List of works by Martin C Taylor

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

scholarly article

A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging

scientific article

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies

scientific article published on 12 March 2020

Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease

scholarly article by Amanda Fortes Francisco et al published October 2018 in Antimicrobial Agents and Chemotherapy

Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population

scientific article published on 2 May 2012

Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert

scientific article published on 23 January 2014

Biological factors that impinge on Chagas disease drug development

scientific article published on 23 August 2017

Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei

scientific article (publication date: February 2011)

Challenges in Chagas Disease Drug Development

scientific article published on 17 June 2020

Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue.

scientific article published on 27 June 2013

Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.

scientific article published on 2 April 2018

Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions

scientific article published on 01 January 2019

Frequent loss of the active site during variant surface glycoprotein expression site switching in vitro in Trypanosoma brucei.

scientific article published on January 1998

Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.

scientific article published on 18 August 2005

Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature

scientific article

Genetic techniques in Trypanosoma cruzi.

scientific article published on January 2011

Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole

scientific article published on 31 October 2017

Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase

scientific article (publication date: November 2013)

Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy

scientific article published on 26 February 2016

Huprines as a new family of dual acting trypanocidal-antiplasmodial agents

scientific article

Imaging the development of chronic Chagas disease after oral transmission

scientific article published in Scientific Reports

In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis

scientific article

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.

scientific article published on 28 January 2012

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection

scientific article published on 20 March 2020

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor

scientific article published in 2022

Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging

scientific article published on 26 May 2015

Lipophilic Guanylhydrazone Analogues As Promising Trypanocidal Agents: An Extended SAR Study

scientific article published on 10 February 2020

Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: an extended SAR study

scientific article published on 21 August 2017

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale

scientific article published on 23 August 2021

Mechanism of genetic exchange in American trypanosomes

scientific article published on February 2003

Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression

scientific article published on April 2007

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity

scientific article

Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity

scientific article published on 27 June 2011

Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity

scientific article published on 07 April 2019

Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation

scientific article published on 07 July 2018

Pathogen imaging applications

scientific article published in August 2017

Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs".

scientific article published on December 2015

Synthesis and Evaluation of Nifurtimox-Adamantane Adducts with Trypanocidal Activity

scientific article published on 27 May 2019

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.

scientific article

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

scientific article published on 2 December 2011

Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA

scholarly article by Andrea Bistrović et al published December 2018 in Journal of Enzyme Inhibition and Medicinal Chemistry

TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum

scientific article published on June 2002

Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.

scientific article published on 16 January 2018

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.

scientific article published on 12 February 2002

The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements

scientific article published on 29 December 2006

The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence

scientific article (publication date: April 2015)

The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase

scientific article published on November 2007

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

scientific article

Trypanocidal activity of aziridinyl nitrobenzamide prodrugs

scientific article published on 2 August 2010

Validation of spermidine synthase as a drug target in African trypanosomes.

scientific article published on January 2008

Vitamin C biosynthesis in trypanosomes: a role for the glycosome

scientific article

pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi

scientific article

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