List of works - Roberto Cappai

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

scientific article

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

scientific article

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

scientific article

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

scientific article published on 20 August 2002

The redox chemistry of the Alzheimer's disease amyloid beta peptide.

scientific article published on 9 February 2007

Packaging of prions into exosomes is associated with a novel pathway of PrP processing.

scientific article

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

scientific article published on 29 January 2012

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

scientific article published on 4 September 2002

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

scientific article published in January 2005

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

scientific article published on 24 March 2011

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

scientific journal article

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

scientific article

Metals and amyloid-beta in Alzheimer's disease

scientific article

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

scientific article published on 9 June 2005

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.

scientific article published in July 2001

Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity

scientific article

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

scientific article published on 16 April 2008

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

scholarly article

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

scientific article (publication date: 9 May 2003)

Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways

scientific article

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

scientific article published in February 2006

Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity

scientific article published in July 2004

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

scientific article

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

scientific article

In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.

scientific article published in September 2007

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge

scientific article

The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126.

scientific article

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide

scientific article published on 13 February 2007

Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth

scientific article published in December 1996

Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

scholarly article

Plasma alpha-synuclein is decreased in subjects with Parkinson's disease

scientific article

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

scientific article published in December 1999

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology

scientific article published on 6 March 2006

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

scientific article published on 24 January 2005

The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.

scientific article

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

scientific article (publication date: 2011)

Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

scientific article

Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions

scientific article published on 20 December 2005

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

scientific article

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

scientific article published on 2 April 2012

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

scientific article published on 30 September 2004

Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation

scientific article

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

scientific journal article

Characterization of PiB binding to white matter in Alzheimer disease and other dementias

scientific article published on 21 January 2009

Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer's disease.

scientific article

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

scientific article

Dopamine and the dopamine oxidation product 5,6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent manner

scientific article

Alpha-synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease

scientific article published on 10 March 2010

Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.

scientific article

The structure of dopamine induced alpha-synuclein oligomers.

scientific article published on 23 March 2010

List of works by Roberto Cappai

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

The redox chemistry of the Alzheimer's disease amyloid beta peptide.

Packaging of prions into exosomes is associated with a novel pathway of PrP processing.

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

Metals and amyloid-beta in Alzheimer's disease

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.

Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge

The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126.

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide

Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth

Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

Plasma alpha-synuclein is decreased in subjects with Parkinson's disease

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

Characterization of PiB binding to white matter in Alzheimer disease and other dementias

Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer's disease.

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

Dopamine and the dopamine oxidation product 5,6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent manner

Alpha-synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease

Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.

The structure of dopamine induced alpha-synuclein oligomers.