List of works - Martin Holcik

A novel cis-acting element from the 3'UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression

scientific article published on 19 April 2013

A novel plasmid gene involved in bacteriophage PRD1 infection and conjugative host-range

article

A search for structurally similar cellular internal ribosome entry sites.

scientific article

An oxygen-regulated switch in the protein synthesis machinery ⬇️

scientific article published on May 6, 2012

Apoptosis: don't get mad, get even!

scientific article published on 01 August 2001

Assessment of selective mRNA translation in mammalian cells by polysome profiling

scientific article

Bacterial DNA Protects Monocytic Cells against HIV-Vpr-Induced Mitochondrial Membrane Depolarization.

scientific article

Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation ⬇️

scientific article published on May 7, 2013

Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation.

scientific article published on February 2016

Characterizing Cellular Responses During Oncolytic Maraba Virus Infection ⬇️

article

Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes

scientific article

Conditionally lethal genes associated with bacterial plasmids ⬇️

scientific article published on November 1, 1997

Conditionally lethal genes in the N pilus region of plasmid pCU1

article

Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?

scientific article

Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs.

scientific article

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation

scientific article

DNM1L-related mitochondrial fission defect presenting as refractory epilepsy

scientific article

Detailed Biochemical and Bioenergetic Characterization of FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion

scientific article published on 25 September 2015

Diseases Associated with Defects in tRNA CCA Addition

scientific article published on 27 May 2020

Distinct patterns of expression of the inhibitor of apoptosis protein cIAP2 during murine embryogenesis

scientific article published in July 2006

Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1.

scientific article published on 27 November 2002

Distinct roles for the cellular inhibitors of apoptosis proteins 1 and 2 ⬇️

scientific article published on March 24, 2011

Drosophila veto puts a stop to cell survival

scientific article published in May 2002

ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism

scientific article published on 22 November 2015

Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial

scientific article

Elevated levels of ribosomal proteins eL36 and eL42 control expression of Hsp90 in rhabdomyosarcoma

scientific article published on 4 October 2016

Endogenous expression of inhibitor of apoptosis proteins in facial motoneurons of neonatal and adult rats following axotomy

scientific journal article

Engaging Cell Death Pathways for the Treatment of Rhabdomyosarcoma

scientific article published in January 2016

Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination

scientific article published on 01 June 2008

For IRES trans-acting factors, it is all about location.

scientific article published on 03 September 2007

Four highly stable eukaryotic mRNAs assemble 3' untranslated region RNA-protein complexes sharing cis and trans components.

scientific article

Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation

scientific article

Heavy metal sensitivities of gene deletion strains for ITT1 and RPS1A connect their activities to the expression of URE2, a key gene involved in metal detoxification in yeast

scientific article published in PLoS ONE

Hexokinase 2 controls cellular stress response through localization of an RNA-binding protein

scientific article

HuR controls mitochondrial morphology through the regulation of BclxL translation.

scientific article

IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1.

scientific article published on 7 April 2014

IRES in distress: translational regulation of the inhibitor of apoptosis proteins XIAP and HIAP2 during cell stress

scientific article published on 01 June 2005

IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress.

scientific article published on 14 September 2011

Impaired activity of CCA-adding enzyme TRNT1 impacts OXPHOS complexes and cellular respiration in SIFD patient-derived fibroblasts.

scientific article published on 18 June 2016

Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival

scientific article published in January 2006

Internal ribosome entry site-mediated translation of Apaf-1, but not XIAP, is regulated during UV-induced cell death.

scientific article published on 4 April 2006

Internal ribosome initiation of translation and the control of cell death.

scientific article

Involvement of yeast HSP90 isoforms in response to stress and cell death induced by acetic acid

scientific article

Lethality and survival of Klebsiella oxytoca evoked by conjugative IncN group plasmids ⬇️

scientific article published on November 1, 1995

Lithium Chloride Sensitivity in Yeast and Regulation of Translation

scientific article published on 10 August 2020

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation ⬇️

scientific article published on September 1, 2013

Loss of cellular inhibitor of apoptosis protein 2 reduces atherosclerosis in atherogenic apoE-/- C57BL/6 mice on high-fat diet

scientific article published on 26 September 2013

Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD)

scientific article

New ways of initiating translation in eukaryotes.

scientific article published on December 2001

Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon

scientific article published on 5 November 2012

Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model

scientific article published on 10 December 2016

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

scientific article

Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

scientific article

Placenta nutrient transport-related gene expression: the impact of maternal obesity and excessive gestational weight gain.

scientific article published on 11 June 2015

Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins

scientific article published on 09 July 2008

Posttranscriptional Regulation of Collagen α1(I) mRNA in Hepatic Stellate Cells ⬇️

scientific article published on September 1, 1997

Prenatal physical activity and diet composition affect the expression of nutrient transporters and mTOR signaling molecules in the human placenta.

scientific article published on 4 December 2014

Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway.

scientific article

RNA structure: new messages in translation, replication and disease. Workshop on the role of RNA structures in the translation of viral and cellular RNAs.

scientific article published on 03 April 2009

RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation.

scientific article

RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha

scientific article

Spurious splicing within the XIAP 5' UTR occurs in the Rluc/Fluc but not the betagal/CAT bicistronic reporter system

scientific article

Strong eukaryotic IRESs have weak secondary structure

scientific article

Structure and mode of action of kikA, a genetic region lethal to Klebsiella oxytoca and associated with conjugative antibiotic-resistance plasmids of the IncN group

scientific article published on May 1996

Subcellular relocalization of a trans-acting factor regulates XIAP IRES-dependent translation.

scientific article published on 7 February 2007

Targeting endogenous inhibitors of apoptosis for treatment of cancer, stroke and multiple sclerosis.

scientific article published on June 2004

The IAP proteins

scientific article published in October 2002

The eIF4G homolog DAP5/p97 supports the translation of select mRNAs during endoplasmic reticulum stress.

scientific article published on 14 November 2007

The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2.

scientific article

The role of IRES trans-acting factors in carcinogenesis.

scientific article published on 23 September 2014

The sensitivity of the yeast, Saccharomyces cerevisiae, to acetic acid is influenced by DOM34 and RPL36A.

scientific article published on 14 November 2017

The translation of an antiapoptotic protein HIAP2 is regulated by an upstream open reading frame

scientific article published on August 2003

The utrophin A 5'-UTR drives cap-independent translation exclusively in skeletal muscles of transgenic mice and interacts with eEF1A2

scientific article published on 6 January 2010

The utrophin A 5'-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers.

scientific article

Translation control in apoptosis

scientific article published on October 1, 2012

Translation mechanism and regulation: old players, new concepts. Meeting on translational control and non-coding RNA.

scientific article published on 15 June 2007

Translational control in stress and apoptosis

scientific article (publication date: April 2005)

Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element.

scientific article published on 11 February 2004

Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6: a novel mechanism of tumor cell survival

scientific article published in February 2004

Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death.

scientific article published in August 2000

Translational upregulation of the X-linked inhibitor of apoptosis.

scientific article published on December 2003

Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2.

scientific article

VPAC2 receptor agonist BAY 55-9837 increases SMN protein levels and moderates disease phenotype in severe spinal muscular atrophy mouse models

scientific article published on 9 January 2014

XIAP, the guardian angel

scientific article published on 01 July 2001

XIAP: apoptotic brake and promising therapeutic target.

scientific article

hnRNP A1 regulates UV-induced NF-kappaB signalling through destabilization of cIAP1 mRNA.

scientific article published on 10 October 2008

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

scientific article

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

scientific article

List of works by Martin Holcik

A novel cis-acting element from the 3'UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression

A novel plasmid gene involved in bacteriophage PRD1 infection and conjugative host-range

A search for structurally similar cellular internal ribosome entry sites.

An oxygen-regulated switch in the protein synthesis machinery ⬇️

Apoptosis: don't get mad, get even!

Assessment of selective mRNA translation in mammalian cells by polysome profiling

Bacterial DNA Protects Monocytic Cells against HIV-Vpr-Induced Mitochondrial Membrane Depolarization.

Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation ⬇️

Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation.

Characterizing Cellular Responses During Oncolytic Maraba Virus Infection ⬇️

Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes

Conditionally lethal genes associated with bacterial plasmids ⬇️

Conditionally lethal genes in the N pilus region of plasmid pCU1

Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?

Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs.

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation

DNM1L-related mitochondrial fission defect presenting as refractory epilepsy

Detailed Biochemical and Bioenergetic Characterization of FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion

Diseases Associated with Defects in tRNA CCA Addition

Distinct patterns of expression of the inhibitor of apoptosis protein cIAP2 during murine embryogenesis

Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1.

Distinct roles for the cellular inhibitors of apoptosis proteins 1 and 2 ⬇️

Drosophila veto puts a stop to cell survival

ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism

Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial

Elevated levels of ribosomal proteins eL36 and eL42 control expression of Hsp90 in rhabdomyosarcoma

Endogenous expression of inhibitor of apoptosis proteins in facial motoneurons of neonatal and adult rats following axotomy

Engaging Cell Death Pathways for the Treatment of Rhabdomyosarcoma

Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination

For IRES trans-acting factors, it is all about location.

Four highly stable eukaryotic mRNAs assemble 3' untranslated region RNA-protein complexes sharing cis and trans components.

Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation

Heavy metal sensitivities of gene deletion strains for ITT1 and RPS1A connect their activities to the expression of URE2, a key gene involved in metal detoxification in yeast

Hexokinase 2 controls cellular stress response through localization of an RNA-binding protein

HuR controls mitochondrial morphology through the regulation of BclxL translation.

IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1.

IRES in distress: translational regulation of the inhibitor of apoptosis proteins XIAP and HIAP2 during cell stress

IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress.

Impaired activity of CCA-adding enzyme TRNT1 impacts OXPHOS complexes and cellular respiration in SIFD patient-derived fibroblasts.

Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival

Internal ribosome entry site-mediated translation of Apaf-1, but not XIAP, is regulated during UV-induced cell death.

Internal ribosome initiation of translation and the control of cell death.

Involvement of yeast HSP90 isoforms in response to stress and cell death induced by acetic acid

Lethality and survival of Klebsiella oxytoca evoked by conjugative IncN group plasmids ⬇️

Lithium Chloride Sensitivity in Yeast and Regulation of Translation

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation ⬇️

Loss of cellular inhibitor of apoptosis protein 2 reduces atherosclerosis in atherogenic apoE-/- C57BL/6 mice on high-fat diet

Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD)

New ways of initiating translation in eukaryotes.

Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon

Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

Placenta nutrient transport-related gene expression: the impact of maternal obesity and excessive gestational weight gain.

Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins

Posttranscriptional Regulation of Collagen α1(I) mRNA in Hepatic Stellate Cells ⬇️

Prenatal physical activity and diet composition affect the expression of nutrient transporters and mTOR signaling molecules in the human placenta.

Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway.

RNA structure: new messages in translation, replication and disease. Workshop on the role of RNA structures in the translation of viral and cellular RNAs.

RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation.

RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha

Spurious splicing within the XIAP 5' UTR occurs in the Rluc/Fluc but not the betagal/CAT bicistronic reporter system

Strong eukaryotic IRESs have weak secondary structure

Structure and mode of action of kikA, a genetic region lethal to Klebsiella oxytoca and associated with conjugative antibiotic-resistance plasmids of the IncN group

Subcellular relocalization of a trans-acting factor regulates XIAP IRES-dependent translation.

Targeting endogenous inhibitors of apoptosis for treatment of cancer, stroke and multiple sclerosis.

The IAP proteins

The eIF4G homolog DAP5/p97 supports the translation of select mRNAs during endoplasmic reticulum stress.

The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2.

The role of IRES trans-acting factors in carcinogenesis.

The sensitivity of the yeast, Saccharomyces cerevisiae, to acetic acid is influenced by DOM34 and RPL36A.

The translation of an antiapoptotic protein HIAP2 is regulated by an upstream open reading frame

The utrophin A 5'-UTR drives cap-independent translation exclusively in skeletal muscles of transgenic mice and interacts with eEF1A2

The utrophin A 5'-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers.

Translation control in apoptosis

Translation mechanism and regulation: old players, new concepts. Meeting on translational control and non-coding RNA.

Translational control in stress and apoptosis

Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element.

Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6: a novel mechanism of tumor cell survival