Search filters

List of works by Roberto Cappai

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

scientific article published on 24 March 2011

6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation

scientific article published on 7 February 2006

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques.

scientific article published on 17 June 2010

A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease

scientific article published on June 2010

A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model.

scientific article published on 16 September 2009

APP involvement in retinogenesis of mice

scientific article published on 27 October 2010

Accumulation of Insoluble α-Synuclein in Dementia with Lewy Bodies

scientific article published on 01 June 2000

Alleviating transcriptional inhibition of the norepinephrine slc6a2 transporter gene in depolarized neurons

scientific article published in January 2010

Alois Alzheimer and Alzheimer's disease: a centennial perspective.

scientific article

Alpha-synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease

scientific article published on 10 March 2010

Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study

article

Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF).

scientific article published in June 2002

Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment

scientific article published in September 1997

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

scientific article published on July 1999

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth.

scientific article published on 19 April 2018

Amyloid beta.

scientific article

Amyloid imaging in Alzheimer's disease and other dementias

scientific article published on 7 April 2009

Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate

scientific article

Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina

scientific article

Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity

scientific article

Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions

scientific article published on 20 December 2005

Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope

scientific article

Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex

scientific article published on 25 October 2018

Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease

scientific article

Characterisation of the effect of knockout of the amyloid precursor protein on outcome following mild traumatic brain injury

scientific article published on 28 February 2012

Characterization of PiB binding to white matter in Alzheimer disease and other dementias

scientific article published on 21 January 2009

Characterization of a polymorphic family of integral membrane proteins in promastigotes of different Leishmania species

article

Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

scientific article published on 01 January 2019

Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice

scientific article published on 21 April 2009

Clioquinol Treatment in Familiar Early Onset of Alzheimer’s Disease

scientific article published on 01 March 2006

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

scientific article published on 30 September 2004

Cloning and analysis of the RESA-2 gene: a DNA homologue of the ring-infected erythrocyte surface antigen gene of Plasmodium falciparum

scientific article published in September 1992

Cloning and sequence of a Leishmania major homologue to the fibrillarin gene

scientific article published in April 1994

Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis.

scientific article

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.

scientific article published on 13 February 2007

Conformational behavior and aggregation of ataxin-3 in SDS.

scientific article published on 22 July 2013

Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence

scientific article published on 25 January 2009

Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivity

scientific article

Copper Coordination by Familial Mutants of Parkinson’s Disease-Associated α-Synuclein

scholarly article by Simon C. Drew et al published 20 October 2009 in Applied Magnetic Resonance

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.

scientific article published in July 2001

Copper binding to the Alzheimer's disease amyloid precursor protein

scientific article

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

scientific article published in December 1999

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

scientific journal article

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

scientific article

Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments

scientific article published on May 2003

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

scientific article published in January 2005

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

scientific article

Correlative studies support lipid peroxidation is linked to PrPres propagation as an early primary pathogenic event in prion disease

scientific article published on 05 October 2005

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

scientific article

Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease.

scientific article published on 30 April 2008

Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease

scientific article

Cu2+Binding Modes of Recombinant α-Synuclein − Insights from EPR Spectroscopy

scientific article published on 22 May 2008

Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer's disease.

scientific article

Detection of prion epitopes on PrP and PrP of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP.

scientific article published in December 2005

Development of a Platinum Complex as an anti‐Amyloid Agent for the Therapy of Alzheimer’s Disease ⬇️

scientific article published on February 10, 2013

Dimeric structures of alpha-synuclein bind preferentially to lipid membranes

scientific article

Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation

scientific article published in March 2003

Dopamine and the dopamine oxidation product 5,6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent manner

scientific article

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

scientific article published on 9 June 2005

Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor-related protein on neurite outgrowth from sympathetic neurons in culture

scientific article published in May 1998

Engineered antibody intervention strategies for Alzheimer's disease and related dementias by targeting amyloid and toxic oligomers.

scientific article published on 16 October 2008

Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

scientific article

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

scientific article published on 16 April 2008

Evaluation of the effects of treatment with sAPPα on functional and histological outcome following controlled cortical impact injury in mice

scientific article published on 16 March 2012

Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine

article

Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione

scientific article published in May 1999

Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease.

scientific article published in October 1997

Expression of human amyloid precursor protein ectodomains in Pichia pastoris: analysis of culture conditions, purification, and characterization

scientific article published in July 1997

Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex.

scientific article published on August 2004

Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: implications for the mechanism of prion formation

scientific article published in March 1999

Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of α-Synuclein†

scientific article published on 08 January 2008

Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation

scientific article

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology

scientific article published on 6 March 2006

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

scientific journal article

Gene knockout of tau expression does not contribute to the pathogenesis of prion disease

scientific article published in November 2011

Generation of a recombinant Fab antibody reactive with the Alzheimer's disease-related Abeta peptide

scientific article published in September 2002

Guanidine hydrochloride denaturation of dopamine-induced α-synuclein oligomers: a small-angle X-ray scattering study

scientific article published on 31 August 2013

Histidine 14 modulates membrane binding and neurotoxicity of the Alzheimer's disease amyloid-beta peptide

scientific article published in January 2010

Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways

scientific article

Identification of a novel amyloid precursor protein processing pathway that generates secreted N‐terminal fragments ⬇️

scientific article published on April 6, 2012

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

scientific article

In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.

scientific article

In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.

scientific article published in September 2007

In vitro characterization of [18F]-florbetaben, an Aβ imaging radiotracer

scientific article published on 11 April 2012

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

scholarly article

Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein.

scientific article published in November 1998

Interaction of linear homologous DNA duplexes via Holliday junction formation.

scientific article published in January 2001

Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity

scientific article published in July 2004

Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.

scientific article

Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126.

scientific article

Iron inhibits neurotoxicity induced by trace copper and biological reductants

scientific article published on 3 February 2004

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

scientific article

Making sense of the amyloid precursor protein: its tail tells an interesting tale.

scientific article

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

scientific article (publication date: 2011)

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

scientific article published on 20 August 2002

Metals and amyloid-beta in Alzheimer's disease

scientific article

Methionine oxidation: Implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease

article

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

scientific article published on 24 January 2005

Modulation of alpha-synuclein aggregation by dopamine: a review.

scientific article published on 15 May 2009

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

scientific article published in February 2006

Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the aggregating species

scientific article

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

scientific article

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

scientific article

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

scientific article

Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

scientific article published in March 2003

Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation

scientific article published on 15 September 2007

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

scientific article published on 4 September 2002

PAMAM Dendrimers as Potential Agents against Fibrillation ofα-Synuclein, a Parkinson's Disease-Related Protein

scientific article published on 01 March 2009

Packaging of prions into exosomes is associated with a novel pathway of PrP processing.

scientific article

Plasma alpha-synuclein is decreased in subjects with Parkinson's disease

scientific article

Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

scholarly article

Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease

scientific article

Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gamma-secretase products

scientific article published in October 1998

Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function

scientific article

Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue

scientific article published on 7 August 2014

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

scientific article

Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth

scientific article published in January 1999

Residues surrounding the glycosylphosphatidylinositol anchor attachment site of PrP modulate prion infection: insight from the resistance of rabbits to prion disease.

scientific article published on 28 April 2010

SERF protein is a direct modifier of amyloid fiber assembly.

scientific article published on 26 July 2012

Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth

scientific article published in December 1996

Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage

scientific article published in February 2003

Solution Conformation and Heparin-induced Dimerization of the Full-length Extracellular Domain of the Human Amyloid Precursor Protein

article

Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity

scientific article published on 25 March 2009

Stimulus pattern dependence of the Alzheimer's disease amyloid-beta 42 peptide's inhibition of long term potentiation in mouse hippocampal slices

scientific article published on 18 March 2009

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

scientific article

Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution

scientific article

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

scientific article (publication date: 9 May 2003)

Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons.

scientific article published in April 2001

Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation

scientific article

Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers

article

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

scientific article published on 29 January 2012

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

scientific article

The Leishmania promastigote surface antigen 2 complex is differentially expressed during the parasite life cycle

scientific article published in November 1995

The N-terminal residues 43 to 60 form the interface for dopamine mediated α-synuclein dimerisation.

scientific article

The Plasmodium falciparum hypoxanthine-guanine phosphoribosyl transferase gene has a 5' upstream intron

scientific article

The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons

scientific article published in December 1999

The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism.

scientific article

The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.

scientific article

The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126.

scientific article

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

scientific article published on 2 April 2012

The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding.

scientific article published on 22 October 2013

The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein.

scientific article published on 15 September 2009

The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110.

scientific article published on 28 August 2013

The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains

scientific article published on 6 January 2011

The neurotransmitter serotonin interrupts α-synuclein amyloid maturation

scientific article published on 2 March 2011

The redox chemistry of the Alzheimer's disease amyloid beta peptide.

scientific article published on 9 February 2007

The structure of dopamine induced alpha-synuclein oligomers.

scientific article published on 23 March 2010

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

scientific article

Variable phenotype of Alzheimer's disease with spastic paraparesis

scientific article published in January 2001

sAPPα rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury

scientific article published on 17 May 2012

α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease

scientific article published on 18 November 2014

Paulina is supported by:

About Paulina

Help