List of works - Michael J. Jurczak

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

scientific article

A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression

scientific article

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

scientific article published on January 2014

Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment

scientific article

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

scientific article published on 28 March 2019

Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance

scientific article published on 04 July 2019

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

scientific article

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.

scientific article

Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

scientific article

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

scientific article published on 9 January 2013

Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance

scientific article published on 30 January 2013

Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice

scientific article

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression

scientific article

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

scientific article published on 16 July 2019

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

scholarly article by Andreas L. Birkenfeld et al published October 2011 in Cell Metabolism

Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

scientific article

Development of insulin resistance in mice lacking PGC-1α in adipose tissues.

scientific article

Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice

scientific article published on 28 November 2011

Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice

scientific article published on November 2011

Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia

scientific article

Generation of a dominant-negative glycogen targeting subunit for protein phosphatase-1.

scientific article

Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.

scientific article

Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways.

scientific article published on 14 February 2006

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

scientific article published on 5 February 2015

Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21.

scientific article

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

scientific article

Hepatic insulin sensitivity is improved in high-fat diet-fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis

scientific article published on 01 November 2019

Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis

scientific article

Hypophosphatemia promotes lower rates of muscle ATP synthesis

scientific article published on 23 June 2016

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

scientific journal article

Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism

scientific article

Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II.

scientific article

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

scientific article

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

scientific article

Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity

scientific article

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

scientific article

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

scientific article

Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.

scientific article published on 11 April 2014

Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome

scientific journal article

PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.

scientific article

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

scientific article

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

scientific article

Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.

scientific article published on 10 May 2016

Reply to Constantin-Teodosiu et al.: mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance

scientific article published on 23 January 2015

Reply to Monetti et al.: Hepatic steatosis and diacylglycerol-mediated hepatic insulin resistance in acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) transgenic mice.

scientific article

Retinol saturase modulates lipid metabolism and the production of reactive oxygen species.

scientific article published on 16 September 2017

Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler

scientific article

Role of caspase-1 in regulation of triglyceride metabolism.

scientific article published on 4 March 2013

SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function ⬇️

scientific article

SGLT2 knockout prevents hyperglycemia and is associated with reduced pancreatic β-cell death in genetically obese mice

scientific article published on 17 August 2018

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

scientific article published on 09 July 2013

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

scientific article published on 7 December 2015

Stranger in a strange land: roles of glycogen turnover in adipose tissue metabolism.

scientific article published on 22 August 2009

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

scientific article

Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance

scientific article published on 19 February 2013

The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells.

scientific article published on 15 November 2014

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

scientific article published on 8 November 2012

The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

scientific article

The role of protein translocation in the regulation of glycogen metabolism.

scientific article published on May 2008

Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance

scientific article

Transgenic overexpression of protein targeting to glycogen markedly increases adipocytic glycogen storage in mice.

scientific article

Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance

scientific article

List of works by Michael J. Jurczak

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.

Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance

Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

Development of insulin resistance in mice lacking PGC-1α in adipose tissues.

Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice

Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice

Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia

Generation of a dominant-negative glycogen targeting subunit for protein phosphatase-1.

Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.

Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways.

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21.

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

Hepatic insulin sensitivity is improved in high-fat diet-fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis

Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis

Hypophosphatemia promotes lower rates of muscle ATP synthesis

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism

Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II.

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.

Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome

PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.

Reply to Constantin-Teodosiu et al.: mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance

Reply to Monetti et al.: Hepatic steatosis and diacylglycerol-mediated hepatic insulin resistance in acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) transgenic mice.

Retinol saturase modulates lipid metabolism and the production of reactive oxygen species.

Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler

Role of caspase-1 in regulation of triglyceride metabolism.

SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function ⬇️

SGLT2 knockout prevents hyperglycemia and is associated with reduced pancreatic β-cell death in genetically obese mice

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

Stranger in a strange land: roles of glycogen turnover in adipose tissue metabolism.

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance

The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells.

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

The role of protein translocation in the regulation of glycogen metabolism.

Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance

Transgenic overexpression of protein targeting to glycogen markedly increases adipocytic glycogen storage in mice.

Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance