List of works by Vsevolod V. Gurevich

A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.

scientific article published on 5 February 2016

A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation

scientific article published on 13 May 2019

A dopamine D2 receptor mutant capable of G protein-mediated signaling but deficient in arrestin binding

scientific journal article

A model for the solution structure of the rod arrestin tetramer

scientific article published on June 2008

A non-GPCR binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling

scientific article published on 04 August 2020

A single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding.

scientific article

ARF6: a newly appreciated player in G protein-coupled receptor desensitization

scientific article

Agonist-receptor-arrestin, an alternative ternary complex with high agonist affinity.

scientific article

Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment

scientific article

Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens

scientific article

Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens

article published in 2009

An eight amino acid segment controls oligomerization and preferred conformation of the two non-visual arrestins

scientific article published on 30 December 2020

An intracellular loop 2 amino acid residue determines differential binding of arrestin to the dopamine D2 and D3 receptors.

scientific article published on 26 September 2008

Analyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKs

scientific article

Anesthetic considerations during percutaneous nephrolithotomy

scientific article published in August 2007

Arrestin Variants Display Differential Binding Characteristics for the PhosphorylatedN-Formyl Peptide Receptor Carboxyl Terminus

scientific article published in Journal of Biological Chemistry

Arrestin binding to calmodulin: a direct interaction between two ubiquitous signaling proteins

scientific article published on 3 October 2006

Arrestin binding to the M(2) muscarinic acetylcholine receptor is precluded by an inhibitory element in the third intracellular loop of the receptor.

scientific article

Arrestin expression in E. coli and purification.

scientific article published on December 2014

Arrestin makes T cells stop and become active

scientific article published on 6 February 2014

Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity.

scientific article published on 22 February 2007

Arrestin mutations: Some cause diseases, others promise cure

scientific article published on 24 October 2018

Arrestin with a single amino acid substitution quenches light-activated rhodopsin in a phosphorylation-independent fashion

scientific article published on 01 June 1997

Arrestin-2 and arrestin-3 differentially modulate locomotor responses and sensitization to amphetamine

scientific article published on 15 April 2017

Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding

scientific article

Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains.

scientific article published on 8 January 2014

Arrestin-3 interaction with maternal embryonic leucine-zipper kinase

scientific article published on 25 July 2019

Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification

scientific article published on 27 December 2018

Arrestin-3-Dependent Activation of c-Jun N-Terminal Kinases (JNKs).

scientific article published on 2 March 2015

Arrestin-dependent activation of JNK family kinases

scientific article published on January 2014

Arrestin-mediated signaling: Is there a controversy?

scientific article published on 01 December 2018

Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain

scientific article (publication date: 6 June 1997)

Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development

scientific journal article

Arrestin2 expression selectively increases during neural differentiation

scientific article published on 01 December 2004

Arrestins and G proteins in cellular signaling: The coin has two sides.

scientific article published on 25 September 2018

Arrestins in apoptosis

scientific article published on January 2014

Arrestins regulate cell spreading and motility via focal adhesion dynamics

scientific article

Arrestins: Critical Players in Trafficking of Many GPCRs

scientific article published on 25 March 2015

Arrestins: Introducing Signaling Bias Into Multifunctional Proteins

scientific article published on 06 September 2018

Arrestins: structural disorder creates rich functionality.

scientific article published on 16 February 2018

Arrestins: ubiquitous regulators of cellular signaling pathways

scientific article

Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2.

scientific article published on 26 February 2002

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

scientific article (publication date: 3 October 1996)

Biased GPCR signaling: Possible mechanisms and inherent limitations

scientific article published on 19 March 2020

Biological role of arrestin-1 oligomerization

scientific article published on 17 September 2020

C-terminal motif of human neuropeptide Y4 receptor determines internalization and arrestin recruitment

scientific article published on 3 November 2016

C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor

scientific article published on 24 April 2015

Calmodulin kinase II inhibition protects against structural heart disease

scientific article published on 27 March 2005

Cleavage of arrestin-3 by caspases attenuates cell death by precluding arrestin-dependent JNK activation

scientific article published on 04 December 2018

Cone arrestin binding to JNK3 and Mdm2: conformational preference and localization of interaction sites

scientific article published on 6 August 2007

Conformation of receptor-bound visual arrestin

scientific article

Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry

scientific article

Conservation of the phosphate-sensitive elements in the arrestin family of proteins

scientific article

Conserved Phosphoprotein Interaction Motif Is Functionally Interchangeable between Ataxin-7 and Arrestins†

scientific article published on 01 June 2000

Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding

scientific article published on 17 July 2013

Corrigendum to "Biased GPCR signaling: Possible mechanisms and inherent limitations" [Pharmacology & Therapeutics 211 (2020) 107540]

scientific article published on 01 July 2020

Critical role of the central 139-loop in stability and binding selectivity of arrestin-1.

scientific article published on 8 March 2013

Critical role of the finger loop in arrestin binding to the receptors

scientific article published on 15 March 2019

Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes

scientific article

Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane Translocation

scientific article

Crystal structure of cone arrestin at 2.3A: evolution of receptor specificity.

scientific article

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

scientific article

Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase

scientific article published on 10 April 2019

Custom-designed proteins as novel therapeutic tools? The case of arrestins

scientific article published on 23 April 2010

Designer adhesion GPCR tells its signaling story

scientific article published on 28 September 2020

Development of an MRI biomarker sensitive to tetrameric visual arrestin 1 and its reduction via light-evoked translocation in vivo

scientific article

Differential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin

scholarly article

Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors

scientific article

Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single photon response in vertebrate phototransduction.

scientific article published on May 2008

Direct binding of visual arrestin to microtubules determines the differential subcellular localization of its splice variants in rod photoreceptors.

scientific article

Dopamine D1 receptor interaction with arrestin3 in neostriatal neurons.

scientific article

Each rhodopsin molecule binds its own arrestin

scholarly article

Elucidation of inositol hexaphosphate and heparin interaction sites and conformational changes in arrestin-1 by solution nuclear magnetic resonance.

scientific article published on 15 November 2010

Engineering visual arrestin-1 with special functional characteristics

scientific article published on 17 December 2012

Enhanced Mutant Compensates for Defects in Rhodopsin Phosphorylation in the Presence of Endogenous Arrestin-1.

scientific article

Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation

scientific article published on 9 April 2009

Enhanced phosphorylation-independent arrestins and gene therapy

scientific article published on January 2014

Exploring GPCR-arrestin interfaces with genetically encoded crosslinkers

scientific article published on 14 September 2020

Extensive shape shifting underlies functional versatility of arrestins

scientific article

Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins

scientific article

Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins

scientific article

Functional comparisons of visual arrestins in rod photoreceptors of transgenic mice

scientific article

Functional expression in vitro of bovine visual rhodopsin

scientific article published on 01 April 1990

Functional role of the three conserved cysteines in the N domain of visual arrestin-1.

scientific article published on 23 May 2017

G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro

scientific article published on 8 July 2015

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).

scientific article published on 13 March 2015

G protein-coupled receptor kinases as regulators of dopamine receptor functions

scientific article published on 10 May 2016

G protein-coupled receptor kinases: more than just kinases and not only for GPCRs

scientific article published on 26 August 2011

GPCR Signaling Regulation: The Role of GRKs and Arrestins

GPCR monomers and oligomers: it takes all kinds

scientific article published on 15 January 2008

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.

scientific article published on 14 March 2015

GPCRs and Signal Transducers: Interaction Stoichiometry

scientific article published on 05 May 2018

GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domain

scientific article

GRKs as Modulators of Neurotransmitter Receptors

scientific article published on 31 December 2020

Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation

scientific article published on 04 January 2008

Hepatic β-arrestin 2 is essential for maintaining euglycemia

scientific article

Heterologous phosphorylation-induced formation of a stability lock permits regulation of inactive receptors by β-arrestins

scientific article published on 16 November 2017

How and why do GPCRs dimerize?

scientific article published on April 2008

How does arrestin assemble MAPKs into a signaling complex?

scientific article published on 10 November 2008

How genetic errors in GPCRs affect their function: Possible therapeutic strategies

scientific article

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.

scientific article published on July 2017

Identification of arrestin-3-specific residues necessary for JNK3 kinase activation

scientific article

Identification of key factors that reduce the variability of the single photon response

scientific article

Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor

scientific article

Identification of receptor binding-induced conformational changes in non-visual arrestins

scientific article

In vitro synthesis of visual rhodopsin for a protein engineering study

In vitro transcription: preparative RNA yields in analytical scale reactions

scientific article published on 01 August 1994

Influence of Arrestin on the Photodecay of Bovine Rhodopsin

scientific article published on 18 September 2015

Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins

scientific article published in February 2005

Insights into congenital stationary night blindness based on the structure of G90D rhodopsin

scientific article

Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin

scientific article published on 31 December 2012

JNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinases

scientific article published on 19 August 2013

Kinetics of rhodopsin deactivation and its role in regulating recovery and reproducibility of rod photoresponse

scientific article

Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease

scientific article

Ligand directed signaling differences between rodent and human κ-opioid receptors

scientific article

Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail

scientific article

Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions

scientific article published on May 2005

Local, nonlinear effects of cGMP and Ca2+ reduce single photon response variability in retinal rods

scientific article published on 05 December 2019

Lysine in the lariat loop of arrestins does not serve as phosphate sensor

scientific article published on 27 June 2020

Manipulation of very few receptor discriminator residues greatly enhances receptor specificity of non-visual arrestins

scientific article

Mapping the arrestin-receptor interface. Structural elements responsible for receptor specificity of arrestin proteins

scientific article published on 6 October 2003

Mdm2 enhances ligase activity of parkin and facilitates mitophagy

scientific article published on 19 March 2020

Mechanism of quenching of phototransduction. Binding competition between arrestin and transducin for phosphorhodopsin.

scientific article published on July 1997

Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice

scientific article published on 17 October 2019

Molecular Defects of the Disease-Causing Human Arrestin-1 C147F Mutant

scientific article published in January 2018

Molecular Mechanisms of GPCR Signaling: A Structural Perspective

scientific article published on 24 November 2017

Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding

scientific article

Multi-scale, numerical modeling of spatio-temporal signaling in cone phototransduction

scientific article published on 25 July 2019

Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypes

scientific article published on 29 March 2014

N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity

scientific article published on 6 November 2002

Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function.

scientific article

Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of GPCRs

scientific article published on 10 November 2017

Nonvisual arrestins function as simple scaffolds assembling the MKK4-JNK3α2 signaling complex

scientific article

Opposing effects of inositol hexakisphosphate on rod arrestin and arrestin2 self-association

scientific article

Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors.

scientific article published on February 2009

Overview of different mechanisms of arrestin-mediated signaling

scientific article

Paradigm Shift is the Normal State of Pharmacology

Partial phosphorylation of the N-formyl peptide receptor inhibits G protein association independent of arrestin binding.

scientific article

Peptide mini-scaffold facilitates JNK3 activation in cells

scientific article published on 12 February 2016

Peptide modifications differentially alter G protein-coupled receptor internalization and signaling bias

scientific article published on 25 July 2014

Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor

scientific article published on 05 June 2020

Plethora of functions packed into 45 kDa arrestins: biological implications and possible therapeutic strategies

scientific article published on 17 August 2019

Position of rhodopsin photoisomerization on the disk surface confers variability to the rising phase of the single photon response in vertebrate rod photoreceptors

scientific article published on 14 October 2020

Preparative in vitro mRNA synthesis using SP6 and T7 RNA polymerases.

scientific article published in June 1991

Progressive reduction of its expression in rods reveals two pools of arrestin-1 in the outer segment with different roles in photoresponse recovery

scientific article

Protein multi-functionality: introduction

scientific article published on 17 August 2019

Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor.

scientific article

Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant

scientific article

Real-time analysis of G protein-coupled receptor reconstitution in a solubilized system

scientific article published on 17 April 2001

Regulation of arrestin binding by rhodopsin phosphorylation level

scientific article published on 11 September 2007

Rich tapestry of G protein-coupled receptor signaling and regulatory mechanisms

scientific article published on 30 May 2008

Robust self-association is a common feature of mammalian visual arrestin-1.

scientific article

Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors.

scientific article published on 24 January 2012

Self-association of arrestin family members

scientific article published on January 2014

Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant

scientific article

Soluble mimics of the cytoplasmic face of the human V1-vascular vasopressin receptor bind arrestin2 and calmodulin

scientific article published on 30 March 2006

Structural Basis of Arrestin-Dependent Signal Transduction.

scientific article published on 7 April 2018

Structural basis of arrestin-3 activation and signaling.

scientific article published on 10 November 2017

Structural determinants of arrestin functions

scientific article published on January 2013

Structure and function of the visual arrestin oligomer

scientific article published on March 2007

Synthetic biology with surgical precision: targeted reengineering of signaling proteins

scientific article published on June 2012

Targeted construction of phosphorylation-independent beta-arrestin mutants with constitutive activity in cells

scientific article published in March 1999

Targeting arrestin interactions with its partners for therapeutic purposes

scientific article published on 18 December 2019

Targeting individual GPCRs with redesigned nonvisual arrestins.

scientific article published on January 2014

The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation

scientific article

The Conformational Equilibrium of the Neuropeptide Y2 Receptor in Bilayer Membranes

scientific article published on 13 August 2020

The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation

scientific article published on 24 November 2020

The differential engagement of arrestin surface charges by the various functional forms of the receptor

scientific article published on 8 December 2005

The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation

scientific article

The finger loop as an activation sensor in arrestin

scientific article published on 06 November 2020

The functional cycle of visual arrestins in photoreceptor cells

scientific article

The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT(2A) receptor induces agonist-independent internalization

scientific article published in May 2003

The interaction with the cytoplasmic loops of rhodopsin plays a crucial role in arrestin activation and binding.

scientific article published in March 2003

The molecular acrobatics of arrestin activation

scientific article

The nature of the arrestin x receptor complex determines the ultimate fate of the internalized receptor

scientific article published on 13 January 2003

The new face of active receptor bound arrestin attracts new partners

scientific article

The origin and evolution of G protein-coupled receptor kinases

scientific article published on 19 March 2012

The rhodopsin-arrestin-1 interaction in bicelles.

scientific article published on January 2015

The role of arrestin alpha-helix I in receptor binding

scientific article published on 31 October 2009

The selectivity of visual arrestin for light-activated phosphorhodopsin is controlled by multiple nonredundant mechanisms

scientific article published in June 1998

The structural basis of arrestin-mediated regulation of G-protein-coupled receptors

scientific article

The structural basis of the arrestin binding to GPCRs

scientific article published on 28 January 2019

The third intracellular loop of alpha 2-adrenergic receptors determines subtype specificity of arrestin interaction

scientific article

Therapeutic potential of small molecules and engineered proteins

scientific article published on January 2014

Transition of arrestin into the active receptor-binding state requires an extended interdomain hinge

scientific article

Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination

scientific article published on 12 April 2011

Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes

scientific article

Use of bacteriophage RNA polymerase in RNA synthesis

scientific article published on 01 January 1996

Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors

scientific article published on September 2015

Using In Vitro Pull-Down and In-Cell Overexpression Assays to Study Protein Interactions with Arrestin

scientific article published on 01 January 2019

Using two-site binding models to analyze microscale thermophoresis data

scientific article published on 17 October 2017

Visual and both non-visual arrestins in their "inactive" conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasm

scientific article published on 31 May 2006

Visual arrestin activity may be regulated by self-association

scientific article published on 01 July 1999

Visual arrestin binding to microtubules involves a distinct conformational change

scientific article published on 6 February 2006

Visual arrestin binding to rhodopsin. Diverse functional roles of positively charged residues within the phosphorylation-recognition region of arrestin.

scientific article

Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina

scientific article published on 20 May 2013

mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin

scientific article published on 22 February 2002

ßarrestin1-biased agonism at human δ-opioid receptor by peptidic and alkaloid ligands.

scientific article

β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion

scientific article published on 11 June 2019

β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

scientific article published on February 2017

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