List of works by Davide Lecca

A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro

scientific article published on 20 August 2016

Agonist-Induced Desensitization/Resensitization of Human G Protein-Coupled Receptor 17: A Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene Ligands

scientific article published on 29 April 2011

CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17

scientific article

Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury

scientific article published on 26 June 2013

Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor

scientific journal article

Comparison and optimization of transient transfection methods at human astrocytoma cell line 1321N1.

scientific article

Deorphanisation of G protein-coupled receptors: A tool to provide new insights in nervous system pathophysiology and new targets for psycho-active drugs

scientific article published on 11 August 2007

Different properties of P2X(7) receptor in hippocampal and cortical astrocytes

scientific article published on 12 March 2009

Differential local tissue permissiveness influences the final fate of GPR17-expressing oligodendrocyte precursors in two distinct models of demyelination

scientific article published on 9 February 2018

Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways?

scientific article published on 5 March 2014

Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor.

scientific article

Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells

scientific article

Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug

scientific article published on 25 February 2019

In vivo silencing of miR-125a-3p promotes myelin repair in models of white matter demyelination

scientific article published on 12 March 2020

Intertwining extracellular nucleotides and their receptors with Ca2+ in determining adult neural stem cell survival, proliferation and final fate

scientific article

Lupin Peptide T9 (GQEQSHQDEGVIVR) Modulates the Mutant PCSK9D374Y Pathway: in vitro Characterization of its Dual Hypocholesterolemic Behavior

scientific article published on 20 July 2019

MicroRNAs change the games in central nervous system pharmacology

scientific article published on 25 June 2019

Microglia is a key player in the reduction of stroke damage promoted by the new antithrombotic agent ticagrelor

scientific article

Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes

scientific article published on April 2008

Pathophysiological Role of Purines and Pyrimidines in Neurodevelopment: Unveiling New Pharmacological Approaches to Congenital Brain Diseases

scientific article published on 19 December 2017

Pathway-Focused Profiling of Oligodendrocytes Over-Expressing miR-125a-3p Reveals Alteration of Wnt and Cell-to-Cell Signaling

scientific article published on 01 April 2020

Pharmacological Properties and Biological Functions of the GPR17 Receptor, a Potential Target for Neuro-Regenerative Medicine.

scientific article

Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation

scientific article

Prenatal Stress Impairs Spinal Cord Oligodendrocyte Maturation via BDNF Signaling in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

scientific article published on 01 December 2020

Purinergic transmission in brain tumors and its impact on drug development

scientific article published on 12 June 2015

Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death

scientific article

Purple Corn Extract as Anti-allodynic Treatment for Trigeminal Pain: Role of Microglia

scientific article published on 05 November 2018

Regulation and signaling of the GPR17 receptor in oligodendroglial cells

scientific article published on 22 February 2020

Regulation of Oligodendrocyte Functions: Targeting Lipid Metabolism and Extracellular Matrix for Myelin Repair

scientific article published on 08 February 2020

Regulation of PC12 cell survival and differentiation by the new P2Y-like receptor GPR17.

scientific article published on 6 January 2010

Role of purinergic signalling in neuro-immune cells and adult neural progenitors

scientific article published on June 2011

SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation

scientific article

The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor

scientific article

The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair

scientific article

The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells

scientific article published on 3 January 2013

The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization

scientific article published on 31 July 2015

Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation

scientific article published on 03 January 2008

Ventral tegmental area/substantia nigra and prefrontal cortex rodent organotypic brain slices as an integrated model to study the cellular changes induced by oxygen/glucose deprivation and reperfusion: Effect of neuroprotective agents

article

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