List of works - Jun Shirakawa

A Randomized Controlled Trial of a Mini Low-Carbohydrate Diet and an Energy-Controlled Diet Among Japanese Patients With Type 2 Diabetes.

scientific article published on 26 January 2018

Bullous Pemphigoid and Dipeptidyl Peptidase 4 Inhibitors: A Disproportionality Analysis Based on the Japanese Adverse Drug Event Report Database

scientific article published on 12 July 2018

Comparison of pre- versus post-meal administration of voglibose in men with or without impaired glucose tolerance

scientific article

Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics.

scientific article published on 30 July 2015

Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions.

scientific article

Correlations of fasting and postprandial blood glucose increments to the overall diurnal hyperglycemic status in type 2 diabetic patients: variations with levels of HbA1c

scientific article published on 19 January 2010

Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation

scientific article published on 10 October 2016

DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid

scientific article published on March 2016

Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice.

scientific article

Double-blind randomized clinical trial of the effects of ezetimibe on postprandial hyperlipidaemia and hyperglycaemia

scientific article published on 9 August 2012

Drug-induced hyperglycemia in the Japanese Adverse Drug Event Report database: association of evelolimus use with diabetes

scientific article published on 02 April 2019

ERRγ-A New Player in β Cell Maturation

scientific article published on 01 May 2016

Effects of liraglutide on β-cell-specific glucokinase-deficient neonatal mice.

scientific article

Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet

scientific article published on 16 May 2017

Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, β-cell functions, and β-cell proliferation in male mice

scientific article published on 08 April 2014

Evaluation of the appropriateness of using glucometers for measuring the blood glucose levels in mice

scientific article published on 6 May 2016

Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts

scientific article

Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass

scientific article

Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion

scientific article published on 20 November 2018

GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice.

scientific article published on 20 May 2017

Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells

scientific article published on 25 June 2013

Glucose- or insulin resistance-mediated β-cell replication: PKCζ integrates the proliferative signaling

scientific article published on August 2016

IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

scientific article published on 05 July 2016

Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets

scientific article published on 24 May 2017

Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance and β-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet

scientific article published on 07 February 2012

Influence of Timing of Insulin Initiation on Long-term Glycemic Control in Japanese Patients with Type 2 Diabetes: A Retrospective Cohort Study

scientific article published on 22 July 2019

Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation

scientific article

LFA-1 decreases the antigen dose for T cell activation in vivo

scientific article published on 21 July 2008

LFA-1-dependent lipid raft recruitment of DNAM-1 (CD226) in CD4+ T cell

scientific article published on 24 April 2006

Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor

scientific article published on 22 October 2020

Lipid-lowering agents inhibit hepatic steatosis in a non-alcoholic steatohepatitis-derived hepatocellular carcinoma mouse model.

scientific article published on 24 December 2015

Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes

scientific article published on 04 March 2019

Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway

scientific article published on 03 January 2020

Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906.

scientific article

Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice

scientific article published on 20 August 2013

Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality

scientific article published on 06 November 2019

Non-alcoholic fatty liver disease adversely affects the glycemic control afforded by sitagliptin

scientific article published on 01 July 2012

Novel factors modulating human β-cell proliferation

scientific article published on September 2016

Nuclear Export of FoxO1 Is Associated with ERK Signaling in β-Cells Lacking Insulin Receptors.

scientific article

Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation

scientific article

Pituitary abscess with panhypopituitarism showing T1 signal hyperintensity of the marginal pituitary area: a non-invasive differential diagnosis of pituitary abscess and pituitary apoplexy

scientific article published on 16 March 2009

Plasminogen activator inhibitor-1 is associated with renal dysfunction independent of BMI and serum lipid levels in patients with type 2 diabetes

scientific article published on 10 April 2012

Potential linkage between dipeptidyl peptidase-4 inhibitor use and the risk of pancreatitis/pancreatic cancer

scientific article published on 27 November 2019

Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes

scientific article

Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation

scientific article published on 7 April 2016

Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes

scientific article published on 25 May 2011

Requirement of the serine at residue 329 for lipid raft recruitment of DNAM-1 (CD226).

scientific article

SUSTAINable management of type 2 diabetes: feasibility of use and safety of semaglutide.

scientific article

Selective and sequential loss of transcriptional factors: A hallmark of β-cell failure in type 2 diabetes?

scientific article published on 28 March 2014

SerpinB1 Promotes Pancreatic β Cell Proliferation

scientific article

Serum Quantitative Proteomic Analysis Reveals Soluble EGFR To Be a Marker of Insulin Resistance in Male Mice and Humans

scientific article

Signaling between pancreatic β cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation

scientific article published on 01 March 2018

Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects

scientific article published on 29 September 2020

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

scientific article published on 20 May 2019

Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy

scientific article published on 19 August 2014

[Glucokinase activators]

scientific article published on 01 May 2012

β-Cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.

scientific article published on 11 February 2014

List of works by Jun Shirakawa

A Randomized Controlled Trial of a Mini Low-Carbohydrate Diet and an Energy-Controlled Diet Among Japanese Patients With Type 2 Diabetes.

Bullous Pemphigoid and Dipeptidyl Peptidase 4 Inhibitors: A Disproportionality Analysis Based on the Japanese Adverse Drug Event Report Database

Comparison of pre- versus post-meal administration of voglibose in men with or without impaired glucose tolerance

Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics.

Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions.

Correlations of fasting and postprandial blood glucose increments to the overall diurnal hyperglycemic status in type 2 diabetic patients: variations with levels of HbA1c

Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation

DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid

Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice.

Double-blind randomized clinical trial of the effects of ezetimibe on postprandial hyperlipidaemia and hyperglycaemia

Drug-induced hyperglycemia in the Japanese Adverse Drug Event Report database: association of evelolimus use with diabetes

ERRγ-A New Player in β Cell Maturation

Effects of liraglutide on β-cell-specific glucokinase-deficient neonatal mice.

Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet

Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, β-cell functions, and β-cell proliferation in male mice

Evaluation of the appropriateness of using glucometers for measuring the blood glucose levels in mice

Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts

Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass

Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion

GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice.

Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells

Glucose- or insulin resistance-mediated β-cell replication: PKCζ integrates the proliferative signaling

IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets

Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance and β-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet

Influence of Timing of Insulin Initiation on Long-term Glycemic Control in Japanese Patients with Type 2 Diabetes: A Retrospective Cohort Study

Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation

LFA-1 decreases the antigen dose for T cell activation in vivo

LFA-1-dependent lipid raft recruitment of DNAM-1 (CD226) in CD4+ T cell

Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor

Lipid-lowering agents inhibit hepatic steatosis in a non-alcoholic steatohepatitis-derived hepatocellular carcinoma mouse model.

Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes

Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway

Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906.

Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice

Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality

Non-alcoholic fatty liver disease adversely affects the glycemic control afforded by sitagliptin

Novel factors modulating human β-cell proliferation

Nuclear Export of FoxO1 Is Associated with ERK Signaling in β-Cells Lacking Insulin Receptors.

Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation

Pituitary abscess with panhypopituitarism showing T1 signal hyperintensity of the marginal pituitary area: a non-invasive differential diagnosis of pituitary abscess and pituitary apoplexy

Plasminogen activator inhibitor-1 is associated with renal dysfunction independent of BMI and serum lipid levels in patients with type 2 diabetes

Potential linkage between dipeptidyl peptidase-4 inhibitor use and the risk of pancreatitis/pancreatic cancer

Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes

Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation

Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes

Requirement of the serine at residue 329 for lipid raft recruitment of DNAM-1 (CD226).

SUSTAINable management of type 2 diabetes: feasibility of use and safety of semaglutide.

Selective and sequential loss of transcriptional factors: A hallmark of β-cell failure in type 2 diabetes?

SerpinB1 Promotes Pancreatic β Cell Proliferation

Serum Quantitative Proteomic Analysis Reveals Soluble EGFR To Be a Marker of Insulin Resistance in Male Mice and Humans

Signaling between pancreatic β cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation

Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy

[Glucokinase activators]

β-Cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.