List of works - Thomas Kukar

Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice

scientific article

Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators

scientific article published on 20 March 2014

Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferase

scientific article

Crystallization and preliminary X-ray crystallographic studies on recombinant rat choline acetyltransferase

scientific article published on 23 January 2004

Disulfide bonds and disorder in granulin-3: An unusual handshake between structural stability and plasticity

scientific article published on 12 June 2017

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

scientific article (publication date: May 2005)

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis

scientific article

FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

article by Daniel J Klionsky et al published January 2021 in Autophagy

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase

scientific article published on 21 April 2008

Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

scientific article

Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations

scientific article published on July 2017

Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane re

scientific article published on 25 August 2011

Medicine. Avoiding unintended toxicity

scientific article published in May 2009

Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily

scientific article

Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations

scientific article published on 07 October 2020

Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.

scientific article

Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.

scientific article published on January 2008

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells

scientific article published on May 2013

Protein microarrays to detect protein-protein interactions using red and green fluorescent proteins.

scientific article

Short Aβ peptides attenuate Aβ42 toxicity in vivo.

scientific article published on 5 December 2017

Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein ⬇️

scientific article published on August 25, 2011

Substrate-targeting gamma-secretase modulators

scientific article published on June 2008

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

scientific article

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia

scientific article

List of works by Thomas Kukar

Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice

Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators

Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferase

Crystallization and preliminary X-ray crystallographic studies on recombinant rat choline acetyltransferase

Disulfide bonds and disorder in granulin-3: An unusual handshake between structural stability and plasticity

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis

FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase

Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations

Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane re

Medicine. Avoiding unintended toxicity

Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily

Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations

Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.

Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells

Protein microarrays to detect protein-protein interactions using red and green fluorescent proteins.

Short Aβ peptides attenuate Aβ42 toxicity in vivo.

Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein ⬇️

Substrate-targeting gamma-secretase modulators

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia