List of works - Klaudia Brix

A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages

scientific article

Abstract 1093: Legumain in colorectal cancer: Unorthodox localization and trafficking

article

Altered dye diffusion and upregulation of connexin37 in mouse aortic endothelium deficient in connexin40.

scientific article

Analysis of Microfilament Organization and Contractile Activities in Physarum

article

Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile

scientific article

Assessment of cytotoxicity exerted by leaf extracts from plants of the genus Rhododendron towards epidermal keratinocytes and intestine epithelial cells

scientific article published on 15 October 2015

Bioactivity in Rhododendron: A Systemic Analysis of Antimicrobial and Cytotoxic Activities and Their Phylogenetic and Phytochemical Origins

scientific article published on 13 April 2017

Biosynthesis of shermilamine B

Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression.

scientific article published on 20 March 2018

Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes

scientific article published on 24 July 2007

Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases

scientific article published in May 2009

Cathepsin B trafficking in thyroid carcinoma cells

scientific article published on 3 August 2011

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

scientific article

Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice.

scientific article published in September 2012

Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

scientific article published on 3 March 2022

Chemically induced changes in the morphology, dynamic activity and cytoskeletal organization of cell fragments

scientific article published on 01 November 1987

Compartmentalization of Proteolysis

article

Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells

scientific article

Coordination of genomic structure and transcription by the main bacterial nucleoid-associated protein HU.

scientific article

Correction: Nuclear Legumain Activity in Colorectal Cancer.

scientific article published on 19 September 2013

Cysteine cathepsins: cellular roadmap to different functions

scientific article published on 06 August 2007

DNA accelerates the inhibition of human cathepsin V by serpins

scientific article

Defects in mitochondrial distribution during the prolonged lag phase of Saccharomyces cerevisiae preceding growth in glycerol as the sole source of carbon

scientific article

Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity ⬇️

article

Differences in Mouse Hepatic Thyroid Hormone Transporter Expression with Age and Hyperthyroidism

scientific article published on 27 May 2015

Differential regulation of monocarboxylate transporter 8 expression in thyroid cancer and hyperthyroidism.

scientific article

EJCB - Molecular basis of protein fates in the secretory and endocytic pathways, and beyond

scientific article published on 15 June 2017

Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon

scientific article published on December 2012

Effects of different space relevant environmental stressors including Lunar Dust on microorganisms and human cells of different tissues

scholarly article published 11 July 2010

Effects of lunar and mars dust simulants on HaCaT keratinocytes and CHO-K1 fibroblasts

article by Maren Rehders et al published April 2011 in Advances in Space Research

Efficacy of protocols for induction of chronic hyperthyroidism in male and female mice

scientific article published on 29 July 2016

Epithelial folding in vitro: studies on the cellular mechanism underlying evagination of thyrocyte monolayers

scientific article published on February 1997

Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors

scientific article

Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells

article

Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells

scientific article published on 01 May 1996

Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level

scientific article published on 30 December 2017

Expression levels of thyroglobulin processing proteases are reduced upon trace amine-associated receptor 1 deficiency in mice

Extracellularly occurring histone H1 mediates the binding of thyroglobulin to the cell surface of mouse macrophages

scientific journal article

Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland

scientific article published on 05 December 2019

Functional analysis of actin fibrils in Physarum polycephalum

Functional and morphological phenotypes in the mouse thyroid gland associated with thyroid-specific Mct8 deficiency

HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration.

scientific article published on December 2004

High expression of the cysteine proteinase legumain in colorectal cancer – Implications for therapeutic targeting

Hyperproliferative hepatocellular alterations after intraportal transplantation of thyroid follicles

scientific article published on January 2000

Induced pinocytosis and cytoskeletal organization in Amoeba proteus — a combined fluorescence and electron microscopic study

scientific article published on 01 July 1989

Interconnection between cathepsin protein levels and thyroid hormone transporters in human thyroid epithelial cells

Interdependence of thyroglobulin processing and thyroid hormone export in the mouse thyroid gland

scientific article

Intestine-specific expression of green fluorescent protein-tagged cathepsin B: proof-of-principle experiments

scientific article published in August 2008

Intestine-specific expression of green fluorescent protein-tagged cathepsin B: proof-of-principle experiments

scientific article published in 2008

Iodination of mature cathepsin D in thyrocytes as an indicator for its transport to the cell surface ⬇️

scientific article published on May 1, 1998

Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis

scientific article published on 19 June 2020

LRP1 modulates APP trafficking along early compartments of the secretory pathway

scientific article published on 3 May 2008

Lysosomal Proteases

article

Metabolome Comparison of Bioactive and Inactive Rhododendron Extracts and Identification of an Antibacterial Cannabinoid(s) from Rhododendron collettianum.

scientific article published on 13 June 2017

Micro Raman spectroscopy for monitoring alterations between human skin keratinocytes HaCaT and their tumorigenic derivatives A5RT3-toward a Raman characterization of a skin carcinoma model

article

Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations

scientific article published on February 2015

Molecules important for thyroid hormone synthesis and action - known facts and future perspectives

scientific article

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

scientific article

Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells

scientific article published on 3 September 2015

Nuclear cysteine cathepsin variants in thyroid carcinoma cells

scientific article published on August 2010

Nuclear cysteine cathepsins in thyroid carcinomas

Nuclear legumain activity in colorectal cancer

scientific article

Paracrine interaction between hepatocytes and macrophages after extrathyroidal proteolysis of thyroglobulin ⬇️

scientific article published on November 1, 1997

Phylogenetic spectrum and analysis of antibacterial activities of leaf extracts from plants of the genus Rhododendron

scientific article published on 18 March 2015

Physarum polycephalum—a new take on a classic model system

article

Procathepsin V Is Secreted in a TSH Regulated Manner from Human Thyroid Epithelial Cells and Is Accessible to an Activity-Based Probe

scientific article published on 30 November 2020

Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges

scientific article

Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation

scientific journal article

Review: Cysteine Proteinases Mediate Extracellular Prohormone Processing in the Thyroid

article

Role of Kallikrein 7 in Body Weight and Fat Mass Regulation

scientific article published on 29 January 2021

Secretion of Antioxidant Peroxiredoxin 4 in Response to Oxidative Stress

Sequestration of microinjected molecular probes from the cytoplasm of Amoeba proteus

scientific article

Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice

scientific article published on 22 December 2017

Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP.

scientific article published on 28 August 2011

Studies on microplasmodia of . VII. Adhesion-dependent changes in the organization of the fibrillar actin system

scientific article published on 01 July 1987

Studies on microplasmodia of Physarum polycephalum

Studies on microplasmodia of Physarum polycephalum : VI. Functional analysis of a cortical and fibrillar actin system by use of fluorescent-analog cytochemistry

scientific article

Studies on microplasmodia ofPhysarum polycephalum

The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice

scientific article published on 28 May 2021

The Thyroid Hormone Transporter Mct8 Restricts Cathepsin-Mediated Thyroglobulin Processing in Male Mice through Thyroid Auto-Regulatory Mechanisms That Encompass Autophagy ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2021

The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length

scientific article

The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction

scientific article published on 13 September 2013

Thyroglobulin type-I-like domains in invariant chain fusion proteins mediate resistance to cathepsin L digestion

scientific article published in November 2000

Thyroid Cathepsin K: Roles in Physiology and Thyroid Disease

Thyroid functions of mouse cathepsins B, K, and L

article published in 2003

Thyroid functions of mouse cathepsins B, K, and L.

scientific article

Thyroid hormone action beyond classical concepts. The priority programme "Thyroid Trans Act" (SPP 1629) of the German Research Foundation

scientific article published on 25 February 2014

Thyroid stimulating hormone upregulates secretion of cathepsin B from thyroid epithelial cells

scientific article published on May 2002

Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study

scientific article published on 17 February 2010

Trace Amine-Associated Receptor 1 Localization at the Apical Plasma Membrane Domain of Fisher Rat Thyroid Epithelial Cells Is Confined to Cilia

scientific article published on 10 June 2015

Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells

scientific article published on 16 June 2021

Trafficking of Full-Length and N-Terminally Truncated Cathepsin B in Human Colorectal Carcinoma Cells

scientific article published on 15 December 2021

Trafficking of lysosomal cathepsin B-green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment

scientific journal article

Treatment of rat thyrocytes in vitro with cathepsin B and L inhibitors results in disruption of primary cilia leading to redistribution of the trace amine associated receptor 1 to the endoplasmic reticulum

scientific article published on 11 July 2019

Understanding the Healthy Thyroid State in 2015.

scientific article

Visualization of kallikreins in thyroid epithelial and carcinoma cells

scholarly article by Eileen Kroll et al published 13 May 2016 in Endocrine Abstracts

List of works by Klaudia Brix

A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages

Abstract 1093: Legumain in colorectal cancer: Unorthodox localization and trafficking

Altered dye diffusion and upregulation of connexin37 in mouse aortic endothelium deficient in connexin40.

Analysis of Microfilament Organization and Contractile Activities in Physarum

Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile

Assessment of cytotoxicity exerted by leaf extracts from plants of the genus Rhododendron towards epidermal keratinocytes and intestine epithelial cells

Bioactivity in Rhododendron: A Systemic Analysis of Antimicrobial and Cytotoxic Activities and Their Phylogenetic and Phytochemical Origins

Biosynthesis of shermilamine B

Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression.

Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes

Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases

Cathepsin B trafficking in thyroid carcinoma cells

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice.

Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

Chemically induced changes in the morphology, dynamic activity and cytoskeletal organization of cell fragments

Compartmentalization of Proteolysis

Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells

Coordination of genomic structure and transcription by the main bacterial nucleoid-associated protein HU.

Correction: Nuclear Legumain Activity in Colorectal Cancer.

Cysteine cathepsins: cellular roadmap to different functions

DNA accelerates the inhibition of human cathepsin V by serpins

Defects in mitochondrial distribution during the prolonged lag phase of Saccharomyces cerevisiae preceding growth in glycerol as the sole source of carbon

Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity ⬇️

Differences in Mouse Hepatic Thyroid Hormone Transporter Expression with Age and Hyperthyroidism

Differential regulation of monocarboxylate transporter 8 expression in thyroid cancer and hyperthyroidism.

EJCB - Molecular basis of protein fates in the secretory and endocytic pathways, and beyond

Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon

Effects of different space relevant environmental stressors including Lunar Dust on microorganisms and human cells of different tissues

Effects of lunar and mars dust simulants on HaCaT keratinocytes and CHO-K1 fibroblasts

Efficacy of protocols for induction of chronic hyperthyroidism in male and female mice

Epithelial folding in vitro: studies on the cellular mechanism underlying evagination of thyrocyte monolayers

Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors

Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells

Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells

Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level

Expression levels of thyroglobulin processing proteases are reduced upon trace amine-associated receptor 1 deficiency in mice

Extracellularly occurring histone H1 mediates the binding of thyroglobulin to the cell surface of mouse macrophages

Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland

Functional analysis of actin fibrils in Physarum polycephalum

Functional and morphological phenotypes in the mouse thyroid gland associated with thyroid-specific Mct8 deficiency

HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration.

High expression of the cysteine proteinase legumain in colorectal cancer – Implications for therapeutic targeting

Hyperproliferative hepatocellular alterations after intraportal transplantation of thyroid follicles

Induced pinocytosis and cytoskeletal organization in Amoeba proteus — a combined fluorescence and electron microscopic study

Interconnection between cathepsin protein levels and thyroid hormone transporters in human thyroid epithelial cells

Interdependence of thyroglobulin processing and thyroid hormone export in the mouse thyroid gland

Intestine-specific expression of green fluorescent protein-tagged cathepsin B: proof-of-principle experiments

Intestine-specific expression of green fluorescent protein-tagged cathepsin B: proof-of-principle experiments

Iodination of mature cathepsin D in thyrocytes as an indicator for its transport to the cell surface ⬇️

Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis

LRP1 modulates APP trafficking along early compartments of the secretory pathway

Lysosomal Proteases

Metabolome Comparison of Bioactive and Inactive Rhododendron Extracts and Identification of an Antibacterial Cannabinoid(s) from Rhododendron collettianum.

Micro Raman spectroscopy for monitoring alterations between human skin keratinocytes HaCaT and their tumorigenic derivatives A5RT3-toward a Raman characterization of a skin carcinoma model

Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations

Molecules important for thyroid hormone synthesis and action - known facts and future perspectives

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells

Nuclear cysteine cathepsin variants in thyroid carcinoma cells

Nuclear cysteine cathepsins in thyroid carcinomas

Nuclear legumain activity in colorectal cancer

Paracrine interaction between hepatocytes and macrophages after extrathyroidal proteolysis of thyroglobulin ⬇️

Phylogenetic spectrum and analysis of antibacterial activities of leaf extracts from plants of the genus Rhododendron

Physarum polycephalum—a new take on a classic model system

Procathepsin V Is Secreted in a TSH Regulated Manner from Human Thyroid Epithelial Cells and Is Accessible to an Activity-Based Probe

Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges

Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation

Review: Cysteine Proteinases Mediate Extracellular Prohormone Processing in the Thyroid

Role of Kallikrein 7 in Body Weight and Fat Mass Regulation

Secretion of Antioxidant Peroxiredoxin 4 in Response to Oxidative Stress

Sequestration of microinjected molecular probes from the cytoplasm of Amoeba proteus

Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice

Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP.

Studies on microplasmodia of . VII. Adhesion-dependent changes in the organization of the fibrillar actin system

Studies on microplasmodia of Physarum polycephalum

Studies on microplasmodia of Physarum polycephalum : VI. Functional analysis of a cortical and fibrillar actin system by use of fluorescent-analog cytochemistry

Studies on microplasmodia ofPhysarum polycephalum

The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice