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List of works by Ian L Megson

2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors

scientific article published on August 2010

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

scientific article published on February 2013

A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium

scientific article published on 01 July 2000

A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

scientific article published in March 2003

A novel electron paramagnetic resonance-based assay for prostaglandin H synthase-1 activity

scientific article (publication date: 28 September 2006)

A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

scientific article published on 31 July 2008

A potential role for extracellular nitric oxide generation in cGMP-independent inhibition of human platelet aggregation: biochemical and pharmacological considerations

scientific article published on March 2005

A randomized crossover study to assess the effect of an oat‐rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes ⬇️

scientific article published on June 22, 2013

Acoustic speed and attenuation coefficient in sheep aorta measured at 5-9 MHz.

scientific article published in June 2006

Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure.

scientific article published on 12 April 2010

Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man

scientific article

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin

scientific article (publication date: 27 February 2003)

Apoptosis and Atherosclerosis: The Role of Nitric Oxide

scholarly article by Catherine Shaw et al published 1 February 2006 in Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry

Association between exposure to environmental tobacco smoke and biomarkers of oxidative stress among patients hospitalised with acute myocardial infarction

scientific article

B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure

scientific article

Bioavailable Concentrations of Delphinidin and Its Metabolite, Gallic Acid, Induce Antioxidant Protection Associated with Increased Intracellular Glutathione in Cultured Endothelial Cells

scientific article published on 7 September 2017

Clearance of dying cells and autoimmunity

scientific article published on June 2007

Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume

scientific article published on 7 January 2010

Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity.

scientific article

Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2

scientific article published on 17 April 2008

Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

scientific article published on 7 May 2009

Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice

scientific article published on 26 October 2005

Development and characterization of glutamyl-protected N-hydroxyguanidines as reno-active nitric oxide donor drugs with therapeutic potential in acute renal failure.

scientific article published on 20 June 2013

Diabetic fatty liver disease is associated with specific changes in blood-borne markers

scientific article published on 01 May 2012

Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs

scientific article published on 18 February 2011

Differential susceptibility to nitric oxide-evoked apoptosis in human inflammatory cells

scientific article published on 15 September 2010

Diffusion of nitric oxide and scavenging by blood in the vasculature

scientific article published on 01 September 1998

Direct Vascular Effects of Protease-Activated Receptor Type 1 Agonism In Vivo in Humans

scientific article published on 02 October 2006

Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals

scientific article

Dissociation of DNA fragmentation from other hallmarks of apoptosis in nitric oxide-treated neutrophils: differences between individual nitric oxide donor drugs

scientific article published in December 2001

Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis

scientific article published on 18 February 2013

Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?

scientific article

Endothelial dysfunction: from molecular mechanisms to measurement, clinical implications, and therapeutic opportunities

scientific article published on September 2008

Exceptional Behavior over the Whole Adsorption−Storage−Delivery Cycle for NO in Porous Metal Organic Frameworks

article

Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits

scientific article published on 28 September 2013

Extracellular nitric oxide release mediates soluble guanylate cyclase-independent vasodilator action of spermine NONOate: comparison with other nitric oxide donors in isolated rat femoral arteries

scientific article published in March 2004

Food intake and dietary glycaemic index in free-living adults with and without type 2 diabetes mellitus

scientific article published on 9 June 2011

GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism

scientific article published on 2 August 2004

Genetic association of the AKT1 gene with schizophrenia in a British population

scientific article published in June 2010

High-capacity hydrogen and nitric oxide adsorption and storage in a metal-organic framework

scientific article published in February 2007

In vivo speciation studies and antioxidant properties of bromine in Laminaria digitata reinforce the significance of iodine accumulation for kelps

scientific article published on 19 April 2013

Inducible nitric oxide synthase activity does not contribute to the maintenance of peripheral vascular tone in patients with heart failure

scientific article published in October 2006

Inhibition of Human Platelet Aggregation by Nitric Oxide Donor Drugs: Relative Contribution of cGMP-Independent Mechanisms

scientific article published on 01 December 2000

Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke

scientific article published on 16 December 2010

Iron-sulphur cluster nitrosyls, a novel class of nitric oxide generator: mechanism of vasodilator action on rat isolated tail artery ⬇️

scientific article published on November 1, 1992

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-α

scientific article published on 29 October 2008

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets

scientific article (publication date: June 2006)

Mechanisms for an effect of acetylcysteine on renal function after exposure to radio-graphic contrast material: study protocol

scientific article

Mechanisms of resolution of inflammation: a focus on cardiovascular disease

scientific article published on May 2011

Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing

scientific article

Metal–organic frameworks for the storage and delivery of biologically active hydrogen sulfide

article

N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial.

scientific article

N-Substituted analogues of S-nitroso-N-acetyl-D,L-penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries

scientific article published in February 1999

NO-Releasing Zeolites and Their Antithrombotic Properties

scientific article published on 01 January 2006

NO-loaded Zn(2+)-exchanged zeolite materials: a potential bifunctional anti-bacterial strategy

scientific article

Neocuproine, a selective Cu(I) chelator, and the relaxation of rat vascular smooth muscle by S-nitrosothiols

scientific article published in July 1997

NiO and Co3O4 nanoparticles induce lung DTH-like responses and alveolar lipoproteinosis

scientific article published on 4 August 2011

Nitric oxide and the mechanism of rat vascular smooth muscle photorelaxation

scientific article

Nitric oxide photogeneration from trans-Cr(cyclam)(ONO)(2)(+) in a reducing environment. activation of soluble guanylyl cyclase and arterial vasorelaxation

scientific article published in January 2010

No association between the PPARG gene and schizophrenia in a British population.

scientific article published on 26 June 2009

Non-heme iron nitrosyls in biology

scientific article

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.

scientific article published on 16 January 2013

Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryl trinitrate-tolerant rat femoral arteries.

scientific article

Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryltrinitrate-tolerant rat femoral arteries

scientific article published in November 2000

Novel role for low molecular weight plasma thiols in nitric oxide-mediated control of platelet function

scientific article published on 23 September 2002

Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

scientific article published on 7 March 2014

Oral vitamin C reduces arterial stiffness and platelet aggregation in humans.

scientific article published in November 1999

Persistent endothelial dysfunction in humans after diesel exhaust inhalation

scientific article

Photochemistry of trans-Cr(cyclam)(ONO)2+, a nitric oxide precursor

scientific article published on 8 April 2011

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

scientific article published on 01 May 2014

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

scientific article

Preserved endothelial vasomotion and fibrinolytic function in patients with acute stent thrombosis or in-stent restenosis

scientific article (publication date: 2003)

Principal component and causal analysis of structural and acute in vitro toxicity data for nanoparticles ⬇️

scientific article

Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes.

scientific article

Prolonged effect of a novel S-nitrosated glyco-amino acid in endothelium-denuded rat femoral arteries: potential as a slow release nitric oxide donor drug

scientific article published in December 1997

Recent developments in nitric oxide donor drugs.

scientific article

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

scientific article

Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose.

scientific article published on September 2008

Ruthenium complexes as nitric oxide scavengers: a potential therapeutic approach to nitric oxide-mediated diseases.

scientific article published on December 1997

S-nitrosothiols for nitrate tolerance

scientific article published on 01 July 1999

Search for schizophrenia susceptibility variants at the HLA-DRB1 locus among a British population

scientific article published on 29 September 2012

Selective modifiers of glutathione biosynthesis and 'repriming' of vascular smooth muscle photorelaxation

scientific article

Sildenafil offers protection against NSAID-induced gastric injury

scientific article published in October 2005

Sildenafil potentiates nitric oxide mediated inhibition of human platelet aggregation

scientific article published in November 2005

Simultaneous and cooperative gas storage and gas production using bifunctional zeolites

article

Surface derivatization state of polystyrene latex nanoparticles determines both their potency and their mechanism of causing human platelet aggregation in vitro

scientific article published on December 2010

Surface functionalization affects the zeta potential, coronal stability and membranolytic activity of polymeric nanoparticles

scientific article published on 28 May 2013

Synthesis, Decomposition, and Vasodilator Action of Some New S-Nitrosated Dipeptides

scientific article published on 01 January 1998

The 2011 survey on hypertensive disorders of pregnancy (HDP) in China: prevalence, risk factors, complications, pregnancy and perinatal outcomes

scientific article

The TGM2 gene is associated with schizophrenia in a British population.

scientific article published in April 2009

The effect of oxidative stress on endothelium-dependent and nitric oxide donor-induced relaxation: implications for nitrate tolerance

scientific article

The functional significance of the TGM2 gene in schizophrenia: A correlation of SNPs and circulating IL-2 levels

article

Therapeutic effects of nitric oxide-aspirin hybrid drugs

scientific article (publication date: December 2006)

Therapeutic potential of N-acetylcysteine as an antiplatelet agent in patients with type-2 diabetes ⬇️

scientific article

Topical application of acidified nitrite to the nail renders it antifungal and causes nitrosation of cysteine groups in the nail plate

scientific article published on 11 July 2007

Vascular effects of apelin in vivo in man.

scientific article

Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles

scientific article published on 12 January 2012

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