scientific article published on 29 December 2008

The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs

scientific article

The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties

scientific article

The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26

scientific article

Zinc-finger UBPs: regulators of deubiquitylation

scientific article

List of works by Christophe Romier

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.

ANP32E is a histone chaperone that removes H2A.Z from chromatin

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines

Assembly of protein complexes by coexpression in prokaryotic and eukaryotic hosts: an overview

Automated unrestricted multigene recombineering for multiprotein complex production

Baculovirus VP1054 is an acquired cellular PURα, a nucleic acid-binding protein specific for GGN repeats.

Characterization and production of protein complexes by co-expression in Escherichia coli

Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants

Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies

Combattre les maladies négligées en ciblant sélectivement leurs enzymes épigénétiques : le cas de la désacétylase 8 (HDAC8) de Schistosoma mansoni

Complex Reconstitution and Characterization by Combining Co-expression Techniques in Escherichia coli with High-Throughput.

Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20)

Crystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly

DNA binding by Sgf11 protein affects histone H2B deubiquitination by Spt-Ada-Gcn5-acetyltransferase (SAGA).

Deciphering correct strategies for multiprotein complex assembly by co-expression: application to complexes as large as the histone octamer

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups

Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation

Dissecting the interaction network of multiprotein complexes by pairwise coexpression of subunits in E. coli

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives

Expression in Escherichia coli: becoming faster and more complex.

Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study

Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni.

Functional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domain

HDAC8: a multifaceted target for therapeutic interventions

Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni

Histone folds mediate selective heterodimerization of yeast TAF(II)25 with TFIID components yTAF(II)47 and yTAF(II)65 and with SAGA component ySPT7.

History of the Strasbourg Society of Biology

Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors

Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family

Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8.

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.

Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni

Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni

Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate 102 as the active site nucleophile

NF-Y Recruitment of TFIID, Multiple Interactions with Histone Fold TAFIIs

Noncanonical Tandem SH2 Enables Interaction of Elongation Factor Spt6 with RNA Polymerase II

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies

One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.

Purification, crystallization, and preliminary x-ray diffraction studies of tRNA-guanine transglycosylase from Zymomonas mobilis

Recognition of single-stranded DNA by nuclease P1: High resolution crystal structures of complexes with substrate analogs ⬇️

Robots, pipelines, polyproteins: enabling multiprotein expression in prokaryotic and eukaryotic cells

Schistosome sirtuins as drug targets

Sequence and structure requirements for specific recognition of HIV-1 TAR and DIS RNA by the HIV-1 Vif protein

Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination

Slight sequence variations of a common fold explain the substrate specificities of tRNA-guanine transglycosylases from the three kingdoms

Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics.

Strategies for bacterial expression of protein-peptide complexes: application to solubilization of papillomavirus E6

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2)

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as Sm HDAC8 Inhibitors for the Treatment of Schistosomiasis

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

TFIID TAF6-TAF9 Complex Formation Involves the HEAT Repeat-containing C-terminal Domain of TAF6 and Is Modulated by TAF5 Protein

The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y

The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger

The histone fold is a key structural motif of transcription factor TFIID.

The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.

The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs

The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties

The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26

Zinc-finger UBPs: regulators of deubiquitylation