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List of works by Timothy E. Hardingham

Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage

scientific article

Alternative splicing in the aggrecan G3 domain influences binding interactions with tenascin-C and other extracellular matrix proteins

scientific article

Arterial mesenchyme and arteriosclerosis. Some aspects of the organization and interaction of connective tissue proteoglycans

scientific article

Articular cartilage cultured with interleukin 1. Increased release of link protein, hyaluronate-binding region and other proteoglycan fragments

scientific article published on September 1986

Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin

scientific article published on 28 April 2014

Binding of oligosaccharides of hyaluronic acid to proteoglycans

scientific article

Biosynthesis of proteoglycans in cartilage.

scientific article

Bone marrow-derived mesenchymal stem cells express the pericyte marker 3G5 in culture and show enhanced chondrogenesis in hypoxic conditions

article

Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus

scientific article

Cartilage proteoglycan depletion in acute and chronic antigen-induced arthritis

scientific article published on 01 May 1989

Cartilage proteoglycans. Structure and heterogeneity of the protein core and the effects of specific protein modifications on the binding to hyaluronate ⬇️

scientific article published on July 1, 1976

Cartilage proteoglycans: structure, interactions and organization

scientific article published in January 1977

Cartilage repair using human embryonic stem cell-derived chondroprogenitors

scientific article

Cartilage tissue engineering approaches applicable in orthopaedic surgery: the past, the present, and the future

scientific article published on January 2012

Cartilage, SOX9 and Notch signals in chondrogenesis

scientific article published on October 2006

Cell- and Tissue-Based Approaches for Cartilage Repair ⬇️

scientific article published on 01 December 2010

Cellular methods in cartilage research: primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells

scientific article published on May 2008

Changes in chondroitin sulphate structure induced by joint disease

Changes in chondroitin sulphate structure induced by joint disease.

scientific article published on October 1995

Changes in glycosaminoglycan epitope levels in knee joint fluid following injury

scientific article published on 01 July 1995

Changes in proteoglycan turnover in experimental canine osteoarthritic cartilage

scientific article published in April 1992

Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of Sox-9 transcription factor.

scientific article

Chondrocyte responses in cartilage and in experimental osteoarthritis

scientific article published on January 1991

Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly.

scientific article published on 7 July 2016

Chondrogenic differentiation of human bone marrow stem cells in transwell cultures: generation of scaffold-free cartilage

scientific article published on 26 July 2007

Chondroitin sulfate and joint disease ⬇️

scientific article published on May 1, 1998

Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva

scientific article

Confocal-FRAP analysis of ECM molecular interactions.

scientific article

Dermatan sulphate proteoglycan from human articular cartilage. Variation in its content with age and its structural comparison with a small chondroitin sulphate proteoglycan from pig laryngeal cartilage

scientific article published on September 1988

Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes.

scientific article published on 7 August 2006

Directed differentiation of human embryonic stem cells toward chondrocytes

scientific article published on 22 October 2010

Effect of Alpinia galanga extract on cartilage degradation and on gene expression in human chondrocyte and synovial fibroblast metabolism

article

Electric birefringence studies of cartilage proteoglycan aggregation

scientific article published on 01 June 1977

Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis

scientific article published on 01 June 1993

Equilibrium-binding studies of pig laryngeal cartilage proteoglycans with hyaluronate oligosaccharide fractions

scientific article

Extending the Paradigm of Osteoarthritis: Comment on the Editorial by McAlindon

scientific article published on 01 March 2016

Extracellular matrix and pathogenic mechanisms in osteoarthritis

scientific article published on January 2008

Fat pad-derived mesenchymal stem cells as a potential source for cell-based adipose tissue repair strategies.

scientific article published on 20 January 2012

Fell-Muir lecture: cartilage 2010 - the known unknowns

scientific article

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

scientific article

Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses

scientific article published on 10 March 2016

Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy.

scientific article

Generating cartilage repair from pluripotent stem cells

scientific article

Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants.

scientific article

Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2.

scientific article published on 3 July 2008

Human link protein gene: structure and transcription pattern in chondrocytes

scientific article

Human meniscus cells express hypoxia inducible factor-1alpha and increased SOX9 in response to low oxygen tension in cell aggregate culture

scientific article published on January 2007

Hyaluronan binding to link module of TSG-6 and to G1 domain of aggrecan is differently regulated by pH.

scientific article

Hyaluronic acid in cartilage and proteoglycan aggregation

scientific article published on June 1974

Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes

scientific article published on 5 August 2009

Hypoxic conditions increase hypoxia-inducible transcription factor 2alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients

scientific article published on January 2007

Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein

scientific article

Increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis does not reflect a permanent change in chondrocyte phenotype

scientific article published on 01 April 1995

Increased release of matrix components from articular cartilage in experimental canine osteoarthritis

scientific article published on 01 May 1992

Inhibition of interleukin-1-induced synovitis and articular cartilage proteoglycan loss in the rabbit knee by recombinant human interleukin-1 receptor antagonist.

scientific article published on May 1991

Isabella Helen Mary Muir CBE. 20 August 1920—28 November 2005

Biographical article

Isolation and sequence of cDNA clones for pig and human cartilage link protein

Macromolecular diffusion of biological polymers measured by confocal fluorescence recovery after photobleaching

scientific article

Mesenchymal stem cells, sources of cells and differentiation potential

scientific article published on January 2012

Modulation of native chondroitin sulphate structure in tissue development and in disease

scientific article published in November 1990

Molecular conformations in proteoglycan aggregation

scientific article

Neutron and X-ray solution-scattering studies of the ternary complex between proteoglycan-binding region, link protein and hyaluronan ⬇️

scientific article published on July 1, 1992

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

scientific article

New approaches to the investigation of hyaluronan networks

scientific article

Notch signaling during chondrogenesis of human bone marrow stem cells

scientific article published on 4 May 2009

Notch signaling through Jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis

scientific article published on 10 January 2008

Novel confocal-FRAP analysis of carbohydrate-protein interactions within the extracellular matrix

scientific article published on 01 January 2001

Order within disorder: aggrecan chondroitin sulphate-attachment region provides new structural insights into protein sequences classified as disordered

scientific article published on December 2010

PhenomeExpress: a refined network analysis of expression datasets by inclusion of known disease phenotypes

scientific article

PhenomeScape: a cytoscape app to identify differentially regulated sub-networks using known disease associations.

scientific article

Physical properties of the hyaluronate binding region of proteoglycan from pig laryngeal cartilage

scientific article published on 01 July 1981

Proteoglycan biosynthesis in chondrocytes: protein A-gold localization of proteoglycan protein core and chondroitin sulfate within Golgi subcompartments.

scientific article published on December 1985

Proteoglycans of cartilage: An assessment of their structure

scientific article published on 01 February 1971

Proteoglycans: many forms and many functions

scientific article published on February 1992

Raised chondroitin sulfate epitopes and hyaluronan in serum from rheumatoid arthritis and osteoarthritis patients

scientific article published on 23 November 2005

Raised serum chondroitin sulfate epitope level in ovarian epithelial cancer

scientific article published on 26 August 2006

Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization

scientific article published on 18 October 2006

Replacement of proteoglycans in embryonic chick cartilage in organ culture after treatment with testicular hyaluronidase

scientific article published on August 1972

Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes

scientific article published in January 2005

SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription

scientific article published in September 2008

SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis

scientific article

Separate effects of exogenous hyaluronic acid on proteoglycan synthesis and deposition in pericellular matrix by cultured chick embryo limb chondrocytes

scientific article published on 01 March 1980

Solution structure and dynamics of cartilage aggrecan

scientific article published in July 2006

Stem cell applications and tissue engineering approaches in surgical practice

scientific article published on 01 April 2009

Stratification of knee osteoarthritis: two major patient subgroups identified by genome-wide expression analysis of articular cartilage.

scientific article published on 22 December 2017

Structural and immunological studies of keratan sulphates from mature bovine articular cartilage

scientific article published on May 1989

Structure and stability of proteoglycan aggregates.

scientific article

Studies on the G3 Domain of Aggrecan from Human Cartilagea

scientific article published on 01 June 1996

The Folded Protein Modules of the C-terminal G3 Domain of Aggrecan Can Each Facilitate the Translocation and Secretion of the Extended Chondroitin Sulfate Attachment Sequence

scientific article published in Journal of Biological Chemistry

The characterisation of mesenchymal stem cells: a stem cell is not a stem cell is not a stem cell

scientific article published on January 2012

The detection of substructures within proteoglycan molecules. Electron-microscopic immuno-localization with the use of Protein A-gold

scientific article published on October 1987

The development of a mature collagen network in cartilage from human bone marrow stem cells in Transwell culture.

scientific article published on 30 October 2015

The effect of temperature on the biosynthesis of chondroitin 4-sulphate in cartilage slices in vitro

scientific article published on 01 September 1970

The epitope characterisation and the osteogenic differentiation potential of human fat pad-derived stem cells is maintained with ageing in later life

scientific article

The formation of proteoglycan aggregates in vitro

The influence of donor and hypoxic conditions on the assembly of cartilage matrix by osteoarthritic human articular chondrocytes on Hyalograft matrices

scientific article published on 05 November 2008

The influence of link protein stabilization on the viscometric properties of proteoglycan aggregate solutions

scientific article published on 01 August 1989

The intracellular localisation of proteoglycans and their accumulation in chondrocytes treated with monensin

scientific article published on 01 February 1985

The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia

scientific article published on 17 March 2006

The molecular basis of the solution properties of hyaluronan investigated by confocal fluorescence recovery after photobleaching

scientific article published on October 1999

The potential of stem cells in the treatment of knee cartilage defects

scientific article published on 03 January 2010

The primary structure of human cartilage link protein

scientific article

The primary structure of human cartilage link protein

scientific article (published 1990-03-11)

The recovery of articular cartilage in explant culture from interleukin-1α: Effects on proteoglycan synthesis and degradation

article

The structure of aggrecan and its turnover in cartilage

scientific article published on 01 February 1995

The sulphation pattern in chondroitin sulphate chains investigated by chondroitinase ABC and ACII digestion and reactivity with monoclonal antibodies

scientific article published on 01 March 1994

The viscoelasticity of self-assembled proteoglycan combs.

scientific article published on January 2008

Tissue engineering: chondrocytes and cartilage

scientific article

Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9.

scientific article

Tumour necrosis factor alpha stimulates nitric oxide production more potently than interleukin-1beta in porcine articular chondrocytes.

scientific article published in August 2002

Two related but distinct chondroitin sulfate mimetope octasaccharide sequences recognized by monoclonal antibody WF6.

scientific article

View from a small island

scientific article published in December 2003

Viscoelastic properties of proteoglycan solutions with varying proportions present as aggregates

scientific article published in January 1987

X-ray fibre diffraction of cartilage proteoglycan aggregates containing hyaluronic acid

scientific article published on September 1974

[Repair of the articular cartilage after exposure to interleukin-1]

scientific article published on 01 December 1996

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