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List of works by Giorgio Sesti

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Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6).

scientific article
Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

scientific article
Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

scientific article (publication date: October 2001)
Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents

scientific article published on 23 March 2010
Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells

scientific article published on 25 March 2004
Pathophysiology of insulin resistance.

scientific article published on December 2006
Uric acid and endothelial dysfunction in essential hypertension

scientific article published on 12 April 2006
Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension

scientific article published in August 2005
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha

scientific article
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study

scientific article
Elevated one-hour post-load plasma glucose levels identifies subjects with normal glucose tolerance but early carotid atherosclerosis

scientific article published on 11 April 2009
Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential

scientific article
Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals.

scientific article published on 12 June 2008
Metabolically Healthy but Obese Women Have an Intermediate Cardiovascular Risk Profile Between Healthy Nonobese Women and Obese Insulin-Resistant Women

scientific article published on 16 May 2007
The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes

scientific article published on 4 April 2006
A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects

scientific article published in May 2003
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study

scientific article published on 7 March 2008
Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance

scientific article published in January 2005
The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy

scientific article
A review of efficacy and safety data regarding the use of liraglutide, a once-daily human glucagon-like peptide 1 analogue, in the treatment of type 2 diabetes mellitus

scientific article
Weight loss in combination with physical activity improves endothelial dysfunction in human obesity

scientific article published in June 2003
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

scientific article
Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes

scientific article published on August 2013
C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport.

scientific article published on 6 February 2007
G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells

scientific article published on 5 January 2004
High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects

scientific article published on 12 March 2014
Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient

scientific article published in September 2002
Cardiometabolic Risk Profiles and Carotid Atherosclerosis in Individuals With Prediabetes Identified by Fasting Glucose, Postchallenge Glucose, and Hemoglobin A1c Criteria

scientific article published on March 7, 2012
Heterogeneous effect of peroxisome proliferator-activated receptor gamma2 Ala12 variant on type 2 diabetes risk

scientific article published on 01 May 2007
The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.

scientific article
Endothelial dysfunction and subsequent decline in glomerular filtration rate in hypertensive patients

scientific article published on 12 July 2010
Endothelial dysfunction, ADMA and insulin resistance in essential hypertension

scientific article published on 24 January 2009
Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type 2 (non-insulin-dependent) diabetic subjects

scientific article published on July 1993
Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells

scientific article published on 22 January 2007
One-Hour Postload Plasma Glucose Levels and Left Ventricular Mass in Hypertensive Patients

scientific article published on April 22, 2011
Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus

scientific article
C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance.

scientific article published in August 2005
Pulse pressure and endothelial dysfunction in never-treated hypertensive patients.

scientific article published in May 2003
The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

scientific article
Nonalcoholic fatty liver disease is associated with low circulating levels of insulin-like growth factor-I.

scientific article
Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms

scientific article published on September 1, 2001
A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

scientific article published on 26 November 2007
Endothelial dysfunction and C-reactive protein are risk factors for diabetes in essential hypertension

scientific article published on 10 October 2007
An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics

scientific article published on 30 October 2009
Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study

scientific article
Endogenous testosterone and endothelial function in postmenopausal women

scientific article published in February 2007
The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes

scientific article
One-hour postload plasma glucose levels are associated with kidney dysfunction

scientific article
Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues

scientific article published on 01 May 1997
Insulin sensitivity, β-cell function, and incretin effect in individuals with elevated 1-hour postload plasma glucose levels.

scientific article published on 22 February 2012

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