List of works - Afshin Samali

40- to 100-kD protein(s) of Helicobacter pylori stimulate DNA synthesis in epithelial cell lines without affecting apoptosis.

scientific article

A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy.

scientific article published on 2 December 2014

Addicted to secrete - novel concepts and targets in cancer therapy

scientific article published on 20 January 2014

An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro.

scientific article published on 29 August 2011

Antioxidant-mediated inhibition of the heat shock response leads to apoptosis

scientific article published on 01 February 1999

Apoptosis -- the story so far....

scientific article

Apoptosis: a mapped path to cell death

scientific article published on 16 November 2007

Apoptosis: cell death defined by caspase activation

scientific article published on 01 June 1999

Assays for detecting the unfolded protein response.

scientific article

BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1.

scientific article published on 25 August 2015

Bcl-2 family on guard at the ER.

scientific article published on 11 March 2009

Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain

scientific article published on 16 October 2018

Bisphenol A-mediated suppression of LPL gene expression inhibits triglyceride accumulation during adipogenic differentiation of human adult stem cells

scientific article

CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization.

scientific article

Caspase-12 and ER-stress-mediated apoptosis: the story so far.

scientific article

Caspases: their intracellular localization and translocation during apoptosis.

scientific article published in July 1999

Cell stress and cell death

scientific article

Cellular longevity: role of apoptosis and replicative senescence

scientific article

Cellular stress responses: cell survival and cell death

scientific article

Cleavage of the calpain inhibitor, calpastatin, during apoptosis

scientific article published on 01 December 1998

Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling

scientific article

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.

scientific article published in June 2019

Controlling the unfolded protein response-mediated life and death decisions in cancer.

scientific article published on 23 March 2015

Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β

scientific article published on 06 January 2020

Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL.

scientific article published on 10 December 2007

DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design

scientific article

Decorated macrocycles via ring-closing double-reductive amination. identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor.

scientific article published on 16 March 2015

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.

scientific article published on 8 June 2015

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

scientific article published in January 2014

Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph(+) leukemia.

scientific article published on January 2015

Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor

scholarly article

Detection of pro-caspase-3 in cytosol and mitochondria of various tissues

scientific article published in July 1998

Determination of apoptosis and necrosis

scientific article published in May 2001

Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL.

scientific article published on July 2006

Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines.

scientific article published on 07 April 2009

Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion

scientific article

Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins.

scientific article

Don't lose heart--therapeutic value of apoptosis prevention in the treatment of cardiovascular disease.

scientific article

Downregulation of miR-17-92 Cluster by PERK Fine-Tunes Unfolded Protein Response Mediated Apoptosis

scientific article published on 06 January 2021

Drugging the unfolded protein response in acute leukemias

scientific article (publication date: 2015)

Dual IRE1 RNase functions dictate glioblastoma development.

scientific article published on 8 January 2018

ER stress contributes to ischemia-induced cardiomyocyte apoptosis

scientific journal article

ER stress responses in the absence of apoptosome: A comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts

article

Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells.

scientific article

Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma.

scientific article published on 31 May 2013

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells

scientific article

Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications

scientific article published on 04 August 2018

Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis.

scientific article published on 14 May 2015

Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival

scientific article published on 22 February 2016

Endoplasmic reticulum stress: at the crossroads of inflammation and metabolism in hepatocellular carcinoma development

scientific article published on 01 September 2014

Enhanced antitumor efficacy of a DR5-specific TRAIL variant over recombinant human TRAIL in a bioluminescent ovarian cancer xenograft model.

scientific article published on 10 March 2009

Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.

scientific article

Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine

scientific article published on 30 October 2006

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction

scientific article published in 2010

HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis.

scientific article published on 31 August 2017

Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM.

scientific article published on 17 September 2014

Heat shock protects PC12 cells against MPP+ toxicity

scientific article

Heat shock proteins increase resistance to apoptosis.

scientific article published on February 1996

Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response

scientific article

Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells

scientific article published in February 2005

Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c.

scientific article published in January 2001

Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes.

scientific article published on December 2003

Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation

scientific article published in March 2007

Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats.

scientific article published on 11 October 2012

In the cut and thrust of apoptosis, serine proteases come of age.

scientific article published on October 2003

Increased Expression of Endoplasmic Reticulum Stress-Related Signaling Pathway Molecules in Multiple Sclerosis Lesions

scientific article published on 01 March 2008

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

scientific article published in Nature Communications

Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β

scientific article published on 16 August 2019

Interleukin-1, interleukin-8, tumour necrosis factor alpha and interferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines.

scientific article published in May 2001

Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?

scientific article published on August 2009

Ischemia/reperfusion injury at the intersection with cell death.

scientific article

Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells.

scientific article published on 18 July 2011

Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors

scientific article published on 04 March 2019

Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment.

scientific article

Methods for monitoring endoplasmic reticulum stress and the unfolded protein response. ⬇️

scientific article

Methods for studying ER stress and UPR markers in human cells.

scientific article published in January 2015

NOXA contributes to the sensitivity of PERK-deficient cells to ER stress.

scientific article

Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim

scientific journal article

Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner. ⬇️

scientific article

Novel roles of the unfolded protein response in the control of tumor development and aggressiveness.

scientific article published on 05 May 2015

On the role of Hsp27 in regulating apoptosis

scientific article (publication date: 2003)

OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/- mice aortas

scientific article published on 12 March 2007

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

scientific article

PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response.

scientific article

Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression

scientific article published on 01 December 1999

Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim.

scientific article published on 2 August 2013

RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells

scientific article published on 5 February 2018

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions

scientific article published on 25 June 2015

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions.

scientific article published on 4 December 2014

Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants.

scientific article

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

scientific article published on 06 May 2022

Regulation of apoptosis by heat shock proteins

scientific article published on 26 May 2014

Regulation of lipid metabolism by the unfolded protein response

scientific article published on 04 January 2021

Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML

scientific article published in Scientific Reports

Role of Bcr-Abl kinase in resistance to apoptosis

scientific article published on January 1997

Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase

scientific article published in July 2007

Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells

scientific article published on 22 October 2020

Stem cells are resistant to TRAIL receptor-mediated apoptosis.

scientific article published in November 2009

Stress management at the ER: regulators of ER stress-induced apoptosis

scientific article published on 17 February 2012

Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress

scientific article published on 28 September 2012

Stressed to death - mechanisms of ER stress-induced cell death.

scientific article published on January 2014

Synthetic constrained peptide selectively binds and antagonizes death receptor 5.

scientific article

TRAIL receptor signalling and modulation: Are we on the right TRAIL?

scientific article

TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt.

scientific article

Targeting AML through DR4 with a novel variant of rhTRAIL

scientific article

Targeting the angio-proteostasis network: Combining the forces against cancer

scientific article published on 21 July 2016

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

scientific article published on 14 October 2009

The IRE1 and PERK arms of the unfolded protein response promote survival of rhabdomyosarcoma cells

scientific article published on 14 July 2020

The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis.

scientific article published on 15 March 2011

The Unfolded Protein Response in Breast Cancer

scientific article published on 21 September 2018

The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation

scientific article published on 01 May 1997

The eIF2α kinases: their structures and functions

scientific article published on 26 January 2013

The integrated stress response.

scientific article published on 14 September 2016

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance

article

The switch from survival responses to apoptosis after chromosomal breaks

scientific article published in August 2004

The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress.

scientific article published on 29 February 2012

The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors

scientific article published on 01 April 2019

Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins.

scientific article

Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders

scientific article published on October 2011

miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts.

scientific article

List of works by Afshin Samali

40- to 100-kD protein(s) of Helicobacter pylori stimulate DNA synthesis in epithelial cell lines without affecting apoptosis.

A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy.

Addicted to secrete - novel concepts and targets in cancer therapy

An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro.

Antioxidant-mediated inhibition of the heat shock response leads to apoptosis

Apoptosis -- the story so far....

Apoptosis: a mapped path to cell death

Apoptosis: cell death defined by caspase activation

Assays for detecting the unfolded protein response.

BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1.

Bcl-2 family on guard at the ER.

Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain

Bisphenol A-mediated suppression of LPL gene expression inhibits triglyceride accumulation during adipogenic differentiation of human adult stem cells

CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization.

Caspase-12 and ER-stress-mediated apoptosis: the story so far.

Caspases: their intracellular localization and translocation during apoptosis.

Cell stress and cell death

Cellular longevity: role of apoptosis and replicative senescence

Cellular stress responses: cell survival and cell death

Cleavage of the calpain inhibitor, calpastatin, during apoptosis

Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.

Controlling the unfolded protein response-mediated life and death decisions in cancer.

Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β

Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL.

DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design

Decorated macrocycles via ring-closing double-reductive amination. identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor.

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph(+) leukemia.

Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor

Detection of pro-caspase-3 in cytosol and mitochondria of various tissues

Determination of apoptosis and necrosis

Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL.

Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines.

Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion

Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins.

Don't lose heart--therapeutic value of apoptosis prevention in the treatment of cardiovascular disease.

Downregulation of miR-17-92 Cluster by PERK Fine-Tunes Unfolded Protein Response Mediated Apoptosis

Drugging the unfolded protein response in acute leukemias

Dual IRE1 RNase functions dictate glioblastoma development.

ER stress contributes to ischemia-induced cardiomyocyte apoptosis

ER stress responses in the absence of apoptosome: A comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts

Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells.

Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma.

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells

Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications

Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis.

Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival

Endoplasmic reticulum stress: at the crossroads of inflammation and metabolism in hepatocellular carcinoma development

Enhanced antitumor efficacy of a DR5-specific TRAIL variant over recombinant human TRAIL in a bioluminescent ovarian cancer xenograft model.

Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.

Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction

HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis.

Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM.

Heat shock protects PC12 cells against MPP+ toxicity

Heat shock proteins increase resistance to apoptosis.

Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response

Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells

Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c.

Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes.

Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation

Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats.

In the cut and thrust of apoptosis, serine proteases come of age.

Increased Expression of Endoplasmic Reticulum Stress-Related Signaling Pathway Molecules in Multiple Sclerosis Lesions

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β

Interleukin-1, interleukin-8, tumour necrosis factor alpha and interferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines.

Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?

Ischemia/reperfusion injury at the intersection with cell death.

Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells.

Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors

Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment.

Methods for monitoring endoplasmic reticulum stress and the unfolded protein response. ⬇️

Methods for studying ER stress and UPR markers in human cells.

NOXA contributes to the sensitivity of PERK-deficient cells to ER stress.

Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim