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List of works by Christian R Kowol

A Dogma in Doubt: Hydrolysis of Equatorial Ligands of PtIV Complexes under Physiological Conditions

scientific article published on 25 April 2019

A quantitative structure-activity approach for lipophilicity estimation of antitumor complexes of different metals using microemulsion electrokinetic chromatography

scientific article

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo.

scientific article

An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent alpha-N-heterocyclic chalcogensemicarbazones

scientific article

Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes

scientific article

Anticancer Activity of Metal Complexes: Involvement of Redox Processes ⬇️

scientific article published on May 11, 2011

Anticancer thiosemicarbazones: chemical properties, interaction with iron metabolism, and resistance development.

scientific article published on 15 January 2018

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis

scientific article published on 16 February 2018

Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46.

scientific article

Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux

scientific article published on 15 November 2020

Comparative studies on the human serum albumin binding of the clinically approved EGFR inhibitors gefitinib, erlotinib, afatinib, osimertinib and the investigational inhibitor KP2187.

scientific article

Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones.

scientific article published on 23 February 2018

Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation

scientific article published on 13 November 2020

Critical assessment of different methods for quantitative measurement of metallodrug-protein associations

scientific article published on 29 August 2018

Differences in protein binding and excretion of Triapine and its Fe(III) complex

scientific article published on 19 October 2015

EGFR-targeting peptide-coupled platinum(IV) complexes.

scientific article

Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones.

scientific article published on 31 July 2007

Enhanced anticancer activity and circumvention of resistance mechanisms by novel polymeric/ phospholipidic nanocarriers of doxorubicin

scientific article published on July 2014

Front Cover: Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity (Chem. Biodiversity 10/2022)

scientific article published in 2022

Gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase.

scientific article published on 22 February 2007

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention

scientific article published on 23 June 2016

Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.

scientific article published in August 2009

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

scientific article published on 15 March 2012

Improving the Stability of EGFR Inhibitor Cobalt(III) Prodrugs

scientific article published on 21 November 2020

Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study.

scientific article

Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer.

scientific article published on 7 September 2017

Investigation of amino acid containing [FeFe] hydrogenase models concerning pendant base effects

scientific article published on 6 August 2009

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.

scientific article published on 02 September 2016

Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.

scientific article published on March 2013

Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

scientific article

Metal Drugs and the Anticancer Immune Response

scientific article published on 29 November 2018

Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney

scientific article published on 03 February 2016

Multifunctional αvβ6 Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting

scientific article

Nanoformulation improves activity of the (pre)clinical anticancer ruthenium complex KP1019.

scientific article published on May 2014

Nanoformulations of anticancer FGFR inhibitors with improved therapeutic index

scientific article published on 16 August 2018

Novel tetracarboxylatoplatinum(IV) complexes as carboplatin prodrugs.

scientific article

Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation

scientific article published on 29 October 2013

Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins

scientific article published on 25 July 2006

Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib

scientific article published on 04 March 2020

Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study

scientific article published on 31 July 2011

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS).

scientific article published on 9 April 2018

Synergistic anticancer activity of arsenic trioxide with erlotinib is based on inhibition of EGFR-mediated DNA double-strand break repair

scientific article published on 2 April 2013

Synthesis and Cytotoxicity of Water-Soluble Dual- and Triple-Action Satraplatin Derivatives: Replacement of Equatorial Chlorides of Satraplatin by Acetates

scientific article published on 02 December 2019

Synthesis and reactivity of the aquation product of the antitumor complex trans-[Ru(III)Cl4(indazole)2]-.

scientific article published on 14 June 2008

Synthesis, Characterization and in vitro Studies of a Cathepsin B-Cleavable Prodrug of the VEGFR Inhibitor Sunitinib

scientific article published on 19 December 2018

Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs.

scientific article published on 5 October 2016

The first metal-based paullone derivative with high antiproliferative activity in vitro.

scientific article published in March 2006

Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance

scientific article published in 2022

Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells.

scientific article published on 30 December 2013

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance.

scientific article

Tumor-targeting of EGFR inhibitors by hypoxia-mediated activation

scientific article published on 30 July 2014

Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes

scientific article published on October 2010

Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS.

scientific article

Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity

scientific article published on 17 December 2012

Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity

scientific article

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