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List of works by Eugenio Montini

A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin

scientific article

AAV serotype 2 vectors preferentially integrate into active genes in mice

scientific article published on July 2003

Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation

scientific article

Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy

scientific article published in June 2012

Chromosomal integration of adenoviral vector DNA in vivo.

scientific article published on 4 August 2010

Comprehensive genomic access to vector integration in clinical gene therapy

scientific article published on 22 November 2009

Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells

scientific article published on October 2014

De(bar)coding aged hematopoiesis in primates

scientific article published on 01 March 2018

Exclusion of PPEF as the gene causing X-linked juvenile retinoschisis

scientific article published in December 1997

Genotoxicity assay for gene therapy vectors in tumor prone Cdkn2a⁻/⁻ mice.

scientific article published in January 2012

Helper-independent and AAV-ITR-independent chromosomal integration of double-stranded linear DNA vectors in mice.

scientific article published in January 2003

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

scientific article (publication date: June 2006)

Identification and characterization of a novel serine-threonine kinase gene from the Xp22 region

scientific article

Identification of SCML2, a second human gene homologous to the Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22

scientific article

Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform

scientific article published on 13 June 2016

In vivo correction of murine tyrosinemia type I by DNA-mediated transposition.

scientific article

In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells

scientific article published on February 2015

Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy.

scientific article

Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial.

scientific article published on 8 June 2016

Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy

scientific article

Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.

scientific article

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

scientific article published on 14 March 2011

Lentiviral vector integration profiles differ in rodent postmitotic tissues

scientific article

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer

scientific article published on 13 January 2013

Lentiviral vector-based insertional mutagenesis identifies genes involved in the resistance to targeted anticancer therapies

scientific article published on 8 September 2014

Liver-directed lentiviral gene therapy in a dog model of hemophilia B.

scientific article

Low therapeutic threshold for hepatocyte replacement in murine phenylketonuria.

scientific article published on August 2005

MID2, a homologue of the Opitz syndrome gene MID1: similarities in subcellular localization and differences in expression during development

scientific article

Opitz G/BBB syndrome in Xp22: mutations in the MID1 gene cluster in the carboxy-terminal domain

scientific article

Pervasive supply of therapeutic lysosomal enzymes in the CNS of normal and Krabbe-affected non-human primates by intracerebral lentiviral gene therapy

scientific article published on 29 March 2016

Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome

scientific article

Preclinical testing of the safety and tolerability of LV-mediated above normal alpha-L-iduronidase expression in murine and human hematopoietic cells using toxicology and biodistribution GLP studies

scientific article published on 18 July 2016

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

scientific journal article

Quest for safety at AAValon

scientific article published on March 24, 2011

Relevance of an academic GMP Pan-European vector infra-structure (PEVI).

scientific article published on December 2010

Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency

scientific article

Shedding of clinical-grade lentiviral vectors is not detected in a gene therapy setting.

scientific article

Targeted genome editing in human repopulating haematopoietic stem cells

scientific article published on 28 May 2014

Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development

scientific article published on 11 February 2008

The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis

scientific article published on 13 November 2012

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

scientific article published on 23 March 2009

The mouse Mid1 gene: implications for the pathogenesis of Opitz syndrome and the evolution of the mammalian pseudoautosomal region

scientific article published in March 1998

Therapeutic benefit of lentiviral-mediated neonatal intracerebral gene therapy in a mouse model of globoid cell leukodystrophy

scientific article

Unaltered repopulation properties of mouse hematopoietic stem cells transduced with lentiviral vectors.

scientific article published on 06 August 2008

Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo

scientific article

VISPA: a computational pipeline for the identification and analysis of genomic vector integration sites

scientific article published on 3 September 2014

Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.

scientific article published on 23 April 2012

Wiskott-Aldrich syndrome protein deficiency in natural killer and dendritic cells affects antitumor immunity

scientific article published on 13 January 2014

adLIMS: a customized open source software that allows bridging clinical and basic molecular research studies

scientific article published on June 2015

miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia

scientific article published in June 2016