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List of works by Bernadette Breiden

Accumulation of glucosylceramide in the absence of the beta-glucosidase GBA2 alters cytoskeletal dynamics.

scientific article

Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.

scientific article published on 22 October 2014

Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis

scientific article published in January 2006

Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements

scientific article published on 28 January 2018

Development of an assay for the intermembrane transfer of cholesterol by Niemann-Pick C2 protein

article

Emerging mechanisms of drug-induced phospholipidosis

scientific article published on 01 December 2019

Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease

scientific article published on 26 September 2013

Ganglioside GM2 catabolism is inhibited by storage compounds of mucopolysaccharidoses and by cationic amphiphilic drugs

scientific article published on 04 May 2019

Ganglioside Metabolism and Its Inherited Diseases

scientific article published on 01 January 2018

Human acid ceramidase: processing, glycosylation, and lysosomal targeting

scientific article (publication date: 21 September 2001)

Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.

scientific article published on 3 March 2017

Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division

scientific article published on 10 April 2018

Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase.

scientific article published on 26 January 2017

Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation

scientific article

Mechanism of Secondary Ganglioside and Lipid Accumulation in Lysosomal Disease

scientific article published on 07 April 2020

Membrane lipids and their degradation compounds control GM2 catabolism at intralysosomal luminal vesicles

scientific article published on 15 April 2019

Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity

scientific article

Membrane-spanning lipids for an uncompromised monitoring of membrane fusion and intermembrane lipid transfer

scientific article published on 11 August 2015

Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation

scientific article published on 11 March 2007

Optimization of submerged keratinocyte cultures for the synthesis of barrier ceramides

scientific article published on 21 August 2007

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. ⬇️

scientific article

Physiological relevance of sphingolipid activator proteins in cultured human fibroblasts

scientific article published in March 2003

Postnatal requirement of the epithelial sodium channel for maintenance of epidermal barrier function

scientific article published on 26 November 2007

Regulation of the NPC2 protein-mediated cholesterol trafficking by membrane lipids

scientific article published on 07 January 2011

Role for LAMP-2 in endosomal cholesterol transport

scientific article published on February 2011

Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion

scientific article published on 23 February 2010

Saposin A Mobilizes Lipids from Low Cholesterol and High Bis(monoacylglycerol)phosphate-containing Membranes

scientific article published in Journal of Biological Chemistry

Saposin B mobilizes lipids from cholesterol-poor and bis(monoacylglycero)phosphate-rich membranes at acidic pH. Unglycosylated patient variant saposin B lacks lipid-extraction capacity

scientific article published on 11 June 2007

Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy

scientific article published on 18 February 2009

Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila

scientific article published on 15 October 2009

Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.

scientific article published in February 2011

Synthetic Glycoforms Reveal Carbohydrate-Dependent Bioactivity of Human Saposin D.

scientific article

TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function

scientific article published on 22 September 2011

The epidermal barrier function is dependent on the serine protease CAP1/Prss8

scientific article

The role of sphingolipid metabolism in cutaneous permeability barrier formation

scientific article published on 15 August 2013

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